International Center for Chemical Sciences
International Center for Chemical Sciences Patent applications | ||
Patent application number | Title | Published |
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20110124044 | Method of producing tibolone metabolites by fermentation with Cunninghamella elegans - A method of producing Δ | 05-26-2011 |
20110124043 | Method of producing tibolone metabolites by fermentation with Gibberella fujikuroi - Method of producing Δ | 05-26-2011 |
20110124042 | Method of producing tibolone metabolites by fermentation with Fusarium lini - Method of producing Δ | 05-26-2011 |
20110124041 | Method of producing tibolone metabolites by fermentation with Rhizopus stolonifer - A new method of producing metabolites of tibolone comprising fermenting tibolone with | 05-26-2011 |
20090137542 | Alpha-glucosidase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones - Sixteen new and one known metabolites were obtained by incubation of tibolone and hydroxytibolones with various fungi. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques. The relative stereochemistry was deduced by 2D NOESY experiment. These metabolites have shown promising inhibitory activities against α-glucosidase enzyme. Seven metabolites exhibited potent inhibitory activity against the α-glucosidase enzyme and were thus found useful in the treatment of diabetes mellitus and other diseases related to the activity of α-glucosidase enzyme. | 05-28-2009 |