IVAX Pharmaceuticals s.r.o.
|IVAX Pharmaceuticals s.r.o. Patent applications|
|Patent application number||Title||Published|
|20110020438||Crystallization Inhibitor and Its Use in Gelatin Capsules - The present invention describes soft gelatin capsules that encapsulate a water-insoluble active ingredient and an excipient composed of a crystallization inhibitor that stabilizes the water-insoluble inhibitor. The crystallization inhibitor being at least one mononacylglycerol compound whose acyl group is a fatty acid residue of 6-18 carbon atoms. The capsule contents are more resistant to turbidity, forming a coarse emulsion, and crystallization of the active ingredient compared with compositions absent the crystallization inhibitor.||01-27-2011|
|20090216031||Process for the isolation of paclitaxel - Paclitaxel is isolated by a process including normal phase chromatography using a polyamide stationary phase and a mixture containing a dialkyl ketone and a less polar solvent as a mobile phase. Suitable dialkyl ketones include acetone or methyl isobutyl ketone. Suitable less polar co-solvents include a (C||08-27-2009|
|20080312447||Process for Isolation of Crystalline Tacrolimus - The invention is a simple process for separation of tacrolimus and its analogues, ascomycin and tsucubamycin B and preparation of enough pure crystalline tacrolimus. The process takes advantage of surprising properties of tacrolimus and involves extraction, purification and crystallization to produce purified crystalline tacrolimus.||12-18-2008|
|20080293110||Process for Isolation of Mycophenolic Acid - Mycophenolic acid can be isolated from fermentation broth easily with low consumption or organic solvents to produce mycophenolic acid that is surprisingly high in purity. The process can be accomplished by addition of a suitable base to the whole fermentation broth. i.e., a suspension obtained by submerged cultivation of a microorganism producing mycophenolic acid, to increase pH of the liquid phase to the value from about (9) to about (13). Mycophenolic acid is thus extracted from the mycelium to the liquid phase and the exhausted mycelium can be separated easily by filtration.||11-27-2008|
|20080269479||Process for Isolation of Macrolide Compounds - Although macrolide compounds are insoluble in water, surprisingly high part of the product was found in the liquid phase of the fermentation broth. Therefore, processing the entire fermentation broth, i.e. the suspension obtained by cultivation of a microorganism producing the required macrolide compound, is highly advisable. This invention teaches a method of processing the entire fermentation broth using cheap and environmentally acceptable solvents.||10-30-2008|
|20080262223||Isolation of Galanthamine From Biological Material - The subject matter of present invention relates to the process for isolation and purification of galanthamine and its derivatives produced by numerous plants.||10-23-2008|
|20080214847||Process for the Separation of Paclitaxel and Cephalomannin - Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be a (C||09-04-2008|
Patent applications by IVAX Pharmaceuticals s.r.o.