MARSHALL UNIVERSITY RESEARCH CORPORATION Patent applications |
Patent application number | Title | Published |
20130295198 | METHODS OF SCREENING CHEMOTHERAPEUTIC AGENTS AND TREATING CANCER - Methods for selecting chemotherapeutic agents for treating a cancer are provided that include the steps of providing a cancer cell sample having a population of bulk cancer cells and a population of cancer stem-like cells, culturing a first portion of the cancer cell sample in a hydrodynamic focusing bioreactor under microgravity conditions and for a period of time to selectively enhance the population of cancer stem-like cells and selectively kill the population of bulk cancer cells, contacting the cancer stem-like cells with one or more chemotherapeutic agents, and then selecting the one or more chemotherapeutic agents for treating the cancer if there is an increase in an amount of cytotoxicity. Methods for treating a cancer are also provided in which the identified chemotherapeutic agents are administered to a subject. Further provided are methods for identifying a test compound useful for treating a cancer. | 11-07-2013 |
20130183352 | NANOFIBER SCAFFOLDS AND METHODS FOR REPAIRING DAMAGED CARDIAC TISSUE - Compositions are provided comprising a nanofiber scaffold that is seeded with one or more relevant cells and has a basketweave configuration that mimics the structure of a tissue, such as a cardiac tissue. Methods for treating damaged cardiac tissue in a subject are also provided and include applying an effective amount of the composition to damaged cardiac tissue. Methods for making nanofiber scaffold compositions are further provided and include electrospinning a biodegradable polymer onto a mandrel to create a mat of electrospun nanofibers, dividing the mat into nanofiber strips; and weaving the strips into a nanofiber scaffold having a basketweave configuration that mimics the structure of a tissue. | 07-18-2013 |
20130040381 | APPARATUS AND METHOD FOR A CONTINUOUS RAPID THERMAL CYCLE SYSTEM - A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means for changing temperature. A path traverses the sectors in a cyclical fashion. In use, a piece of tubing or other means for conveying is placed along the path and a reaction mixture is pumped or otherwise moved along the path such that the reaction mixture is repetitively heated or cooled to varying temperatures as the reaction mixture cyclically traverses the sectors. The reaction mixture thereby reacts to form a product. In particular, polymerase chain reaction reactants may continuously be pumped through the tubing to amplify DNA. The temperature control body is preferably a single aluminum cylinder with a grooved channel circling around its exterior surface, and preferably has wedge-shaped or pie-shaped sectors separated by a thermal barrier. | 02-14-2013 |
20120139262 | MOTION INDUCED ELECTRIC GENERATOR - A motion induced electric generator is mounted to a vehicle or conveyance to harness the oscillatory motion generated during travel of the vehicle or conveyance, and may be coupled to at least one device or system, such as an external rail car lighting system, a global positioning device, a diagnostic device, or a combination thereof. Once the motion of the vehicle is harnessed and translated into usable and/or storable energy, the current or voltage is transmitted directly to the units for immediate consumption or for storage in a battery, capacitor, or a combination thereof. | 06-07-2012 |
20110184157 | Methods of Producing Bacterial Alginates - Methods for mass producing bacterial alginate, bacterial cultures for producing alginate, and pharmaceutical compositions containing bacterial alginate are contemplated. | 07-28-2011 |
20110008786 | METHODS OF DETECTING AND CONTROLLING MUCOID PSEUDOMONAS BIOFILM PRODUCTION - Compositions and methods for detecting and controlling the conversion to mucoidy in | 01-13-2011 |
20100062435 | Methods for Stem Cell Production and Therapy - The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to methods for rapidly increasing the life span of stem cell populations without culture supplements in simulated microgravity conditions. The present invention also relates to methods for increasing the sensitivity of cancer stem cells to chemotherapeutic agents by culturing the cancer stem cells under microgravity conditions and in the presence of omega-3 fatty acids. The methods of the present invention can also be used to proliferate cancer cells by culturing them in the presence of omega-3 fatty acids. The present invention also relates to methods for testing the sensitivity of cancer cells and cancer stem cells to chemotherapeutic agents by culturing the cancer cells and cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce tissue for use in transplantation by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors by culturing stem cells or cancer stem cells under microgravity conditions. The methods of the present invention can also be used to produce cellular factors and growth factors to promote differentiation of cancer stem cells under microgravity conditions. | 03-11-2010 |
20090264316 | Ultraviolet/Ozone Patterned Organosilane Surfaces - UV/ozone treatment can be used to alter the hydrophobicity of organosilane coated surfaces. Methods are contemplated for producing micropatterned surfaces by coating a surface with an organosilane to produce an organosilane surface; and exposing the organosilane surface to ultraviolet light in the presence of oxygen, wherein the micropatterned organosilane surface is produced without the use of photoresist. Methods for producing substrate-micropatterned surfaces further are also contemplated. Suitable substrates include nucleotides, proteins, carbohydrates, and cells. The organosilane coated devices of the present invention may be used in, for example, arrays. | 10-22-2009 |