| LOS ALAMOS NATIONAL LABORATORY Patent applications |
| Patent application number | Title | Published |
|---|
| 20120071430 | SYNTHETIC ANALOGS OF BACTERIAL QUORUM SENSORS - Bacterial quorum-sensing molecule analogs having the following structures: | 03-22-2012 |
| 20110160090 | Nanocrystal-Based Lateral Flow Microarrays and Low-Voltage Signal Detection Systems - The invention provides semiconductor nanocrystal-based lateral flow microarrays (SN-LFM), assays using SN-LFM, signal amplification strategies, optical detection devices for collecting data from SN-LFM assays, and integrated sample-to-answer SN-LFM assay/detection devices. | 06-30-2011 |
| 20110117540 | Highly Simplified Lateral Flow-Based Nucleic Acid Sample Preparation and Passive Fluid Flow Control - Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays. | 05-19-2011 |
| 20100009441 | POLYNUCLEOTIDES ENCODING ANTI-SULFOTYROSINE ANTIBODIES - The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and sulfated forms of such proteins, using any number of immunological assays, such ELISAs, immunoblots, Western Blots, immunoprecipitations, and the like. Using a phage-display system, single chain antibodies (scFvs) were generated and screened against tyrosine-sulfated synthetic peptide antigens, resulting in the isolation of scFvs that specifically recognize sulfotyrosine-containing peptides and/or demonstrate sulfotyrosine-specific binding in tyrosine sulfated proteins. The VH and VL genes from one such sulfotyrosine-specific scFv were employed to generate a full length, sulfotyrosine-specific immunoglobulin. | 01-14-2010 |
