| Massachusetts General Hospital Patent applications |
| Patent application number | Title | Published |
|---|
| 20110236397 | LIMITED PROTEOLYSIS OF CD2AP AND PROGRESSION OF RENAL DISEASE - Compositions which specifically block cathepsin L function in podocytes, compositions which protect cytoskeletal adaptor protein (CD2AP) for degradation, compositions which modulate expression or function of cytoskeletal adaptor protein (CD2AP), protect against renal diseases or disorders. Methods of treatment in vivo involve use of one or more compositions. | 09-29-2011 |
| 20110109017 | METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL - The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein. | 05-12-2011 |
| 20090326659 | HIGH MODULUS CROSSLINKED POLYETHYLENE WITH REDUCED RESIDUAL FREE RADICAL CONCENTRATION PREPARED BELOW THE MELT - The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein. | 12-31-2009 |
| 20090136940 | PHOSPHORAMIDITE NUCLEOSIDE ANALOGS - Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or several reporter groups, organic molecules, bio-molecules, small molecules or other chemical groups at the internucleoside phosphotriesters. Oligonucleotides including the monomers have a number of uses in therapeutic, diagnostic, and research applications. | 05-28-2009 |
| 20090029322 | Use of Stem Cells, Method of Tissue Engineering, Use of Dental Tissues and Tooth Biological Substitute - The present invention is related to the use of stem cells of an animal species for obtainment of biological tooth substitute, in whole or in parts, to be implanted in organism of the same animal strain, wherein said stem cells can be adult cells. The present invention still aims to develop a method of tissue engineering for culturing cells capable to form dental tissue for production of a tooth biological substitute. The said dental tissue can used for the treatment of people suffering from loss, fail or lack of these tissues, and also for cosmetic use of those tissues for a morphological modifying on a patient dentition, for example, the patient may desire to, or need to, have a bigger or smaller dentition for any aesthetic reason. | 01-29-2009 |
| 20080256030 | FINE-GRAINED AUTHORIZATION FRAMEWORK - A system and method for controlling access to an instance method on an instance-specific basis by intercepting an invocation of the instance method on an instance. | 10-16-2008 |
| 20080216570 | Isometric Strength testing apparatus - An isometric strength testing device includes a base for selectively supporting either a chair or a wheelchair for the subject to be tested. A pair of limb supports are positioned on the base, one to immobilize an arm and the other a leg of the subject. Each support includes a band carrying a load cell for generating a signal measurement of the force applied to the cell. Goniometers are associated with the supports for establishing appropriate angles of the subject's limbs at the knee and elbow. A computer connected to the force plates processes and displays data generated by the load cells. | 09-11-2008 |
