INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM) Patent applications |
Patent application number | Title | Published |
20160047810 | METHODS TO OBTAIN A NOVEL CLASS OF GRAM NEGATIVE BACTERIA ANTIBIOTICS WHICH TARGET AN UNKNOWN CELL DIVISION ASSOCIATED PROTEIN LOP1 - The present invention relates to methods to identify substances which affect bacterial cell division by interfering with the function of LOP1, comprising bringing into contact a purified protein selected from the group: FtsZ, FtsQ, FtsL, FtsI and FtsN; with purified LOP1 protein and then assaying the formation of complexes between LOP1 and the selected purified protein in the presence and absence of a substance to be tested and then selecting substances from step b) which affect the formation of complexes when present. The present invention also relates to inhibitors of the activity and expression of LOP 1. | 02-18-2016 |
20130137096 | Diagnosis of Hereditary Spastic Paraplegias (HSP) by Identification of a Mutation in the ZFVYE26 Gene or Protein - The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or protein (spastizin), wherein said mutation is indicative of a hereditary spastic paraplegias (HSP). | 05-30-2013 |
20120114596 | TSLP PROMOTES IMMUNE EVASION AND PERSISTENCE OF VIRUSES - It relates to the treatment or prevention of a chronic viral infection with a Thymic Stromal Lymphopoietin (TSLP) antagonist thereby avoiding immune evasion and persistence of the virus. It also provides a method of prognosing the evolution of a cervical dysplasia by TSLP expression in a sample of said cervical dysplasia. | 05-10-2012 |
20100240033 | CONSTITUTIVELY ACTIVE MUTANTS OF THE PROLACTIN RECEPTOR - The invention relates to constitutively active mutants of the prolactin receptor (PRLR), wherein an Ile residue at position 76 or at position 146 of the mature form of said receptor has been substituted by another amino acid residue. The invention also provides methods useful for the diagnosis, prognosis, or treatment of diseases involving the PRLR. | 09-23-2010 |
20100167957 | METHODS FOR PRODUCING ACTIVE SCFV ANTIBODIES AND LIBRARIES THEREFOR - The present disclosure describes scFv antibody libraries, antibodies isolated from the libraries, and methods of producing and using the same. | 07-01-2010 |
20090202622 | VIROSOME-LIKE VESICLES COMPRISING GP41-DERIVED ANTIGENS - The present invention relates to a virosome-like vesicle comprising at least a gp41-derived antigen or an analogue thereof, said gp41-derived antigen being located to the external surface of and/or encapsulated inside said vesicle and being in a convenient configuration for conferring said virosome-like vesicle with an ability to induce an immune response against a gp41 protein or a human immunodeficiency virus (HIV). | 08-13-2009 |
20090017073 | Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof - A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1: and bringing said cells into contact with a molecule related to compositions comprising a molecule related to MTP and use of a molecule related to MTP for modulating inflammation and/or apoptosis. | 01-15-2009 |