| MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Patent applications |
| Patent application number | Title | Published |
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| 20120135884 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 05-31-2012 |
| 20120135542 | METHODS AND MATERIALS FOR DIAGNOSING LIGHT CHAIN AMYLOIDOSIS - This document relates to methods and materials involved in diagnosing light chain amyloidosis. For example, methods and materials for using exosomes to diagnose a mammal (e.g., a human) as having immunoglobulin light chain amyloidosis are provided. | 05-31-2012 |
| 20120130392 | NECROSECTOMY ASSIST DEVICE - Endoscopic approach necrosectomy assist devices and methods of use to collect necrotic pancreatic tissue. One embodiment of the device includes a body, an expandable cap on a distal end of the body, an actuating mechanism for causing the cap to move between a reduced diameter retracted state and an expanded diameter operational state, a tissue collecting band on the cap, and a band actuating mechanism. Another embodiment of the invention includes a handle and a scoop on the handle. The scoop is movable between a reduced diameter retracted state and an expanded diameter operational state. The scoop is formed from a shape memory material and is self biased to the operational state. Blades, rake tips, cutters or abrasive can be included on the scoop. | 05-24-2012 |
| 20120130391 | IMPLANTING ORGAN PORTS - This document relates to medical devices (e.g., organ ports such as transapical heart ports) and methods and materials for implanting and using such medical devices. For example, organ ports and entry devices that can be used to implant an organ port are provided. | 05-24-2012 |
| 20120130248 | METHOD AND APPARATUS FOR MULTIPLE-WAVE DOPPLER VELOCITY METER - A method and system for determining a velocity of a moving object such as a body or a stream. The object is irradiated in a non-collinear configuration with multiple ultrasound waves overlapping in a region-of-interest (ROI) of the object. An response wave, resulting from the non-linear interaction among the incident waves and the object, is detected and the frequency variations of the response wave are determined. Data representing a Doppler-shift of this frequency is further determined and processed to calculate the velocity of the moving object. | 05-24-2012 |
| 20120130234 | SYSTEM AND METHOD FOR TUMOR ANALYSIS AND REAL-TIME BIOPSY GUIDANCE - A system and method for molecular breast imaging (MBI) provides enhanced tumor analysis and, optionally, a real-time biopsy guidance. The system includes a detector head including a gamma ray detector and a collimator. The collimator include multiple collimation sections having respectively different spatially-oriented structures. In addition or alternatively, the multiple collimating section have respectively different collimation characteristics. An image of the tissue acquired with the system may include spatially separate image portions containing image information about the same portion of the imaged tissue. A system is optionally configured to acquire updatable images to provide real-time feedback about the biopsy procedure. | 05-24-2012 |
| 20120125792 | DEVICES, KITS AND METHODS FOR SURGICAL FASTENING - Devices, kits and methods used to deliver provide radioactive material and a buttress element in a variety of procedures that typically involve the use of a stapler to fasten the buttress material to tissue are described herein. The radioactive material is provided to deliver radiation energy to the tissue. One or more medically useful agents may be provided in addition to the radioactive material. | 05-24-2012 |
| 20120116432 | TISSUE SECTIONING BLADE - A cutting device or tissue sectioning blade is disclosed that includes a blade body including a straight cutting edge, a back edge located opposite the straight cutting edge, a first end extending from the back edge to the straight cutting edge, and a second end located opposite the first end and extending from the back edge to the straight cutting edge. | 05-10-2012 |
| 20120114755 | METHODS AND MATERIALS FOR TISSUE REPAIR - This document relates to methods and materials for treating tendon injury. Specifically, methods and materials for preventing adhesion formation and promoting tissue healing following tendon injury and surgical repair are provided. | 05-10-2012 |
| 20120108514 | LONG ACTING ATRIAL NATRIURETIC PEPTIDE (LA-ANP) AND METHODS FOR USE THEREOF - Materials and Methods related to making and using natriuretic polypeptides having a mutation that results in an extended carboxy terminus. | 05-03-2012 |
| 20120107248 | IMAGING GASTROINTESTINAL VOLUMES AND MOTILITY - This disclosure relates to contrast agents and compositions comprising the same that are capable of blocking the hydrogen/potassium adenosine triphosphatase enzyme system, and more particularly to the use of such compositions for imaging stomach and colon volume and motility. | 05-03-2012 |
| 20120107243 | PEPTIDE-MEDIATED NON-COVALENT DELIVERY OF ACTIVE AGENTS ACROSS THE BLOOD-BRAIN BARRIER - The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents. | 05-03-2012 |
| 20120101770 | FALL DETECTION - A fall detection device may be uniquely associated with a wearer. The fall detection device may predict whether a fall event is imminent based on kinematic information of the wearer's body. The device may also confirm whether the wearer actually experienced a fall event based on additional kinematic information. | 04-26-2012 |
| 20120100533 | METHOD FOR DETERMINING THE CARDIO-GENERATIVE POTENTIAL OF MAMMALIAN CELLS - This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation. | 04-26-2012 |
| 20120092247 | COMPUTER INPUT DEVICE - Computer input devices are described herein for use in manipulating digital images on a display apparatus. | 04-19-2012 |
| 20120077263 | METHODS AND MATERIALS FOR ISOLATING EXOSOMES - This document relates to methods and materials involved in obtaining exosomes. For example, methods and materials for obtaining exosomes from biological samples such as urine samples are provided. | 03-29-2012 |
| 20120071987 | REMOVABLE AND/OR RETRIEVABLE STENTS AND KITS - Stents, kits and methods of using the stents are described herein. The stents may include one or more features that assist in removal and/or retrieval of the stent after deployment. | 03-22-2012 |
| 20120064626 | B7-H7 ANTIBODIES AND METHOD OF USE - The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 03-15-2012 |
| 20120059459 | TREATING CONGESTIVE HEART FAILURE - This document relates to materials and methods for circulatory bypass of a ventricle in the heart of a mammal. For example, materials and methods for bypassing a permanently or temporarily impaired left ventricle in the heart of a mammal (e.g., a human) are provided. | 03-08-2012 |
| 20120059225 | EXPANDABLE SPACE-OCCUPYING TISSUE RETRACTORS - This document provides methods and materials for retracting tissue during a minimally invasive surgical procedure (e.g., an endoscopic surgical procedure). For example, methods and materials for using an expandable space-occupying tissue retractor during an endoscopic surgical procedure such as a laparoscopic cholecystectomy procedure or a NOTES procedure are provided. | 03-08-2012 |
| 20120058047 | METHOD OF USING AN ANTI-CD137 ANTIBODY AS AN AGENT FOR RADIOIMMUNOTHERAPY OR RADIOIMMUNODETECTION - The current invention relates to the development and methods of use of a recombinant agonistic antibody anti-human CD137, and glycosylation variants thereof. These antibodies act as anti-cancer agents and/or immune modulators that are effective in shrinking solid tumors or other cancerous indications and preventing their recurrence. The types of cancer for which the contemplated antibody is effective in treating also include leukemia and lymphoma. In a preferred embodiment the recombinant antibodies of the current invention were produced in and purified from the milk of transgenic animals. In another preferred embodiment of the current invention the agonistic anti-CD137 antibodies of the invention can be conjugated to radionuclides for radioimmunodetection or radioimmunotherapeutic purposes, or conjugated to a toxin for enhanced therapeutic treatment of various cancers. | 03-08-2012 |
| 20120040432 | METHODS AND MATERIALS FOR DELIVERING MOLECULES - This document relates to methods and materials involved in delivering molecules to a mammal. For example, methods and materials for using nanoparticles to increase the half-life and the bioavailability of molecules administered to a mammal are provided. | 02-16-2012 |
| 20120035072 | KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS - The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD. | 02-09-2012 |
| 20120029548 | ISOMARK NEEDLE - A device for marking a treatment isocenter on a patient's body includes a base including alignment indicia; a marker disposed over the base and positioned relative to the indicia for marking the isocenter on the patient's body; and an actuator for actuating the marker and causing a mark indicating the isocenter to be made on the patient's body. The actuator can include a button and a spring coupled to the marker. Compressing the actuator causes the marker to travel through an ink well prior to piercing the patient's skin. The device is disposable as intended for a single use. | 02-02-2012 |
| 20120022558 | TISSUE LIGATION DEVICES AND METHODS - Devices and methods for ligating structures where the loop of the ligation element can be temporarily pre-tightened without locking the loop. This pre-tightening without locking allows the loop of the ligation element to be loosened and repositioned, if necessary, before locking the loop around the anatomical structure. | 01-26-2012 |
| 20120021920 | RADIATION THERAPY BIOMARKERS - Materials and methods related to using biomarkers for prediction of response to radiation therapy. | 01-26-2012 |
| 20120008841 | SIMULTANEOUS DUAL WINDOW/LEVEL SETTINGS FOR DISPLAY OF CT COLONOGRAPHY IMAGES - A method for processing and displaying colonography image data. First distance tissue pixels representative of tissue within a first distance of gas pixels representative of gas are processed with a first window/level setting to generate a first setting set of image pixels. Second distance tissue pixels representative of tissue within a second distance of the gas pixels are processed with a second window/level setting to generate a second setting set of image pixels. The second distance is a distance greater than the first distance. A colonography image including both the first and second setting sets of image pixels is then displayed. | 01-12-2012 |
| 20110319762 | INTRAVASCULAR ULTRASOUND DETECTION OF BLOOD-FLOW DISTRIBUTION IN AN ARTERIAL WALL - A system and method for quantitative determination of density of vasa vasorum in an arterial wall that utilizes a detection of temporal and/or spatial displacement of blood-flow with the use of intravascular ultrasound system. Locations of extrema in the spatial distribution can be identified to detect vascular defects. The system and method support a clinically-useful application for early detection of indicators of diseases, such as coronary atherosclerosis. | 12-29-2011 |
| 20110319756 | Method for Ultrasound Vibrometry Using Orthogonal Basis Functions - A method for measuring a mechanical property of a subject includes using an ultrasound transducer to apply ultrasonic vibration pulses to a location in a subject in order to induce shear waves at multiple prescribed orthogonal frequencies in the subject. The ultrasound transducer is directed by an excitation signal that is composed of multiple orthogonal basis functions, each having a given frequency component corresponding to the prescribed orthogonal frequencies. The power level of each orthogonal basis function is independently adjustable. The excitation signal can be sparsely sampled, or portions of the excitation signal can be removed in order to improve tissue vibration and to provide for the interleaving ultrasonic vibration and detection pulses. Ultrasonic detection pulses are applied to at least one motion detection point, from which echo signals are received. From the received echo signals, a motion signal is determined, from which mechanical properties of the subject are calculated. | 12-29-2011 |
| 20110315741 | SURGICAL STAPLER DELIVERY SYSTEMS AND METHODS OF ASSEMBLING THE STAPLERS - Surgical stapler delivery systems and methods of using the delivery systems to deliver and assemble surgical staplers are described herein. | 12-29-2011 |
| 20110306517 | REDUCING IRF4, DUSP22, OR FLJ43663 POLYPEPTIDE EXPRESSION - This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided. | 12-15-2011 |
| 20110298476 | APPLICATION OF OPEN AND/OR SHORT STRUCTURES TO BISECT DE-EMBEDDING - Application of open and short structures may result in improved accuracy in determination of ABCD parameters of a substantially symmetric THRU for purposes of bisect de-embedding. Either one or both of the open and/or short techniques may be used to improve results of an ABCD optimization algorithm. Bisect de-embedding may then be performed to determine the ABCD parameters of a device under test based on the ABCD parameters of the substantially symmetric THRU and measured s-parameters of the substantially symmetric THRU and the embedded device under test. | 12-08-2011 |
| 20110282144 | DIAGNOSTIC CAPSULES, DELIVERY/RETRIEVAL SYSTEMS, KITS AND METHODS - Diagnostic capsules, a variety of diagnostic capsule delivery systems for delivering a diagnostic capsule into an animal or human body cavity (e.g., into an animal or human bladder through a urethra), a variety of diagnostic capsule retrieval systems, a variety of kits that include diagnostic capsule delivery and retrieval systems and diagnostic capsules, and methods of using the same are described herein. | 11-17-2011 |
| 20110270843 | SPECIALIZED SEARCH ENGINES - A specialized search engine tool designed for subject matter experts facilitates access to information relevant to their area of expertise available on public domains over the Internet. The specialized search engine represents the collection of thousands of links that are sorted, resorted, categorized and placed into databases that interact with one another. The specialized search engine may permit a user to compare results from multiple databases and automatically submit their search query to many popular searchable databases and web sites from a central web page, without having to individually visit each site. In one example, the specialized search engine is a medical search engine. | 11-03-2011 |
| 20110270284 | MUSCULO-SKELETAL MESH AND FIXATION SYSTEM - A surgical mesh product and a method for attaching the surgical method product to a patient's bodily tissue. The surgical mesh product includes a fixation structure can be a grommet, an interwoven fiber or thread, or a reinforcing material. The fixation structure strengthens the mesh material (e.g. enhances the rip and/or tear strength) at locations where screws, tacks or other fasteners will be applied to secure the mesh product to a patient. The surgical mesh product is suitable for use in hernia repair. | 11-03-2011 |
| 20110270275 | METHODS AND DEVICES FOR LIGATING TUBULAR STRUCTURES - The devices and methods described herein may be used to ligate tissue, e.g., tubular structures where access is limited by using a sheath to deliver one or more sutures that can be deflected such that the end of the sheath forms a curve. | 11-03-2011 |
| 20110270056 | DETERMINATION OF PHOTODYNAMIC THERAPY (PDT) TREATMENT PARAMETERS - A photodynamic therapy system and methods determine the amount (concentration) of a photosensitizer agent present in the target tissue. The system may also determine the tissue oxygenation. The system may also determine light dosimetry parameters based on the amount of photosensitizer in the tissue and/or the tissue oxygenation. | 11-03-2011 |
| 20110269810 | SELECTIVE INHIBITORS OF C-JUN N-TERMINAL KINASE - Compositions and methods for treating, preventing, or ameliorating one or more symptoms, disorders, or conditions associated with particular c-Jun N-terminal kinase(s) (JNKs) activity are provided. Compositions contain small molecules such as pyrazoloanthrones. | 11-03-2011 |
| 20110251454 | Colonoscopy Tracking and Evaluation System - A system for tracking and evaluating a colonoscopy procedure performed using an endoscope includes a tracking subsystem, a processing subsystem and a display subsystem. The tracking subsystem provides information representative of the location of the endoscope within a patient's colon during the procedure. The processing subsystem generates visualization metrics from images produced by the endoscope during the procedure. The display subsystem is coupled to the tracking and processing subsystems to generate a visual display of the patient's colon with information representative of the visualization metrics at associated colon locations. | 10-13-2011 |
| 20110245468 | B7-H5, A COSTIMULATORY POLYPEPTIDE - B7-HS costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein. | 10-06-2011 |
| 20110244547 | SULFOTRANSFERASE 1E1 SEQUENCE VARIANTS - Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described. | 10-06-2011 |
| 20110236916 | METHODS AND MATERIALS FOR DETECTING COLORECTAL NEOPLASM - The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor associated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal. | 09-29-2011 |
| 20110233395 | VITAMIN D DEFICIENCIES - Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided. | 09-29-2011 |
| 20110217731 | PATHOLOGY SAMPLE PROCESSING WORKSTATION - A pathology sample processing workstation. The samples are positioned on containers having RFID tags and processed at stations having RFID transceivers coupled to a computer. Information regarding the samples can stored on the RFID tags and retrieved using the transceivers. | 09-08-2011 |
| 20110191082 | INTERACTIVE PLANNING TOOL AND SIMULATION SYSTEM FOR CRYOABLATION SURGERY - A cryoablation procedure at a surgery site is planned and simulated. One or more pre-procedure planning images of the surgery site are displayed on a user interface. Positioning of one or more virtual cryoprobes relative to the one or more pre-procedure planning images on the user interface is facilitated. Properties of the one or more virtual cryoprobes are selectable. Ice ball formation at the surgery site is then simulated based on the position and properties of the virtual cryoprobes. The simulated ice ball formation is based at least in part on tissue properties of the surgery site at each image unit of the one or more pre-procedure planning images. Boundaries of the simulated ice ball formation on the one or more pre-procedure planning images are then displayed. | 08-04-2011 |
| 20110190756 | MAPPING AND ABLATION CATHETER SYSTEM - A mapping and ablation catheter system including a radio frequency ablation source having an output, a mapping device, a catheter, and two or more capacitive components. The catheter may include two or more catheter electrodes, wherein two of the two or more catheter electrodes may be electrically coupled to the mapping device. Each of the two or more catheter electrodes may be electrically coupled to a capacitive component, wherein each capacitive component may be electrically coupled to the output of the radio frequency ablation source such that energy delivered to each catheter electrode of the two or more catheter electrodes passes through the capacitive component. | 08-04-2011 |
| 20110190660 | Biopsy Devices - Tissue biopsy devices having improved safety, adaptability, and firing power and speed. | 08-04-2011 |
| 20110184010 | METHOD OF TREATING MANTLE CELL LYMPHOMA - This invention provides the use of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) in the treatment or inhibition of mantle cell lymphoma. | 07-28-2011 |
| 20110183885 | NEO-TRYPTOPHAN - Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77. | 07-28-2011 |
| 20110183328 | DETECTING NEOPLASM - This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided. | 07-28-2011 |
| 20110144411 | SYSTEMS AND METHODS FOR MAGNETIC-ASSISTED THERAPEUTIC AGENT DELIVERY - Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces. | 06-16-2011 |
| 20110137102 | STEREOTACTIC INTRACRANIAL TARGET LOCALIZATION GUIDANCE SYSTEMS AND METHODS - Systems and methods of intracranial target localization using non-radiological direct surface imaging of one or more of the upper teeth. | 06-09-2011 |
| 20110131030 | LINK ANALYSIS COMPLIANCE AND CALIBRATION VERIFICATION FOR AUTOMATED PRINTED WIRING BOARD TEST SYSTEMS - A transmission line on a printed wiring board is tested and printed wiring board manufacturing variability is assessed. A response of the transmission line to a signal test pattern is measured. A network including a plurality of components connected by the transmission line is then simulated. The simulated network is based on the measured scattering parameters and virtual models representative of each of the components in the network. A system-level output response of the simulated network to a simulated input signal is analyzed, and the printed wiring board is characterized based on a comparison of the system-level output response to a printed wiring board performance metric threshold. | 06-02-2011 |
| 20110118820 | MAGNETIC MEDICAL APPARATUS, KITS, AND METHODS - Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed. | 05-19-2011 |
| 20110112569 | NAVIGATION AND TISSUE CAPTURE SYSTEMS AND METHODS - Navigation and tissue capture systems and methods for navigation to and/or capture of selected tissue using the innate electrical activity of the selected tissue and/or other tissue are described. In the context of left atrial appendage closure, the systems and methods can be used to navigate to the left atrial appendage and capture/control the appendage while a closure instrument (suture, clip, ring) is placed over the appendage and tightened down or a closure method (ablation, cryogenic procedures, stapling, etc.) is performed to close the left atrial appendage. The use of innate electrical activity for navigating devices may be used in connection with other tissues and/or areas of the body. | 05-12-2011 |
| 20110105883 | REAL TIME MOTION INFORMATION CAPTURE IN AN MRI ENVIRONMENT - Systems, methods and articles of manufacture are disclosed for capturing motion information in a magnetic resonance imaging (MRI) environment. A light sink in the MRI environment may detect light emitted from a plurality of light sources. Each of the plurality of light sources may emit light of a different frequency. Further, each of the plurality of light sources may be located at a different spatial position in the MRI environment. The detected light may be analyzed. A change in spatial position of the light sink may be computed based on the analysis. | 05-05-2011 |
| 20110105882 | CORRECTING SUBJECT MOTION IN MULTIPLE RESOLUTIONS IN MAGNETIC RESONANCE IMAGING - Systems, methods and articles of manufacture are disclosed for compensating for motion of a subject during an MRI scan of the subject. k-space data may be received from the MRI scan of the subject. A first graphical image may be generated from a first set of data elements from the k-space data. Similarly, a second graphical image may be generated from a second set of data elements from the k-space data. An offset in pixels may be determined by which to translate the second graphical image from the first graphical image to compensate for the motion. The k-space data may be modified at a sub-pixel offset relative to the determined offset. A motion-compensated graphical image of the subject may be generated from the modified k-space data. Doing so reduces the search space evaluated to sharpen images generated from the k-space data. | 05-05-2011 |
| 20110105781 | Process for the Synthesis of Long-Chain Fatty Acids - This invention relates to processes for preparing long-chain fatty acids of Formula I: | 05-05-2011 |
| 20110104306 | NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS - The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent. | 05-05-2011 |
| 20110104049 | METHOD OF USING AN ANTI-CD137 ANTIBODY AS AN AGENT FOR RADIOIMMUNOTHERAPY OR RADIOIMMUNODETECTION - The current invention relates to the development and methods of use of a recombinant agonistic antibody anti-human CD137, and glycosylation variants thereof. These antibodies act as anti-cancer agents and/or immune modulators that are effective in shrinking solid tumors or other cancerous indications and preventing their recurrence. The types of cancer for which the contemplated antibody is effective in treating also include leukemia and lymphoma. In a preferred embodiment the recombinant antibodies of the current invention were produced in and purified from the milk of transgenic animals. In another preferred embodiment of the current invention the agonistic anti-CD137 antibodies of the invention can be conjugated to radionuclides for radioimmunodetection or radioimmunotherapeutic purposes, or conjugated to a toxin for enhanced therapeutic treatment of various cancers. | 05-05-2011 |
| 20110101978 | MOTION INFORMATION CAPTURE AND AUTOMATIC MOTION CORRECTION FOR IMAGING SYSTEMS - Systems, methods and articles of manufacture are disclosed for compensating for motion of a subject during an MRI scan of the subject. k-space data may be received from the MRI scan of the subject. Motion information may be received for the subject. Based on the received motion information, a translational motion of the subject may be determined between a first point in time and a second point in time. A search space for motion correction may be reduced using the determined change and an error margin of the capturing technique. A motion-compensated, graphical image of the subject may be generated using the reduced search space. | 05-05-2011 |
| 20110082539 | MINIMALLY INVASIVE AORTIC VALVE REPLACEMENT - A minimally invasive method of implanting a prosthetic aortic valve includes forming a surgical site within a patient's chest that includes a first access port, a second access port, a viewing port and a delivery port. A camera is inserted into the viewing port. The native aortic valve leaflets may each be grasped and removed via tools inserted through the first and second access ports. The prosthetic aortic valve may be delivered through the delivery port to the valve annulus using a delivery device. The prosthetic aortic valve is implanted at the valve annulus and the delivery device is withdrawn. A surgeon may perform the remotely operated steps while viewing images provided by the camera. | 04-07-2011 |
| 20110070252 | MAGE-A3/HPV 16 PEPTIDE VACCINES FOR HEAD AND NECK CANCER - The present invention relates to Trojan antigens, and immunogenic compositions comprising the Trojan antigens. The present invention also relates to methods of generating an immune response in a subject using the Trojan antigens or immunogenic compositions. The present invention further relates to methods of treating squamous cell carcinoma of the head and neck (SCCHN) using the Trojan antigens and immunogenic compositions of the present invention. | 03-24-2011 |
| 20110065178 | DENDRITIC CELL POTENTIATION - A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and methods for using the compositions to treat or immunize individuals. | 03-17-2011 |
| 20110045458 | Detection of Enterovirus - This document describes methods and materials relating to viral diagnostics, and more particularly to the detection of enterovirus. For example, primers and probes for the detection of enterovirus are provided. Articles of manufacture containing such primers and probes for detecting enterovirus are further provided. | 02-24-2011 |
| 20110038829 | METHODS AND MATERIALS FOR TREATING DIARRHEA - This document relates to methods and materials for administering bile acid sequestrants to treat conditions associated with diarrhea. For example, formulations designed for the delivery of a bile acid sequestrant (e.g., colesevelam) to treat diarrhea are provided. | 02-17-2011 |
| 20110034865 | Colonic Lavage Catheter - A colonic lavage catheter includes a head attached at an end of a suction tube and having both rearward and lateral fluid discharge openings. A pair of tubes extend along the suction tube with their ends attached to the head to place the rearward and lateral fluid discharge openings in fluid communication with a source of pressurized fluid. The suction tube includes a plurality of suction orifices through the outer wall along its length proximate the catheter head. A cleaning process may be performed by inserting the catheter head into the colon and then discharging fluid through the rearward openings to advance the catheter. At points along the colon, pressurized fluid may be discharged through the lateral discharge openings to lavage the adjacent walls of the colon, with suction being applied to draw the dislodged material into the suction tube through the suction orifices. | 02-10-2011 |
| 20110022059 | Device for Immobilizing a Primary Instrument and Method Therefor - Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems. | 01-27-2011 |
| 20110022058 | Device for Immobilizing a Primary Instrument and Method Therefor - Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems. | 01-27-2011 |
| 20110019935 | Reducing Noise in an Image - A computer-implemented method for reducing noise in an image includes receiving a first image in a computer system. The first image depicts an interior of an item and is generated using a technique that provides imaging at selected depths in the item. The first image represents a first interior section having a first thickness. The method includes determining a modification for the first image using a second image of the interior. The second image represents a second interior section encompassing the first interior section and has a second thickness greater than the first thickness. The method includes storing the modification in association with the first image. | 01-27-2011 |
| 20110014716 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MACULAR DEGENERATION - The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications. | 01-20-2011 |
| 20110014678 | SULFOTRANSFERASE 1E1 SEQUENCE VARIANTS - Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described. | 01-20-2011 |
| 20110014240 | SINGLE CYCLE REPLICATING ADENOVIRUS VECTORS - This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided. | 01-20-2011 |
| 20110009980 | OBESITY TREATMENT AND DEVICE - A method and apparatus are disclosed for treating obesity includes an artificial fistula created between gastrointestinal organs such as between the stomach and the colon. The method includes selecting an implant comprising a passageway having an internal lumen with an inlet end and an outlet end. The passageway is positioned passing through a first wall of first gastrointestinal organ (for example, passing through the wall of the stomach) and a second wall of a second gastrointestinal organ (for example, passing through the wall of the large intestine) with the inlet end disposed within an interior of the first gastrointestinal organ and with the outlet disposed within an interior of the second gastrointestinal organ. | 01-13-2011 |
| 20100324119 | REDUCING IRF4, DUSP22, OR FLJ43663 POLYPEPTIDE EXPRESSION - This document relates to the activity of interferon regulatory factor 4 (IRF4) in T-cell lymphomas. For example, methods and materials involved in reducing the expression of an IRF4 polypeptide in T-cell lymphoma cells and identifying agents having the ability to reduce expression of an IRF4 polypeptide in T-cell lymphoma cells are provided. This document also relates to reducing DUSP22 or FLJ43663 polypeptide activity in T-cell lymphomas. For example, methods and materials involved in reducing the expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells and identifying agents having the ability to reduce expression of DUSP22 polypeptides and/or FLJ43663 polypeptides in T-cell lymphoma cells are provided. | 12-23-2010 |
| 20100305051 | NATRIURETIC ACTIVITIES - This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided. | 12-02-2010 |
| 20100298202 | BRI POLYPEPTIDES AND REDUCING AB AGGREGATION - This document relates to methods and materials for reducing Aβ aggregation. For example, methods and materials related to the use of BRI polypeptides (e.g., BRI2 polypeptides) and fragments of BRI polypeptides (e.g., a BRI23 polypeptide) to reduce Aβ aggregation in mammals are provided. | 11-25-2010 |
| 20100297658 | DETECTING METHYLATED MAMMALIAN NUCLEIC ACID IN STOOL - This document includes methods and materials for enriching and detecting cancer markers. For example, this document includes methods and materials for enriching methylated mammalian nucleic acid from stool samples. | 11-25-2010 |
| 20100292602 | SEIZURE FORECASTING, MICROSEIZURE PRECURSOR EVENTS, AND RELATED THERAPEUTIC METHODS AND DEVICES - A multiscale recording and stimulation system for identifying and responding to epileptiform activity. The system includes the use of microelectrode arrays (e.g., 10-100 micron electrodes with 100-500 micron spacing) to monitor iEEG activity of submillimeter regions or islands in the epileptogenic zone of brain tissue (e.g., independent microdomains in the range of 100-1000 micron diameter). | 11-18-2010 |
| 20100266611 | Enhancement of Immune Responses By 4-1BB-Binding Agents - This invention features methods of enhancing immune responses in mammalian subjects and in vitro methods of enhancing the response of a T cell. Also embodied by the invention are methods of receiving and preventing the induction of energy in T cells. | 10-21-2010 |
| 20100251180 | RADIAL MENU SELECTION WITH GESTURES - Embodiments of the invention are generally related to graphical user interfaces (GUIs), and more specifically to selecting items from a radial menu. More specifically, embodiments of the invention provide a complex set of gestures which, when performed using a screen pointer, facilitate fast and accurate selection of radial menu items from a radial menu. The gestures may generally involve a first movement of the screen pointer to activate a desired radial menu item, and a second predefined movement of the screen pointer within a predefined selection zone to select the radial menu item. | 09-30-2010 |
| 20100251179 | RADIAL MENU SELECTION WITH OVERSHOOT CAPABILITY - Embodiments of the invention are generally related to graphical user interfaces (GUIs), and more specifically to selecting items from a radial menu. More specifically, embodiments of the invention provide a complex set of gestures which, when performed using a screen pointer, facilitate fast and accurate selection of radial menu items from a radial menu. The gestures may generally involve a first movement of the screen pointer to activate a desired radial menu item, and a second predefined movement of the screen pointer to select the radial menu item. | 09-30-2010 |
| 20100248239 | METHODS AND MATERIALS FOR DETECTING FRAGILE X MUTATIONS - This document relates to methods and materials involved in detecting Fragile X mutations and assessing the methylation state of Fragile X alleles. For example, methods and materials for detecting Fragile X alleles using polymerase chain reaction and a hybridization probe (e.g., a non-radioactively labeled hybridization probe) are provided. | 09-30-2010 |
| 20100248223 | ASSESSING OUTCOMES FOR BREAST CANCER PATIENTS - This document provides methods and materials related to assessing the likely outcome for mammals (e.g., humans) with cancer (e.g., breast cancer). For example, methods and materials for using the ratio of HOXB13 polypeptide expression to IL-17BR polypeptide expression, CYP2D6 genotype, medication history, or combinations thereof to determine the likelihood of a breast cancer patient to experience breast cancer relapse or death are provided. | 09-30-2010 |
| 20100247488 | Paramyxoviridae Virus Preparations - This document involves methods and materials related to obtaining Paramyxoviridae virus preparations. | 09-30-2010 |
| 20100222228 | COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING IRRITABLE BOWEL SYNDROME - The present invention relates generally to therapy and diagnosis of disorders associated with chronic visceral hypersensitivity (CVH), and in particular irritable bowel syndrome (IBS). In particular, this invention relates to the polypeptides as well as to the polynucleotides encoding these polypeptides, wherein said polypeptides are shown to be associated with CVH. These polypeptides and polynucleotides are useful in the diagnosis, treatment and/or prevention of disorders associated with CVH, in particular in the diagnosis, treatment and/or prevention of disorders associated with IBS. | 09-02-2010 |
| 20100198238 | APPARATUS AND METHODS FOR PERIVALVULAR LEAK OCCLUSION - Apparatus and methods for occluding perivalvular leaks located around the periphery of implanted replacement valves. The apparatus and methods may include both distal and proximal covers adapted for placement over a perivalvular leak, with the covers retained in position by tension between the proximal and distal flanges. The distal and proximal covers may be capable of collapsing into a delivery configuration amenable for delivery to an internal body location through a lumen of a delivery catheter and a deployment configuration in which a flange of the cover extends radially outward such that the flange defines a first major surface facing the opposing cover. | 08-05-2010 |
| 20100196935 | TREATING PRE-ECLEMPSIA AND CARDIOVASCULAR DISEASES - This document relates to methods and materials involved in identifying, predicting, and treating pre-eclampsia or a cardiovascular disease (e.g., atherosclerosis) in mammals. For example, methods and materials involved in using serum levels of HtrA polypeptides to identify pre-eclampsia or a cardiovascular disease, using HTRA polymorphisms to predict pre-eclampsia or a cardiovascular disease, and using HtrA antibodies to treat pre-eclampsia or a cardiovascular disease in mammals (e.g., humans) are provided. | 08-05-2010 |
| 20100183646 | MAGE-A3/HPV 16 PEPTIDE VACCINES FOR HEAD AND NECK CANCER - The present invention relates to Trojan antigens, and immunogenic compositions comprising the Trojan antigens. The present invention also relates to methods of generating an immune response in a subject using the Trojan antigens or immunogenic compositions. The present invention further relates to methods of treating squamous cell carcinoma of the head and neck (SCCHN) using the Trojan antigens and immunogenic compositions of the present invention. | 07-22-2010 |
| 20100178707 | VITAMIN D DEFICIENCIES - Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided. | 07-15-2010 |
| 20100160339 | TREATING PANCREATITIS - This document provides methods and materials related to treating pancreatitis. For example, methods and materials relating to the use of a tyrosine kinase inhibitor to pancreatitis are provided. | 06-24-2010 |
| 20100158811 | ASSESSING BRAIN ANEURYSMS - This document provides methods and materials related to assessing brain conditions within mammals. For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) with a brain aneurysm is likely to experience brain aneurysm rupture are provided. | 06-24-2010 |
| 20100143365 | METHODS AND MATERIALS RELATED TO ANTI-AMYLOID ANTIBODIES - This document provides methods and materials related to anti-amyloid antibodies. For example, anti-amyloid antibodies, methods for making anti-amyloid antibodies, and methods for using an anti-amyloid antibody to treat or prevent an amyloid condition (e.g., AD) are provided. | 06-10-2010 |
| 20100142783 | AXIAL CENTERLINE FOLLOWING DISPLAY OF CT COLONOGRAPHY IMAGES - A method for displaying colonography images includes presenting a series of axial images of the colon at sequential locations along the colon centerline. Each image is generally centered on the centerline and presents a field of view parallel to the axial plane. | 06-10-2010 |
| 20100142776 | OBLIQUE CENTERLINE FOLLOWING DISPLAY OF CT COLONOGRAPHY IMAGES - A method for displaying colonography images includes presenting a series of oblique images of the colon at sequential locations along the colon centerline. Each image is generally centered on the centerline, presents a field of view generally perpendicular to the centerline, and is oriented with the bottom of the colon down. | 06-10-2010 |
| 20100128945 | SYNCHRONIZATION OF X-RAY SOURCE POSITION DURING CARDIAC-GATED COMPUTED TOMOGRAPHY - A method for temporally imaging a cyclic body structure during a predetermined phase of its cycle using a CT scanner of the type having a rotating radiation source. In one embodiment the image or other display is generated using data produced when the radiation source is at a predetermined position when the body structure is in the predetermined phase. The method can be performed by using only data collected when the radiation source is at the predetermined position and the body structure is in the predetermined phase, by stimulating the body structure so the phase of the body structure and location of the radiation source are synchronized, or by controlling the motion of the radiation source so the location of the radiation source and the phase of the body structure are synchronized. | 05-27-2010 |
| 20100121046 | COLLECTING AND PROCESSING COMPLEX MACROMOLECULAR MIXTURES - This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided. | 05-13-2010 |
| 20100119536 | Naturally Processed Measles Virus Peptides From Class II HLA Molecules - A preparation of peptides eluted from class II HLA molecules is disclosed. Methods of decreasing measles infections comprising inoculating human patients with a vaccine comprising one or more of the peptides and methods of diagnosing measles infections or immunity comprising analyzing human patients for the presence of one or more of the peptides or antibodies to the peptide(s) are also disclosed. | 05-13-2010 |
| 20100099182 | SYSTEM FOR MONITORING THE LOCATION OF TRANSGENES - A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene confers the activity of the sodium iodide symporter (NIS) to a host cell which expresses the transgene. Subsequent administration of labeled iodine results in transport of the labeled iodine into the cell bearing the NIS, which can then be localized and measured using standard imaging techniques. The system is particularly useful for monitoring the location of therapeutic transgenes and tissue-specific distribution of the therapeutic gene product. | 04-22-2010 |
| 20100092970 | DETERMINING THE PHASE OF DUPLICATED CYP2D6 ALLELES - This document relates to methods and materials involved in detecting duplicated CYP2D6 alleles (e.g., CYP2D6/CYP2D7−CYP2D6 arrangements) in mammals (e.g., humans). | 04-15-2010 |
| 20100069925 | DEVICES AND METHODS FOR LIGATING ANATOMICAL STRUCTURES - Devices and methods for ligating anatomical structures are provided herein. In particular, the devices and methods provided herein can be used to ligate the left atrial appendage. | 03-18-2010 |
| 20100066506 | ASYNCHRONOUS COMMUNICATION SYSTEM FOR REMOTE MONITORING OF OBJECTS OR AN ENVIRONMENT - A system provides for remote monitoring using asynchronous code division multiple access (CDMA) communication techniques between a base station and one or more transponders. Each transponder is attached or otherwise associated with an object or an environment to be monitored. Upon receipt of an interrogation signal, a transponder generates and transmits a coded transponder signal containing the monitored data. The coded transponder signal is generated using a spreading code. Each transponder is associated with a unique, mutually exclusive set of spreading codes. Each spreading code is based on a unique transponder address and the monitored data to be sent. A detector asynchronously monitors received signals for any of the available spreading codes. Once the detector detects a particular spreading code, the base station can identify the source transponder and extract the monitored data. | 03-18-2010 |
| 20100057811 | CONTEXT-SENSITIVE TERM EXPANSION WITH MULTIPLE LEVELS OF EXPANSION - Articles of manufacture and systems for searching collections of data using context sensitive expanded term searching are provided. The collection of data may be a relational database, text document, or any other type of searchable collection of data. In either case, a query including a search condition based on a specified search term may be modified to include additional conditions based on a set of expanded (e.g., conceptually-related) search terms. For some embodiments, a user may be given the ability to control the level of expansion and the context in which the terms may be expanded. | 03-04-2010 |
| 20100057209 | TEMPOROMANDIBULAR JOINT FOSSA-EMINENCE PROSTHESIS - A fossa-eminence prosthesis having a nonanatomic surface that is relatively flatter than the native fossa. The articular eminence of the patient can be surgically reduced before implanting the prosthesis. | 03-04-2010 |
| 20100030251 | DEVICES AND METHODS FOR CROSSING CHRONIC TOTAL OCCLUSIONS - Devices and methods for crossing total chronic occlusions in body lumens (e.g., blood vessels, etc.). The devices and methods may involve guidewire assisted delivery of a device designed to both traverse a chronic total occlusion (CTO) and create a passageway through the CTO for a treatment device (e.g., an angioplasty balloon, stent, etc.). Some devices of the present invention may include an expandable sleeve constructed of material that expands in response to temperature changes. In other devices, an expandable sleeve may be provided in which two or more interlocking cylindrical sections can be arranged such that the cylindrical sections have a first, smaller diameter at which the expandable sleeve can be inserted through a CTO. The expandable sleeve also has a second, larger diameter that can be achieved by moving the two or more interlocking cylindrical sections relative to each other such that the expandable sleeve moves from the first diameter to the second diameter when the expandable sleeve is located across the CTO. In other aspects, a guide catheter may include a friction-enhanced outer surface to assist in maintaining the guide catheter in a selected location during use. The friction-enhanced property may be provided using, e.g., materials with an increased coefficient of friction, adding features to the surface of an otherwise smooth guide catheter, etc. | 02-04-2010 |
| 20100028914 | ASSESSING LUNG NODULES - This document provides methods and materials related to distinguishing malignant solitary pulmonary nodules from benign solitary pulmonary nodules in mammals (e.g., humans). | 02-04-2010 |
| 20100016744 | FETAL HEART RATE MONITORING SYSTEM - A fetal heart rate monitoring system includes an ultrasonic transducer for transmitting a signal to a patient and for receiving a reflected heart beat monitoring signal. A monitoring system coupled to the ultrasonic transducer processes the heart beat monitoring signal and produces heart beat information representative of the monitored heart rate. A mechanical or electronic steering system coupled to the ultrasonic transducer controls the location of the signal transmitted to the patent and/or the location of the received heart beat monitoring signal. A control system coupled to the monitor and steering system controls the steering system as a function of the heart beat monitoring signal to optimize the quality of the heart beat information in the received heart beat monitoring signals. | 01-21-2010 |
| 20100009445 | RARE EARTH NANOPARTICLES - This document provides methods and materials related to rare earth particles such as rare earth nanorods (e.g., inorganic lanthanide hydroxide nanorods). For example, rare earth (e.g., lanthanide) particles such as europium hydroxide nanorods, methods and materials for making rare earth particles (e.g., europium hydroxide nanorods), and methods and materials for using rare earth particles (e.g., europium hydroxide nanorods) as an imaging agent and/or to promote angiogenesis are provided. | 01-14-2010 |
| 20090324492 | Treatment for Central Nervous System Disorders - Compositions that include an Aβ polypeptide linked to a non-Aβ polypeptide are described, as well as methods of using such compositions. | 12-31-2009 |
| 20090318875 | DEVICES AND METHODS TO TREAT NASAL PASSAGES - Some embodiments of a nasal implant delivery system may provide minimally invasive insertion of one or more implants in suitable tissue planes of the nasal rim, the lateral nasal wall, or both. Such a delivery system may be minimally invasive in that it does not require a surgical intervention or an incision that cuts a portion of the nasal tissue. Rather, in some embodiments, the nasal implant delivery system may include a needle or other cannula device having a curvature at the distal portion adapted to penetrate into a targeted tissue plane in the nasal rim, the lateral nasal wall, the nasal septum, or the columella. Also, some embodiments of a delivery system can be used to apply a nasal rigidity supplement to internal or external portions of the nasal rim, the lateral nasal wall, or other nasal structures. | 12-24-2009 |
| 20090311715 | IDENTIFYING CORONARY OR SOFT TISSUE CALCIFICATION - This document relates to methods and materials involved in identifying calcification (e.g., coronary calcification or soft tissue calcification) in mammals and assessing thrombotic risk in mammals. For example, methods and materials involved in using microvesicles as a marker to determine whether or not a mammal (e.g., a human) has calcification or an elevated risk of thrombosis are provided. In addition, methods and materials for determining the amount and source of microvesicles are provided. | 12-17-2009 |
| 20090306471 | ACCESSING A BODY CAVITY THROUGH THE URINARY TRACT - Some embodiments of the system described herein provide transvesical access to a body cavity (e.g., the peritoneum, the bladder, the ureter, the renal pelvis, or the retroperitoneum). For example, such a transvesical approach may provide access to the peritoneal cavity through an opening formed in the bladder wall or other structures in the urinary tract (e.g., ureter, renal pelvis, or the like). Thus, the transvesical approach through the bladder wall permits a surgeon to examine, conduct surgical or therapeutic procedures, or a combination thereof inside peritoneal cavity. Further, the transvesical access to the peritoneal cavity or another body cavity provides the opportunity to use flexible or rigid endoscopes, depending upon the procedure being performed. | 12-10-2009 |
| 20090304747 | USE OF DMSO AND BOTULINUM TOXIN THERAPY FOR URINARY INCONTINENCE AND RELATED DISORDERS - This disclosure provides a method of treating urologic and related disorders, for example, urinary incontinence, in women through the administration of a composition comprising a neurotoxin and DMSO. Methods for making and using the described compositions are also provided. | 12-10-2009 |
| 20090297471 | Methods For Autologous Stem Cell Transplantation - Materials and methods for obtaining populations of lymphocytes and administering the population of lymphocytes to a subject are disclosed herein. In particular, disclosed herein are materials and methods for obtaining lymphocyte populations that contain at least about 0.5×10 | 12-03-2009 |
| 20090281507 | Hemostatic Devices and Methods For Use Thereof - Materials and Methods for reducing or preventing bleeding and associated side effects during and after percutaneous medical procedures. | 11-12-2009 |
| 20090239935 | RNA-HELICASE AS A MARKER FOR RARE TUMORS - Method for the diagnosis of diseases in a mammal, preferably in a human, wherein a probe from the mammal is examined with a view to an elevated level of RNA helicase and the elevated level of RNA helicase indicates the disease. The disease refers to esophagus carcinoma, pancreas carcinoma, stomach carcinoma, hepatocellular carcinoma, hepatoblastoma and cholangiocellular carcinoma. | 09-24-2009 |
| 20090221936 | ACTIVITY-CONTINGENT WEIGHT LOSS SYSTEM - An activity-contingent weight loss method and system. The system includes measuring information representative of caloric expenditure during one day, and prescribing a caloric allowance for the following day as a function of the caloric expenditure during the previous day. | 09-03-2009 |
| 20090220997 | Stimulating G Protein-Coupled Receptors - This document provides methods and materials related to activating GPCRs. For example, methods and materials for activating GPCRs present on cells (e.g., human cell) as well as methods and materials for identifying GPCR agonists are provided. | 09-03-2009 |
| 20090197342 | Marker for Inflammatory Conditions - Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described. | 08-06-2009 |
| 20090196825 | CD38 AND OBESITY - This document provides methods and materials relating to obesity. For example, methods and materials related to treating obesity and identifying agents having the ability to treat obesity are provided. | 08-06-2009 |
| 20090187187 | Controlling Coagulum Formation - Some embodiments of a medical instrument can be configured to reduce the formation of coagulum by delivering a negative charge bias to conductive surfaces that interface with blood or bodily tissue during a medical procedure. The application of the negative charge at the instrument-blood interface can reduce the fibrinogen deposition and the formation of coagulum because fibrinogen molecules in general are negatively charged at neutral pH levels. In addition, some embodiments of the instrument may be configured to irrigate the instrument-blood interface with RGD/ClfA peptides, a bicarbonate solution (or other high pH solution), or both to further repel the fibrinogen and thereby inhibit the formation of coagulum. Accordingly, some embodiments of the medical instrument can substantially reduce the risks of thromboembolism during particular medical procedures. | 07-23-2009 |
| 20090176317 | Soluble B7-H1 - This document features methods of evaluating mammals by assessing expression of B7-H4 in the vasculature. | 07-09-2009 |
| 20090170756 | CHIMERIC NATRIURETIC PEPTIDES - Peptides of | 07-02-2009 |
| 20090170754 | TREATING LIVER DISEASES - This document provides methods and materials related to treating liver conditions. For example, the methods and materials relating to the use of cAMP inhibitors to treat liver conditions are provided. | 07-02-2009 |
| 20090138976 | ANIMAL MODEL FOR HEPATITIS C VIRUS INFECTION - The current document relates to transgenic rodents that have a nucleic acid molecule encoding a hepatocyte mitogen polypeptide. | 05-28-2009 |
| 20090136961 | Novel compositions and methods for identification, assessment, prevention, and therapy of ovarian cancer - The present invention is directed to the identification of markers that can be used to determine whether ovarian cancer is sensitive or resistant to a therapeutic agent. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with sensitivity or resistance to a therapeutic agent. Thus, by examining the expression of the individual markers of a marker set, also referred to as the expression profile of the marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of the ovarian cancer. | 05-28-2009 |
| 20090131880 | Device And Methods For Reducing Cardiac Valve Regurgitation - Devices and methods that may be used to reduce valve regurgitation are disclosed by locating a body across the regurgitant valve. When the valve closes, the body obliterates/ameliorates the regurgitant orifice in the valve, thereby reducing or preventing valve regurgitation. The body may be expandable. The devices may be implantable such that they can remain in place within a subject for extended periods of time. | 05-21-2009 |
| 20090123963 | BIOPSY SAMPLE MOUNT AND PROCESSING METHOD - A biopsy sample mount and processing method. One embodiment of the sample mount includes a rounded mass of hydrophilic or liquid absorbing material. Tissue samples can be releasably placed on the material mass in a known structural orientation and the mount and sample immersed in fixative. The mass of material will swell when absorbing the fixative, causing the tissue sample to release from the mass of material. The tissue sample is then removed from the fixative and correctly oriented for tissue processing for diagnostic use. | 05-14-2009 |
| 20090118817 | Magnetic Medical Apparatus, Kits, and Methods - Medical devices with surfaces on which viable biologic cells are magnetically attracted and retained are disclosed along with methods of magnetic coating. The medical devices can be located in a carrier liquid containing high concentrations of magnetic cells before or after implantation. The carrier liquid with magnetic cells may be contact with the medical device in vitro or in vivo. In either case, the carrier liquid may have a concentration of magnetic cells that is high enough to facilitate coating of the medical device within an acceptable period of time, e.g., several hours or less. Magnetization of medical devices before, during, and/or after implantation and apparatus for performing the same are disclosed. Degaussing of magnetic medical devices is also disclosed. | 05-07-2009 |
| 20090117550 | Assessing brain aneurysms - This document provides methods and materials related to assessing brain conditions within mammals. For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) with a brain aneurysm is likely to experience brain aneurysm rupture are provided. | 05-07-2009 |
| 20090111746 | MODULATING TOLL-LIKE RECEPTOR ACTIVITY - This description provides methods and materials related to modulating Toll-like receptor activity. For example, methods and materials for increasing or decreasing the responsiveness of a TLR4 polypeptide are provided. | 04-30-2009 |
| 20090099493 | DIP JOINT EXTENSION SPLINT - Finger splints for use in connection with distal interphalangeal (DIP) joint fractures are disclosed. The splints include a ring element for positioning around a finger at a location proximal to the distal interphalangeal (DIP) joint and include an extension member that extends over the DIP joint and attaches to the fingernail. | 04-16-2009 |
| 20090087416 | B7-H3 AND B7-H4, NOVEL IMMUNOREGULATORY MOLECULES - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 04-02-2009 |
| 20090076367 | Monitoring Intraocular Pressure - Some embodiments of the system described herein provide non-invasive intraocular pressure monitoring throughout an extended period. Such monitoring systems can be used for the diagnosis and management of glaucoma patients and those at risk for glaucoma. In some embodiments, the monitoring system provides intraocular pressure monitoring in the patient's normal environment without the need to house the patient in a sleep laboratory. | 03-19-2009 |
| 20090075863 | Periosteal Tissue Grafts - This document relates to methods and materials involved in making and using periosteal tissue grafts in vivo. For example, materials and methods for obtaining grafts comprising periosteal tissue are provided. | 03-19-2009 |
| 20090072846 | HIGH FREQUENCY DIFFERENTIAL TEST PROBE FOR AUTOMATED PRINTED WIRING BOARD TEST SYSTEMS - A differential test probe for a printed wiring board test system includes a probe body having a proximal end and a distal end. Each of a plurality of coaxial cables extending from the proximal end to the distal end. The plurality of coaxial cables each includes a center conductor having an axial aperture at the distal end. The differential test probe also includes a plurality of signal pins that are each mounted in the axial aperture of the center conductor of one of the plurality of coaxial cables to electrically couple the signal pin to the center conductor. A plurality of ground pins are coupled to the probe body and selectively arranged relative to the plurality of signal pins to provide multiple signal to ground paths between the plurality signal pins and the plurality ground pins. | 03-19-2009 |
| 20090072845 | LINK ANALYSIS COMPLIANCE AND CALIBRATION VERIFICATION FOR AUTOMATED PRINTED WIRING BOARD TEST SYSTEMS - A transmission line on a printed wiring board is tested and printed wiring board manufacturing variability is assessed. A response of the transmission line to a signal test pattern is measured. A network including a plurality of components connected by the transmission line is then simulated. The simulated network is based on the measured scattering parameters and virtual models representative of each of the components in the network. A system-level output response of the simulated network to a simulated input signal is analyzed, and the printed wiring board is characterized based on a comparison of the system-level output response to a printed wiring board performance metric threshold. | 03-19-2009 |
| 20090069243 | NATRIURETIC ACTIVITIES - This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided. | 03-12-2009 |
| 20090068683 | MARKERS FOR PREECLAMPSIA - This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided. | 03-12-2009 |
| 20090062237 | EVALUATING IMMUNE COMPETENCE - This document relates to methods and materials involved in evaluating immune competence in a subject. For example, methods and materials for evaluating immune competence in a subject to BK virus (BKV) are provided. Also provided are isolated peptides, compositions, and methods useful for evaluating whether or not a subject is BKV immunocompetent. Also provided are methods for treating BK virus nephropathy in a subject that is BKV immune incompetent. | 03-05-2009 |
| 20090054818 | SPINAL ORTHOSES - A thoracolumbosacral and a lumbosacral orthosis with sagittal-coronal control are disclosed. The orthoses have two rigid anterior and posterior plastic shells. The anterior shell extends from the pelvis to the sternum. The posterior shell extends from the pelvis and terminates just inferior to the scapular spine. An interior surface of the anterior shell has pressure pads that apply pressure to locations on the patient's anterior torso and the interior surface of the posterior shell has pressure pads that apply pressure to locations on the patient's posterior torso when the anterior shell and the posterior shell are secured to the patient's torso. The pressure pads may be inflatable air bladders. | 02-26-2009 |
| 20090043387 | IMPLANTATION OF MAGNETS IN BONE TO REDUCE CONTACT PRESSURE - Permanent magnets are implanted in bone to unload compressive forces at joints using the repulsive force therebetween. A porous metal container is implanted first and becomes fixed in place by bone growth. The permanent magnet is then inserted in the container and retained in place. A magnet prescription system includes a display and input device which enables a user to alter parameters such as magnet size, strength and placement and calculate and display the repulsive force that will result. | 02-12-2009 |
| 20090043383 | GENETICALLY MODIFIED HEART VALVE XENOGRAFTS - The invention relates to heart valve xenografts from transgenic pigs having a disruption of an α1-3 galactosyl transferase nucleic acid sequence and use of the xenografts for treating a patient. | 02-12-2009 |
| 20090030317 | ULTRASONIC IMAGING DEVICES, SYSTEMS, AND METHODS - Ultrasonic imaging devices, systems and methods that may be used to image difficult to reach locations such as internal body cavities, etc. The ultrasonic imaging devices may be embodied in endoscopes that include one ore more channels for delivering instruments and other items to the location at which the imaging is occurring or the imaging devices may be provided in the form of a probe or other device that may, for example, be delivered through a channel located in an endoscope. | 01-29-2009 |
| 20090022747 | B7-H3 AND B7-H4, NOVEL IMMUNOREGULATORY MOLECULES - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 01-22-2009 |
| 20090018315 | B7-H3 and B7-H4, Novel Immunoregulatory Molecules - The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides. | 01-15-2009 |
| 20090004149 | METHOD FOR LIMITING THE GROWTH OF CANCER CELLS USING AN ATTENUATED MEASLES VIRUS - A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 10 | 01-01-2009 |
| 20080305515 | Pathology Sample Processing Workstation - A pathology sample processing workstation. The samples are positioned on containers having RFID tags and processed at stations having RFID transceivers coupled to a computer. Information regarding the samples can stored on the RFID tags and retrieved using the transceivers. | 12-11-2008 |
| 20080302187 | Vibroacoustic System for Vibration Testing - Forces are applied to a device under test and its mechanical response is measured by a laser vibrometer ( | 12-11-2008 |
| 20080287752 | EAR CANAL PHYSIOLOGICAL PARAMETER MONITORING SYSTEM - Physiological parameters are monitored from within an ear canal. A sensor module, which is mountable within the ear canal, includes at least one sensor operable to sense the physiological parameters and to generate signals based on the sensed physiological parameters. A processor, which is in communication with the sensor module, processes the signals from the at least one sensor and generates data related to the physiological parameters. | 11-20-2008 |
| 20080273781 | Electronic Stool Subtraction in Ct Colonography - A method for processing CT colonography input image voxel data representative of 3-dimensional images of a colon having gas and stool tagged with stool tagging agent, to remove the stool from the images. The input image voxel data is generated by an imaging instrument having a characteristic point spread function representative of instrument blurring. The point spread function of the instrument can be empirically determined, and the image data processed as a function of the point spread function to accurately identify and remove the tagged stool. In one embodiment of the invention, portions of the image data representative of the tagged stool and colon tissue are dilated as a function of the point spread function. In another embodiment, portions of the image data representative of the tagged stool are convolved with the point spread function to determine the fractional amount of stool present in the image portions, and the tagged stool subtracted by reducing the intensities of the associated portions of the image by an amount proportional to the fractional amount of stool present. | 11-06-2008 |
| 20080241930 | Paramyxoviridae Virus Preparations - This document involves methods and materials related to obtaining Paramyxoviridae virus preparations. | 10-02-2008 |
| 20080233117 | REDUCING TUMOR GROWTH - This document provides methods and materials for reducing tumor growth in a mammal. For example, methods and materials for using PLVAP inhibitors to reduce tumor growth in a mammal (e.g., a human) are provided. | 09-25-2008 |
| 20080221698 | Semi-Constrained 1st Carpometacarpal Implant Arthroplasty - A first carpometacarpal joint implant. One embodiment of the invention includes proximal and distal components. The proximal component includes a fixation portion for attachment to one or more elements of a patient's distal carpal row, a ball-type joint portion cantilevered off the fixation portion, and a skid having a concave surface opposite the ball-type joint for engaging a patient's scaphoid bone. The distal component has a fixation portion for attachment to a patient's thumb metacarpal, and a socket-type joint portion that cooperates with the ball-type joint portion of the proximal component. | 09-11-2008 |
| 20080220433 | DETECTING METHYLATED MAMMALIAN NUCLEIC ACID IN STOOL - This document includes methods and materials for enriching and detecting cancer markers. For example, this document includes methods and materials for enriching methylated mammalian nucleic acid from stool samples. | 09-11-2008 |
| 20080214943 | Detection of Blood Flow Using Emitted Light Absorption - Perfused tissue is illuminated and light passing through the tissue or reflected from it is detected to produce an electrical signal. Amplitude pulses corresponding to the subject's heart beat are detected in the electrical signal and the areas of these pulses are calculated to produce blood flow values indicative of the blood volume pumped by the heart. The blood flow values may be used alone or in combination with other measured cardiac parameters to evaluate cardiac function. | 09-04-2008 |
| 20080213214 | Treating Cardiovascular Tissue - This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue are provided. | 09-04-2008 |
| 20080200556 | Amine Compounds And Inhibiting Neurotrasmitter Reuptake - The invention relates to amine compounds as well as methods and materials involved in modulating neurotransmitter reuptake. For example, the invention provides amine compounds, methods for synthesizing amine compounds, and methods for inhibiting neurotransmitter reuptake. | 08-21-2008 |
| 20080197903 | Clock Pulse Duty Cycle Control Circuit for a Clock Fanout Chip - A clock pulse duty cycle control circuit for receiving an input clock signal and for providing an output clock signal having a desired duty cycle. An error signal generator includes a differential integrator that is connected to receive the output clock signal. The differential integrator integrates the output clock signal to produce a time-varying DC error signal representative of a difference between the output clock signal duty cycle and the desired duty cycle. A duty cycle corrector includes a differential integrator connected to receive the input clock signal and the error signal. The differential integrator integrates the input clock signa to produce a correction stage clock signal. The differential integrator causes the slopes of the input clock signal edges to be adjusted as a function of the error signal. A buffer including a high gain amplifier is connected to receive the correction stage clock signal and squares the edges of the clock signal to produce the output clock signal. | 08-21-2008 |
