MEDRx Co., Ltd. Patent applications |
Patent application number | Title | Published |
20150216796 | Microneedle Array Coated with Drug Composition - The present invention provides a microneedle array which makes it possible to quantitatively and accurately inject a drug into the skin. | 08-06-2015 |
20150174249 | Composition for Patch Preparation Comprising Drug, Organic Solvent, Lipophilic Mass Base, and Powder - The present disclosure provides a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug. | 06-25-2015 |
20140066471 | EXTERNAL PREPARATION COMPOSITION COMPRISING FATTY ACID-BASED IONIC LIQUID AS ACTIVE INGREDIENT - Disclosed is an external preparation composition having good transdermal absorbability. An external preparation composition having excellent transdermal absorbability can be produced by dissolving a medicinal substance or a salt thereof in a fatty acid-based ionic liquid to form a composite ionic composition of the medicinal substance. The external preparation composition can be used as a liquid preparation, an ointment, a cream, a plaster or the like, and enables to provide a preparation having excellent transdermal absorbability. | 03-06-2014 |
20130226112 | PERCUTANEOUS ABSORBENT AND ADHESIVE SHEET FOR SKIN PATCH - The invention provides an adhesive sheet for adhesion to the skin, as well as a transdermal absorption preparation containing the adhesive sheet and a drug or a pharmaceutically acceptable salt thereof in the adhesive layer of the adhesive sheet. The adhesive sheet comprises a support and an adhesive layer formed on the support, wherein the adhesive layer contains at least a thermoplastic elastomer, and more than 300 parts by weight of liquid paraffin per 100 parts by weight of the elastomer, and wherein the adhesive layer contains not more than 10 wt % of a tackifier. | 08-29-2013 |
20130224262 | TRANSDERMAL PREPARATION - The invention provides a transdermal absorption preparation showing sufficient adhesiveness on adhesion to the skin, causing low skin irritation, and capable of well controlling releaseability of lidocaine. The transdermal absorption preparation contains a support and an adhesive layer formed on the support. The adhesive layer contains a drug, as well as a thermoplastic elastomer, more than 300 parts by weight of liquid paraffin per 100 parts by weight of the elastomer, not more than 10 wt % of a tackifier, lidocaine, and an organic acid. | 08-29-2013 |
20130209660 | MICRO-NEEDLE COATING METHOD - Since all methods of applying a drug liquid to a tip portion of a microneedle are application of the drug liquid in an open system, evaporation of the solvent from the drug liquid is unavoidable, such that the concentration of the drug liquid changes easily, and a large amount of the drug liquid is necessary. The invention provides a method of applying a drug to a pin-frog-shaped microneedle by using a small amount of the solution and without variation of the concentration of the drug liquid. A member having plural grooves is produced, and one end thereof is immersed in a drug liquid tank to fill the grooves with the drug liquid. The drug can be uniformly applied to a tip portion of the microneedle by setting the pin-frog-shaped microneedle to pass through the drug liquid in the grooves. | 08-15-2013 |
20130006187 | ADHESIVE PATCHING AID FOR MICRONEEDLE ADHESIVE SKIN PATCH - The invention provides an applicator that holds a microneedle to facilitate puncture of the skin and includes an assisting tool as a supporting base to set the microneedle and an adhesive sheet such as a tape and the like, on the side face of the assisting tool to enable close adhesion of the microneedle puncturing the skin. | 01-03-2013 |
20120184916 | APPLICATOR DEVICE OF PINHOLDER TYPE MICRONEEDLE - Provided is a microneedle device which protects a microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture to administer a drug. By studying the relationship between the device to be pressed to the skin and the height of the elevation of the skin surface during the pressing, it is found that there is a positive correlation between the placement and interval of skin fixing members and the height of the elevation of the skin. It is furthermore found that the elevated skin surface is always parallel to the flat plate of the device. This reveals that since the microneedle installed in the device can be inserted at right angle to the skin surface, the skin can reliably be punctuated avoiding the breakage etc. of the small needles of the microneedle. Thus, a microneedle patch which is easily portable and ensures convenient drug administration to the skin can be produced. | 07-19-2012 |
20120184563 | COMPOSITION FOR EXTERNAL APPLICATION COMPRISING ARIPIPRAZOLE AND ORGANIC ACID AS ACTIVE INGREDIENTS - [Summary] An external preparation formulation superior in the transdermal absorbability has been desired as a new administration route of aripiprazole. Transdermal absorption of aripiprazole has been enabled for the first time by appropriately combining aripiprazole and an organic acid (particularly fatty acid with low lipophilicity). That is, it has been found that more superior transdermal absorbability can be achieved by forming a salt by using a compound showing lipophilicity within the range of −1.5-2, such as fatty acid and the like. It has been further found that the transdermal absorbability is remarkable improved by appropriately selecting the solvent composition. As a result, since a new dosage form of aripiprazole other than oral preparation has been developed, a new transdermal absorption preparation of aripiprazole can be provided. | 07-19-2012 |
20120080119 | MEDICATION LIQUID SUPPORTING JIG AND METHOD OF APPLYING MEDICATION TO MICRO-NEEDLE USING SAME - Provided are a jig for uniformly applying a drug liquid to a microneedle, and a method of applying a drug to a microneedle using same. Grooves of a number corresponding to the number of rows of small needles of a microneedle are formed in the surface of a flat plate jig or of a roller-like jig, and a drug liquid is filled and held in the grooves. The drug liquid is applied to the microneedle by inserting the small needles of the microneedle into the surface of the drug liquid held in the narrow grooves, and immersing the small needles in the drug liquid. By this, the drug liquid is uniformly applied to the small needles of the microneedle without unevenness between the central section and the peripheral section of each microneedle, and thus the microneedles having good quality can be easily manufactured. | 04-05-2012 |
20120029434 | APPLICATOR FOR MICRONEEDLE ARRAY - Provided is a microneedle device which protects microneedle, has an easily portable shape, is free from such problems as breakage of small needles in the step of puncturing the skin with the microneedle, and ensures appropriate skin puncture for administering a drug. By studying the relationship between a device to be pressed to the skin and the height of an elevation on the skin surface under the pressing and thus producing a device equipped with microneedle that are embedded in a concave part having a definite depth, the microneedle can be surely and easily inserted and punctured into the skin while avoiding such problems as breakage of the small needles of the microneedle. Thus, a microneedle patch formulation, which is easily portable and ensures convenient drug administration to the skin, can be produced. | 02-02-2012 |
20110294860 | AQUEOUS ORAL PREPARATION OF STABLE AMLODIPINE - The invention provides a stable and rapidly disintegrable aqueous oral preparation (liquid or jelly preparation) of amlodipine. The liquid preparation comprises an anionic surfactant having a sulfuric acid group or a sulfonic acid group as a stabilizer in an aqueous solution of amlodipine, at pH 5-7, while the jelly preparation further comprises a gelling agent, a fine powder solid, and a gelling regulator. | 12-01-2011 |
20110092438 | Composition for external application comprising transcription factor decoy as active ingredient - The present invention provides an external preparation composition of transcription factor decoy of good skin permeability, the composition comprising a transcription factor decoy dissolved in a fatty acid-based ionic liquid obtained from a fatty acid having 2 to 20 carbon atoms and an organic amine compound having 4 to 12 carbon atoms. | 04-21-2011 |
20100036002 | PHARMACEUTICAL COMPOSITION COMPRISING POROUS DRY MATRIX - The invention provides a porous dry matrix preparation comprising at least a polymeric thickener and an excipient ingredient, wherein (1) the content of the polymeric thickener is down to 0.5 w/w % and up to 14 w/w %, (2) the content of the excipient ingredient is down to 30 w/w % and up to 80 w/w %, (3) the void ratio is not less than 20%, and (4) the water activity is not more than 0.55, or water content is not more than 10 w/w %. | 02-11-2010 |
20100029704 | SALT OF NONSTEROIDAL ANTI-INFLAMMATORY DRUG AND ORGANIC AMINE COMPOUND AND USE THEREOF - The invention provides a salt, particularly an ionic liquid, of a non-steroidal anti-inflammatory drug (NSAID) comprising a carboxylic acid and an organic amine compound, as well as a method of producing such a salt. | 02-04-2010 |
20100004608 | PROCESS FOR PRODUCING MICRONEEDLE OF THERMOSENSITIVE SUBSTANCE - The invention provides a method of producing a microneedle. A jig is heated to a temperature above the level at which a temperature-sensitive material that exhibits thermoplastic deformation becomes viscoplastic, the jig is brought into contact with the temperature-sensitive material, and then the jig is pulled part from the temperature-sensitive material to elongate the portion of the temperature-sensitive material in contact with the jig, whereby acicular projections are formed. | 01-07-2010 |
20090264664 | PREPARATION FOR EXTERNAL APPLICATION COMPRISING SALT OF MAST CELL DEGRANULATION INHIBITOR HAVING CARBOXYL GROUP WITH ORGANIC AMINE - Mast cell degranulation inhibitors having a carboxyl group have not been developed as external preparations due to the low transdermal permeability thereof. By formulating external preparations thereof, side effects on the internal organs by oral administration can be avoided. Some of the mast cell degranulation inhibitors show drastically inferior photostability, which is also one cause of suppressed development of the drug as an external preparation. | 10-22-2009 |