| LIPOGEN LTD. Patent applications |
| Patent application number | Title | Published |
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| 20110212922 | PROCESSES FOR THE PREPARATION OF PHOSPHATIDE SALTS - The present invention discloses processes a process for the preparation of phosphatide-salt complexes, the process including the steps of: using at least one raw material lecithin as a substrate; and enzymatically processing at least one raw material lecithin with phospholipase-D, racemic or enantiomerically-pure serine, and/or amine in an aqueous carboxylate-salt-complex solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatide-salt complexes having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed at a pH in the range of about 4.5-8.0 at a temperature in the range of about 25-60° C. Preferably, the aqueous carboxylate-salt-complex solution is formed from an aqueous solution of a carboxylic acid with a chain length of C2-C8 and a salt in an approximately 1:2 (weight per weight) acid-to-salt ratio. | 09-01-2011 |
| 20110098249 | COMPOSITIONS AND METHODS OF TREATMENT FOR ALLEVIATING PREMENSTRUAL SYNDROME SYMPTOMS - The present invention discloses pharmaceutical/nutritional compositions for alleviating symptoms associated with premenstrual syndrome (PMS) and methods of treatment for PMS using such pharmaceutical/nutritional composition including: at least 2% (w/w) phosphatidyl-L-serine, or salts thereof, out of a total composition, as an effective ingredient, wherein: the phosphatidyl-L-serine has a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the phosphatidyl-L-serine is produced by enzymatic reaction of at least one raw material lecithin with phospholipase-D; at least one raw material lecithin is selected from the group consisting of: a vegetal lecithin and a non-vegetal lecithin; and the phospholipase-D is selected from the group consisting of: vegetal phospholipase-D, bacterial-originated enzyme phospholipase-D, and a combination of vegetal phospholipase-D and bacterial-originated enzyme phospholipase-D. Preferably, the structural fatty-acid chain is a saturated, hydrogenated fatty-acid chain. Preferably, the phosphatidyl-L-serine is derived from a dairy lecithin. | 04-28-2011 |
| 20100036141 | PROCESSES FOR THE PREPARATION OF PHOSPHATIDES - The present invention discloses processes for the preparation of phosphatides and salts thereof, the processes including the steps of using at least one raw material lecithin as a substrate and a water-insoluble surfactant-matrix material having a particulate size greater than about 0.01 mm; and enzymatically processing at least one raw material lecithin with the water-insoluble surfactant-matrix material, phospholipase-D, racemic or enantiomerically-pure amino acid, and/or amine and salts in a pH-buffered aqueous solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatides, or the salts thereof, having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed in the presence of a buffer having a pH in the range of about 4.5-8.0. Preferably, the step of processing is performed in the presence of a calcium salt. | 02-11-2010 |
