| MASSACHUSETTS EYE AND EAR INFIRMARY Patent applications |
| Patent application number | Title | Published |
|---|
| 20120115925 | Allelic Variants Associated with Advanced Age-Related Macular Degeneration - The invention relates to allelic variants and haplotypes of the Complement Factor H (CFH) gene, the Complement Component 3 (C3) gene, and the Complement Factor D (CFD) gene, associated with either an elevated or a reduced risk that an individual will develop age-related macular degeneration (AMD), methods of diagnosing such risk in an individual based on the presence or absence of such variants, and methods and reagents for diagnosis and treatment of AMD. | 05-10-2012 |
| 20110294121 | METHODS AND COMPOSITIONS FOR PROGNOSING, DETECTING, AND TREATING AGE-RELATED MACULAR DEGENERATION - The invention provides methods and compositions for determining whether a subject is at risk of developing age-related macular degeneration, for example, the wet or neovascular form of age-related macular degeneration. The method involves determining whether the subject has a protective variant and/or a risk variant at a polymorphic site in the HTRA1 gene. In addition, the invention provides a method of treating or slowing the progression of age-related macular degeneration by reducing the expression of the HTRA1 gene, or reducing the biological activity of the HTRA1 gene product. | 12-01-2011 |
| 20100292758 | OPTICAL STIMULATION OF THE BRAINSTEM AND/OR MIDBRAIN, INCLUDING AUDITORY AREAS - Apparatus and method for optical- or optical-and-electrical stimulation of midbrain and/or brainstem tissue (e.g., auditory nerve pathways). Peripheral neural stimulation using infrared lasers has been demonstrated in several systems; however, optical stimulation of the central nervous system (CNS) has not been previously described. In some embodiments of the present invention, radiant energy exposure of the cochlear nucleus using a mid-wavelength infrared laser generates optically-evoked auditory brainstem responses (oABRs). In an experiment, the cochlear nuclei of adult male Sprague-Dawley rats were exposed using a suboccipital craniotomy approach. In one embodiment, different regions of left cochlear nucleus were acutely stimulated with a 200- or 400-micron-diameter optical fiber placed on the surface of the brainstem, using 50- to 750-microsecond pulses of 1849-nm to 1865-nm-wavelength radiation at a rate of 10 to 40 Hz and power levels ranging from 10% to 80% of 5 watts. oABRs were recorded during the period of optical stimulation. | 11-18-2010 |
| 20100239637 | CONTACT LENS DRUG DELIVERY DEVICE - The present invention relates generally to devices and methods for administering one or more active agents to the eye of a human or animal patient in need thereof, and more particularly to devices for application to the cornea which release active agent to the eye in a controlled manner. | 09-23-2010 |
| 20100094137 | METHODS AND SYSTEMS FOR OBSERVATION OF TYMPANIC FUNCTION - Methods and systems for endoscopic observation of tympanic function. | 04-15-2010 |
