KUMAMOTO UNIVERSITY Patent applications |
Patent application number | Title | Published |
20140029758 | ACOUSTIC SIGNAL PROCESSING DEVICE, ACOUSTIC SIGNAL PROCESSING METHOD, AND ACOUSTIC SIGNAL PROCESSING PROGRAM - An acoustic signal processing device includes a frequency domain transform unit configured to transform an acoustic signal to a frequency domain signal for each channel, a filter coefficient calculation unit configured to calculate at least two sets of filter coefficients of a filter for each section having a predefined number of frames with respect to a sampled signal obtained by sampling the frequency domain signal transformed by the frequency domain transform unit for each frame such that the magnitude of a residual calculated based on a filter compensating for the difference in transfer characteristics between the channels of the acoustic signal is minimized, and an output signal calculation unit configured to calculate an output signal of a frequency domain based on the frequency domain signal transformed by the frequency domain transform unit and at least two sets of filter coefficients calculated by the filter coefficient calculation unit. | 01-30-2014 |
20130281510 | siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis - The invention relates to a method of treating ocular amyloidosis by reducing TTR expression in a subject by administering a double-stranded ribonucleic acid (dsRNA) that targets a TTR gene to the retinal pigment epithelium of the subject. | 10-24-2013 |
20130068034 | MICROMATERIAL STRAIN MEASUREMENT APPARATUS AND METHOD THEREFOR TECHINICAL FIELD - A measurement unit for tensile or compressive stress can includes a CCD camera for detecting an interference light, the interference light being formed with a measurement beam from a measured region and a reference beam from a reference mirror. A first objective lens can have the reference mirror. An image processing apparatus can measure the three-dimensional shape of the measured region from the position of the first objective lens at which the interference light provides the maximum contrast and can measure the distance between two gauge points on the basis of the three-dimensional shape. When strain is generated on a micromaterial, the strain against the measured tensile stress is measured on the basis of the tensile stress and the distance between the two gauge points. | 03-21-2013 |
20120058491 | METHOD FOR INDUCTION OF DIFFERENTIATION OF ES CELL - It is an object of the present invention to establish a system for reliably differentiating an ES cell into a hepatic cell. The present invention provides a method for inducing the differentiation of an ES cell into a hepatic cell, which comprises, in the presence of an M15 cell, culturing a mammal-derived ES cell in the presence of activin and bFGF, and then culturing the ES cell in the presence of dexamethasone, HGF, and oncostatin M. | 03-08-2012 |
20110229487 | THERAPEUTIC AGENT COMPRISING ANTIBODY CAPABLE OF SPECIFICALLY BINDING TO HUMAN HMGB-1 AS ACTIVE INGREDIENT - Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect. | 09-22-2011 |
20110044995 | ANTI-HIV MONOCLONAL ANTIBODY - The present invention provides a monoclonal antibody that recognizes the V3 loop of the envelope glycoprotein gp120 of AIDS virus, which is any one selected from the following antibodies:
| 02-24-2011 |
20100219068 | Harmful Gas Treatment Apparatus and Water Treatment Apparatus - A harmful gas treatment apparatus and a water treatment apparatus uses an electrochemical device provided with a solid electrolyte membrane having ion conductivity. A first electrochemical device provided with an anode on one surface of a hydrogen ion conductive electrolyte membrane and a cathode on the other surface thereof is combined with a second electrochemical device provided with an anode on one surface of a hydroxyl ion conductive electrolyte membrane and a cathode on the other surface thereof. Both cathodes are disposed so as to face each other within an electrochemical reaction tank. Each of the cathodes is provided with TiO | 09-02-2010 |
20090239806 | GLYPICAN-3 (GPC3)-DERIVED TUMOR REJECTION ANTIGENIC PEPTIDES USEFUL FOR HLA-A2-POSITIVE PATIENTS AND PHARMACEUTICAL COMPRISING THE SAME - It is an object of the present invention to identify a glypican-3-derived peptide which can bind to HLA-A2 and activate human killer T cells, so as to provide a means for carrying out an immunotherapy which is able to target approximately 40% of Japanese patients suffering from several types of cancers, which express GPC3 at a high level. The present invention provides a peptide of any of the following (A) or (B):
| 09-24-2009 |
20090215716 | NITROGUANOSINE-3' 5'-CYCLIC MONOPHOSPHATE COMPOUND AND PROTEIN KINASE G ACTIVATING AGENT - An object of the present invention is to provide a novel compound that is an agonist of guanosine-3′,5′-cyclic monophosphate and has an effect of activating protein kinase G. The present invention provides 8-guanosine-3′,5′-cyclic monophosphate compound which is represented by the following formula, and a pharmaceutical composition, especially a protein kinase G activating agent, which contains the 8-guanosine-3′,5′-cyclic monophosphate compound as an active ingredient. | 08-27-2009 |
20090111095 | NOVEL DIAGNOSTIC KIT FOR MALIGNANT MELANOMA - The object of the present invention is to find out another tumor marker which is useful for early diagnosis of melanoma, and provide a diagnostic kit and diagnostic method for malignant melanoma using such marker. The present invention provides a diagnostic kit for malignant melanoma, which comprises an antibody against SPARC and an antibody against GPC3. | 04-30-2009 |
20090022692 | THERAPEUTIC AGENT FOR HEART DISEASE USING MAP KINASE TNNI3K - An object to be achieved by the present invention is to provide a therapeutic means for heart disease such as myocardial ischemia or myocardial infarction. The present invention provides a therapeutic agent for heart disease which comprises a myocardial progenitor cell expressing MAP kinase TNNI3K at a high level as an active ingredient. | 01-22-2009 |