MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA Patent applications |
Patent application number | Title | Published |
20130216630 | BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY - This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials pre-loaded with certain amounts of osteoclastic activity inhibitors for use in methods to control and/or induce bone growth in primates. | 08-22-2013 |
20120277879 | OSTEOGENIC DEVICE FOR INDUCING BONE FORMATION IN CLINICAL CONTEXTS - This invention relates to an osteogenic device for the de novo induction of bone formation in a mammal. The device contains a at least one transforming growth factor-&bgr;3 isoform and a retention matrix. The device is introduced by direct injection or surgical implantation into an area where de novo bone formation is desired and, once implanted, the retention matrix acts to retain the TGF-&bgr;3 isoform at its place of introduction and forms a scaffold for generated bone, the induction of which is promoted by the TGF-&bgr;3 isoform. The device may be used to induce bone growth where bone has been debrided in a surgical procedure and it may also be used to transform neoplastic primary and/or metastatic secondary masses into bone thus facilitating surgical debridement thereof. | 11-01-2012 |
20110307074 | BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY - This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials pre-loaded with certain amounts of osteoclastic activity inhibitors for use in methods to control and/or induce bone growth in primates. | 12-15-2011 |
20080248116 | COMPOSITION FOR STIMULATING DE NOVO BONE INDUCTION - This invention relates to a composition for stimulating de novo bone induction in a mammal, to the use of this composition in stimulating de novo bone induction in a mammal and to a method of treating a mammal to stimulate de novo bone induction. The use and method involve introducing the composition, preferably by local injection, into the mammal at a site where de novo bone induction is desired. The composition consists of a combination of a bone morphogenetic protein and a reconstituted basement membrane which, in a preferred embodiment of the invention is Matrigel®. The Matrigel® serves, at least partly, to retain the bone morphogenetic protein at the site of introduction for a period sufficient to trigger a bone differentiation cascade. | 10-09-2008 |