JOHNSON & JOHNSON RESEARCH PTY LIMITED Patent applications |
Patent application number | Title | Published |
20130344040 | PROCESS FOR THE PREPARATION OF A COMPOSITION OF GENETICALLY MODIFIED HEMATOPOIETIC PROGENITOR CELLS - Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection. | 12-26-2013 |
20110143338 | NUCLEIC ACID ENZYMES AND COMPLEXES AND METHODS FOR THEIR USE - The present invention relates to methods that utilise multi-component nucleic acid complex (MNA complex) cascades. The MNA complexes may have cleavage or ligase activity. Further, the invention provides cascades which may include one or more DNAzymes. The invention also provides methods which use these cascades for the identification, detection and quantification of targets. | 06-16-2011 |
20100305186 | METHODS FOR MEDIATING GENE SUPPRESSION - The present invention is concerned with methods for enhancing gene suppression in cells and in particular it is concerned with improved methods for enhancing RNAi-mediated gene silencing by manipulation of factors associated with RNAi. The present invention is also concerned with methods for identifying factors which down-regulate as well as those which up-regulate RNAi. It is also concerned with genetic constructs useful for enhancing or modulating gene silencing and cells harbouring such constructs. | 12-02-2010 |
20100221711 | Respiratory Syncytial Virus (RSV) Viral Load Detection Assay - The invention concerns a method for the extraction of nucleic acids from biological samples e.g. tissue material or sputum derived from human or animal species and the quantitative detection thereafter of said nucleic acids e.g. in terms of viral load, more specifically RSV viral load detection. | 09-02-2010 |
20100136536 | Molecular Switches And Methods For Their Use - The present invention relates to compositions and methods that allow the manipulation of the catalytic activity of multi-component nucleic acid complexes. Further, the invention provides methods which use these compositions and methods to create molecular sensors, molecular switches, and/or modulators or propagators of autocatalytic self-replicating cascades and other iterative processes. More particularly, the invention relates to compositions allowing self-assembly of active and inactive multicomponent nucleic acid complexes, methods of making such compositions, and methods for use. | 06-03-2010 |
20090239816 | Multitargeting Interfering RNAs And Methods Of Their Use And Design - Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are used to modulate expression of the target sequences. Such a multitargeting interfering RNA approach provides a powerful tool for gene regulation. | 09-24-2009 |
20090192103 | Multitargeting Interfering RNAs Having Two Active Strands And Methods For Their Design And Use - Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are used to modulate expression of the target sequences. The multitargeting interfering RNA molecules have two strands that target multiple target sites on one or more pre-selected RNA molecules. Such a multitargeting interfering RNA approach provides a powerful tool for gene regulation. | 07-30-2009 |