INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS Patent applications |
Patent application number | Title | Published |
20160139126 | METHOD FOR THE PROGNOSIS AND TREATMENT OF CANCER METASTASIS - The present invention relates to a method for the prognosis of bone metastasis in triple negative (including basal-like) breast cancer or, alternatively, ER+ breast cancer (including luminal A and B) which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level, amplification or translocation. The invention also relates to a method for predicting early bone metastasis in a subject suffering breast cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of triple negative (including basal-like) breast cancer metastasis or, alternatively, ER+ breast cancer (including luminal A and B) metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering breast cancer and for classifying a subject from breast cancer into a cohort. | 05-19-2016 |
20160032400 | METHOD FOR THE PROGNOSIS AND TREATMENT OF CANCER METASTASIS - The present invention relates to a method for the prognosis of bone metastasis in cancer which comprises using a probe to determine if a gene of interest is amplified in a primary tumor sample. Likewise, the invention also relates to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise using a probe to determine the expression level of a gene of interest, or the amplification or translocation of a gene of interest. The invention also relates to a method for predicting early bone metastasis in a subject suffering cancer. The invention also relates to a c-MAF inhibitor as therapeutic agent for use in the treatment of cancer metastasis. The invention relates to kits for predicting bone metastasis and predicting the clinical outcome of a subject suffering from bone metastasis. Finally, the invention relates to a method for typing of a subject suffering cancer and for classifying a subject from cancer into a cohort. | 02-04-2016 |
20150307918 | INVERSE MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION (iMLPA), AN IN VITRO METHOD OF GENOTYPING MULTIPLE INVERSIONS - It is described here a new method for improvement genotyping of a large number of inversions mediated by inverted repeats through a fast and high-throughput assay. The assay is based on Multiplex Ligation-dependent Probe Amplification, adapted for the detection of genomic structural variants, particularly adapted to inversions detection (iMLPA). By comparison with other techniques used to genotype inversions one by one, like inverse PCR, iMLPA has shown a very high sensibility, reproducibility and accuracy. Besides, iMLPA is the fastest method to determine the inversion genotypes in large sets of samples. | 10-29-2015 |
20150236234 | ELECTRONIC PLATFORM COMPRISING AN ABO3 TYPE CRYSTAL AND GRAPHENE, METHOD FOR ITS MANUFACTURE AND CHIP COMPRISING THE SAME - An electronic platform comprising a substrate made of a ABO3 crystal ( | 08-20-2015 |
20150219555 | APPARATUS FOR MEASURING LIGHT SCATTERING - Apparatus for measuring light scattering of a sample comprising a light beam source, means for collimating the beam and making it impinge on the sample in a perpendicular direction, at least one light sensor, and at least one spatial filter between the sample and the optical sensor, provided with two apertures, means for measuring the total power reaching the sensor and means for measuring the power of beams with a low k vector after the beam traverses the filter. The invention provides thus a simplified, portable and compact device for measuring different parameters like haze, turbidity, etc. can be built, for any sample and without the need of changing detectors. | 08-06-2015 |
20140295330 | OPTICALLY TRANSPARENT AND ELECTRICALLY CONDUCTIVE COATINGS AND METHOD FOR THEIR DEPOSITION ON A SUBSTRATE - The present inventions relates to a substrate for a photolithographic mask comprising a coating deposited on a rear surface of the substrate, wherein the coating comprises (a) at least one electrically conducting layer, and (b) wherein a thickness of the at least one layer is smaller than 30 nm, preferably smaller than 20 nm, and most preferably smaller than 10 nm. | 10-02-2014 |
20140121171 | TREATMENT FOR MUSCULAR DYSTROPHIES - miRNA-21 inhibitors and pharmaceutical compositions including an miRNA-21 inhibitor together with pharmaceutical excipients and carriers for use in the treatment of a muscular dystrophy and/or a muscular dystrophy-like myopathy. Particularly, the miRNA-21 inhibitors and pharmaceutical compositions including the same are for use in the regeneration of skeletal muscle in muscular dystrophy and/or a muscular dystrophy-like myopathy patients. | 05-01-2014 |
20140017753 | BIOGAS PRODUCTION - A process for the production of biogas from biodegradable material is disclosed, the process comprising the steps of: (a) adding the biodegradable material to the reactor; (b) inoculating a microorganisms; (c) adding a colloidal solution of surface-modified iron oxide nanoparticles to the reactor; (d) providing anaerobic conditions; (e) carrying out an anaerobic digestion; and (f) collecting the biogas; wherein the steps (a), (b) and (c) can be carried out in any order. | 01-16-2014 |
20120103669 | METAL TRANSPARENT CONDUCTORS WITH LOW SHEET RESISTANCE - The present invention relates to a transparent electrode comprising an ultra thin metal conductor ( | 05-03-2012 |
20110194172 | OPTICAL PARAMETRIC OSCILLATOR WITH OPTIMIZED OUTPUT COUPLING - An optical parametric oscillator including a nonlinear crystal pumped by a laser source and an optical resonator, including an optical interferometer, which determines a level of output coupling of the oscillator, allowing high stability, broad wavelength tuning, and output power level optimization. | 08-11-2011 |
20100265514 | ALL-OPTICAL FIBER INTERFEROMETER - A compact and stable interferometer is easily built only with fusion splices. The air-holes of a microstructured fiber are intentionally collapsed in the vicinity of the splices and this broadens the propagating optical mode, allowing coupling from core to cladding modes. The transmission spectrum is sinusoidal and of single frequency, indicating predominant interference between the fundamental core mode ( | 10-21-2010 |
20100060976 | OPTICAL PARAMETRIC OSCILLATOR - A synchronously-pumped optical parametric oscillator (OPO | 03-11-2010 |
20100055719 | Screening method for identifying new aminoacyl-tRNA synthetase inhibitors - The method comprising: a) obtaining a gene sequence codifying a naturally occurring aminoacyl-tRNA synthetase; b) engineering the gene codifying for said aminoacyl-tRNA synthetase, resulting into an aminoacyl-tRNA synthetase with a defective activity, with the proviso that the engineering does not affect the functionality of the catalytic site of the enzyme; c) cloning the gene resulting from step (b) in an expression vector; d) transforming isolated mammalian cells with the expression vector resulting from step (c); e) growing the recombinant cells resulting from step (d) in a nutrient medium under conditions which allow the expression of the engineered aminoacyl-tRNA synthetase, resulting the expression into cell death or a decrease in the rate of cell division; f) providing a substance to be tested to the medium resulting from step (e); and g) analyzing the resulting cell growth, wherein if there is an increase in cell growth, then the substance selectively inhibits the activity of the engineered aminoacyl-tRNA synthetase and does not affect to its cellular ortholog, resulting in that said substance is a candidate to drug. | 03-04-2010 |
20090291465 | Screening Method for Identifying New Drugs - A screening method for identifying new drugs A screening method for identifying a candidate to drug wherein said method 5 comprises the following steps: a) obtaining an expression vector which comprises a gene sequence codifying a naturally occurring pathogenic non-discriminating tRNA synthetase; b) transforming isolated mammalian cells with the expression vector; c) growing the recombinant cells resulting from (b) in a nutrient medium under conditions which allow the expression of the 10 pathogenic tRNA synthetase, resulting the expression of the pathogenic tRNA synthetase into cell death or a decrease in the rate of cell division; d) providing a substance to be tested; and e) analyzing the resulting cell growth, wherein if there is an increase in cell growth, then the substance selectively inhibits the activity of the pathogenic tRNA synthetase and does 15 not affect to its cellular ortholog, resulting that said substance is a candidate to drug. | 11-26-2009 |
20090069569 | CYCLOADDITION OF AZIDES AND ALKYNES - This invention provides a process which comprises contacting, in a reaction zone, at least one organic azide, at least one alkyne, and at least one N-heterocyclic carbene copper compound in which the ligands are either (i) a halide and an N-heterocyclic carbene or (ii) two N-heterocyclic carbenes and a BF | 03-12-2009 |
20080212179 | METHOD OF OPTICAL MANIPULATION OF SMALL-SIZED PARTICLES - Method and system of optical manipulation of micrometer-sized objects, which comprises the steps of placing a pattern ( | 09-04-2008 |