| ISIS INNOVATION LIMITED Patent applications |
| Patent application number | Title | Published |
|---|
| 20120121646 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 05-17-2012 |
| 20120114666 | NEUROLOGICAL AUTOIMMUNE DISORDERS - The invention relates to a method of diagnosing an autoimmune neurological disorder in a mammal comprising the step of detecting, in a bodily fluid sample from the mammal, autoantibodies to an epitope of at least one Kv1-complex protein; and related methods, assay kits, isolated or purified autoantibody or antibody fragments, or uses thereof. | 05-10-2012 |
| 20120107802 | METHOD FOR SEQUENCING A HETEROPOLYMERIC TARGET NUCLEIC ACID SEQUENCE - The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore. | 05-03-2012 |
| 20120076818 | IMMUNOGENIC COMPOSITION AND USE THEREOF - The invention relates to an immunogenic composition comprising an adenoviral vector and a pox viral vector, or two different adenoviral vectors, wherein one or more of the vectors encodes one or more target antigens; and related methods, uses and kits. | 03-29-2012 |
| 20120070355 | Methods and Apparatus for the Production of Carbon-Containing Materials - The present invention provides various methods and apparatus for the production of fullerenes and other carbon-containing materials. In some aspects, the invention provides an arc chamber comprising a graphite element support, wherein the support comprises a rotatable frame adapted for moving each graphite element towards and away from an arc discharge position. In other aspects, the invention provides a collection chamber for collecting carbon-containing materials produced in an arc chamber, wherein the collection chamber comprises an inlet and a rotatable element arranged to direct the carbon-containing material to a wall of the collection chamber, wherein the sectional area occupied by the rotatable element increases with distance from the inlet. In other aspects, the invention provides a collection chamber comprising means for isolating the collection chamber from an arc discharge apparatus and an inlet for the introduction of solvent into the collection chamber. | 03-22-2012 |
| 20120062986 | FOCUSING APPARATUS AND METHOD - A focusing apparatus for use with an optical system having a high NA objective lens includes an image forming and capturing mechanism for forming an image in an intermediate image zone and for capturing an image by receiving and refocusing light from a selected focal plane within the intermediate image zone, and a focus adjusting mechanism for adjusting the position of the selected focal plane within the intermediate image zone. The image forming and capturing mechanism includes at least one high NA lens. In use, spherical aberration introduced by the high NA objective lens is reduced. | 03-15-2012 |
| 20120041309 | MAPPING AND CHARACTERIZATION OF CAVITATION ACTIVITY - Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source. | 02-16-2012 |
| 20120034214 | METHODS AND KITS FOR DETERMINING THE PROGNOSIS OF PULMONARY SARCOIDOSIS - The invention provides a method for determining the prognosis of pulmonary sarcoidosis in an individual subject, comprising conducting gene expression analysis on a sample from the subject. The sample is obtained by bronchoscopy under procedural methods not requiring general anaesthesia. | 02-09-2012 |
| 20120021311 | Hydrogen Storage Material - Novel mixed alkali metal borohydrides are disclosed which can be used as hydrogen storage materials. Processes for producing the mixed alkali metal borohydrides and their use in hydrogen storage devices are also described. | 01-26-2012 |
| 20110311965 | METHODS OF ENHANCING TRANSLOCATION OF CHARGED ANALYTES THROUGH TRANSMEMBRANE PROTEIN PORES - The invention relates to enhancing translocation of a charged analyte through a transmembrane protein pore. Translocation is enhanced by increasing the net opposing charge of the barrel or channel and/or entrance of the pore. The invention also relates to pores enhanced in accordance with the invention. | 12-22-2011 |
| 20110302992 | APPARATUS FOR MEASUREMENT OF GAS CONCENTRATIONS IN BREATH - A device for measuring oxygen uptake and carbon dioxide production by a respiring subject based on the use of absorption spectroscopy. An absorption spectrometer using cavity enhanced absorption spectroscopy at 763 nm to measure oxygen concentration and direct absorption or wavelength modulation spectroscopy at 2.0035 μm for carbon dioxide concentration is incorporated into a breathing tube in proximity to the respiring subject. This provides measurements of oxygen and carbon dioxide concentration with a good temporal resolution which can be combined with measurements of flow rate as a function of time to obtain oxygen uptake and carbon dioxide production on a breath-by-breath basis. The device can also measure the concentration of water vapour and of anaesthetic gases in exhaled breath. | 12-15-2011 |
| 20110300128 | USE OF FOXP2 AS A MARKER FOR ABNORMAL LYMPHOCYTES AND AS A TARGET FOR THERAPY OF DISORDERS ASSOCIATED WITH ABNORMAL LYMPHOCYTES - The present invention is directed to a method for detecting abnormal lymphocytes said method comprising detecting an amount or expression of the FOXP2 gene in lymphocytes in a sample, wherein an increased amount or expression of the FOXP2 gene in said lymphocytes indicates the presence of abnormal lymphocytes. Additionally, the invention concerns a method for detecting or assessing a condition associated with the presence of abnormal lymphocytes. The methods of the invention may also be useful for diagnosing myeloma or MGUS or for determining the prognosis for patients with lymphoma, myeloma or MGUS. The severity of bone disease or bone colonisation of tumours may also be able to be predicted. Further, treatment of conditions associated with the presence of abnormal lymphocytes using an agent which inhibits FOXP2 expression and/or FOXP2 activity is provided. An antibody which binds to the N-terminus of FOXP2 has also been developed. | 12-08-2011 |
| 20110272688 | ARYL-ARYL DENDRIMERS - Light emitting devices are described which incorporate, as the light emitting element, a dendrimer of which the constituent dendrons include a conjugated dendritic structure comprising aryl and/or heteroaryl groups connected to each other via bonds between sp | 11-10-2011 |
| 20110269629 | SUPERCONDUCTING MATERIALS - Partially or fully saturated doped graphene materials are found to be superconducting. The saturation is with hydrogen or halogen. Doping is performed by substitution of carbon atoms or by applying an electric field. Diamond nano-rods are also found to be superconducting. These materials can be used in electronic devices having a gate. | 11-03-2011 |
| 20110254950 | VISUAL TRACKING OF OBJECTS IN IMAGES, AND SEGMENTATION OF IMAGES - A method is discussed of tracking objects in a series of n-D images ( | 10-20-2011 |
| 20110237956 | INVESTIGATION OF PHYSICAL PROPERTIES OF AN OBJECT - An imaging system for an object such as human or animal tissue uses scattering of an illuminating electromagnetic wave by acoustic vibrations to generate a scattered electromagnetic wave including Doppler components shifted from the frequency of the illuminating electromagnetic wave by frequencies of the acoustic vibration and multiples thereof. An acoustic transducer apparatus applies acoustic vibrations localised in two or three dimensions in a plurality of regions. A transmitter simultaneously illuminates the object with an illuminating electromagnetic wave that has a frequency in the range from 100 MHz to 100 GHz, the vibration direction of the acoustic vibration having a component parallel to the propagation direction of the illuminating electro-magnetic wave. A receiver receives the scattered electromagnetic wave. A signal processing apparatus derives characteristics of the Doppler components, and stores image data representing the derived characteristic. | 09-29-2011 |
| 20110237666 | HYDROXYBUTYRATE ESTER AND MEDICAL USE THEREOF - A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia. | 09-29-2011 |
| 20110236418 | Materials and Methods for Improved Vaccination - The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes. | 09-29-2011 |
| 20110229880 | GENE SILENCING - The invention provides a mirtron or a gene capable of expressing a mirtron for use in modifying the expression of a target gene in a mammalian cell to prevent or treat a disease, the sequence of the mirtron comprising: (i) a 5′ splice site; (ii) a 3′ splice site; (iii) a branch-point recognition sequence; (iv) a 3′ polypyrimidine tract greater than 15 nucleotides in length; and (v) an antisense sequence that is at least partially complementary to a sequence in the target gene. | 09-22-2011 |
| 20110201044 | TUBERCULOSIS DIAGNOSTIC TEST - A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided. | 08-18-2011 |
| 20110199000 | CHARGED PARTICLE ACCELERATOR AND RADIATION SOURCE - A method of accelerating charged particles using a laser pulse fired through a plasma channel contained in a capillary, wherein the plasma waveguide has deviations along its length that cause deviations in the plasma density contained therein, the deviations in plasma density acting to promote charged particle injection into a wake of a passing laser pulse. A radiation source based on a laser-driven plasma accelerator in a plasma waveguide in which the plasma waveguide and/or laser injection process is/are controlled so as to produce an undulating path for the laser pulse through the waveguide, the undulation exerting a periodic transverse force on charged particles being accelerated in the wake of the laser pulse, the resulting charged particle motion causing controlled emission of high frequency radiation pulses. | 08-18-2011 |
| 20110195451 | Protein Expression - An isolated DNA molecule having a sequence which comprises in a 5′ to 3′ direction (i) one or more promoter elements, (ii) the geneof interest, and (iii) a poly-adenylation 5 signal, and (iv) a terminator element, and expressing the geneof interest incorporated into the DNA molecule in an expression system, and use of said molecule to enhance expression of a gene of interest. | 08-11-2011 |
| 20110171234 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 07-14-2011 |
| 20110171220 | PD-1 SPECIFIC ANTIBODIES AND USES THEREOF - One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject. | 07-14-2011 |
| 20110171215 | PD-1 SPECIFIC ANTIBODIES AND USES THEREOF - One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject. | 07-14-2011 |
| 20110163270 | Metal-Containing Dendrimers - This invention relates to a hat emitting device which comprises at least one layer that contains an organometallic dendrimer having a core comprising a metal cation. The invention also relates to organometallic dendrimers and methods for producing the same. | 07-07-2011 |
| 20110153246 | UTILITY METERING - An apparatus has an input section arranged to receive values representative of the total instantaneous supply of electrical current as a function of time from an alternating voltage supply. Current waveforms comprising sets of values representative of the cyclic waveform of the electric current supply are obtained. A delta waveform generator calculates the difference between a current waveform and an earlier current waveform. An edge detector is arranged to detect an edge or edges in the delta waveform. An analysis section is arranged to identify at least one appliance load based at least on information on the edge or edges detected by the edge detector, and to determine the electrical energy consumed by said appliance load. Another apparatus has an input section arranged to receive values representative of the current supplied to an installation, such as a house. A store contains appliance data characteristic of the use of electricity by each of a plurality of appliances. A processor is arranged to analyse the received values to detect when an appliance is switched on and determine the fractional change in resistance of a heating appliance from the when it is switched on until it reaches its operating temperature. This information is used to identify what the particular appliance is, and to determine the electrical energy consumption by that appliance. A utility meter for metering the use of at least one utility supplied to a plurality of appliances is also disclosed. An input section is arranged to receive values representative of the use of a first utility. A store contains appliance data characteristic of the use of utilities by each of a plurality of appliances. A processor is arranged to analyse the received values and to determine information on the use of a second utility by each appliance, based on the received values and appliance data. | 06-23-2011 |
| 20110130449 | Assay for Monitoring Activity of Jmjd6 - The invention provides a method for assaying Jmjd6 activity. | 06-02-2011 |
| 20110130346 | PEPTIDE CONJUGATES FOR DELVERY OF BIOLOGICALLY ACTIVE COMPOUNDS - A construct comprising a cell delivery peptide covalently attached to a biologically active compound suitable for delivery of said biologically active compound into cells, wherein optionally the cells are cardiac muscle, skeletal muscle, smooth muscle or contractile cells. | 06-02-2011 |
| 20110112186 | DIAGNOSTIC METHODS - This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy. | 05-12-2011 |
| 20110109406 | Microwave Cavity Sensor - Apparatus comprising: a radio frequency (RF) Robinson oscillator comprising: a resonator comprising a sensor rhumbatron, the sensor rhumbatron comprising a cavity member, the cavity member having a re-entrant boss member, the re-entrant boss member being arranged to project into a cavity portion of the cavity member; a feedback element arranged to provide positive radio frequency (RF) feedback to the cavity member thereby to increase a quality factor Q of the cavity member, the feedback element having first and second terminals coupled to the cavity member, the apparatus being operable to cause the oscillator to oscillate at a resonant frequency; and an output arranged to provide a signal that varies according to a value of at least one electrical parameter of the oscillator, said at least one electrical parameter being selected from amongst an electromagnetic loss and a resonant frequency. | 05-12-2011 |
| 20110099673 | STAGE FOR SCANNING PROBE MICROSCOPY AND SAMPLE OBSERVATION METHOD - It is an object of the invention to provide a stage for scanning probe microscopy that can be used in any kind of SPM and can effectively irradiate light to a sample and a solution near the sample without irradiated light blocked by a cantilever. The stage for scanning probe microscopy of the invention is a stage for scanning probe microscopy for fixing a sample substrate that mounts a sample to be observed thereon and has optical transparency and includes an opening that is provided below a portion where the sample substrate is fixed and that has an opening area included within the sample substrate in plan view. Light is radiated from a bottom surface of the sample substrate onto the sample through the opening. | 04-28-2011 |
| 20110086049 | Receptor Modulators - Method of identifying a modulator of CD28 comprising comparing a structural model of a candidate modulator with a structural model of CD28 to thereby determine whether the modulator will bind to CD28, wherein the structural model is derived from, or comprises, structural coordinates of a crystal of: (i) CD28, (ii) a fragment of CD28, or (iii) a homologue of (i) or (ii). The crystal of CD28 in a soluble form complexed with the Fab fragment of a mitogenic (superagonistic) antibody has been obtained and used for the determination of the 3D-structure of the receptor. The application also relates to modulators of superagonistic signalling for any receptor of the CD28 family, i.e. to superagonistic antibodies and chimeric proteins thereof, and to the screening of the superagonistic modulators. In the methods of screening, the binding of the candidate modulators to a portion of the receptor proximal to the cell membrane is investigated. | 04-14-2011 |
| 20110059908 | COMPOSITIONS COMPRISING LIPOTEICHOIC ACID FOR USE IN TREATING PLEURAL EFFUSION OR PNEUMOTHORAX - The present invention relates to lipoteichoic acid T for use in treating pleural effusion or pneumothorax. The present invention also relates to the use of lipoteichoic acid T (LTA-T) in the manufacture of a medicament for treating pleural effusion or pneumothorax. The present invention also relates to a kit comprising a pharmaceutical composition comprising lipoteichoic acid T and instructions indicating that the composition is for use as a pleurodesis agent. In addition, the present invention relates to a method of treating pleural effusion or pneumothorax comprising administration of lipoteichoic acid T to a subject. | 03-10-2011 |
| 20110059501 | Protein Glycosylation - The present invention relates to methods for glycosylating a protein in which the protein is modified to include an alkyne and/or an azide group. The invention further relates to a protein glycosylated by these methods. | 03-10-2011 |
| 20110056561 | BRANCHED MATERIALS FOR PHOTOVOLTAIC DEVICES - The invention provides a dye-sensitized photovoltaic device which comprises: a first electrode; a second electrode; and, disposed between the first and second electrodes: an electron acceptor material which comprises a semiconductive metal oxide, a redox mediator material, and a photosensitizing dye which comprises a dendrimer of formula (I): [X] | 03-10-2011 |
| 20110044912 | Diagnostic And Therapeutic Epitope, And Transgenic Plant - A peptide analogue which is not more than 50 amino acids in length, and which is capable of being recognized by a T cell receptor that recognizes an epitope comprising sequence | 02-24-2011 |
| 20110030367 | LINEAR MULTI-CYLINDER STIRLING CYCLE MACHINE - An improved method and system for removing blockage from hydrocarbon transfer conduits ( | 02-10-2011 |
| 20110017218 | TREATMENT SYSTEM - Treatment of a pneuomothroax or other condition wherein unwanted fluid is present in a pleural cavity is achieved using a system comprising a chest device ( | 01-27-2011 |
| 20100330668 | Interaction Between the VHL Tumour Suppressor and Hypoxia Inducible Factor, and Assay Methods Relating Thereto - The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF α subunit sequences which may modulate this interaction. | 12-30-2010 |
| 20100328136 | Resonant Reflector Assembly and Method - A resonant radar reflector assembly comprising first and second reflector members ( | 12-30-2010 |
| 20100321162 | Wireless Backscatter Interrogation of Passive, Resonant Sensor-LC-Tags - A sensor comprising: a sensor resonant radar reflector member; and a sensor element, the sensor reflector member being configured to resonate at a resonant frequency when irradiated by radio frequency radiation of a corresponding frequency, the sensor being further configured whereby exposure of the sensor element to a target measurand causes a change in the resonant frequency of the sensor reflector member. | 12-23-2010 |
| 20100298294 | KETONE BODIES AND KETONE BODY ESTERS AS BLOOD LIPID LOWERING AGENTS - The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject. Alternatively, compositions comprising racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol, R-1,3 butandiol or combinations thereof can be formulated as nutritional supplements (also referred to as nutritional compositions) or incorporated into therapeutic compositions containing a) anti-hypertensive agents; b) anti-inflammatory agents; c) glucose lowering agents; or d) anti-lipemic agents) which are administered to a subject, optionally in combination with a low fat diet, in order to cause a reduction or lowering of: serum cholesterol levels; triglyceride levels; serum glucose levels, serum homocysteine levels, inflammatory proteins (e.g., C reactive protein) and/or hypertension in treated subjects. Alternatively, compositions disclosed herein can be administered alone, or in combination with other therapeutic agents to prevent or reverse vascular disease. | 11-25-2010 |
| 20100297647 | POLYMERASE-BASED SINGLE-MOLECULE SEQUENCING - The invention relates to an assay method for determining the base sequence in a nucleic acid sample which comprises detection of a single base in said sequence using a polymerase modified to include at least one fluorophore and a dark quencher group; detecting and deducing the amount of energy transfer. | 11-25-2010 |
| 20100297638 | MOLECULAR ADAPTORS - The invention relates to transmembrane protein pore for use in detecting a analyte in a sample. The pore comprises a molecular adaptor that facilitates an interaction between the pore and the analyte. The adaptor is covalently attached to the pore in an orientation that allows the analyte to be detected using the pore. | 11-25-2010 |
| 20100294924 | ION SPECTRUM ANALYSING APPARATUS AND METHOD - An ion spectrum analysing apparatus ( | 11-25-2010 |
| 20100292307 | Construct - A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii). | 11-18-2010 |
| 20100288651 | MULTI-WALLED CARBON NANOTUBE SENSOR COMPRISING INTERCALATING SPECIES AND METHOD OF DETECTION - There is provided a method of detecting an analyte in a sample, which comprises the steps of contacting the sample with a working electrode in the presence of an electrolyte and determining the electrochemical response of the working electrode to the sample, wherein the working electrode comprises a multi-walled carbon nanotube (MWCNT) and wherein detection takes place in the presence of a species which is capable of forming an intercalation compound with a carbon host material. Electrochemical sensors and compositions suitable for use in said method are also provided. | 11-18-2010 |
| 20100285050 | Compositions and Methods - The invention relates to a composition suitable for inducing a T cell mediated immune response against an influenza virus in a vertebrate, said composition comprising nucleic acid encoding one or more epitopes of one or more internal proteins of influenza virus, wherein said composition comprises nucleic acid encoding at least two said epitopes, at least one epitope being from each of two or more internal proteins of influenza virus. The invention also relates to uses of same and to methods involving same. | 11-11-2010 |
| 20100284809 | WATER TURBINE - A water turbine is disclosed comprising a rotor mounted to be rotatable about an axis. The rotor comprises at least three blades for causing the rotor to rotate about the axis when the blades are located in flowing water. The rotor comprises a plurality of members in the form of a triangulated structure, and at least one of said members comprises one of said blades. | 11-11-2010 |
| 20100276347 | PORTABLE WATER PURIFICATION DEVICE - A gravity driven portable water purification device ( | 11-04-2010 |
| 20100240106 | MUTANT ENZYMES - This invention relates to mutant enzymes with enhanced properties and processes for oxidation of organic compound substrates using such enzymes. | 09-23-2010 |
| 20100216249 | DNA-Based Biosensors - There is described a method of detection of the protein-dependent coincidence of DNA in a sample which comprises detection using luminescence of one or more luminophores introduced into DNA with one, two or more DNA fragments which fragments are bound using one or more DNA-binding proteins. | 08-26-2010 |
| 20100179413 | DETERMINATION AND DISPLAY OF MATERIAL PROPERTIES - The invention provides for the visualisation of conventional and parametric images of materials as they are progressively distorted during examination. A conventional image is displayed simultaneously alongside one or more parametric images derived from the original image data, with the parametric images displaying mechanical properties such as elasticity and mobility. The mobility values are calculated from the tracking error obtained from a motion or strain estimation algorithm applied to a sequence of image frames. The values of elasticity and mobility are displayed in a colour overlay on the conventional image background and the transparency of the overlay is varied according to the parameter values to de-emphasise less relevant values. | 07-15-2010 |
| 20100127251 | Aryl-Aryl Dendrimers - Light emitting devices are described which incorporate, as the light emitting element, a dendrimer of which the constituent dendrons include a conjugated dendritic structure comprising aryl and/or heteroaryl groups connected to each other via bonds between sp | 05-27-2010 |
| 20100115277 | METHOD AND DEVICE FOR MUTUAL AUTHENTICATION - A method of authenticating communication between a first and second party (or node) over an insecure, high bandwidth communications network, in which the first party (C) authenticates the second party (M) using a communications protocol comprising a first communications phase through a first communications channel over the insecure, high bandwidth communications network to establish a secure mode of communications between the first and second party, followed by a second communications phase of receiving information from the second party over a second communications channel, such as an empirical channel, and enabling a user to make a human comparison of the information received from the second party with information generated by the first party thereby enabling the user to authenticate the second party in the event of the information from both parties agrees. | 05-06-2010 |
| 20100105883 | PENTALENES - The present invention relates to per-substituted pentalene compounds, including permethylpentalene and precursors thereof. In particular, the invention provides substituted pentalene compounds and methods of preparing substituted pentalene compounds; complexes of metals with substituted pentalene compounds and methods for their production; and the use of complexes of metals with substituted pentalene compounds in catalysis. | 04-29-2010 |
| 20100096983 | ORGANIC PHOSPHORESCENT MATERIAL AND ORGANIC OPTOELECTRONIC DEVICE - The invention provides a cyclometallated complex comprising the structure of formula I | 04-22-2010 |
| 20100072886 | Metal-Containing Dendrimers - This invention relates to a light emitting device which comprises at least one layer that contains an organometallic dendrimer having a core comprising a metal cation. The invention also relates to organometallic dendrimers and methods for producing the same. | 03-25-2010 |
| 20100068783 | TAILORED CONTROL OF SURFACE PROPERTIES BY CHEMICAL MODIFICATION - A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are SP defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -L | 03-18-2010 |
| 20100053735 | FOCUSING APPARATUS AND METHOD - A focusing apparatus for use with an optical system having a high NA objective lens ( | 03-04-2010 |
| 20100047284 | METHOD FOR REDUCING SPASMS COMPRISING TREATMENT WITH AN AGENT THAT ELEVATES THE LEVEL OF ONE OR MORE CYCLIC NUCLEOTIDES IN THE MUSCLE - This invention relates to methods for preventing or reducing spasms in smooth muscle, using an agent that elevates the level of one or more nucleotide in the muscle, or an agent which comprises a toxin. The invention also relates to the use of such agents in the manufacture of a medicament for preventing or reducing spasms in smooth muscle. | 02-25-2010 |
| 20100041075 | Tuberculosis Diagnostic Test - A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided. | 02-18-2010 |
| 20100008908 | Treatment of Heart Failure - The treatment of heart failure by administering a therapeutically effective amount of an agent that inhibits hypoxia-inducible factor (HIF). Such agents include small molecule chemical agents and biological agents. | 01-14-2010 |
| 20090326238 | ASYMMETRIC DENDRIMERS - Asymmetric light-emitting dendrimers having the formulae: (a) CORE-[DENDRITE1]n[DENDRITE2]m and (b) CORE-[DENDRITE]n are disclosed. | 12-31-2009 |
| 20090313475 | Security in Computing Networks - A system for verifying the security of communications between a set of nodes via a high-bandwidth, insecure communications channel. A number of embodiments are described for enabling authenticated communication between the nodes in an environment wherein there is a high bandwidth Dolev-Yao network amongst the nodes and non-spoofable, low-bandwidth empirical channels between each pair of nodes. | 12-17-2009 |
| 20090311244 | Screening Method - This invention relates to a novel screening method that identifies simple molecular markers that are predictive of whether a particular disease condition is responsive to a specific treatment. Also, a method of diagnosing the susceptibility of an individual suffering from a disease to treatment with an HDAC inhibitor is provided. Also provided is a method of treating a proliferative disease or a condition which involves a change in cell differentiation or growth rate in a patient. | 12-17-2009 |
| 20090297551 | ADJUVANT - This invention relates to a novel adjuvant comprising a transfection reagent, and to uses of this adjuvant. In particular, the adjuvant may be used in compositions for eliciting an immune response and in vaccines. | 12-03-2009 |
| 20090294298 | Detection of Phenols - According to the present invention, phenols may be detected using an electrochemical sensor comprising a final compound, a working electrode and an electrolyte in contact with the working electrode, wherein the first compound operatively undergoes a redox reaction at the working electrodes to form a second compound which operatively reacts in situ with the phenol, wherein said redox reaction has a detectable redox couple and wherein the sensor is adapted to determine the electrochemical response of the working electrode to the consumption of said second compound on reaction with the phenol. The phenol may be, for example, cannabinoid or a catechin compound. | 12-03-2009 |
| 20090286858 | ASSAYS FOR MODULATORS OF ASPARAGINYL HYDROXYLASE - The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. | 11-19-2009 |
| 20090208475 | MINA53 ASSAYS - The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53. | 08-20-2009 |
| 20090206428 | Direct Electron Detector - An electron detector ( | 08-20-2009 |
| 20090186352 | DNA Conformation - Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression. | 07-23-2009 |
| 20090169089 | Cell Analysis - A system for performing cell population classification in respect of a biological sample. An image is captured in respect of an optical conduit array containing a plurality of cells and signals received therefrom are used to derive a classification scheme defining classes of cells. This scheme is then applied to classify the cells and data representative of the classes and respective locations in the conduit array of the cells. | 07-02-2009 |
| 20090162334 | PRODUCTION AND USE OF REGULATORY T CELLS - An ex vivo method for generating a population of Treg capable of suppressing rejection of an organ or tissue transplant from a donor animal, comprises culturing CD4 | 06-25-2009 |
| 20090148867 | UNIVERSAL FLUORESCENT SENSORS - A probe comprises: (1) a target binding site moiety which is attached to a first fluorescent polypeptide; (ii) a mimic moiety which is capable of binding to the target binding site moiety and is attached to a second fluorescent polypeptide; and (iii) a linker which connects the two fluorescent polypeptides and which allows the distance between said fluorescent polypeptides to vary, said fluorescent polypeptides being so as to display fluorescence resonance energy transfer (FRET) between them, wherein the linker comprises one or more of: (1) a sequence capable of being recognised and bound by an immobilized component; (2) a protease cleavage site; (3) a non-analyte binding site; (4) two or more copies of the sequence (SerGly | 06-11-2009 |
| 20090099084 | Treatment - The invention provides use of a TSG-6 polypeptide, or a polynucleotide encoding an TSG-6 polypeptide, in the manufacture of a medicament for the treatment or prevention of a bone disease or condition associated with bone resorption by osteoclasts. | 04-16-2009 |
| 20090097116 | Optical Element and Method of Production - A method of producing an optical element that has spatial variation in refractive index is disclosed. The method comprises: providing a curable liquid crystal composition; applying a spatially varying electric field to the liquid crystal composition to induce a desired spatial variation in refractive index; and curing the liquid crystal composition while the electric field is still applied to fix the spatial variation in refractive index when the electric field is removed. | 04-16-2009 |
| 20090054362 | COMPOUNDS - The present invention provides novel aptamer derivatives which are useful in binding to and neutralising viruses. Pharmaceutical formulations comprising the aptamers and the use of the aptamers in screening for useful compounds are also provided. | 02-26-2009 |
| 20080305503 | Diagnostic Test - The invention provides a method of diagnosing | 12-11-2008 |
| 20080274475 | HLA-E BINDING - The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound affects the binding of HLA-E to the cells. The HLA-E property of binding to CD94/NKG2 receptors on NK cells and a subset of CD8+ T cells is useful for targeting CD94/NKG2+ cells for a variety of purposes such as identification, isolation, killing or inactivation. | 11-06-2008 |
| 20080245670 | Electrochemical Detection of Arsenic - Electrochemical methods and materials for the detection of arsenic. In one aspect, arsenic is detected using a working electrode comprising particulate platinum. In another aspect, arsenic is detected using an electrode comprising indium tin oxide and particulate gold. Also provided are methods for the production of electrodes which involve the electrodeposition of gold onto indium tin oxide. | 10-09-2008 |
| 20080227848 | Assays - A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate. | 09-18-2008 |
| 20080226678 | Compositions for Immunizing Against Mycobacterium - A method for generating a T cell immune response in a host involving administering a vectored vaccine comprising a non-replicating or replication impaired viral vector expressing the translation product of a mycobacterial antigen 85A gene. Vectored vaccines and uses thereof are also provided. Also provided is a method of inducing a CD8 and a CD4 memory T cell response against an antigen using an adenovirus vector expressing an antigen or an immunogenic fragment thereof. | 09-18-2008 |
| 20080221848 | Biomolecular Structure Determination Involving Swarm Intelligence - A method and computer program for determining biomolecular structures from experimental data that includes ambiguous experimental observables comprising the steps of: creating a swarm of molecular structure generators; having the ability to allow the communication between said generators via a global set of molecular restraints; determining said molecular structure in a cooperative manner by using self-optimization of a multi-agent system. In one embodiment, NOESY spectra are used to calculate inter-proton distances of the biomolecular structure and said distances are used as molecular restraints. Moreover, the method involves restrained molecular dynamics simulations, e.g. by simulated annealing. | 09-11-2008 |
| 20080212103 | Ultra-Short Optical Pulse Measurement Using a Thick Nonlinear Crystal - The invention provides a pulse measurement apparatus and corresponding method. The apparatus comprises: a splitter for splitting a pulse to be measured into two sub-pulses propagating along different beam paths; a non-linear medium, capable of up-conversion of radiation propagating therethrough, arranged in said beam paths; at least one element for interfering the up-converted pulses resulting from propagation of the two sub-pulses in the non-linear medium; and detection apparatus for detecting the result of the interference to obtain at least one of spectral and temporal characteristics of the pulse to be measured. In the non-linear medium, each sub-pulse can be resolved into an o-wave component and an e-wave component propagating through the medium at a predetermined angle, and the phase-matching function for up-conversion by interaction of the o-wave component with the e-wave component in the non-linear medium is selected such that up-conversion is substantially independent of frequency for one of the o-wave or e-wave over a predetermined frequency range, and is frequency selective for the other of the o-wave and e-wave. This phase-matching function produces spectrally-sheared up-converted replicas of the pulse to be measured. | 09-04-2008 |
