KYOTO UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160137985 | METHOD FOR PRODUCING RENAL PROGENITOR CELLS, AND DRUG COMPRISING THE SAME - The present invention provides: a method for producing renal progenitor cells from intermediate mesoderm cells, which comprises a step of culturing intermediate mesoderm cells in a medium containing a TGFβ signaling activator(s) and a BMP inhibitor(s); the renal progenitor cells produced by the method; a pharmaceutical composition comprising the renal progenitor cells; and a therapeutic drug for kidney diseases comprising the renal progenitor cells. | 05-19-2016 |
20160122716 | METHOD OF EFFICIENTLY INDUCING CARDIOMYOCYTES - The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating embryoid bodies obtained during the production process, and allowing reaggregation of the resulting cells to allow formation of embryoid bodies. | 05-05-2016 |
20160113917 | MEDICINAL COMPOSITION FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR SHRINKING SAME - Provided is a pharmaceutical composition which enables the inhibition of formation and/or enlargement of cerebral aneurysm or the regression of cerebral aneurysm. The pharmaceutical composition for the inhibition of formation and/or enlargement of cerebral aneurysm or for the regression of cerebral aneurysm of the present invention, which includes a S1P | 04-28-2016 |
20160110476 | RELATIONSHIP GRAPH INTERLINKAGE SYSTEM - A relationship graph interlinkage system includes a plurality of relationship graph databases | 04-21-2016 |
20160108366 | Method for Inducing Exocrine Pancreatic Cells - An object of the present invention is to provide a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells. The above object is achieved by providing a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells using a culture solution containing a histone deacetylase inhibitor and/or a ligand protein for a Notch signal, and a protein kinase C activator. | 04-21-2016 |
20160103133 | METHOD FOR DETERMINING PROGNOSIS OF CANCER - The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject. | 04-14-2016 |
20160047049 | APPARATUS FOR FORMING METAL OXIDE FILM, METHOD FOR FORMING METAL OXIDE FILM, AND METAL OXIDE FILM - A method for forming a metal oxide film, the method including: forming a source solution containing metal into a mist, heating a substrate, supplying the source solution formed into a mist onto a first main surface of the substrate through a first supply path, and supplying hydrogen peroxide through a second path different from the first supply path onto the first main surface of the substrate, where the method further includes, in the following order, preliminarily preparing data showing a relationship among a molar ratio of an amount of the hydrogen peroxide to an amount of the zinc in the source solution, a carrier concentration of the metal oxide film, and a mobility of the metal oxide film, determining an amount of the hydrogen peroxide supplied with the data, and supplying the determined amount of the hydrogen peroxide through the second path onto the first main surface of the substrate. | 02-18-2016 |
20160047037 | FILM FORMATION METHOD - In a film formation method, a mist of a solution is sprayed onto a substrate to form a film on the substrate. A film formation is then suspended. The substrate is then exposed to plasma. | 02-18-2016 |
20160017508 | METHOD FOR MANUFACTURING ELECTROLYTIC COPPER - Provided is a method for producing electrolytic copper having a low Ag content by successfully suppressing the Ag concentration in an electrolytic solution. The electrolytic copper production method involves a step in which blister copper comprising Ag is used as an anode, and electrolysis is carried out under sulfuric acid acidity while maintaining the anode electric potential at a relatively low electric potential in comparison to the electric potential of the Ag elution. | 01-21-2016 |
20160004787 | RELATIONAL GRAPH DATABASE SYSTEM - There is provided a novel method that generates relational graph data. A relational graph database system | 01-07-2016 |
20160000810 | Method For Treating Eye Diseases - The present invention provides a pharmaceutical composition for removing drusen, suppressing formation of drusen, and/or treating and/or preventing age-related macular degeneration comprising the compound of formula (I) wherein Ra is independently selected from the group consisting of halo, hydroxy, alkyl, halo-substituted alkyl, aryl, halo- or alkyl-substituted aryl, alkoxy, hydroxy- or carboxy-substituted alkoxy, aryloxy, halo- or alkyl-substituted aryloxy, CHO, C(O)-alkyl, C(O)-aryl, C(O)-alkyl-carboxyl, C(O)-alkylene-carboxy ester and cyano, and m is an integer selected from 0 to 4. | 01-07-2016 |
20150353888 | METHOD FOR INDUCING ASTROCYTES - The present invention provides a method for producing astrocytes from neural progenitor cells, the method comprising: (1) culturing neural progenitor cells in a culture medium comprising a neurotrophic factor; (2) dissociating the cells obtained in the step (1); and (3) subjecting the cells obtained in the step (2) to adherent culture in a culture medium comprising a neurotrophic factor using an uncoated culture vessel. | 12-10-2015 |
20150352233 | Polypeptide and Imaging Method - A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3); | 12-10-2015 |
20150344913 | RECOMBINANT MICROORGANISM AND METHOD FOR PRODUCING A SUBSTANCE USING THE SAME - This invention provides a recombinant microorganism into which an acyl-CoA reductase exerting excellent activity in a reduction reaction involving the use of acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding a protein (a) or (b) below introduced into a host microorganism: (a) a protein comprising the amino acid sequence of SEQ ID NO: 2; or (b) a protein comprising an amino acid sequence having 70% or higher identity to the amino acid sequence of SEQ ID NO: 2 and having activity for synthesizing an aldehyde compound from acyl-CoA. | 12-03-2015 |
20150344851 | RECOMBINANT MICROORGANISM AND METHOD FOR PRODUCING A SUBSTANCE USING THE SAME - This invention provides a recombinant microorganism into which an acyl-CoA reductase exhibiting excellent activity in a reduction reaction using acyl-CoA as a substrate has been introduced. Such recombinant microorganism comprises a nucleic acid encoding an acyl-CoA reductase comprising any of characteristic Common sequences 1 to 3 introduced into a host microorganism. | 12-03-2015 |
20150320020 | FIBROTIC NON-HUMAN ANIMAL, AND USE THEREOF - The present invention provides a non-human animal IKKβ which shows fibrosis of tissue, since it lacks IKKβ gene in a myofibroblast- and/or smooth muscle cell-specific manner. Since the non-human animal shows pathology highly similar to scleroderma, it is extremely useful as an animal model of scleroderma. | 11-12-2015 |
20150290618 | POROUS POLYMER METAL COMPLEX, GAS ADSORBENT, AND GAS SEPARATION DEVICE AND GAS STORAGE DEVICE USING SAME - An object of the present invention is to provide a porous polymer metal complex which can be used as a gas adsorbent and contains two or more types of similar ligands. A porous polymer metal complex is provided expressed by [CuX] | 10-15-2015 |
20150266937 | VACCINE FOR TREATMENT OF TAUTOPATHY - This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phospholylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly. | 09-24-2015 |
20150260800 | DEVICE FOR ESTIMATING PARAMETERS OF BATTERY, AND ESTIMATION METHOD - A device for estimating parameters of battery capable of improving, by using simple calculations, estimation accuracy of a parameter and the like of a battery equivalent circuit model will be provided. | 09-17-2015 |
20150231622 | METAL NANOPARTICLE COMPLEX AND METHOD FOR PRODUCING SAME - The present invention provides a metal nanoparticle composite having a structure, in which metal nanoparticles are dispersed in an organic structure, the organic structure including: a structure of a porous coordination polymer (PCP) or metal-organic framework (MOF) containing a metal and a polyvalent ligand capable of reducing the metal; and carbon. | 08-20-2015 |
20150231284 | MOLECULAR PROBE FOR IMAGING OF PANCREATIC ISLET AND THE PRECURSOR, AND USE OF THE SAME - A precursor of molecular probe for imaging of pancreatic islets is provided. A polypeptide represented by any one of the following formulae (1) to (4), or a polypeptide having a homology with the foregoing polypeptide. | 08-20-2015 |
20150228918 | SOLAR CELL - A solar cell includes a translucent member disposed on the incident side of sunlight, an electrode member disposed on the opposite side from the incident side of sunlight and includes a positive electrode and a negative electrode, and an electricity-generating layer that is disposed between the translucent member and the electrode member and is composed of carbon nanotubes, the electricity-generating layer including a p-type first carbon nanotube layer that is disposed near the electrode member and is electrically connected to the positive electrode, and an n-type second carbon nanotube layer that is disposed near the translucent member and is partially electrically connected to the negative electrode | 08-13-2015 |
20150225421 | COMPOUND AND PHARMACEUTICAL COMPOSITION FOR NEUROPSYCHOLOGICAL DISORDER OR MALIGNANT TUMOR - The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the pharmaceutical composition, or a method for preventing, improving, inhibiting the development of, and/or treating neuropsychological disorders or malignant tumors with the use of the compound and the pharmaceutical composition. One or more embodiments disclose a compound expressed by the following general formula (I) or (II) or a pharmaceutically acceptable salt of the compound: | 08-13-2015 |
20150207089 | ELECTRICITY-GENERATING LAYER OF SOLAR CELL, METHOD FOR PRODUCING SAME, AND SOLAR CELL - An electricity-generating layer of a solar cell includes a carbon nanotube group containing vertically oriented carbon nanotubes. A fullerene is encapsulated in the carbon nanotube, an n-type dopant | 07-23-2015 |
20150202327 | MOLECULAR ASSEMBLY USING BRANCHED AMPHIPHILIC BLOCK POLYMER, AND DRUG TRANSPORTATION SYSTEM - The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units. | 07-23-2015 |
20150184168 | TRANSLATIONAL CONTROL SYSTEM USING RNA-PROTEN INTERACTION MOTIF - A translational control method using an RNA-protein interaction motif is provided. The method comprises a step of introducing an mRNA having: a 5′UTR regulation structure comprising: (1) a cap structure at the 5′ terminus, (2) a spacer positioned on the 3′ side of the cap structure, and (3) one or more RNA motifs positioned on the 3′ side of the spacer, which comprises an RNA-protein interaction motif-derived nucleotide sequence or a variant thereof; and a nucleotide sequence encoding a target protein gene on the 3′ side of the 5′UTR regulation structure, into a cell in the presence of a protein specifically binding to the RNA motifs, wherein a translational level is decreased as the number of bases of the spacer decreases, and the translational level is decreased as the number of the RNA motifs increases. | 07-02-2015 |
20150181185 | IMAGE PROCESSING DEVICE AND ENDOSCOPE DEVICE - An image processing device, comprising an image obtaining means that obtains color endoscopic image data, a color space conversion means that converts a color space of the color endoscopic image data to an HSI color space based on hue, saturation and intensity or an HSV color space based hue, saturation and a value, a lesion pixel judgment means that judges, for each of pixels constituting a color endoscopic image, whether or not each pixel is a lesion portion based on the hue and the saturation, a lesion pixel counting means that counts a number of lesion pixels which is a number of pixels judged to be the lesion portion, a lesion index calculation means that calculates a lesion index based on the number of lesion pixels; and a lesion index display means that displays the lesion index. | 06-25-2015 |
20150133467 | SCREENING METHOD, PROTEIN INSTABILITY AND/OR STABILITY INDUCERS, AND PROTEIN ACTIVITY ASSESSMENT - Provided is a screening method with which it is possible to determine the cause of a decrease or an increase in the amount of a target protein that is expressed by a cell. One or a plurality of embodiments include: conducting cultivation that includes bringing an assay cell into contact with a test substance, and measuring a relative amount (A) of the target protein in relation to an internal standard; conducting cultivation in which an assay cell is not brought into contact with a test substance, and measuring a relative amount (B) in relation to an internal standard; comparing the relative amount (A) and the relative amount (B); and, based on the comparison, selecting a candidate substance that induces instability and/or stability in the target protein. The assay cell is a cell that is able to express mRNA of the target protein and mRNA of the internal standard protein under the identical regulation of gene expression, or a cell having a means for expressing mRNA of the target protein and mRNA of the internal standard protein under the identical regulation of gene expression. | 05-14-2015 |
20150116660 | FUNDUS OBSERVATION APPARATUS AND FUNDUS IMAGE ANALYZING APPARATUS - In a fundus observation apparatus, an optical system detects interference light generated by superposing signal light having traveled by way of an eye fundus and reference light having traveled by way of a reference optical path. An image forming part forms a cross sectional image based on detection results of the interference light. A specifying part analyzes the cross sectional image to specify an abnormal region located in the vicinity of central fovea of the eye fundus. The association information generating part calculates the distance between the central fovea and the abnormal region and generates association information in which the direction of the abnormal region relative to the central fovea and the distance are associated with each other. The evaluation information generating part generates evaluation information for evaluating the state of the eye fundus based on the association information. | 04-30-2015 |
20150104820 | METHOD FOR PRODUCTION OF EOSINOPHIL FROM PLURIPOTENT STEM CELL - The present invention relates to a method for producing human eosinophils from human pluripotent stem cells. More specifically, the present invention provides a method for producing human eosinophils from human pluripotent stem cells, which method comprises the steps of: (1) co-culturing, in the presence of VEGF, human pluripotent stem cells with cells separated from the AGM region of a mammalian fetus; (2) performing suspension culture using a medium comprising IL-3, IL-6, Flt3 ligand, SCF, TPO and serum; (3) performing suspension culture using a medium comprising IL-3, SCF, GM-CSF and serum; and, optionally, (4) performing suspension culture using a medium comprising IL-3, IL-5 and serum. | 04-16-2015 |
20150097162 | MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE, AND LIGHTING DEVICE - Provided is an organic electroluminescent element which has improved driving voltage and improved current efficiency. An organic electroluminescent element having the above-mentioned improved characteristics is provided by using, as a material for organic electroluminescent elements, a polycyclic aromatic compound in which a nitrogen atom and another heteroatom or a metal atom (X) are adjacent to each other in a non-aromatic ring. | 04-09-2015 |
20150087060 | METHOD FOR INDUCING ERYTHROPOIETIN-PRODUCING CELL - An object of the present invention is to provide a method for inducing the differentiation of erythropoietin-producing cells from human pluripotent stem cells. The above object is achieved by providing a method for inducing the differentiation of erythropoietin-producing cells from human pluripotent stem cells using a medium containing a specific growth factor and a specific compound. | 03-26-2015 |
20150065779 | TREATMENT PLANNING DEVICE, TREATMENT PLANNING METHOD, AND PROGRAM THEREFOR - This treatment planning device calculates position information for specific locations for a plurality of times corresponding to a time course on the basis of the positions of markers positioned in the vicinity of the specific locations, and generates a three-dimensional range for the specific locations for each of the plurality of times. In addition, the treatment planning device generates representative range information, which represents a range that includes the entire three-dimensional ranges for the specific locations for each of the plurality of times, tracks the position information for the specific locations for each of the plurality of times, and calculates the amount of radiation to be emitted in the range for the specific locations represented by representative range information when radiation is emitted for a prescribed time period in the range for the specific locations represented by the representative range information. | 03-05-2015 |
20150056130 | CONTINUOUS PRODUCTION METHOD OF HYDROGEN - The present invention provides a continuous production method of hydrogen which is able to produce hydrogen, which is clean energy, simply and continuously without using ammonia. The invention of the continuous production method of hydrogen includes a hydrogen production step comprising introducing mayenite (Ca | 02-26-2015 |
20150034901 | SEMICONDUCTOR LIGHT EMITTING ELEMENT - A semiconductor light emitting element includes an electrode | 02-05-2015 |
20150011008 | METHOD OF TRANSFERRING GENE INTO ALGAL CELL INVOLVING UTILIZING MULTIPLE SQUARE-WAVE PULSES IN THREE STEPS - To provide a technology that solves the above-mentioned problems, and is directly applicable to eukaryotic algal cells with cell-wall, the technology enabling gene transfer and transformation to be performed with high efficiency and good reproducibility irrespective of species of algae. Also provided is a method of transferring an exogenous gene into a eukaryotic algal cell, the method comprising performing electroporation using multiple square-wave pulses to the solution containing a cell of a green alga with cell-wall, and a nucleic acid molecule by the following three steps: applying a square-wave electric pulse (first electric pulse) with a high voltage for a short period of time under the condition that its total electric energy falls within a predetermined range; then applying a square-wave electric pulse (second electric pulse) with a low voltage for a long period of time two or more times; and then applying a square-wave electric pulse (third electric pulse) that is opposite in polarity to the second electric pulse, with a low voltage for a long period of time, two or more times. | 01-08-2015 |
20140363888 | METHOD FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO INTERMEDIATE MESODERM CELLS - The present invention provides a method for inducing differentiation of a human pluripotent stem cell into an intermediate mesoderm cell without the use of a growth factor. Such method comprises performing culture in a medium containing a specific compound, so as to induce differentiation of a human pluripotent stem cell into an intermediate mesoderm cell. | 12-11-2014 |
20140363825 | MARKER FOR DETECTING COLORECTAL CANCER OR ESOPHAGEAL CANCER AND METHOD FOR EXAMINING SUCH CANCER - This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein. | 12-11-2014 |
20140361226 | Negative Electrode Active Material and Use of Same - This invention relates to an anode active material comprising at least one iron oxide selected from the group consisting of amorphous iron oxides, ferrihydrite, and lepidocrocite. The invention also relates to a lithium ion secondary battery anode material comprising the anode active material as a constituent component, a lithium ion secondary battery anode comprising the lithium ion secondary battery anode material, and a lithium ion secondary battery comprising the lithium ion secondary battery anode. | 12-11-2014 |
20140350201 | CONJUGATED DIENE POLYMER AND METHOD FOR PRODUCING SAME - Conjugated diene polymer comprising at least a conjugated diene monomer unit, the conjugated diene polymer has a number-average molecular weight (Mn) in terms of polystyrene of 1,000 to 1,000,000, a ratio (Mw/Mn) of a weight-average molecular weight (Mw) to the number-average molecular weight (Mn) of lower than 2.0 and the polymer bears a halogen atom at a terminal of the polymer chain. Method for producing the conjugated diene polymer comprises subjecting a monomer containing at least a conjugated diene to living radical polymerization using a polymerization initiator comprising a halogenocyclopentadienyl triorganophosphine η | 11-27-2014 |
20140343863 | METHOD FOR EVALUATING VITALITY OF PLANT, AND MEASUREMENT SYSTEM AND EVALUATION SYSTEM - The present invention discloses a method for evaluating vitality of a plant including (a) a step of measuring a delayed luminescence of a leaf of each plant of a group of plants subject to evaluation to obtain data of delayed luminescence amount, and (b) a step of processing data of a plurality of delayed luminescence amounts thus obtained to evaluate a plant exhibiting a delayed luminescence amount not less than a preset upper limit threshold as an individual of poor growth or evaluate a plant exhibiting a delayed luminescence amount not more than a preset lower limit threshold as an individual of good growth, and a measurement system and an evaluation system used for the method. | 11-20-2014 |
20140343034 | Skin barrier function improving agent - [PROBLEM] The problem to be solved by the invention is to provide a novel pharmaceutical use of a JAK inhibitor. | 11-20-2014 |
20140342075 | FROZEN DESSERT AND FROZEN DESSERT MATERIAL - A frozen dessert improved in shape retention without an adverse effect on the properties of the frozen dessert such as viscosity, texture and flavor is provided. | 11-20-2014 |
20140335090 | THERAPEUTIC AGENT FOR CANCER, AND METHOD FOR DETERMINING PROGNOSIS OF CANCER - Disclosed are a novel therapeutic agent for cancer such as esophageal squamous cell carcinoma, a method for predicting the prognosis of cancer, and a method for detecting, or predicting the prognosis of, cancer such as esophageal squamous cell carcinoma using a sample that can be collected less invasively. The therapeutic agent for cancer comprises as an effective component an antibody that undergoes antigen-antibody reaction with FGFRL1 to suppress the growth of cancer cells, or an antigen-binding fragment thereof. The method for predicting the prognosis of cancer comprises investigating the expression level of FGFRL1 in a cancer tissue separated from a living body, and, in this method, a high expression level of FGFRL1 indicates poor prognosis. The method for detecting cancer comprises measuring FGFRL1 or a fragment thereof extracted from a body tissue, or FGFRL1 or a fragment thereof in blood separated from a living body, and, in this method, a higher concentration of FGFRL1 or the fragment thereof contained therein than the concentration of FGFRL1 or the fragment thereof in the tissue or blood of a healthy individual indicates the presence of cancer. | 11-13-2014 |
20140333723 | OBSERVATION SYSTEM, OBSERVATION PROGRAM, AND OBSERVATION METHOD - An observation system includes a microscope optical system, an image pickup unit, an image pickup control unit, a detection unit, and an observation control unit. The image pickup unit is configured to take an image of a field-of-view range of the microscope optical system. The image pickup control unit is configured to cause the image pickup unit to take images of an observation sample in the field-of-view range at a plurality of focal positions and generate detection images. The detection unit is configured to detect a three-dimensional position of an observation target object in the observation sample from the detection images. The observation control unit is configured to fit the field-of-view range of the microscope optical system to the three-dimensional position. | 11-13-2014 |
20140320620 | LESION EVALUATION INFORMATION GENERATOR, AND METHOD AND COMPUTER READABLE MEDIUM THEREFOR - A lesion evaluation information generator including a processor configured to, when executing processor-executable instructions stored in a memory, determine a hue value and a saturation value of each of pixels of an endoscopic image based on an acquired endoscopic color image data, determine, for at least a part of the pixels of the endoscopic image, a correlation value between color information of each individual pixel and reference color data, based on a hue correlation value between the hue value of each individual pixel and a reference hue value of the reference color data, and a saturation correlation value between the saturation value of each individual pixel and a reference saturation value of the reference color data, and generate an evaluation value for evaluating a severity of a lesion in the endoscopic image, by integrating the correlation value of each individual pixel. | 10-30-2014 |
20140309131 | METHOD FOR SCREENING INDUCED PLURIPOTENT STEM CELLS - The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers. | 10-16-2014 |
20140303334 | CATALYST FOR LIVING RADICAL POLYMERIZATION AND POLYMERIZATION METHOD - A nonmetallic compound having an ionic bond with a halide ion is used as a catalyst for living radical polymerization. Even if a radical initiator is not used, a monomer can be subjected to a radical polymerization to obtain a polymer having narrow molecular weight distribution. The cost of the living radical polymerization can be remarkably reduced, and it is made possible to prevent adverse effects of using a radical initiator (such as side reactions). The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst necessary, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor, etc. The catalyst can be applied to various monomers and enables synthesis of high molecular weight polymers. | 10-09-2014 |
20140295209 | Material having pores on surface, and method for manufacturing same - This invention makes it possible to impart bioactivity to a variety of materials by sandblasting to form pores in the surface thereof. | 10-02-2014 |
20140256043 | SMALL CHEMICAL COMPOUND WHICH PROMOTES INDUCTION OF DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS AND METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS USING SAID SMALL CHEMICAL COMPOUND - A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of ES cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of ES cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells. Another purpose of the present invention is to provide the thus-induced insulin-producing cells. Provided are: an agent for promoting induction of the differentiation of stem cells derived from a mammal into insulin-producing cells, which contains a compound that is selected from the group consisting of dopamine metabolism inhibitors, serotonin metabolism inhibitors, acetylchotine, acetylcholine degrading enzyme inhibitors and acetylcholine receptor activators; and a method for inducing differentiation using the agent for promoting induction of differentiation. | 09-11-2014 |
20140255317 | PREPARATION COMPRISING HEXOSE-6-PHOSPHATE-MODIFIED CHOLESTEROL DERIVATIVE - Provided is a compound represented by the general formula (1) (where: G represents a hexose-6-phosphate residue; and L represents a divalent linker group). | 09-11-2014 |
20140247852 | END-FACE-EMITTING PHOTONIC CRYSTAL LASER ELEMENT - When an end-face-emitting photonic crystal laser element | 09-04-2014 |
20140242653 | METHOD FOR PRODUCING PYRUVIC ACID FROM ALGINIC ACID - A method for producing pyruvic acid from polysaccharide alginic acid that is contained in large amounts in brown algae using the ability to assimilate alginic acid possessed by a lactate-dehydrogenase-gene-deficient | 08-28-2014 |
20140238268 | CONDENSED TANNIN-CONTAINING COMPOSITION TO BE CURED BY APPLYING HEAT/PRESSURE THERETO - Provided are a composition from which a biomass material can be obtained with low energy through a simple process and facility, a formed body obtained from the composition, and a method for producing the formed body. A composition according to the present invention is a composition to be cured by applying heat/pressure thereto, the composition including an element in the form of powder or small pieces, and 8% by weight or more of condensed tannin and 8% by weight or more of a saccharide selected form the group consisting of a monosaccharide and an oligosaccharide. The saccharide is preferably sucrose, glucose, fructose, maltose, xylose, or lactose. Preferably, the composition further includes an acid catalyst. | 08-28-2014 |
20140234643 | THERMAL EXPANSION SUPPRESSING MEMBER AND ANTI-THERMALLY-EXPANSIVE MEMBER - Provided are a thermal expansion suppressing member having negative thermal expansion properties and a metal-based anti-thermally-expansive member having small thermal expansion. More specifically, provided are a thermal expansion suppressing member, including at least an oxide represented by the following general formula (1), and an anti-thermally-expansive member, including a metal having a positive linear expansion coefficient at 20° C., and a solid body including at least an oxide represented by the following general formula (1), the metal and solid being joined to each other: (Bi | 08-21-2014 |
20140234341 | ACUTE HEPATIC INSUFFICIENCY DEPRESSANT AND METHOD FOR EVALUATING DRUG EFFICACY THEREOF - The present invention provides a therapeutic agent for acute liver failure containing a hepatocyte growth factor (HGF), particularly an agent for treating fulminant hepatitis or late onset hepatic failure or suppression of progression of acute liver failure without hepatic coma to fulminant hepatitis or late onset hepatic failure. The present invention also provides a method for evaluating the efficacy of HGF including measuring the amount of α-fetoprotein (liver regeneration biomarker) and/or soluble Fas (anti-apoptotic biomarker) in a sample obtained from a liver injury patient administered with HGF. | 08-21-2014 |
20140221615 | POROUS SCAFFOLD MATERIAL, AND METHOD FOR PRODUCING SAME - Provided are a scaffold material that functions as a scaffold material for two weeks or more in vivo and causes substantially no foreign-body reaction, and a method for producing the scaffold material. Specifically, a porous scaffold material comprising collagen fibers is provided. | 08-07-2014 |
20140217470 | Ga2O3 SEMICONDUCTOR ELEMENT - Provided is a high-quality Ga | 08-07-2014 |
20140206083 | HUMAN PLURIPOTENT STEM CELLS INDUCED FROM UNDIFFERENTIATED STEM CELLS DERIVED FROM A HUMAN POSTNATAL TISSUE - Establishment of human pluripotent stem cells having properties close to human ES cells with the genome of the patient per se that can circumvent immunological rejection of transplanted cells from cells derived from a postnatal human tissue are described. Human pluripotent stem cells can be induced by introducing three genes of Oct3/4, Sox2 and Klf 4, or three genes of Oct3/4, Sox2 and Klf 4 plus the c-Myc gene or a histone deacetylase (HDAC) inhibitor of undifferentiated stem cells present in various human postnatal tissues in which each gene of Tert, Nanog, Oct3/4 and Sox2 has not undergone epigenetic inactivation. | 07-24-2014 |
20140194308 | USE OF MYELIN BASIC PROTEIN AS A NOVEL GENETIC FACTOR FOR RHEUMATOID ARTHRITIS - A novel genetic factor for rheumatoid arthritis is searched for and used as a diagnostic marker. | 07-10-2014 |
20140193836 | NOVEL MARKERS FOR DOPAMINERGIC NEURON PROGENITOR CELLS - The present invention provides a method for selecting dopaminergic neuron progenitor cells, which comprises detecting any one or more of markers selected from the group consisting of CD15 (SSEA-1), CD24, CD46, CD47, CD49b, CD57, CD58, CD59, CD81, CD90, CD98, CD147, CD184, Disalogangliosid GD2, SSEA-4, CD49f, SERINC4, CCR9, PHEX, TMPRSS11E, HTR1E, SLC25A2, Ctxn3, Cc17, Chrnb4, Chrna3, Kcnv2, Grm2, Syt2, Lim2, Mboat1, St3ga16, Slc39a12, Tacr1, Lrtm1, Dscam and CD201. | 07-10-2014 |
20140187784 | RADIOACTIVE QUINOLINONE DERIVATIVE AND PHARMACEUTICAL DRUG COMPRISING THE SAME - It is intended to provide a radioactive compound that has higher selectivity for CYP11B2 than that for CYP11B1, exhibits highly selective accumulation in the adrenal gland compared with blood and organs adjacent to the adrenal gland, and permits commercial supply. The present invention provides a radioactive quinolinone derivative represented by the predetermined general formula or a salt thereof. | 07-03-2014 |
20140186253 | METAL NANOPARTICLE-PCP COMPLEX AND MANUFACTURING METHOD THEREFOR - Provided is a composite, including a metal nanoparticle inside a porous coordination polymer (PCP), in which the PCP is formed of a metal ion and an organic ligand. | 07-03-2014 |
20140180045 | LIFESAVING SUPPORT APPARATUS AND LIFESAVING SUPPORT SYSTEM - A lifesaving support apparatus includes: a sensor section which is adapted to be attachable to a patient, and which is configured to acquire information of blood flow of the patient; a determining section which, based on the information of blood flow, is configured to determine whether or not a use of an automatic external defibrillator is necessary; and an outputting section which is configured to notify a rescuer of information which is determined by the determining section. | 06-26-2014 |
20140170458 | MOLTEN SALT BATTERY - A separator ( | 06-19-2014 |
20140168657 | OPTICAL TOMOGRAPHY DEVICE - An optical tomography device | 06-19-2014 |
20140166501 | ELEMENT RECOVERY METHOD AND ELEMENT RECOVERY APPARATUS - An element recovery method and an element recovery apparatus are provided by which an element containing a high-purity rare earth element can be recovered at low cost. The element recovery method includes the steps of: preparing molten salt containing a rare earth element; and controlling electric potentials in a pair of electrode members at prescribed values while keeping the pair of electrode members in contact with the molten salt, thereby depositing the rare earth element existing in the molten salt on one of the pair of electrode members. In this way, as compared with the conventional wet separation method, an element such as a rare earth element that is to be recovered can be directly recovered from the molten salt in which the element is dissolved, so that the steps of the recovery method can be simplified and reduced in cost. | 06-19-2014 |
20140148416 | Agent for Treatment of Eye Diseases - The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) | 05-29-2014 |
20140139238 | SOLUTION TESTING EQUIPMENT - There is provided solution testing equipment which can detect an output variation of a THz oscillation device using a THz wave (hν) by contacting a liquid or cells on an RTD oscillation device, and can reduce the size and weight thereof. The solution testing equipment includes: a THz oscillation device configured to radiate the THz wave I | 05-22-2014 |
20140137289 | Method For Accumulating A Protein In Plant Cell - A method for accumulating a protein in a plant cell, in which by co-expressing a gene which encodes a polypeptide having an ability to form an ER body, and a gene which encodes a target protein having an endomembrane system migration signal peptide at the N-terminus and having an ER retention signal peptide at the C-terminus in the plant cell, the target protein or a protein in which the N-terminus domain of the target protein is lacking is accumulated in an ER body formed in the plant cell. | 05-15-2014 |
20140134038 | ANTI-THERMALLY-EXPANSIVE RESIN AND ANTI-THERMALLY-EXPANSIVE METAL - Provided are resin-based and metal-based anti-thermally-expansive members each having small thermal expansion. More specifically, provided are an anti-thermally-expansive resin and an anti-thermally-expansive metal, each including a resin or a metal having a positive linear expansion coefficient at 20° C. and a solid particle dispersed in the resin or metal, in which the solid particle includes at least an oxide represented by the following general formula (1): (Bi | 05-15-2014 |
20140128252 | PEROVSKITE OXIDE CONTAINING HYDRIDE ION, AND METHOD FOR MANUFACTURING SAME - [Problem] Many oxide-ion conductors exhibit high functionality at high temperatures due to the large weight and charge of oxide ions, and it has been difficult to achieve the functionality at low temperatures. | 05-08-2014 |
20140127807 | Method for Promoting Differentiation of Pluripotent Stem Cells into Cardiac Muscle Cells - The present invention relates to a composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells, and a method for inducing differentiation of pluripotent stem cells into cardiac muscle cells and a method for preparing cardiac muscle cells | 05-08-2014 |
20140127806 | MODIFIED LAMININ AND USE THEREOF - Provided are a modified laminin having a cell-growth regulatory molecule bound to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the δ chain N-terminus of laminin or a heterotrimeric laminin fragment, a method for culturing cells in the presence of the modified laminin, a method for establishing iPS cells in the presence of the modified laminin, and a culture substrate coated with the modified laminin. Human stem cells cultured in a xeno-free environment with the use of the modified laminin of the present invention can be provided as highly safe human stem cells applicable to regenerative medicine. | 05-08-2014 |
20140127128 | Molecular Probe for Imaging of Pancreatic Islets and Use of the Same - To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides: | 05-08-2014 |
20140114078 | ORGANIC SEMICONDUCTOR - An organic semiconductor represented by the following formula (1). | 04-24-2014 |
20140110938 | INDUCTION HEATING APPARATUS AND POWER GENERATION SYSTEM COMPRISING THE SAME - An induction heating apparatus includes a rotor having a rotation shaft, and a stator having a heating portion disposed at a distance from the rotor. A coil that generates magnetic flux in a direction of the heating portion is provided in the rotor. The heating portion is formed of a composite material of a magnetic material and a conductive material, and has a structure in which a magnetic material portion and a conductive material portion are combined. When the coil is in a position opposed to the heating portion, a cross-sectional area of the magnetic material portion is smaller than an area of linkage of magnetic flux generated by the coil in the heating portion, and the conductive material portion is disposed to surround a periphery of the magnetic material portion. A flow passage in which the heating medium circulates is provided in the heating portion. | 04-24-2014 |
20140106240 | AIR CATHODE FOR AIR BATTERIES AND AIR BATTERY - The present invention is to provide an air cathode for air batteries, having excellent high-rate discharge performance, and an air battery comprising the air cathode. | 04-17-2014 |
20140099243 | PHOTOSENSITIVE RESIN COMPOSITION FOR FORMING BIOCHIP, AND BIOCHIP - It is intended to obtain a photosensitive resin composition that is capable of forming a highly fine pattern with a high aspect ratio while attaining the high adhesion of the pattern to a substrate, having low autofluorescence, and being exceedingly suitable for producing a biochip that causes exceedingly low damage on cultured cells. The photosensitive resin composition for forming a biochip of the present invention contains: an epoxy compound (A1) of a particular structure having an oxycyclohexane skeleton having an epoxy group; an epoxy compound (A2) of a particular structure which is a polyvalent carboxylic acid derivative having an epoxidized cyclohexenyl group; a cationic photoinitiator (B); and a solvent (C). | 04-10-2014 |
20140088306 | RADIOACTIVE FLUORINE-LABELED QUINOXALINE COMPOUND - Provided is a compound effective as a diagnostic imaging probe targeting amyloid and an agent for Alzheimer's disease diagnosis including the compound. | 03-27-2014 |
20140081605 | DTM ESTIMATION METHOD, DTM ESTIMATION PROGRAM, DTM ESTIMATION DEVICE, AND METHOD FOR CREATING 3-DIMENSIONAL BUILDING MODEL, AND REGION EXTRACTION METHOD, REGION EXTRACTION PROGRAM, AND REGION EXTRACTION DEVICE - In DTM estimation, no pixel data is present within a unit grid in a predetermined range linked to extract a river region. For data excluding the river region, a first maximum slope value is set and DTM is estimated. A local slope is calculated from the estimated DTM. If the slope exceeds value, a second maximum slope value greater than the first is set and DTM is estimated again. In region extraction, for extracting a building region based on a photograph, different discretization widths are set, and brightness values of data are discretized into values discretely set by each discretization widths. Pixels having identical value in a discretized image are linked, and a region having a rectangle shape is extracted as candidate of a building region. From the respective different discretization widths extracted, a region is employed, as a building region, in decreasing order of closeness shape to a rectangle. | 03-20-2014 |
20140073533 | COMPOSITION AND METHOD FOR PREDICTING RESPONSE TO TRASTUZUMAB THERAPY IN BREAST CANCER PATIENTS - This invention relates to a composition and a method for prediction of a response to Trastuzumab therapy in a breast cancer patient, and more specifically, a composition, a kit, a DNA chip, and a method for predicting a response to Trastuzumab therapy by using polynucleotides each comprising a nucleotide sequence represented by any of SEQ ID NOs: 1 to 9, 11 to 19, and 21 to 23 in the Sequence Listing or a nucleotide sequence derived therefrom by substitution of u with t, mutants thereof, derivatives thereof, or fragments thereof comprising at least 16 continuous nucleotides, or a polynucleotide comprising a complementary sequence thereof, and using an increase or decrease in Her2 protein expression level as an indicator. | 03-13-2014 |
20140061031 | PROCESSING METHOD UTILIZING CLUSTER - A processing method having excellent processing performance at a low flow rate is provided. A method for processing a surface of a sample uses reactive clusters produced by adiabatic expansion of a gas mixture ejected from a nozzle into a vacuum processing chamber. The gas mixture contains a reactive gas chlorine trifluoride, a first inert gas argon, and a second inert gas xenon. The gas mixture in an inlet of the nozzle has a pressure of 0.4 MPa (abs) or more. The reactive gas constitutes 3% by volume or more and 10% by volume or less. The first inert gas constitutes 40% by volume or more and 94% by volume or less. The second inert gas constitutes 3% by volume or more and 50% by volume or less of the gas mixture. | 03-06-2014 |
20140057287 | NOVEL CARDIOMYOCYTE MARKER - The present invention provides a method for production or detection of a cardiomyocyte(s) and/or cardiac progenitor cell(s), comprises extracting a cardiomyocyte(s) and/or cardiac progenitor cell(s) from a cell population comprising cardiomyocytes and/or cardiac progenitor cells using as an index VCAM1 positivity. | 02-27-2014 |
20140056859 | METHOD FOR PRODUCING MYOCARDIAL SHEET FROM EMBRYONIC STEM CELLS - The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet. | 02-27-2014 |
20140055139 | NMR Detection Probe - A cooled NMR detection probe including a detection coil and an internal structure ( | 02-27-2014 |
20140055138 | NMR Detection Module - An NMR (nuclear magnetic resonance) detection module (such as an NMR probe) mounted in a vacuum vessel permits a transmit/receive coil to be cooled efficiently and to be placed closer to a sample container. The NMR detection module includes a core module (detection module) ( | 02-27-2014 |
20140036947 | EDGE-EMITTING SEMICONDUCTOR LASER ELEMENT - The present edge-emitting semiconductor layer element includes two-dimensional photonic crystals | 02-06-2014 |
20140030809 | METHOD FOR PRODUCING EPITHELIAL STEM CELLS - An object of this invention is to provide a method, etc., for efficiently proliferating a pluripotent epithelial somatic stem cell. A method for producing an epithelial somatic stem cell comprising Steps (A) and (B) below:
| 01-30-2014 |
20140020761 | ORGANIC DYE MATERIAL AND DYE-SENSITIZED SOLAR CELL USING SAME - Provided is an inexpensive and high-performance dye compound that does not use an expensive precious metal and does not require the use of a strong electron-withdrawing group. The compound is formed such that a boron substituent is introduced into a heteroatom-containing π electron-based backbone containing a double bond between carbon and the heteroatom to obtain a compound in which a backbone having boron and a coordination bond in a molecule thereof is used as a π electron-accepting backbone. | 01-23-2014 |
20140014882 | FULLERENE DERIVATIVE AND PHOTOELECTRIC CONVERSION DEVICE USING SAME - The present invention provides a fullerene derivative having an electron donating group adjacent to the fullerene nucleus, represented by formula (I) which exhibits a high LUMO energy and a high open circuit voltage based thereon and which is highly compatible with polymers and excellent in charge mobility and charge separation ability: | 01-16-2014 |
20140012027 | Method for Producing Fluorine-Containing Substituted Compound and Fluorine-Containing Substituted Compound - A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound. | 01-09-2014 |
20140011103 | PROTON CONDUCTOR, METHOD FOR MANUFACTURING PROTON CONDUCTOR, AND FUEL CELL - A proton conductor includes a metal ion, an oxoanion, and a molecule capable of undergoing protonation or deprotonation, in which the oxoanion and/or the molecule capable of undergoing protonation or deprotonation coordinates to the metal ion to form a coordination polymer. The oxoanion is preferably a monomer. The oxoanion is exemplified by at least one selected from the group consisting of phosphate ion, hydrogenphosphate ion, and dihydrogenphosphate ion. The molecule capable of undergoing protonation or deprotonation is exemplified by at least one selected from the group consisting of imidazole, triazole, benzimidazole, benzotriazole, and derivatives of them. | 01-09-2014 |
20140005399 | POLYCYCLIC AROMATIC COMPOUND | 01-02-2014 |
20130338273 | EMULSION BINDER, AQUEOUS PIGMENT INK FOR INKJET CONTAINING SAME, AND METHOD FOR PRODUCING EMULSION BINDER - Disclosed is an emulsion binder containing an A-B block copolymer. The A-B block copolymer has a number average molecular weight of 5,000 to 100,000, and a polydispersity index (weight average molecular weight/number average molecular weight) of not greater than 1.7. The polymer block A has an acid value of 0 to 30 mgKOH/g and a glass transition point of not higher than 60° C. The polymer block B has an acid value of 75 to 250 mgKOH/g. The A-B block copolymer has been neutralized with an alkaline material, and has been allowed to self-emulsify in an aqueous medium to form emulsion particles having an average particle size of 30 to 300 nm. | 12-19-2013 |
20130331506 | ORGANIC-INORGANIC COMPOSITE, COMPOSITE COMPOSITIONS OF ORGANIC AND INORGANIC COMPOUNDS, AND INK - Provided is an organic-inorganic composite having two or more kinds of light emission sites. When the organic-inorganic composite is caused to emit light, each of emission colors in each of light emission sites is independently maintained as a emission color that is shown when each of the light emission sites is independently caused to emit light. | 12-12-2013 |
20130330822 | METHOD FOR PRODUCING DENDRITIC CELLS FROM PLURIPOTENT STEM CELLS - A dendritic cell is produced from pluripotent stem cells by culturing pluripotent stem cells by the following steps: (1) performing adherent culture in a medium which comprises a BMP family protein but does not comprise serum; (2) performing adherent culture in a medium which comprises VEGF but does not comprise serum; (3) performing adherent culture in a medium which comprises a hematopoietic factor but does not comprise serum; and (4) performing suspension culture in a medium which does not comprise serum. | 12-12-2013 |
20130330608 | MOLTEN SALT BATTERY - The molten salt used as an electrolyte of a molten salt battery is a mixed salt between a salt in which the anion is an ion represented by [R1-SO | 12-12-2013 |
20130330541 | METAL OXIDE - Provided is a piezoelectric material excellent in piezoelectricity. The piezoelectric material includes a perovskite-type complex oxide represented by the following General Formula (1). | 12-12-2013 |
20130292839 | POROUS SILICON MATERIAL - Provided are a method for producing a porous silicon material filled with a metal, the method including the steps of rendering hydrophobic a porous silicon substrate having pores from 1 to 5 nm in diameter, and depositing a metal into the pores of the porous silicon substrate by the electrodeposition of the porous silicon substrate; a method for producing a metallic nanoparticle or a nanofiber, the method including the steps of producing a porous silicon material filled with a metal, dissolving the silicon contained in the porous silicon material filled with a metal; a metallic nanoparticle or a nanofiber obtained by using the method for producing a metallic nanoparticle or a nanofiber: and a porous silicon material formed from a porous silicon substrate having pores from 1 to 5 nm in diameter and a resistivity of 5 to 20 Ω·cm, the pores of which are filled with a metal. | 11-07-2013 |
20130288880 | Sic ceramic material, sic ceramic structure, and their fabrication methods - A SiC ceramic material includes a bundle of SiC continuous fibers in a porous SiC ceramic matrix, has thermal insulation properties, a high level of strength and a high degree of toughness. A SiC ceramic structure is made of the SiC ceramic material. It is produced by preparing a pressure-sintered compact using a slurry prepared by mixing SiC powder and carbon powder in a liquid and by gasifying and releasing the carbon powder. The SiC ceramic structure can be produced by heating a reaction preparation containing a bundle of SiC continuous fibers and Si powder to a temperature equal to or higher than the melting point of silicon causing a reaction of the carbon component and Si powder and thereby obtaining a reaction-sintered compact, and by gasifying and releasing the carbon component from the reaction-sintered compact. The SiC ceramic can be produced by a chemical vapor deposition method. | 10-31-2013 |
20130288277 | IMMUNOASSAY OF COFILIN 1 PROTEIN - An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein. | 10-31-2013 |
20130281622 | PRODUCTION METHOD FOR PARTICLE BOARD AND FIBER BOARD - Provided is a production method for particle boards or fiber boards which achieves production efficiency greater than that of conventional production methods. A production method for a particle board or a fiber board, comprising the step of adding polycarboxylic acid into a plant-derived product that has been segmented or formed into fibers, and further comprising the step of adding a small amount a compound having one or more types of an isocyanate group to the plant-derived product and/or the polycarboxylic acid. | 10-24-2013 |
20130273588 | METHOD FOR SCREENING DRUGS FOR SUPPRESSING INFLAMMASOME ACTIVITY - The present invention provides a method for screening drugs for suppressing inflammasome activity, using macrophages derived from induced pluripotent stem cells (iPS cells) having mutant NLRP3 gene. | 10-17-2013 |
20130273442 | AIR ELECTRODE FOR METAL-AIR BATTERY, MEMBRANE/AIR ELECTRODE ASSEMBLY FOR A METAL-AIR BATTERY HAVING SUCH AIR ELECTRODE, AND METAL-AIR BATTERY - An air electrode ( | 10-17-2013 |
20130267929 | METHOD FOR OPERATING A DEVICE FOR DELIVERING A SUBSTANCE TO BE INTRODUCED, AND METHOD FOR DELIVERING A SUBSTANCE TO BE INTRODUCED - Provided are a method for delivering a substance to be introduced and a method for operating a device for delivering a substance to be introduced, in which, in a subject, by supplying the substance to be introduced to a site different from a target site and thereafter applying pressure to the target site in the subject, the substance to be introduced is delivered into the target site. | 10-10-2013 |
20130267671 | LIVING RADICAL POLYMERIZATION METHOD - Provided is a low-cost, highly active, environmentally friendly living radical polymerization method which does not require a radical initiator. Even if a catalyst is not used, a living radical polymerization method can be conducted by controlling the amount of the oxygen in the gaseous phase in the reaction vessel within a suitable range. A monomer having a radical-reactive unsaturated bond can be subjected to a radical polymerization reaction to obtain a polymer having narrow molecular weight distribution. The cost of the living radical polymerization can be remarkably reduced. The present invention eliminates the disadvantages of the conventional catalysts such as toxicity, low solubility, coloring/odor and the like, and is significantly more environmentally friendly and economically efficient than conventional living radical polymerization methods. | 10-10-2013 |
20130267030 | EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of producing induced pluripotent stem cells by contacting a somatic cell with a nuclear reprogramming substance and one or more of such proteins and nucleic acids that encode such proteins. The invention further provides an induced pluripotent stem cell that has an exogenous nucleic acid encoding such a protein, as well as agents for use in the aforesaid methods. | 10-10-2013 |
20130251636 | MRI CONTRAST AGENT CONTAINING COMPOSITE PARTICLES - Intended is to provide an MRI contrast agent that tends not to be phagocytized by reticuloendothelial cells and that has improved dispersion stability. The present invention is an MRI contrast agent containing composite particles, wherein the composite particles are those with polymer graft chains bound to surfaces of microparticles at a very high density sufficient to allow steric repulsion to occur between the graft chains, the micoparticles are inorganic microparticles that exhibit superparamagnetism, and the polymer graft chains have a number average molecular weight (Mn) of at least 30,000. Preferably, the MRI contrast agent is for tumor diagnosis. | 09-26-2013 |
20130245257 | COMPOUND HAVING HETERO RING SKELETON, AND PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUND USING THE AFOREMENTIONED COMPOUND AS ASYMMETRIC CATALYST - The invention provides a compound having a heterocyclic skeleton of formula (I): | 09-19-2013 |
20130244262 | CARDIOMYOCYTE- AND/OR CARDIAC PROGENITOR CELL-PROLIFERATING AGENT AND METHOD FOR PROLIFERATING CARDIOMYOCYTES AND/OR CARDIAC PROGENITOR CELLS - The present invention provides a cardiomyocyte- and/or cardiac progenitor cell-proliferating agent comprising at least one compound selected from the group consisting of: a GSK3β inhibitor, ERK dephosphorylation inhibitor, Raf activator, CaMK2 inhibitor and p38 inhibitor; and a method for proliferating cardiomyocytes and/or cardiac progenitor cells using the agent. | 09-19-2013 |
20130243026 | TWO-DIMENSIONAL PHOTONIC CRYSTAL SURFACE EMITTING LASER - Provided is a two-dimensional photonic crystal surface emitting laser having an active layer for generating light of a predetermined wavelength range by an injection of electric current and a two-dimensional photonic crystal layer provided on one side of the active layer, the layer having a plate-shaped base member in which modified refractive index areas whose refractive index differs from that of the base member are arranged. | 09-19-2013 |
20130241399 | WHITE LIGHT-EMITTING GLASS, GLASS-COVERED LIGHT-EMITTING ELEMENT, AND LIGHT-EMITTING DEVICE - A glass emitting white light in itself, and a light-emitting element and a light-emitting device covered with the glass as stated above are provided. The white light-emitting glass is a glass emitting fluorescence at a region having a wavelength of 380 nm to 750 nm by excitation light with a wavelength of 240 nm to 405 nm, not containing crystal, and containing SnO | 09-19-2013 |
20130227718 | LINKER FOR UNIMOLECULAR FRET BIOSENSOR BASED ON PRINCIPLE OF FLUORESCENCE RESONANCE ENERGY TRANSFER - A linker for a unimolecular FRET biosensor based on a principle of fluorescence resonance energy transfer, the linker including: a polypeptide containing 52 to 400 amino acids residues, wherein at least 45% of a total number of the amino acid residues are glycine, alanine, or both thereof, and at least 10% of the total number of the amino acid residues are alanine. | 08-29-2013 |
20130225642 | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS - The present invention provides a prophylactic or therapeutic agent for amyotrophic lateral sclerosis, containing a 1,3-diphenylurea derivative or multikinase inhibitor. | 08-29-2013 |
20130225492 | Sustained-Release Pharmaceutical Composition - Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected from monosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition. | 08-29-2013 |
20130225443 | METHOD OF EXAMINING POLYCYSTIC KIDNEY DISEASE AND METHOD OF SCREENING FOR THERAPEUTIC AGENT OF THE DISEASE - The present invention provides a method of examining polycystic kidney disease or a complication of polycystic kidney disease using a gene(s) selected from the group consisting of NTNG1, POSTN, TNC, KAL1, BST1, ACAT2, INSIG1, SCD, HSD3B1, KRT7, USP40, SULT1E1, BMP6, CD274, CTGF, E2F7, EDN1, FAM43A, FRMD3, MMP10, MYEOV, NR2F1, NRCAM, PDCK1, PLXNA2, SLC30A3, SNAI1, SPOCD1, MMP1, TFPI2, HMGA2, KRTAP4-7, KRTAP4-8, KRTAP4-9, MYPN, RPPH1, and SIAE, and a method of screening for a therapeutic agent or a preventive agent therefore, and further vascular endothelial cells or vascular mural cells obtained via differentiation induction from iPS cells formed from a somatic cell of a subject suffered from polycystic kidney disease and having cerebral aneurysm as a complication. | 08-29-2013 |
20130211016 | COMPOSITE COMPOSITION OF INORGANIC OXIDE PARTICLES AND SILICONE RESIN, METHOD OF MANUFACTURING THE SAME, TRANSPARENT COMPOSITE, AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing a composite composition, having: bonding a dispersant to the surfaces of inorganic oxide particles to provide dispersibility in a hydrophobic solvent to the inorganic oxide particles, and then dispersing the inorganic oxide particles in a hydrophobic solvent; substituting the dispersant bonded to the surfaces of the inorganic oxide particles with a surface modifier, which is a polydimethylsiloxane-skeleton polymer having one functional group at one terminal end, in the hydrophobic solvent in which the organic oxide particles are dispersed to bond the functional group of the polydimethylsiloxane-skeleton polymer to the surfaces of the inorganic oxide particles; and conjugating a silicone resin and the inorganic oxide particles obtained in the previous step, wherein the surface thereof is modified by bonding the polydimethylsiloxane-skeleton polymer having one functional group at one terminal end thereof, to obtain a composite composition. | 08-15-2013 |
20130205612 | THIN FILM MULTILOCULAR STRUCTURE MADE OF COLLAGEN, MEMBER FOR TISSUE REGENERATION CONTAINING THE SAME, AND METHOD FOR PRODUCING THE SAME - A new structure made of collagen for improving promotion of nerve tissue regeneration, curing and regeneration of a defective part of a soft biological tissue and so on without using laminin or nerve growth factor (NGF), and a member for tissue regeneration including the same. The structure made of collagen has a thin film multilocular formation and is therefore a new structure different from a colloid form, a gel form, and a fiber form. When the new structure made of collagen is used as a member for tissue regeneration, surprisingly, promotion of regeneration, shortening of a treatment period, functional recovery, or the like of bodily tissue such as nerve tissue, subdermal tissue, submucosal tissue, membranous tissue, fat tissue, muscle tissue, skin tissue, and gingival tissue can be improved. When the structure is used in a patient having neuropathic pain, the member has an effect on the disappearance of the pain. | 08-15-2013 |
20130203677 | BIOACTIVE PEPTIDE - The present invention provides a pharmaceutical or a food that comprises, as an active ingredient, at least one peptide selected from the group consisting of Val-Tyr-Leu-Pro-Arg, Tyr-Leu-Pro-Arg, and Leu-Pro-Arg, or an analog thereof. | 08-08-2013 |
20130196064 | PROCESS FOR PRODUCING BLOCK POLYMER, COATED PIGMENT AND AQUEOUS PIGMENT DISPERSION - Disclosed are an aqueous pigment dispersion containing at least a pigment, water, a high-molecular dispersant, and an alkali. The high-molecular dispersant is a diblock polymer having a formula (1) of A-B or a triblock polymer having a formula (2) of A-B-C. The diblock or triblock polymer is a diblock or triblock polymer obtained by polymerizing addition-polymerizable monomers with a radical generator while using an organic iodide as a polymerization initiating compound and an organic phosphorus compound, organic nitrogen compound or organic oxygen compound as a catalyst. Also disclosed are a production method and use of the aqueous pigment dispersion. With the high-molecular dispersant obtained by a simple living radical polymerization process free of the problems of conventional living radical polymerization and having a precisely-controlled molecular structure, the aqueous pigment dispersion can be obtained with the pigment dispersed in it. | 08-01-2013 |
20130189289 | VACCINE FOR TREATMENT OF TAUTOPATHY - This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly. | 07-25-2013 |
20130184241 | Naphthalene Derivative - The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) | 07-18-2013 |
20130183759 | METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells by inhibiting p38 function in the step of somatic cell nuclear reprogramming. The p38 function can be inhibited by bringing an inhibitor selected from the group consisting of (1) a chemical inhibitor of p38 (2) a dominant negative mutant of p38 or a nucleic acid that encodes the same, (3) a nucleic acid selected from the group consisting of siRNAs and shRNAs targeted to p38 and DNAs that encode the same and (4) an inhibitor of p38 pathway into contact with a somatic cell and the like. The present invention also provides an agent for improving the efficiency of establishment of induced pluripotent stem cells, which contains an inhibitor of p38 function, particularly an inhibitor selected from the group consisting of (1) a chemical inhibitor of p38 (2) a dominant negative mutant of p38 or a nucleic acid that encodes the same, (3) a nucleic acid selected from the group consisting of siRNAs and shRNAs targeted to p38 and DNAs that encode the same and (4) an inhibitor of p38 pathway. Moreover, the present invention provides a production method of iPS cells, which includes bringing a nuclear reprogramming substance and an inhibitor of p38 function into contact with a somatic cell. | 07-18-2013 |
20130183757 | METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - Provided is a method of improving the efficiency of iPS cell establishment, comprising bringing one or more factors selected from the group consisting of proteins belonging to cyclin D family and nucleic acids that encode the same into contact with a somatic cell, in the step of nuclear reprogramming of the somatic cell. Also provided are a method of producing an iPS cell comprising the step of bringing the factor(s) and nuclear reprogramming substance(s) into contact with a somatic cell, an iPS cell comprising a nucleic acid that encodes a protein belonging to cyclin D family that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate. | 07-18-2013 |
20130183753 | METHOD FOR PROMOTING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO CARDIAC MUSCLE CELLS - The present invention relates to a composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells, and a method for inducing differentiation of pluripotent stem cells into cardiac muscle cells and a method for preparing cardiac muscle cells. | 07-18-2013 |
20130178892 | STATIN-LOADED COILS FOR ACCELERATION OF ORGANIZATION AFTER ENDOVASCULAR COILING OF ANEURYSMS - The present invention provides a vascular treatment material which has high safety, and also can exert high organization acceleration effect. The present invention also provides a commercially available vascular treatment material, which is easy to produce and can be easily sterilized, and also can be stored for a long period. Disclosed is a vascular treatment material including a coil on which statin is loaded. It is preferred that a wire forming the coil is made of at least one kind of metal selected from platinum, tungsten, gold, cobalt, chromium, titanium, niobium, aluminum, tantalum, iron, nickel and the like. The vascular treatment material of the present invention is particularly useful, which is placed in a blood vessel for embolization treatment, or which accelerates organization for prevention of recanalization of aneurysm or for prevention of rupture of aneurysm. | 07-11-2013 |
20130167255 | SCREENING METHOD FOR ANTICANCER DRUGS - Use of an animal model of spontaneous metastasis bearing a tumor derived from a cell line RM72 (Accession No. NITE BP-1110) allows simultaneous evaluation of tumorigenesis and spontaneous cancer metastasis. Use of a screening method using the animal model of spontaneous metastasis allows the obtainment of a substance having an anticancer activity and/or an anti-metastatic activity. Use of another screening method for selecting a substance that increases the expression of RECK in a cancer cell allows the obtainment of a substance that can serve as an active ingredient in an anticancer drug. | 06-27-2013 |
20130164848 | CELL CULTURE CONTAINER AND CELL CULTURE METHOD USING THE CONTAINER - A well has a pair of side surfaces, and one of the side surfaces is in contact with a compartment of a first channel with a gas-permeable membrane being interposed therebetween and the other side surface is in contact with a compartment of a second channel with a gas-permeable membrane being interposed therebetween. The well is filled with a liquid cell culture medium, and in such a state, a high-concentration gas and a low-concentration gas, which are different in the concentration of a specific component from each other, are allowed to flow through the first and second channels, respectively, to form a concentration distribution of the specific component in the well. | 06-27-2013 |
20130143321 | METHOD OF INDUCING DIFFERENTIATION FROM PLURIPOTENT STEM CELLS TO GERM CELLS - This invention provides a method of producing an epiblast-like cell (EpiLC) from a pluripotent stem cell, which comprises culturing the pluripotent stem cell in the presence of activin A; a method of producing a primordial germ cell-like (PGC-like) cell a pluripotent stem cell, which comprises culturing the EpiLC obtained by the method above in the presence of BMP4 and LIF. Also provided are a cell population containing PGC-like cells as obtained by the method, and reagent kits for the EpiLC- and PGC-like cell-induction from a pluripotent stem cell. | 06-06-2013 |
20130143225 | VARIANT REVERSE TRANSCRIPTASE - The present invention provides a versatile mutant reverse transcriptase with high thermal stability, a nucleic acid thereof and a method for producing a mutant reverse transcriptase, a versatile kits for reverse transcription and detection, a method for improving thermal stability of a nucleic acid-related enzyme, which significantly improves thermal stability of a nucleic acid-related enzyme, and a reverse transcription method, which efficiently performs a reverse transcription. An amino acid residue in a nucleic acid interaction region of a wild-type enzyme is substituted with a positively-charged amino acid residue or a nonpolar amino acid residue, to form a nucleic acid interaction region having a positive effective charge larger than the nucleic acid interaction region of a wild-type enzyme. | 06-06-2013 |
20130137099 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS - An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a mammalian multicellular organism more precisely, a method for identifying efficiently substances and gene regions that affect alternative splicing in a mammalian multicellular organism, and the like by utilizing the alternative splicing reporter system. Specifically, the present invention relates to a method for detecting alternative splicing in a mammalian multicellular organism, and a method for identifying substances and gene regions that affect alternative splicing in a mammalian multicellular organism, which use a DNA construct in which at least two different reporter genes are inserted into a specific gene that undergoes alternative splicing, or a combination of DNA constructs (a combination of at least two different DNA constructs) in which DNA construct a reporter gene is inserted into a specific gene that undergoes alternative splicing. | 05-30-2013 |
20130125359 | PIEZOELECTRIC MATERIAL, PIEZOELECTRIC DEVICE, AND METHOD OF PRODUCING THE PIEZOELECTRIC DEVICE - Provided are a bismuth-based piezoelectric material whose insulation property is improved while its performance as a piezoelectric body is not impaired and a piezoelectric device using the piezoelectric material. The piezoelectric material includes a perovskite-type metal oxide represented by the following general formula (1): | 05-23-2013 |
20130122586 | METHOD OF CULTURING PANCREATIC ISLET-LIKE TISSUES BY A TISSUE COMPLEX OF PANCREAS-DERIVED NON-ENDOCRINAL EPITHELIAL CELLS AND VASCULAR ENDOTHELIAL CELLS - According to embodiments, a method of producing insulin-producing tissues (IPTs) by culturing comprises: preparing non-endocrinal epithelial cells (NEECs) and vascular endothelial cells (VECs), which have been isolated or originated from postnatal pancreata, preferably by capturing of NEECs by collagen; culturing in vitro the NEECs and the VECs at least partly separately from each other; and then generating in vitro a tissue complex (IPTs) that contains both the NEECs and the VECs. In another embodiment, the native islet cells are seeded on a monolayer of VECs that have preferably been separately cultured and purified. In a further embodiment, a method of enriching NEECs comprises: culturing NEECs adhering to a container or substrate; removing NEECs by treating with a tissue-dissociation enzyme to leave left-over cells (LOCs) still attached on the container or substrate; and culturing NEECs in a medium conditioned by, or in the presence of the LOCs. | 05-16-2013 |
20130122536 | METHOD FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELL INTO INTERMEDIATE MESODERM CELL - The present invention relates to: a method for producing an intermediate mesoderm cell from a human pluripotent stem cell, comprising a step of culturing the human pluripotent stem cell in a medium containing Activin A and Wnt or a functional equivalent of Wnt and a step of culturing cells in a medium containing BMP and Wnt or a functional equivalent of Wnt; to a method for producing a metanephric cell from the intermediate mesoderm cell produced by the first method; to a human pluripotent stem cell having a foreign reporter gene in the chromosome wherein the gene is expressed interlocked with the expression of endogenous OSR1; to a method for screening for an inducer for differentiation into intermediate mesoderm using the human pluripotent stem cell; and to a kit for inducing the differentiation into an intermediate mesoderm cell. | 05-16-2013 |
20130121358 | SEMICONDUCTOR SURFACE LIGHT-EMITTING ELEMENT AND METHOD OF MANUFACTURING THEREOF - A semiconductor surface light-emitting element of this invention is provided with a photonic crystal layer | 05-16-2013 |
20130115622 | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS - Provided are a prophylactic and therapeutic agent for amyotrophic lateral sclerosis containing an HMG-CoA reductase inhibitor and a method of screening for a prophylactic and therapeutic drug for amyotrophic lateral sclerosis using an induced pluripotent stem cell derived from a patient with amyotrophic lateral sclerosis. | 05-09-2013 |
20130102768 | EFFICIENT METHOD FOR NUCLEAR REPROGRAMMING - A method of preparing induced pluripotent stem cells, comprising a nuclear reprogramming step with a nuclear reprogramming factor in the presence of miRNA, wherein said miRNA has a property of providing a higher nuclear reprogramming efficiency in the presence of said miRNA than in the absence thereof. | 04-25-2013 |
20130089870 | METHOD FOR SELECTING HUMAN INDUCED PLURIPOTENT STEM CELLS - The present invention provides a method for selecting human induced pluripotent stem (iPS) cells which can be safely used for transplantation. That is, the present invention provides a method for selecting human iPS cells having reduced differentiation resistance, comprising the steps of: (1) inducing differentiation of human iPS cells; (2) detecting remaining undifferentiated cells after the step (1); and (3) selecting human iPS cells whose rate of remaining undifferentiated cells detected in step (2) is equivalent to or not more than that of control cells. | 04-11-2013 |
20130088232 | Solid-State NMR Spectrometer, Sample Holder Therefor, and Method of Solid-State NMR Spectroscopy - A high-resolution solid-state NMR spectrometer which can measure a disklike sample. The spectrometer includes: a stator having an air bearing disposed within the static magnetic field, the rotor being disposed in the stator; and an engaging mechanism mounted in a one-end portion of the rotor and detachably holding a sample holder that holds the disklike sample. | 04-11-2013 |
20130075697 | ULTRAVIOLET IRRADIATION APPARATUS - Provided is a compact ultraviolet irradiation apparatus which is capable of emitting ultraviolet radiation with high efficiency. | 03-28-2013 |
20130071919 | METHOD OF SELECTING INDUCED PLURIPOTENT STEM CELL - The present invention provides a method of selecting a highly safe induced pluripotent stem cell, which includes comprehensively detecting the sequence of an expression vector used for induction of the induced pluripotent stem cell, in the nucleic acid in the cell, and a kit used for the method. | 03-21-2013 |
20130065311 | METHOD OF NUCLEAR REPROGRAMMING - A method of producing an induced pluripotent stem cell includes introducing into a somatic cell one or more non-viral expression vectors. The vectors include one or more of an Oct family gene, a Klf family gene, a Sox family gene, a Myc family gene, a Lin family gene, and Nanog gene. The somatic cell is then cultured in a medium that supports pluripotent stem cells. At least a portion of the one or more introduced non-viral expression vectors is not substantially integrated in the chromosome. | 03-14-2013 |
20130059386 | INDUCED PLURIPOTENT STEM CELLS PRODUCED WITH OCT3/4, KLF AND SOX - The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells. | 03-07-2013 |
20130053567 | METHOD FOR PRODUCING SILYLENOL ETHERS - The invention relates to a method for producing silyl enol ether compound (3) by reacting ketone or aldehyde compound (1) with allylsilane compound (2) in the presence of a base and 0.00001 to 0.5 equivalents of an acid catalyst relative to ketone or aldehyde compound (1). | 02-28-2013 |
20130052132 | Method for Producing Radioactively Labeled Polypeptide - The present invention relates to a method for producing a polypeptide. The method includes labeling a molecular probe precursor represented by an amino acid sequence of the formula (1) using a labeling compound capable of labeling a lysine or lysine derivative: | 02-28-2013 |
20130045977 | TGF-beta SIGNAL TRANSDUCTION INHIBITOR - The present invention provides a compound represented by the following formula (I) or a physiologically acceptable salt thereof, and use thereof for the prophylaxis or treatment of TGF-β-related diseases: | 02-21-2013 |
20130042916 | NOVEL PORPHYRIN COMPLEX AND USE THEREOF - An object of the present invention is to provide a novel porphyrin complex having excellent light collection characteristics and a dye-sensitized solar cell using the porphyrin complex as a sensitizing dye. The porphyrin complex of the present invention as a means for achieving the object is characterized by comprising a porphyrin derivative and a metal atom. The porphyrin derivative has a carboxyaryl group, which is optionally substituted on the aryl ring, attached to at least one of four meso positions of a porphyrin ring optionally substituted at the β-position and also has a diarylamino group, which is optionally substituted on one or both of the aryl rings, attached to at least either of a meso position adjacent thereto and a meso position opposite thereto. | 02-21-2013 |
20130040387 | METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO SKELETAL MUSCLE OR SKELETAL MUSCLE PROGENITOR CELLS - A method for inducing the differentiation of pluripotent stem cells into skeletal muscle or skeletal muscle progenitor cells is provided. Specifically, a method for producing artificial skeletal muscle or skeletal muscle progenitor cells from human pluripotent stem cells is provided, comprising the following steps of: (1) culturing human pluripotent stem cells by suspension culture; (2) culturing a cell population after suspension culture by adhesion culture; (3) dissociating cells after adhesion culture; and (4) culturing the dissociated cells by adhesion culture. Artificial skeletal muscle or induced skeletal muscle progenitor cells prepared by the method are also provided. | 02-14-2013 |
20130039843 | APPARATUS FOR FORMING METAL OXIDE FILM, METHOD FOR FORMING METAL OXIDE FILM, AND METAL OXIDE FILM - A film forming apparatus ( | 02-14-2013 |
20130039375 | PHOTONIC CRYSTAL SURFACE EMISSION LASER - A photonic crystal surface emission laser includes an active layer, and a photonic crystal layer made of a plate-shaped slab provided with modified refractive index area having a refractive index different from that of the slab, the modified refractive index areas being arranged on each of the lattice points of a first rhombic-like lattice and a second rhombic-like lattice in which both diagonals are mutually parallel and only one diagonal is of a different length, wherein a | 02-14-2013 |
20130038860 | BLOOD ANALYSIS APPARATUS AND BLOOD ANALYSIS METHOD - A blood analysis apparatus includes an analysis section. The analysis section is configured to compare a measurement spectrum obtained regarding red blood cells with a standard spectrum of heme, biliverdin, and bilirubin, and cause the measurement spectrum to belong to any one of the standard spectra. | 02-14-2013 |
20130034858 | METHOD FOR DIAGNOSING A PROTEIN MISFOLDING DISEASE USING NERVE CELLS DERIVED FROM IPS CELLS - The present invention provides a method for detecting onset of, or the risk of development of, a protein misfolding disease, and a method for predicting the age of onset of a protein misfolding disease using nerve cells derived from iPS cells. The present invention also provides a kit to be used in these methods. | 02-07-2013 |
20130029423 | METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - Provided are a method of improving the efficiency of establishment of iPS cells, comprising the step of contacting one or more substances selected from the group consisting of members of the GLIS family (e.g., GLIS1) and nucleic acids that encode the same and one or more substances selected from the group consisting of members of the Klf family and nucleic acids that encode the same, with a somatic cell, an iPS cell comprising an exogenous nucleic acid that encodes a member of the GLIS family or a member of the Klf family, that can be obtained by the method, and a method of producing a somatic cell by inducing the differentiation of the iPS cell. | 01-31-2013 |
20130028890 | METHOD FOR DETECTING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR 4 AS INDICATOR, METHOD FOR TREATING DISEASES USING THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION FOR IMMUNOSTIMULATION, AND METHOD FOR TREATING DISEASES USING THE COMPOSITION - An object of the present invention is to provide a technique to distinguish between T | 01-31-2013 |
20130017606 | METHOD OF SEPARATING PANCREATIC ISLET - The present invention provides a pancreatic islet isolation method comprising the steps of (1) injecting a protection solution containing a protease inhibitor into the pancreatic duct of an procured pancreas; (3) digesting the pancreas into which the protection solution has been injected; and (4) purifying the digested pancreatic tissue using a purification solution containing a density gradient reagent. The present invention also provides a protection solution for injection into the pancreatic duct, a pancreas preservation solution for the two-layer method, and an islet purification solution. | 01-17-2013 |
20130012626 | RESIN-TREATED PIGMENT, METHOD FOR PRODUCING THE PIGMENT, AND PIGMENT DIPERSION - Disclosed are a resin-treated pigment characterized in that the resin-treated pigment comprises a pigment and a polymer of an unsaturated bond-containing monomer, a weight ratio of the pigment to the polymer (pigment:polymer) is from 50 to 95 to from 5 to 50, and the polymer is a block copolymer comprising from 5 to 70 mass % of an addition-polymerizable monomer having a UV-absorbing group; a production process of the resin-treated pigment; and a pigment dispersion using the resin-treated pigment. | 01-10-2013 |
20130011924 | METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO MESODERMAL CELLS - The present invention provides a method for inducing differentiation of pluripotent stem cells into mesodermal cells, comprising the step of culturing pluripotent stem cells in a serum-free medium without forming an embryoid body and without coculturing with cells from a different species. | 01-10-2013 |
20130007920 | STOMATA-INCREASING AGENT, POLYPEPTIDE, METHOD FOR INCREASING NUMBER AND/OR DENSITY OF STOMATA IN PLANT, AND METHOD FOR INCREASING YIELD OF PLANT - A stomata-increasing agent containing a compound capable of increasing the number and/or density of stomata in a plant, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 6 or a variant thereof, a method for increasing the number and/or density of stomata in a plant and a method for increasing the yield of a plant are provided. | 01-03-2013 |
20130003768 | PHOTONIC CRYSTAL LASER - A photonic crystal laser capable of producing a radially-polarized halo-shaped laser beam having a smaller width than conventional beams includes: an active layer; a ring-shaped photonic crystal including a plate-shaped base body on one side of the active layer, the base body having a number of modified refractive index areas of the same shape, the modified refractive index areas having a refractive index different from the base body and periodically arranged in the circumferential direction of a ring, and each of the modified refractive index areas being asymmetrically shaped with respect to an axis extending through the center of the modified refractive index area in the radial direction of the ring; a first and second electrode facing each other across the active layer and the ring-shaped photonic crystal; and a window provided in the second electrode capable of allowing passage of a laser light generated from the ring-shaped photonic crystal. | 01-03-2013 |
20120330024 | RADIOACTIVE IODINE LABELED ORGANIC COMPOUND OR SALT THEREOF - The present invention is a compound represented by the following formula (1) or a salt thereof. Furthermore, the present invention is an imaging agent used for imaging a tau protein, the imaging agent containing a compound represented by the formula (1) below or a salt thereof. In the formula (1), R | 12-27-2012 |
20120329940 | ALKOXYSILYL GROUP-CONTAINING BLOCK COPOLYMER, METHOD FOR PRODUCING THE SAME, RESIN-TREATED PIGMENT, AND PIGMENT DISPERSION - Disclosed are an alkoxysilyl-containing A-B block copolymer formed from (meth)acrylate monomers as constituent monomers, characterized in that a polymer block of A chain has a number average molecular weight (Mn) of from 1,000 to 50,000 and a molecular weight distribution (Mw/Mn) of not greater than 1.6, a polymer block of B chain comprises alkoxysilyl-containing (meth)acrylate units as constituent monomer units, and the A-B block copolymer as a whole has a molecular weight distribution of not greater than 1.6, a process for the production of the block copolymer, a resin-treated pigment, and a pigment dispersion. | 12-27-2012 |
20120325545 | CONDUCTIVE FILM AND METHOD FOR ITS PRODUCTION - To provide a method for producing a conductive film with excellent transparency and conductivity by a simple method suitable for large-area production. | 12-27-2012 |
20120319533 | PIEZOELECTRIC THIN FILM, PIEZOELECTRIC ELEMENT, AND MANUFACTURING METHOD THEREOF - Provided are a piezoelectric thin film having good piezoelectricity in which a rhombohedral structure and a tetragonal structure are mixed, and a piezoelectric element using the piezoelectric thin film. The piezoelectric thin film includes a perovskite type metal oxide, in which the perovskite type metal oxide is a mixed crystal system of at least a rhombohedral structure and a tetragonal structure, and a ratio between an a-axis lattice parameter and a c-axis lattice parameter of the tetragonal structure satisfies 1.15≦c/a≦1.30. The piezoelectric element includes on a substrate: the above-mentioned piezoelectric thin film; and a pair of electrodes provided in contact with the piezoelectric thin film. | 12-20-2012 |
20120312987 | ULTRAFAST ELECTRON DIFFRACTION DEVICE - An ultrafast electron diffraction device for irradiating a sample with a bunch of electrons in an ultrashort pulse in order to perform an ultrafast analysis of the sample. The ultrafast electron diffraction device includes: a) a laser emitter for delivering an ultrashort pulse laser having a pulse width of not more than 1 ps onto a target which is a material for generating electrons at an intensity of not less than 1017 W/cm | 12-13-2012 |
20120279553 | SOLAR CELL, SOLAR CELL PANEL, AND DEVICE COMPRISING SOLAR CELL - A solar cell ( | 11-08-2012 |
20120277351 | CELLULOSE NANOFIBERS - The present invention provides a novel production method of a cellulose nanofiber and a novel cellulose nanofiber. | 11-01-2012 |
20120276636 | METHOD FOR IMPROVING INDUCED PLURIPOTENT STEM CELL GENERATION EFFICIENCY - The present invention provides a method for improving iPS cell generation efficiency, which comprises a step of introducing a Myc variant having the following features: (1) having an activity to improve iPS cell generation efficiency which is comparative to, or greater than that of c-Myc; and (2) having a transformation activity which is lower than that of c-Myc; or a nucleic acid encoding the variant, in a nuclear reprogramming step. Also, the present invention provides a method for preparing iPS cells, which comprises a step of introducing the above Myc variant or a nucleic acid encoding the variant and a combination of nuclear reprogramming factors into somatic cells. Moreover, the present invention provides iPS cells comprising the nucleic acid encoding the Myc variant which can be obtained by the above method, and a method for preparing somatic cells which comprises inducing differentiation of the iPS cells. | 11-01-2012 |
20120273911 | PHOTOELECTRIC TRANSDUCER - A photoelectric transducer ( | 11-01-2012 |
20120270290 | PENTOSE TRANSPORTER - Disclosed is the production of useful substances such as bioethanol from pentose through effective use of biomass resources. Specifically, the invention discloses the following: Use of HGT2 gene or an expression product protein thereof as a xylose transporter. A xylose and/or L-arabinose transporter as an expression product protein of a gene selected from the group consisting of HGT2 gene, XUT1 gene, and HXT2.4 gene. Use of a gene selected from the group consisting of HGT2 gene, XUT1 gene, and HXT2.4 gene as a xylose and/or L-arabinose transporter. A method for producing bioethanol, the method comprising introducing into yeast at least one gene selected from the group consisting of HGT2 gene, XUT1 gene, and HXT2.4 gene, and culturing the yeast in the presence of a biomass that contains xylose and/or L-arabinose. | 10-25-2012 |
20120244619 | COMPOSITION FOR PROMOTING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO CARDIAC MUSCLE CELLS WHICH COMPRISES NITROVIN - The present invention provides a composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells which comprises nitrovin, a method for inducing differentiation of pluripotent stem cells into cardiac muscle cells by using nitrovin and a method for preparing cardiac muscle cells by using nitrovin. | 09-27-2012 |
20120231346 | ELECTROCHEMICAL DEVICE USING SOLID POLYMER ELECTROLYTE USING FINE POLYMER COMPOSITE PARTICLES - The invention provides n electrochemical device containing a negative electrode having a negative electrode material layer at least on a surface; a positive electrode having a positive electrode material layer at least on a surface; and a solid polymer electrolyte of fine composite particles disposed between the negative electrode and the positive electrode. Each of the fine composite particles comprises a polymer brush layer of polymer graft chains. The fine composite particles form a substantially three-dimensional ordered array structure, and a continuous ion-conductive network channel is formed in each gap of the fine particles. The negative or positive electrode or electrode material layer have gaps filled with the fine composite particles. A contact interface between the solid electrolyte and the electrode material layer or the electrode is a polymer brush layer composed of polymer graft chains | 09-13-2012 |
20120225837 | MEDICINAL AGENT FOR DISEASE ASSOCIATED WITH EPSTEIN-BARR VIRUS, AND METHOD FOR SCREENING OF THE MEDICINAL AGENT - 1-(2-Fluoro-4-thio-β-D-arabinofuranosyl)-5-methyluracil exhibits an anti-EB virus activity, and is therefore effective as a prophylactic or therapeutic agent for a disease associated with an EB virus. Each of a plasmid capable of expressing EB virus-TK and a plasmid capable of expressing human-TK is introduced into a TK-defect cell, thereby producing two types of cells respectively having the plasmids introduced therein. By using the two types of cells, it is possible to screen a medicinal agent which has cytotoxicity against the cell having the plasmid capable of expressing EB virus-TK introduced therein but has no toxicity against the cell having the plasmid capable of expressing human-TK introduced therein. In this manner, it becomes possible to screen a medicinal agent which specifically exhibits an anti-EB virus activity. | 09-06-2012 |
20120220790 | CYCLOPARA (HETERO) ARYLENE COMPOUND AND METHOD FOR PRODUCING SAME - Provided are a cyclopara(hetero)arylene compound and a method for producing the same. More specifically, provided is a cycloparaphenylene compound represented by Formula (I): | 08-30-2012 |
20120220004 | ETHANOL PRODUCTION FROM OCEAN BIOMASS - An object of the present invention is to provide a method for producing ethanol from polysaccharide alginate contained in a large amounts in brown algae, using the alginate assimilation capacity of the | 08-30-2012 |
20120219552 | ANTIBODY RECOGNIZING TURN STRUCTURE IN AMYLOID BETA - Provided is a therapeutic method exclusively targeting an amyloid β protein (Aβ) having a specific turn structure of Aβ. Specifically provided is an antibody which specifically recognizes an amyloid β having a turn structure at amino acids positions 22 and 23. Also provided are a medicinal composition comprising, as the active ingredient, an antibody specifically recognizing a toxic conformer of amyloid β, an assay kit for a toxic conformer of amyloid β, a diagnostic for Alzheimer's disease, etc. | 08-30-2012 |
20120214911 | COMPOSITION CONTAINING MICROFIBRILLATED PLANT FIBERS - This invention provides a polyolefin-based molded article containing microfibrillated plant fibers having high strength and high elastic modulus. Specifically, the present invention provides a composition comprising (1) a polymeric compound having a primary amino group, (2) a polymeric compound modified with maleic anhydride, (3) microfibrillated plant fibers, and (4) a polyolefin; and a molded article obtained by subjecting the composition to heat treatment. | 08-23-2012 |
20120214243 | METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - Provided are a method of improving iPS cell establishment efficiency, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B to a somatic cell, particularly to a somatic cell on which Lin28 is ineffective or less effective than Lin28B in improving iPS cell establishment efficiency, and a method of producing an iPS cell, comprising the step of transferring Lin28B or a nucleic acid that encodes Lin28B and a nuclear reprogramming substance to a somatic cell. Also provided are an iPS cell comprising a nucleic acid that encodes Lin28B, that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate into a somatic cell. | 08-23-2012 |
20120214104 | METHOD FOR PRODUCING MICROSTRUCTURE - The disclosed method for producing a microstructure can form a complicated three-dimensionally formed microstructure with few steps. | 08-23-2012 |
20120196360 | METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS - Provided is a method of producing an iPS cell, comprising bringing (a) Oct3/4 or a nucleic acid that encodes the same, (b) Klf4 or a nucleic acid that encodes the same, and (c) Sox2 or a nucleic acid that encodes the same, as well as (d1) L-Myc or a nucleic acid that encodes the same and/or (d2) a functional inhibitor of p53, into contact with a somatic cell. It is preferable that (a) a nucleic acid that encodes Oct3/4, (b) a nucleic acid that encodes Klf4, (c) a nucleic acid that encodes Sox2, (d1) a nucleic acid that encodes L-Myc and (e) a nucleic acid that encodes Lin28 or Lin28 | 08-02-2012 |
20120171717 | METHOD OF SELECTING SAFE PLURIPOTENT STEM CELLS - Provided is a method of selecting highly safe pluripotent stem cells that do not exhibit differentiation resistance, comprising the steps of (1) inducing a pluripotent stem cell to differentiate, (2) culturing the cell under conditions for maintaining undifferentiated state, (3) detecting the generation of an undifferentiated cell by the cultivation, and comparing the finding with a control, and (4) selecting a pluripotent stem cell whose detected value is not more than a control generation value. | 07-05-2012 |
20120164731 | METHOD OF INDUCING DIFFERENTIATION FROM PLURIPOTENT STEM CELLS TO SKELETAL MUSCLE PROGENITOR CELLS - Provided is a method of producing a skeletal muscle progenitor cell using a pluripotent stem cell, particularly an iPS cell, the method comprising the step 1) of culturing a pluripotent stem cell under serum-free conditions, and in the presence of Activin A, to allow the cell to differentiate into a PDGFRα-positive mesodermal cell, and the step 2) of culturing the mesodermal cell under serum-free conditions, and in the presence of a Wnt signal inducer, to allow the cell to differentiate into a skeletal muscle progenitor cell. Also provided are a cell population containing a skeletal muscle progenitor cell as obtained by the method, and a skeletal muscle regeneration promoting agent and therapeutic agent for muscular diseases such as muscular dystrophy, the promoting agent or agent comprising the skeletal muscle progenitor cell as an active ingredient. | 06-28-2012 |
20120164125 | NUCLEIC ACID CLEAVING AGENT - A nucleic acid cleaving agent having a cleaving activity specific to a desired cleavage site in a nucleic acid such as large DNA, which comprises (1) a nucleic acid cleaving moiety, and (2) at least two zinc finger proteins bound to the nucleic acid cleaving moiety, wherein at least one of the zinc finger proteins can specifically bind to a nucleotide sequence located upstream from the target cleavage site, and at least one of the remaining zinc finger proteins can specifically bind to a nucleotide sequence located downstream from the target cleavage site. | 06-28-2012 |
20120161104 | ULTRAVIOLET IRRADIATION DEVICE - An ultraviolet irradiation device having a simple structure without using a pn junction, which can efficiently utilize a surface plasmon polariton and can emit ultraviolet light of a specific wavelength at a high efficiency. The device has at least one semiconductor multilayer film element and an electron beam irradiation source which are provided in a container having an ultraviolet-ray transmitting window and is vacuum-sealed, wherein the film element has an active layer formed of In | 06-28-2012 |
20120156684 | SELECTION METHOD OF INDUCED PLURIPOTENT STEM CELLS - The present invention relates to a method for selecting induced pluripotent stem (iPS) cells. More particularly, the present invention provides: a method for selecting an iPS cell, comprising the steps of: (1a) measuring the expression level of an exogenous nuclear reprogramming gene(s) in a test iPS cell; and (2a) selecting an iPS cell in which the expression level(s) of an exogenous nuclear reprogramming gene(s) is/are less than or equal to the expression level(s) in control iPS cells; and a method for selecting an iPS cell, comprising the steps of: (1b) measuring the expression level of an exogenous nuclear reprogramming gene(s) and the sum the expression levels of the exogenous nuclear reprogramming gene(s) and the corresponding endogenous gene iPS cell; and (2b) selecting an iPS cell in which the ratio of the expression level of an exogenous nuclear reprogramming gene(s) relative to the sum of the expression levels of the exogenous transgene(s) and the corresponding endogenous gene(s) is less than 1 to the ratio in the control iPS cell. | 06-21-2012 |
20120156132 | TARGETING AGENT TO NEWLY FORMED BLOOD VESSELS - It is an object of the present invention to provide a targeting agent that enables drug delivery to a neovascular site and the imaging of such a neovascular site, utilizing the effect of the agent to accumulate in the neovascular site. The present invention provides a targeting agent to a neovascular site, which comprises a gelatin-like protein. | 06-21-2012 |
20120148639 | SUBSTRATE FOR FEEDING CELLS AND/OR TISSUES, CELL/TISSUE-FEEDER AND METHOD FOR THE PRODUCTION OF THE SAME, METHOD FOR THE REGENERATION OF TISSUES, AND METHOD FOR THE PRODUCTION OF POROUS BODIES - A substrate for feeding cells and/or tissues which is composed of a porous body having a thin film surface and a porous surface and which can be used in the regenerative medical techniques. A cell/tissue feeder is produced by cultivating tissues on the porous surface of the porous body. Cells are seeded on the porous surface of the body, followed by the cultivation of the cells to thus form and/or regenerate tissues. An aqueous solution of silk proteins, to which a water-soluble organic solvent is added, is introduced into a mold whose bottom or top surface is surface-roughened, followed by freezing the aqueous solution and then thawing the frozen aqueous solution to form a porous body having a thin film surface and a porous surface. | 06-14-2012 |
20120142093 | METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO NEURAL PRECURSOR CELLS - The present invention provides a method for inducing differentiation of pluripotent stem cells into neural precursor cells, comprising culturing the pluripotent stem cells in the presence of a small molecule BMP inhibitor, and induced neural precursor cells prepared by this method. | 06-07-2012 |
20120141646 | STERILIZER FOR FOODS - Disclosed is a sterilizer for foods, which contains calcinated calcium or calcium hydroxide and has a higher sterilizing activity than conventional sterilizers. The sterilizer is made up of an aqueous solution or an aqueous dispersion prepared by blending calcinated calcium or calcium hydroxide, ethanol, and sodium lactate. | 06-07-2012 |
20120136131 | POLYMERIZATION INITIATOR FOR LIVING RADICAL POLYMERIZATION - Provided is a method of living radical polymerization which does not necessitate complicated and intricate synthesis of a dormant species and which is highly efficient. A halogenated derivative compound is used as a dormant species for initiating living radical polymerization. The derivative compound is obtained by halogenating an alcohol compound having a non-conjugated structure or an amine compound having a non-conjugated structure with a halogenating agent capable of halogenating an alcohol or amine. A radical produced by elimination of halogen from the halogenated derivative compound is allowed to react with the unsaturated bond of the monomer. Thus, the monomer, which has a radical-reactive unsaturated bond, is polymerized by living radical polymerization. Preferably, the halogenating agent is a compound (NIS or the like) which also has a function as a catalyst. | 05-31-2012 |
20120129172 | METHOD FOR SELECTING CLONE OF INDUCED PLURIPOTENT STEM CELLS - To efficiently identify and select a clone from clones of induced pluripotent stem cells (iPS cell) having low tumor formation rate in vivo when allowed to differentiate and transplanted in a living body, iPS cells of the clones are induced to differentiate, undifferentiated cells among the cells after the induction of differentiation are detected, and a clone having the content of the undifferentiated cell below a control is selected. | 05-24-2012 |
20120124706 | SCANNING PROBE MICROSCOPE AND METHOD FOR DETECTING PROXIMITY OF PROBES THEREOF - A scanning probe microscope includes: a first and second probes for scanning a sample while maintaining the distance to the sample surface; crystal oscillators holding each of the first and second probes; and a modulation oscillator for providing the first probe with a vibration of a specific frequency which is different from the resonant frequency of each crystal oscillator. A control unit monitors the vibration of the specific frequency of the first and second probes, detects proximity of the first probe and the second probe to each other based on the change of the specific frequencies, and controls the drive of the first and second probes. | 05-17-2012 |
20120114219 | IMAGE PROCESSING APPARATUS, INCUBATION OBSERVING APPARATUS, AND IMAGE PROCESSING METHOD - An image processing apparatus includes an outline extracting processing unit inputting a phase contrast image of a cell colony acquired by an observing unit, and extracting an outline of the cell colony, an extracting unit extracting a feature quantity of an outline part of the cell colony based on brightness information at an outside and brightness information at an inside of the outline on the phase contrast image, and an automatic discriminating unit automatically discriminating whether or not the cell colony is an iPS cell colony based on a discriminant criterion determined in advance and the feature quantity extracted by the extracting unit. | 05-10-2012 |
20120112187 | METHOD FOR FORMING METAL OXIDE FILM, METAL OXIDE FILM AND APPARATUS FOR FORMING METAL OXIDE FILM - The present method of forming a metal oxide film can increase production efficiency while maintaining the low resistance of the metal oxide film. The present method of forming a metal oxide film includes first misting a solution containing a metallic element and ethylenediamine; meanwhile, heating a substrate; and then, supplying the misted solution onto a first main surface of the substrate. | 05-10-2012 |
20120101391 | BLOOD VESSEL WALL ANALYZING DEVICE AND BLOOD VESSEL WALL ANALYZING METHOD - The present invention relates to a blood vessel wall analyzing apparatus provided with a structure enabling accurate measurement of plaque components in a blood vessel wall in a state that reduces the burden on a patient. In the blood vessel wall analyzing apparatus ( | 04-26-2012 |
20120100516 | PORTABLE PRACTICE TOOL FOR HEART MASSAGING IN CARDIOPULMONARY RESUSCITATION - Provided is a training box that is a practice tool for learning heart massaging (sternal compression) through experience; is low-cost, small-sized, light weight, and easy to transport; retains durability under repeated use; and on which AED use procedures can also be drilled. The portable practice tool for heart massaging in cardiopulmonary resuscitation is characterized by being provided with a chest-mockup main unit ( | 04-26-2012 |
20120095227 | COMPOUND HAVING HETERO RING SKELETON, AND PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUND USING THE AFOREMENTIONED COMPOUND AS ASYMMETRIC CATALYST - The present invention provides a compound having a heterocyclic skeleton, which is represented by of the formula (I): | 04-19-2012 |
20120087863 | Peptide Derivative and Use of the Same - A new peptide derivative is provided. The peptide derivative is represented by the following general formula (I), | 04-12-2012 |
20120085918 | ION BEAM IRRADIATION DEVICE AND METHOD FOR SUPPRESSING ION BEAM DIVERGENCE - To improve an efficiency of utilizing electrons and efficiently suppress an ion beam spread by a space charge effect while eliminating a need for a special magnetic pole structure by effectively using a space in the vicinity of a magnet, there are provided an ion source, a collimating magnet and a plurality of electron sources, wherein the electron sources are arranged in a magnetic field gradient region formed on an ion beam upstream side or ion beam downstream side of the collimating magnet and arranged outside a region passed by the ion beam, and an irradiation direction of the electrons is directed to supply the electrons to the magnetic field gradient region. | 04-12-2012 |
20120078117 | BLOOD VESSEL INNER WALL ANALYZING DEVICE AND BLOOD VESSEL INNER WALL ANALYZING METHOD - The present invention relates to a blood vessel inner wall analyzing apparatus provided with a structure for more accurately analyzing components of substances adhered to the inner walls of blood vessels. A blood vessel inner wall analyzing apparatus ( | 03-29-2012 |