Inspire Pharmaceuticals, Inc. Patent applications |
Patent application number | Title | Published |
20130274214 | METHOD FOR TREATING BLEPHARITIS - This invention relates to methods of treating blepharitis. The methods comprise identifying a patient suffering from blepharitis, and topically administering to the eyes of the patient an effective amount of azithromycin and an effective amount of a retinoid. The method is useful in relieving blepharitis signs and symptoms. This invention also relates to a pharmaceutical composition comprising azithromycin and a retinoid such as retinyl palmitate. | 10-17-2013 |
20130172324 | METHOD FOR TREATING CARDIOVASCULAR DISEASES USING RHO KINASE INHIBITOR COMPOUNDS - This invention is directed to methods of preventing or treating diseases or conditions associated with excessive cell proliferation, remodeling, inflammation, and vasoconstriction. Particularly, this invention is directed to methods of treating cardiovascular diseases or conditions such as stent restenosis and thrombosis, vascular thrombosis, cerebral vasospasm, atherosclerosis, systemic hypertension, cardiac hypertrophy, and sexual dysfunction. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel Rho kinase inhibitor compound to treat the disease. | 07-04-2013 |
20130158014 | METHOD FOR TREATING DISEASES ASSOCIATED WITH ALTERATIONS IN CELLULAR INTEGRITY USING RHO KINASE INHIBITOR COMPOUNDS - This invention is directed to methods of preventing or treating diseases or conditions associated with alterations in cellular integrity including alterations in endothelial permeability, excessive cell proliferation or tissue remodeling. Particularly, this invention is directed to methods of treating diabetic nephropathy, malaria, or cancer. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel rho kinase inhibitor compound to treat the disease. | 06-20-2013 |
20130131106 | BIFUNCTIONAL RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE - This invention relates to synthetic bifunctional compounds comprising a first rho-associated kinase (ROCK) inhibiting compound and a second pharmaceutically active compound with complementary activity; the first and the second compounds are covalently linked by a biologically labile bond. This invention also relates to methods of making such compounds. The invention also relates to methods of using such bifunctional compounds in the prevention or treatment of diseases or conditions that are affected or can be assisted by altering the integrity or rearrangement of the cytoskeleton. Particularly, this invention relates to methods of treating ophthalmic diseases such as disorders in which intraocular pressure is elevated, for example primary open-angle glaucoma, using the bifunctional compounds. | 05-23-2013 |
20130131059 | METHOD FOR TREATING OPHTHALMIC DISEASES USING KINASE INHIBITOR COMPOUNDS IN PRODRUG FORMS - This invention is directed to prodrugs of rho kinase (ROCK) inhibitors. These prodrugs are in general the ester or the amide derivatives of the parent compounds. These prodrugs are often weak inhibitors of ROCK, but their parent compounds have good activities. Upon instillation into the eyes, the ester or the amide group of these prodrugs is rapidly hydrolyzed into alcohol, amine, or acid, and the prodrugs are converted into the active base compounds. The prodrugs of ROCK inhibitors provide several advantages such as delivery of higher concentrations of the active species into the target site and reduction of ocular discomfort. The invention is also directed to a method of treating ophthalmic diseases such as glaucoma, allergic conjunctivitis, macular edema, macular degeneration, and blepharitis, by administering an effective amount of a ROCK prodrug compound of Formula I to the eyes of the patient in need of. | 05-23-2013 |
20120000941 | MEDICINE DISPENSER - A medicine dispenser is provided. The dispenser includes a container having a spout on a first end thereof for dispensing a medicine and defining a generally elongate base on a second end thereof. The base has a width greater than a width of the spout and further defines a sidewall having a pair of opposing sidewall portions that have generally continuous biconvex cross-sections and extend from respective wide ends of the spout and the base. The dispenser is configured for dispensing medicines of a high viscosity. | 01-05-2012 |
20120000936 | MEDICINE DISPENSER - A medicine dispenser is provided. The dispenser includes a container for holding a medicine. The container has a spout on a first end for dispensing the medicine and a first cap is selectively engageable with the spout. A second cap is selectively engageable about the first end of the container and has a first major surface longitudinally spaced-apart therefrom. The first major surface extends laterally at least partially outside of a periphery of the spout to form a base for supporting the container on a proximal surface. | 01-05-2012 |
20080214490 | METHOD OF PROMOTING CERVICAL AND VAGINAL SECRETIONS - The present invention provides a method of stimulating cervical and vaginal secretions in a mammal by treatment with P2Y | 09-04-2008 |