| KYOWA HAKKO BIO CO., LTD. Patent applications |
| Patent application number | Title | Published |
|---|
| 20120118756 | PROCESS FOR PRODUCTION OF REDUCED GLUTATHIONE - Provided is a superior method of producing reduced glutathione by electroreduction of oxidized glutathione. In a method of producing reduced glutathione by electroreduction of oxidized glutathione using a cathode cell and an anode cell separated from each other by a separating membrane, oxidized glutathione is produced using an aqueous oxidized glutathione solution with pH 2.0-3.0 comprising a conducting agent other than acid as a solution in the cathode cell. | 05-17-2012 |
| 20120034669 | PROCESS FOR PRODUCING USEFUL SUBSTANCE - The present invention provides a process for producing a useful substance which comprises culturing a transformant obtained by transforming a microorganism capable of producing the useful substance with a DNA encoding a protein in a medium, wherein the protein has an activity to improve growth of a high concentration oxygen-requiring microorganism under low oxygen concentration; forming and accumulating the useful substance in a culture; and collecting the useful substance from the culture. | 02-09-2012 |
| 20120034660 | PROCESS FOR PRODUCING OPTICALLY ACTIVE SUCCINIMIDE DERIVATIVES AND INTERMEDIATES THEREOF - A process for producing optically active succinimide derivatives as key intermediates of (3R)-2′-(4-bromo-2-fluorobenzyl)spiro{pyrrolidine-3,4′(1H)-pyrrolo[1,2-a]pyrazine}-1′,2,3′,5(2′H)-tetraone, which comprises the following reaction steps. | 02-09-2012 |
| 20120015409 | PROCESS FOR PRODUCING L-AMINO ACID - The present invention provides a method of improving efficiency of a fermentative production of an L-amino acid. To be specific, the present invention provides a process for producing a L-amino acid, comprising culturing a microorganism wherein the activity of the protein described in any one of (1) to (3) below is higher than that of the parent strain in a medium to produce the L-amino acid and accumulate the L-amino acid in the medium, and then collecting the L-amino acid from the medium: | 01-19-2012 |
| 20110318781 | CYCLODIPEPTIDE SYNTHETASE AND ITS USE FOR SYNTHESIS OF CYCLO(Tyr-Xaa) CYCLODIPEPTIDES - Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof. | 12-29-2011 |
| 20110312042 | METHOD FOR PRODUCING AMINO ACID - According to the present invention, a process for producing an amino acid using a microorganism in which aspartate aminotransferase activity is decreased or deleted, and which has the capability of producing and accumulating the amino acid is provided. | 12-22-2011 |
| 20110244528 | PROCESS FOR PRODUCING USEFUL SUBSTANCE - The present invention provides a process for efficiently producing a useful substance; and a microorganism which belongs to coryneform bacteria and which can be used in the process. The present invention provides a process for producing a useful substance by using a microorganism belonging to coryneform bacteria, the microorganism having an ability to take a sugar, which is taken into a cell via a phosphotransferase system (PTS), into a cell via a system other than the PTS, and having an ability to produce a useful substance. | 10-06-2011 |
| 20110172468 | METHOD FOR PRODUCING ALCOHOL, METHOD FOR PRODUCING HYDROGEN OR SYNTHESIS GAS USING THE METHOD FOR PRODUCING ALCOHOL, AND ALCOHOL - One object of the present invention is to provide a method for producing an alcohol which can produce a target alcohol containing a remarkably low content of the sulfur compound(s), and the present invention provides a method for producing an alcohol comprising a separation process which reduces the content of sulfur compound(s) in a crude alcohol containing at least the sulfur compound(s) through desulfurization treatment in which the crude alcohol is contacted with a separation membrane based on a pervaporation method, thereby a content of the sulfur composition in the crude alcohol is decreased. | 07-14-2011 |
| 20110124059 | METHOD FOR PRODUCTION OF L-GLUTAMINE - According to the present invention, it is possible to provide a microorganism belonging to the genus | 05-26-2011 |
| 20110091942 | PROCESS FOR PRODUCTION OF CIS-4-HYDROXY-L-PROLINE - Development of a method of economically and efficiently producing cis-4-hydroxy-L-proline. The present invention provides L-proline cis-4-hydroxylase. This enzyme may be derived from | 04-21-2011 |
| 20100311837 | METHOD FOR IMPROVING STORAGE STABILITY OF GLUTATHIONE - The invention provides a method of improving the preservation stability of glutathione in a solid composition containing glutathione and arginine. In particular, glutathione and arginine are made to be coexistent with an organic acid such as citric acid, tartaric acid, ascorbic acid, malic acid, malonic acid, succinic acid, fumaric acid, maleic acid and the like. The amount of the organic acid to coexistent with glutathione and arginine is generally 0.1-2 parts by weight relative to 1 part by weight of arginine. | 12-09-2010 |
| 20100292332 | RAPID-ACTING, BLOOD-ARGININE-LEVEL-INCREASABLE ORAL PREPARATION COMPRISING CITRULLINE AND ARGININE - The present invention provides a rapid-acting, blood arginine level-increasing oral preparation containing citrulline or a salt thereof and arginine or a salt thereof as active ingredients. The rapid-acting, blood arginine level-increasing oral preparation of the present invention can rapidly and effectively increase blood arginine level after ingestion, and can rapidly provide an arginine ingestion effect. | 11-18-2010 |
| 20100279334 | CYCLODIPEPTIDE SYNTHASES (CDSS) AND THEIR USE IN THE SYNTHESIS OF LINEAR DIPEPTIDES - Use of CDSs in the synthesis of linear dipeptides, and applications thereof for the in vivo and in vitro synthesis of linear dipeptides, in particular Phe-Leu, Leu-Phe, Phe-Phe, Phe-Tyr, Tyr-Phe, Leu-Leu, Leu-Tyr, Tyr-Leu, Phe-Met, Met-Phe, Leu-Met, Met-Leu, Tyr-Met, Met-Tyr, Met-Met, Tyr-Tyr, Ile-Met, Met-Ile, Leu-Ile, Ile-Leu using the corresponding polynucleotides. | 11-04-2010 |
| 20100272633 | METHOD FOR PRODUCING ALCOHOL, METHOD FOR PRODUCING HYDROGEN OR SYNTHESIS GAS USING THE METHOD FOR PRODUCING ALCOHOL, AND ALCOHOL - A method for producing an alcohol of the present invention provides an alcohol having the total sulfur content of 10 ppm by weight or less, by subjecting an alcohol having the total sulfur content of 30 ppm by weight or more and the propanols content of 200 ppm to at least one desulfurization treatment selected from at least one of a desulfurization treatment by a reaction process, a desulfurization treatment with a physical adsorbent, and a desulfurization treatment with a chemical adsorbent. | 10-28-2010 |
| 20100261749 | METHOD OF PREVENTING OR AMELIORATING PSORIASIS USING PYRROLOQUINOLINE QUINONE COMPOUNDS - It is an object of the present invention to provide a safe and highly effective preventing or ameliorating agent for skin psoriasis. | 10-14-2010 |
| 20100255174 | CITRULLINE-CONTAINING BEVERAGE - The invention provides an easy-to-drink beverage that contains citrulline, wherein the generation of bad odors due to storage or heating is suppressed. In particular, the invention provides a beverage that contains citrulline and citric acid, as well as sodium citrate or disodium hydrogen phosphate. | 10-07-2010 |
| 20100249028 | ORAL COMPOSITION - An object of the present invention is to provide an oral composition useful for promoting collagen synthesis and the like. The present invention can provide an oral composition containing collagen or gelatin or a degradation product thereof, and hydroxyproline or a salt thereof. The weight ratio of alanine and hydroxyproline contained in the amino acids obtained by hydrolyzing the oral composition is preferably 1:1.5-150. | 09-30-2010 |
| 20100248307 | PEPTIDE PRODUCTION METHOD - According to the present invention, a protein having peptide-synthesizing activity, a DNA encoding the protein, a recombinant DNA containing the DNA, a transformant obtained via transformation with the recombinant DNA, a process for producing a protein having peptide-synthesizing activity using the transformant and the like, a process for producing a peptide using a protein having peptide-synthesizing activity, and a process for producing a peptide using as an enzyme source a culture or the like of a transformant or a microorganism producing a protein having peptide-synthesizing activity are provided. | 09-30-2010 |
| 20100203592 | METHOD FOR PRODUCTION OF GLUTATHIONE OR GAMMA-GLUTAMYLCYSTEINE - The invention provides a process for producing glutathione or γ-glutamylcysteine by culturing in a medium a microorganism with a higher activity of a protein having an activity to transport intracellular glutathione to the outside of cells, and a higher activity of a protein involved in glutathione or γ-glutamylcysteine biosynthesis, compared with that of the parent strain, forming and accumulating glutathione or γ-glutamylcysteine in the medium, and recovering the glutathione or γ-glutamylcysteine from the culture. | 08-12-2010 |
| 20100190815 | HYPERTENSION-AMELIORATING AGENT - It is an objective of the present invention to provide a safe and highly effective hypertension-ameliorating agent. | 07-29-2010 |
| 20100137226 | FATIGUE-REDUCING AGENT - A pharmaceutical product, a functional food or the like has been demanded which can reduce the fatigue in a tired person and enables the tired person to lead a fulfilled life. Disclosed is a fatigue-reducing agent. The fatigue-reducing agent comprises ornithine or a salt thereof and glutathione or a salt thereof as active ingredients. | 06-03-2010 |
| 20100129867 | METHOD FOR PRODUCING DIPEPTIDE - The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and
| 05-27-2010 |
| 20100129866 | METHOD FOR PRODUCTION OF DIPEPTIDE - According to the present invention, a protein having dipeptide-synthesizing activity, a DNA encoding the protein, a recombinant DNA containing the DNA, a transformant obtained via transformation with the recombinant DNA, a process for producing a protein having dipeptide-synthesizing activity using the transformant or the like, a process for producing a dipeptide using a protein having dipeptide-synthesizing activity, and a process for producing a dipeptide using a culture or the like of a transformant or a microorganism that produces a protein having dipeptide-synthesizing activity as an enzyme source are provided. | 05-27-2010 |
| 20100120126 | MICROORGANISMS PRODUCING DIPEPTIDES AND PROCESS FOR PRODUCING DIPEPTIDE USING THE MICROORGANISMS - Microorganisms in which the activities of one or more kinds of peptidases and one or more kinds of proteins having peptide-transporting activity are reduced or lost and which have the ability to produce a dipeptide. Also, microorganisms in which the activities of three or more kinds of peptidases are reduced or lost and which have the ability to produce a dipeptide, and a process for producing dipeptides using the microorganisms. | 05-13-2010 |
| 20100099847 | CRYSTAL OF GLUTATHIONE AND PROCESS FOR PRODUCTION THEREOF - Disclosed is a crystal of glutathione having an average width of 7 to 40 μm and an average particle diameter of 10 to 60 μm, preferably having an angle of repose of 53 degree or less, more preferably having a crude specific volume of 5.0 cm | 04-22-2010 |
| 20100093780 | INSULIN RESISTANCE IMPROVING AGENT - An object of the present invention is to provide a safe and highly effective insulin resistance improving agent or therapeutic agent for type II diabetes. According to the present invention, an insulin resistance improving agent or a therapeutic agent for type II diabetes comprising a compound represented by general formula (I) | 04-15-2010 |
| 20100093646 | METHOD FOR ENHANCING MEMORY IN NORMAL INDIVIDUAL - The present invention provides a method for enhancing memory in a normal individual, particularly in an individual of middle or advanced age who is regarded as clinically normal. The method for enhancing memory in a normal individual comprises administration of a peptide consisting of Leu and Ile or a modified form thereof. | 04-15-2010 |
| 20100087383 | INTRACEREBRAL OXIDATION INHIBITOR AND USE THEREOF - The present invention relates to an intracerebral oxidation inhibitor for preventing the onset of mental deterioration, which has early therapeutic effects. Specifically, the present invention relates to: an intracerebral oxidation inhibitor comprising a peptide consisting of Leu and Ile or a modified form thereof as an active ingredient; and a prophylactic or therapeutic agent for mental deterioration comprising the peptide consisting of Leu and Ile or a modified form thereof as an active ingredient and having effects of inhibiting intracerebral oxidation. | 04-08-2010 |
| 20100048948 | GLUTATHIONE PREPARATION AND METHOD FOR PRODUCTION THEREOF - The present invention relates to a method of improving the preservation stability of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. In addition, the present invention relates to a production method of a glutathione preparation, which is characterized by mixing glutathione and an arginine-acidic amino acid salt. By the production method, a glutathione preparation that resists quality deterioration can be provided. Moreover, the present invention relates to a preservation method of glutathione, which is characterized by allowing glutathione to co-exist with an arginine-acidic amino acid salt. By the preservation method, quality deterioration of glutathione during preservation can be suppressed. | 02-25-2010 |
| 20100040715 | COMPOSITION CONTAINING AGARICUS BLAZEI MURILL - The invention provides a composition containing a fruit body of | 02-18-2010 |
| 20100004335 | ORAL PREPARATION FOR PREVENTING OR IMPROVING SKIN DRYNESS - An oral preparation for the prophylaxis or improvement of dry skin accompanied by atopic dermatitis, xeroderma, chapped hand, chapped skin and the like is provided. The present invention can provide an oral preparation for the prophylaxis or improvement of dry skin, which comprises citrulline or a salt thereof as an active ingredient. | 01-07-2010 |
| 20090306340 | METHOD FOR PURIFICATION OF OLIGOPEPTIDES - The present invention provides: a method for purifying an oligopeptide, which comprises a step of contacting a solution comprising the oligopeptide and a neutral amino acid with an ion exchange resin in an effective pH range; the method for purifying an oligopeptide, which comprises (a) a step of passing a solution comprising the oligopeptide and the neutral amino acid through a column packed with an ion exchange resin, and (b) a step of eluting the oligopeptide contacted with the ion exchange resin with an eluting solvent; the above method using a weakly acidic cation exchange resin; the above method using a weakly basic anion exchange resin, etc. | 12-10-2009 |
| 20090264616 | Cyclodipeptide Synthetases and Their Use for Synthesis of Cyclo(Leu-Leu) Cyclodipeptide - Isolated, natural or synthetic polynucleotides and the polypeptides encoded by said polynucleotides, that are involved in the synthesis of cyclodipeptides, the recombinant vectors comprising said polynucleotides or any substantially homologous polynucleotides, the host cell modified with said polynucleotides or said recombinant vectors and also methods for in vitro and in vivo synthesizing cyclo(Leu-Leu) cyclodipeptide and its derivatives and applications thereof. | 10-22-2009 |
| 20090258399 | METHOD FOR PRODUCTION OF AMINO ACID - According to the present invention, there are provided a microorganism belonging to Enterobacteriaceae wherein a function of CsrB RNA or CsrC RNA has been decreased or lost, and which has the ability to produce and accumulate an amino acid, and a process wherein the microorganism is cultured in a medium to produce and accumulate the amino acid in the culture, and the amino acid is recovered from the culture. | 10-15-2009 |
| 20090130723 | Methods for Purifying Amino Acids - In the method for separating and purifying histidine from a culture containing the amino acid, the culture containing histidine and microbial cells is charged onto the top of a column filled with a carrier particle whose particle size is 350 μm or more and which has an ability to adsorb histidine and then an eluent is passed through the column whereby accomplishing the separation and purification of histidine, and preferably in the step mentioned above, a strong acid cation exchange resin is employed as a carrier particle whereby accomplishing the separation and purification of histidine. | 05-21-2009 |
