LES LABORATORIES SERVIER Patent applications |
Patent application number | Title | Published |
20140088197 | MIXED CRYSTAL AGOMELATINE (FORM VIII), PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME - The present invention provides a mixed crystalline form VIII of agomelatine, its method of preparation, application and pharmaceutical composition. The said mixed crystal consists mainly of crystalline form VI of agomelatine. The said mixed crystalline form is stable and has good reproducibility. Through stability tests, it has been found to be superior to the crystalline form VI in terms of stability. As a result, the crystalline form VIII of the present invention possesses advantages in pharmaceutical preparation. | 03-27-2014 |
20130267738 | AGOMELATINE INTERMEDIATES AND PREPARATION METHOD THEREOF - The present invention relates to the intermediate compounds for preparation of agomelatine, as well as the preparation methods thereof. The intermediate of the present invention for preparation of agomelatine is compound A as shown in the following formula. Also provided are two novel intermediate compounds. When we use these new intermediate compounds to prepare agomelatine, it is simple to manipulate, well-controlled and with high purity, without complicated operations such as rectification and column chromatography separation, and suitable for industrial production. Meanwhile, the preparation methods of the two new intermediates themselves is simple and high yield, only using the most commonly-used 7-methoxy-tetralone as original starting material and undergoing one step of reaction to obtain the intermediates, followed by one more step of converting the intermediate compounds to desired product agomelatine. Said reaction processes are greatly simplified, with the reaction yield being improved and the difficulty in purification of previous method being overcome, as compare with the previous technique for preparation of agomelatine. Typically, the yield of the present invention is over 70%. | 10-10-2013 |
20110130370 | Pharmaceutical composition comprising a strontium salt, vitamin D and A cyclodextrin - A pharmaceutical composition comprising a strontium salt, vitamin D and a cyclodextrin. | 06-02-2011 |
20100063158 | Crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it - Crystalline form III of the compound of formula (I): | 03-11-2010 |