| JOHANNES GUTENBERG UNIVERSITÄT MAINZ Patent applications |
| Patent application number | Title | Published |
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| 20110243995 | Method for Rational Mutagenesis of Alpha/Beta T-Cell Receptors and Correspondingly Mutated MDM2-Protein Specific Alpha/Beta T-Cell Receptors - The invention relates to the rational mutagenesis of polypeptides of α/β T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific α/β T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof. | 10-06-2011 |
| 20110114487 | APPARATUS, METHOD, AND GEL SYSTEM FOR ANALYTICAL AND PREPARATIVE ELECTROPHORESIS - The present invention relates to an electrophoresis apparatus comprising a gel chamber for receiving electrophoresis medium, a removable gel system, which is arranged in the gel chamber, having a separation gel for the electrophoretic separation of biological molecules such as nucleic acids or proteins, electric contact elements for generating an electric field through the separation gel, optionally a lid for fastening on the gel chamber, characterized in that the separation gel is delimited at least at one side by a spacer element which is in the form of a collector and comprises a plurality of sample collection containers, which are arranged one next to the other, for fractionating and for collecting the electrophoretically separated molecules. The invention further relates to a method for the electrophoretic separation and collection of biological molecules by way of a two-dimensional gel electrophoresis. | 05-19-2011 |
| 20100310471 | ANTIOXIDANT AND PARAMAGNETIC HEPARIN-NITROXIDE DERIVATIVES - The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisation of glycosaminoglycan carboxyl or amino groups. The heparin-nitroxide derivatives are useful as therapeutic or diagnostic agents. This invention further concerns novel methods for the production of the heparin-nitroxide agents, and methods of their uses for specifically targeting and labelling of biological vessels. The inventions also suggest the uses of the heparin-nitroxide derivatives for treatment of oxidative stress-mediated diseases. Furthermore, the heparin-nitroxide derivatives according to the present invention are in particular useful for electron paramagnetic resonance imaging (EPRI), for magnetic resonance imaging (MRI), and for preservation of biological transplants. | 12-09-2010 |
