| LONZA BIOLOGICS PLC. Patent applications |
| Patent application number | Title | Published |
|---|
| 20110104745 | METHOD OF EXPRESSING RECOMBINANT PROTEIN IN CHO CELLS - Method for enhancing the transfection rate of a mammalian expression vector in CHO cells. | 05-05-2011 |
| 20110040075 | ANTIBODY PURIFICATION BY PROTEIN A AND ION EXCHANGE CHROMATOGRAPHY - A novel method for selectively removing leaked protein A from antibody purified by means of protein A affinity chromatography is disclosed. | 02-17-2011 |
| 20100240097 | MAMMALIAN EXPRESSION VECTOR WITH A HIGHLY EFFICIENT SECRETORY SIGNAL SEQUENCE - The present invention relates to a mammalian cell based expression and secretion system and the expression and secretion of recombinant proteins by using secretory signal peptides. The present invention also relates to an expression cassette useful for the secretion of a heterologous gene from a mammalian cell, in particular a CHO cell. The present invention is also directed to a method of secreting a heterologous protein from mammalian cells such as CHO cells. | 09-23-2010 |
| 20100160602 | METHOD FOR PREDICTING PROTEIN AGGREGATION AND DESIGNING AGGREGATION INHIBITORS - The present invention provides methods of predicting protein aggregation and designing aggregation inhibitors. One such method for predicting potential protein aggregation inhibiting peptide sequences, includes the steps of: a) identifying a peptide sequence forming at least part of an aggregation region in a target protein; b) testing whether said peptide sequence forms part of a β-sheet; c) if a positive result is achieved in step b), extracting the adjacent strands of that sheet; d) identifying residues in the adjacent strands to said peptide sequence whose side chains interact with said peptide sequence, those residues forming a potential protein aggregation inhibiting peptide sequence. The present invention also provides methods of designing compounds using the residues identified in the above method; compounds produced by the methods and computer programs for carrying out the above methods. | 06-24-2010 |
| 20080312425 | Ion Exchange Chromatography and Purification of Antibodies - A novel method for purifying antibody and other product protein concomitant with removing aggregates made up from single product protein species is devised. | 12-18-2008 |
