| Medizinische Hochschule Hannover Patent applications |
| Patent application number | Title | Published |
|---|
| 20120136452 | KNEE JOINT PROSTHESIS AND RELATED METHOD - The present invention relates to a knee joint prosthesis having a tibial component and a femoral component. The tibial component includes a fixation portion fixed to an upper end of a prepared tibia and a ceramic bearing portion presenting articulation surface(s). The femoral component is fixed to a lower end of a prepared femur and comprises a ceramic body portion presenting articulation surface(s). The respective articulation surfaces of the tibial and femoral components are configured for essentially congruent engagement over a full range of movement of the prosthesis, and the bearing portion of the tibial component is adapted for movement relative to the fixation portion. Also disclosed is an apparatus and a method for finishing articulation surfaces of ceramic components of a knee joint prosthesis, including the steps of combining the ceramic bearing portion and the ceramic body portion, and imparting relative movement to the bearing portion and/or the body portion. | 05-31-2012 |
| 20120129193 | DEVICE AND METHOD FOR ANALYSING CELLS - There is provided a carrier substrate for nonspecific immobilization of living bacterial and/or eukaryotic cells, especially of animal cells, which can be present as single cells, cell agglomerates or tissue sections. The surface of the carrier substrate is provided at least sectionally with a layer having or consisting of oligonucleic acids, preferably having ribonucleic acids covalently coupled to the carrier substrate, e.g. RNA, preferably single-stranded or double-stranded DNA. | 05-24-2012 |
| 20120020504 | LIGHT ACTIVATED HEARING DEVICE - The invention relates to a hearing aid device for humans with impaired hearing, who have an at least partially functional cochlea and a functional nervous signalling pathway from the cochlea via the auditory nerve to the brain. The hearing aid device contains a receiver, a transducer of the sound or other acoustic signals into electrical current serving as a signal representing a sound, a pulsed irradiation source connected to the transducer for receiving the electrical current and for generating modulated pulsed irradiation in dependence from the electrical current, and preferably one or more optical fibres optically coupled to the exit of the pulsed irradiation source, wherein the optical path for conduction of irradiation within the device ends directly opposite a functional element of the natural vibration transduction pathway, e.g. adjacent the skull, the tympanic membrane, the hammer, the incus, the stapes, the outside of the cochlea, the otic capsule, the round window membrane, or the oval window membrane. | 01-26-2012 |
| 20110311966 | DETECTION CONJUGATE AND METHOD FOR ANALYSIS - The invention provides a combination of reagents as a test kit containing a detection conjugate having a binding portion and a reagent for deactivating of the fluorochrome portion by interaction with the linker. The binding portion especially is an antibody portion. The detection conjugate has a fluorochrome portion connected to the antibody portion, and a linker connected to the fluorochrome portion, wherein the linker comprises an oligonucleotide. The fluorochrome portion can be deactivated by hydrolysis of the linker or by specific hybridization of a quencher having an oligonucleotide to the linker. | 12-22-2011 |
| 20110293560 | METHOD FOR DETERMINING IMMUNE SYSTEM ACTIVITY AND MEDICAMENT FOR INFLUENCING SAME - A method for the determination of the state of the immune system, e.g. the state of activity and activation, respectively, of the immune system, using the determination of presence of a blood or peripheral mononuclear cell or plasma marker. The marker can be determined directly, e.g. by determination of its titre using a specific antibody against the marker, or indirectly, e.g. by the determination of the mRNA encoding the marker. Further, the invention relates to the use of the protein corresponding to the marker analysed in the analytical method, as a medicament, especially for influencing, e.g. for activating the immune system, more specifically for activating the cytotoxicity of NK cells as well as for activating the cytotoxicity and the proliferation of T-cells. | 12-01-2011 |
| 20110104275 | METHODS AND KITS FOR TREATING CLUSTER HEADACHE DISORDERS - The invention features methods and kits employing bromolysergide in therapies for the treatment of cluster headache disorders. | 05-05-2011 |
| 20110086367 | PHARMACEUTICALS FOR INFLUENCING THE REACTION OF THE HUMAN IMMUNE SYSTEM - The present invention uses the potency and efficacy of human glycoprotein-A repetitions predominant protein (GARP), the gene of which is located on chromosome 11q13-11q14 in the reprogramming of antigen-specific effector T-helper cells, which are CD4 | 04-14-2011 |
| 20100228359 | IMPLANT OF CROSS-LINKED SPIDER SILK THREADS - The present invention provides the use of spider silk threads for the production of tissue implants for medical use. A scaffolding matrix is provided for implantation, which matrix is comprised of spider silk thread and/or segments of spider silk threads which are cross-linked. The cross-linked spider silk thread segments essentially maintain a three-dimensional shape into which it is formed by pressing between moulds. The three-dimensional shape obtainable by moulding is sufficiently stable to be used as an implant or for colonizing by mammalian cells while essentially maintaining the three-dimensional shape. In a further embodiment, the scaffolding matrix of cross-linked spider silk segments is at least partially covered by cells autologous or heterologous to the implant recipient. The matrix colonized with cells is obtainable by in vitro cultivation of isolated cells in suspension with the scaffolding matrix. | 09-09-2010 |
| 20100198317 | COCHLEA STIMULATOR - The invention provides a cochlea stimulator for implantation comprising optical fibres of which are coupled to an irradiation source that is controlled by a modulator to generate irradiation specific for a pre-determined range of sound-frequencies. The cochlea stimulator effects a frequency-specific activation of the organ of Corti needed for speech perception especially in noisy environment and more complex sounds. For imparting excitation signals which are generated by modulated pulsed laser irradiation conducted within an optical fibre in order to elicit nervous signals in residual functional organ of Corti sections, the auditory prosthesis preferably contains optical fibres which are dimensioned to terminate in end sections within the cochlea at different sites or sections of the organ of Corti. e.g. having different lengths for locating their end sections at different internal parts of the cochlea. | 08-05-2010 |
| 20100197995 | LIGHT ACTIVATED HEARING AID DEVICE - The invention relates to a hearing aid device for humans with impaired hearing, who have an at least partially functional cochlea and a functional nervous signalling pathway from the cochlea via the auditory nerve to the brain. The hearing aid device contains a receiver, a transducer of the sound or other acoustic signals into electrical current serving as a signal representing a sound, a pulsed irradiation source connected to the transducer for receiving the electrical current and for generating modulated pulsed irradiation in dependence from the electrical current, and preferably one or more optical fibres optically coupled to the exit of the pulsed irradiation source, wherein the optical path for conduction of irradiation within the device ends directly opposite a functional element of the natural vibration transduction pathway, e.g. adjacent the skull, the tympanic membrane, the hammer, the incus, the stapes, the outside of the cochlea, the otic capsule, the round window membrane, or the oval window membrane. | 08-05-2010 |
| 20090275818 | APPARATUS AND SYSTEM FOR INSERTION OF AN IMPLANT - The present invention provides an apparatus for insertion of a flexible implant into a body section of an implant recipient, the apparatus comprising an elongate guiding section having a longitudinal axis and an inner volume for removably receiving the implant, an elongate first receiving member connected at its first end to a first actuator arranged for moving the first receiving member within the guiding section in parallel to the axis of the guiding section, a first control device for controlling the actuation of the first actuator, wherein first receiving member at its second end opposite its first end carries a gripping unit for releasably gripping a proximal end of the implant, a second actuator for controlling the configuration of the implant, and a second control device for controlling the actuation of the second actuator. | 11-05-2009 |
| 20090197953 | Pharmaceutical composition for the specific treatment of acute myeloid leukemia - The present invention provides the use of all-trans retinoic acid for the production of a pharmaceutical composition for the treatment of acute myeloid leukemia, which use is characterized in that the patients are selected from the group of non-M3 acute myeloid leukemia patients according to a physiologic concentration, e.g. a level of MN1 below a certain critical level analysed in total blood cells, preferably analysed in bone marrow cells. The critical level of MN1 can be determined according to known methods, e.g. by specific determination of the presence of MN1, e.g. using specific anti-MN1 antibody, e.g. in an ELISA or in another immuno specific assay. Preferably, the level of MN1 is determined at its transcription level, e.g. as the concentration of mRNA encoding MN1. | 08-06-2009 |
| 20090041826 | Tissue Implant and Process for Its Production - The present invention relates to a process for producing an implant for medical purposes, to the implant obtainable by the process, and to the bioreactor used for the production of the implant. The implants of the invention can be used as implantable prostheses having essentially the functional characteristics of the following tissues: ligaments and tendons, bone and chondrogenic tissues, e.g. intervertebral discs, and combinations of bone tissue with cartilage tissue, e.g. sections of joints having the cartilaginous surface of a joint surface hacked by bone tissue. According to the invention, a porous matrix material is incubated under cell culture conditions with cells while the matrix is exposed to positive pressure on one side and negative pressure on another side for effective colonization of the matrix. | 02-12-2009 |
