International Center for Chemical Sciences

Patent application number	Title	Published
International Center for Chemical Sciences Patent applications
20110124044	Method of producing tibolone metabolites by fermentation with Cunninghamella elegans - A method of producing Δ	05-26-2011
20110124043	Method of producing tibolone metabolites by fermentation with Gibberella fujikuroi - Method of producing Δ	05-26-2011
20110124042	Method of producing tibolone metabolites by fermentation with Fusarium lini - Method of producing Δ	05-26-2011
20110124041	Method of producing tibolone metabolites by fermentation with Rhizopus stolonifer - A new method of producing metabolites of tibolone comprising fermenting tibolone with	05-26-2011
20090137542	Alpha-glucosidase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones - Sixteen new and one known metabolites were obtained by incubation of tibolone and hydroxytibolones with various fungi. Their structures were elucidated by means of a homo and heteronuclear 2D NMR and by HREI-MS techniques. The relative stereochemistry was deduced by 2D NOESY experiment. These metabolites have shown promising inhibitory activities against α-glucosidase enzyme. Seven metabolites exhibited potent inhibitory activity against the α-glucosidase enzyme and were thus found useful in the treatment of diabetes mellitus and other diseases related to the activity of α-glucosidase enzyme.	05-28-2009