| IMPERIAL INNOVATIONS LIMITED Patent applications |
| Patent application number | Title | Published |
|---|
| 20120132594 | AQUEOUS SOLVENTS FOR HYDROCARBONS AND OTHER HYDROPHOBIC COMPOUNDS - A method of solubilising in an aqueous medium a hydrocarbon or a hydrophobic compound having a hydrocarbon skeleton that carries one or more heteroatom-containing functional groups, e.g. hydroxyl, carboxylic acid or aldehyde (CHO) groups. The method comprises contacting the hydrocarbon or the hydrophobic compound with the aqueous medium that includes at least one non-ionic surfactant containing a hydrophilic part and a hydrophobic part, the hydrophilic part comprising a polyhydroxylated moiety and the hydrophobic part comprising a hydrocarbon chain containing at least 12 carbon atoms, e.g. ethoxylated sorbitol. The amount of surfactant used is sufficient to form micelles including a core formed of the hydrocarbon or the hydrophobic compound. | 05-31-2012 |
| 20120118242 | ABSORBENT MATERIAL - An absorbent composition is manufactured and used in cat litter. The composition includes: a particulate inorganic mineral, one or more superabsorbent polymers (SAP) dispersed between the particles of the mineral, and a hydrophilic binder capable of binding the mineral and the SAP into discrete granules. The granular material produced has water absorbency characteristics comparable to that of more expensive bentonite-products. The mineral may be waste quarry fines that would otherwise have to be disposed of. Such fines are widely available, in contrast to bentonite that must be shipped from a restricted number of locations, which is environmentally damaging and associated with excessive product miles. The granules can be made by mixing the mineral and the super absorbent polymer to form a slurry, draining the water from the slurry and optionally pressing the resulting filter cake, mixing the binder with the wet filter cake and granulating the resulting composition. | 05-17-2012 |
| 20120070852 | ASSAY - The present invention relates to an assay for transferases. The assay comprises a first moiety comprising a transferase substrate and a second moiety capable of binding to the transferase substrate after it has been acted on by the transferase. One of the first and second moieties comprises a fluorophore and the other of the first and second moieties causes a change in fluorescence of the fluorophore. Thus, when the second moiety binds the transferase substrate after it has been acted on by the transferase, a change in fluorescence can be detected. The assay allows for agents that modulate the activity of the transferase to be screened. | 03-22-2012 |
| 20120058597 | FABRICATION METHOD FOR THIN-FILM FIELD-EFFECT TRANSISTORS - A thin-film field-effect transistor is formed by forming a dielectric layer adjacent a gate, forming a source region and a drain region, and forming a semiconductor layer on the dielectric layer. The semiconductor layer is deposited by spray pyrolysis and comprises a material selected from a group comprising: oxides; oxide-based materials; mixed oxides; metallic type oxides; group I-IV, II-VI, III-VI, IV-VI, V-VI and VIII-VI binary chalcogenides; and group I-II-VI, II-II-VI, II-III-VI, II-VI-VI and V-II-VI ternary chalcogenides. | 03-08-2012 |
| 20120028881 | METHODS AND REAGENTS FOR DIAGNOSING ATHEROMA - The invention provides a method of diagnosing atheroma in an individual, the method comprising providing a sample from the individual, determining the level of lysozyme in the sample and assessing whether the level is indicative of atheroma in the individual. The invention also provides the use of a reagent which selectively identifies lysozyme in the assessment of atheroma in an individual. | 02-02-2012 |
| 20110274675 | Therapeutically Useful Molecules - A T cell receptor molecule (TCR) containing an alpha chain portion and a beta chain portion wherein the alpha chain portion contains three complementarily determining regions (CDRs): CDR1α: SSYSPS CDR2α: YTSAATL CDR3α: VVSPFSGGGADGLT or comprising or consisting of SPPSGGGADGLT and the beta chain portion contains three complementarity determining regions (CDRs): CDR1β: DFQATT CDR2β: SNEGSKA CDR3β: comprising SARDGGEG or comprising or consisting of RDGGEGSETQY, or wherein up to three amino acid residues in one or more CDRs are replaced by another amino acid residue. The invention also includes polynucleotides encoding the TCR molecules, and host cells containing the said polynucleotides. Patient derived T cells may have the polynucleotides encoding the TCR molecules introduced therein, and the engineered T cells may be introduced into the patient in order to combat a WT1-expressing malignancy. | 11-10-2011 |
| 20110262041 | KEYPOINT DESCRIPTOR GENERATION BY COMPLEX WAVELET ANALYSIS - The present invention relates to a method of generating a keypoint descriptor for identifying an object in an image or in a sequence of images, the keypoint descriptor being substantially invariant to a transformation of the object in the image. The method includes receiving object data representing an object for identification in an image; processing said object data to generate at least one basis function representing a feature having undergone at least one transformation or a transformation sequence across several consecutive frames, optionally using transformations that are out of the image plane to recognise objects from multiple views; modifying a prototype wavelet function based on said at least one basis function to generate a plurality of modified wavelet functions; comparing the plurality of modified wavelet functions with the at least one basis function; selecting a modified wavelet function of said plurality of modified wavelet functions based on the comparison of the plurality of modified wavelet functions with the at least one basis function; and processing an input image or input orientation field according to said selected modified wavelet function to generate the keypoint descriptor. The present invention further relates to a method of identifying an object in an image using a keypoint descriptor; and apparatus and computer software for implementing a method in accordance with the present invention. | 10-27-2011 |
| 20110261446 | OPTICAL ARRANGEMENT FOR OBLIQUE PLANE MICROSCOPY - An optical arrangement for oblique plane microscopy includes a first optical subassembly having an objective lens that receives light from a sample in use, and configured to produce an intermediate image of the sample, and a second optical subassembly focused on the intermediate image. Optical axes of the first and second subassemblies are at an angle to each other at the point of the intermediate image, such that the second subassembly images an oblique plane in the intermediate image, corresponding to an oblique plane in the sample. An oblique plane microscopy method is performed by directing an incident light beam through the objective lens to illuminate or excite the oblique plane in the sample, and receiving light from the sample through the same objective lens. The incident light beam is incident on the sample at an angle of substantially 90° relative to the light beam received from the sample. | 10-27-2011 |
| 20110245460 | SOLVENT RESISTANT DIAFILTRATION OF PEPTIDES, PNA OR OLIGONUCLEOTIDES - According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesising the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound. | 10-06-2011 |
| 20110245384 | Process for the production of a functionalised carbon nanomaterial - The invention provides a process for the production of a functionalised carbon (nano)material comprising heating a carbon (nano)material in an inert atmosphere to produce a surface-activated carbon (nano)material and incubating said surface-activated carbon (nano)material with a chemical species capable of reacting with the surface-activated carbon (nano)material. | 10-06-2011 |
| 20110236312 | NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS - The invention provides compounds that comprise a 4′-thio nucleoside that is a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope attached via a triazole link to the N-3 position. Methods for preparing such compounds and uses of the compounds in medicine are also provided. | 09-29-2011 |
| 20110224405 | DEGRADABLE SUPPORTS FOR TIDE SYNTHESIS - According to the present invention, there is provided a process for synthesis of a first compound selected from peptides, oligonucleotides, and peptide nucleic acids, which comprises synthesis of the first compound linked to a soluble support, wherein the soluble support is degraded following the synthesis so that it can be separated from the first compound. | 09-15-2011 |
| 20110210757 | APPARATUS AND METHOD TO MEASURE PROPERTIES OF POROUS MEDIA - A method to determine properties of a porous material, in which: a porous sample is prepared and sealed; first the sample is evacuated to near vacuum; then a non-wetting and electrically conducting fluid is passed through the sample at a known pressure and the volume of the fluid taken up by the sample is measured; then a small differential pressure is applied across the sample and the flow rate of the fluid through the sample is measured; and an alternating current is passed through the sample and the resistance across the sample is measured. | 09-01-2011 |
| 20110195024 | ISATIN DERIVATIVES FOR USE AS IN VIVO IMAGING AGENTS - Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed. | 08-11-2011 |
| 20110189669 | METHODS OF AIDING IN THE DIAGNOSIS OF PROSTATE CANCER - The current invention provides a method for aiding in the assessment of prostate cancer (including metastatic prostate cancer) and/or benign prostate hyperplasia in a patient, wherein the method comprises the step of determining the level of Glycine N-methyltransferase (GNMT) nucleic acid and/or protein in a sample from the patient. The invention also provides compounds that target Glycine N-methyltransferase (GNMT) protein and/or nucleic acid for use in treating prostate cancer. Also provided are screening methods for selecting a compound considered to be useful in treating prostate cancer, comprising the steps of determining the ability of a test compound to reduce GNMT activity and selecting a compound that reduces GNMT activity. The invention also provides methods for aiding in the diagnosis of prostate cancer in a patient comprising obtaining a sample from the patient and assessing said sample for a marker of GNMT activity. | 08-04-2011 |
| 20110144765 | Process For Producing Porous Scaffolds From Sinterable Glass - The invention relates to a process for producing a porous glass construct with interconnected porosity, the resulting porous construct and its use as a macroporous scaffold in bone repair and regeneration. | 06-16-2011 |
| 20110142902 | Hypoxia Inducing Factor (HIF) Stabilising Glasses - The present invention relates to a glass composition formulated to provide the controlled release of certain transition metal ions to regulate the cellular hypoxia pathway and the use of these hypoxia-pathway regulating glasses in medicine and in biomedical research, including in the repair, restoration or regeneration of diseased or damaged tissue. | 06-16-2011 |
| 20110137195 | Method and Apparatus for Monitoring Respiratory Activity - A method of monitoring respiratory activity includes obtaining a respiration sound signal. The respiration sound signal is processed to identify a frequency component corresponding to respiration, and an amplitude related parameter of the component is measured. If the measured parameter is in an indeterminate region then a temporal domain related parameter of the identified frequency component is measured. An apparatus for monitoring respiratory activity is also disclosed. | 06-09-2011 |
| 20110137126 | ENDOSCOPE - An endoscope includes a light source operable to generate coherent incident light, and a plurality of imaging optical fibres that are arranged in a fibre bundle, arranged to receive light at a proximal end of the fibre bundle, and arranged to transmit light to a distal end of the fibre bundle. The endoscope further includes a spatial light phase modulator between the light source and the fibre bundle, and arranged to receive the incident light from the light source and to adjust the relative phase of the incident light entering each of the plurality of imaging optical fibres. | 06-09-2011 |
| 20110131690 | Scanning Ion Conductance Microscopy - The subject invention concerns methods for interrogating a surface using scanning ion conductance microscopy (SICM). In one embodiment, a method of the invention comprises the steps of:
| 06-02-2011 |
| 20110123592 | Biomaterials - The invention relates to a biomaterial having a latent form of a growth factor immobilised thereon, and to a method of producing the biomaterial, comprising immobilising the latent form of the growth factor on the biomaterial. The biomaterial may be used in medicine, such as in tissue regeneration or repair. | 05-26-2011 |
| 20110118435 | BIMETALLIC CATALYTIC COMPLEXES FOR THE COPOLYMERISATION OF CARBON DIOXIDE AND AN EPOXIDE - The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)-X, and the use thereof in polymerising carbon dioxide and an epoxide. | 05-19-2011 |
| 20110113859 | LOW-VOLTAGE THIN-FILM FIELD-EFFECT TRANSISTORS - A low-voltage thin-film field-effect transistor is formed by forming a gate, forming a dielectric layer on the surface of the gate, forming a source region and a drain region, and forming a semiconductor layer adjacent the dielectric layer. The dielectric layer is formed as a native oxide layer by oxidizing the surface of the gate. The semiconductor layer is deposited by spray pyrolysis. The dielectric layer may be functionalized with a self-assembling monolayer dielectric layer. The dielectric layer may be formed as a self-assembling monolayer, without first forming a native oxide (or other) dielectric layer. | 05-19-2011 |
| 20110080802 | FLUID FLOW MODIFICATION APPARATUS - A fluid flow modification apparatus for creating turbulence in a moving fluid includes turbulence-creating elements arranged in a fractal configuration, each element having a first surface portion against which the fluid can flow and a second surface portion along which the fluid can flow, and further includes an insert for arrangement to obstruct the flow of fluid between adjacent second surface portions of at least two turbulence-creating elements. A support holds the turbulence-creating elements in the fluid to allow movement of the fluid relative to the turbulence-creating elements and the insert. The insert may be attachable to at least two turbulence-creating elements, such that the arrangement of the inserts is symmetrical about a centre point of the fluid flow field for improved mixing. | 04-07-2011 |
| 20110077380 | CARBOHYDRATE LACTONE POLYMERS - The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources. | 03-31-2011 |
| 20110053239 | METHODS - A method of pre-treating lignocellulosic and cellulosic biomass for utilization of carbohydrate or lignin from the biomass, the method comprising the steps of inoculating the lignocellulosic biomass with lignocellulose degrading brown rot fungus and incubating the inoculated biomass under conditions in which growth of the lignocellulose degrading brown rot is promoted. The incubation may be under conditions in which growth of the lignocellulose degrading brown rot is promoted is terminated after less than 50 days or before substantial depletion of glucose in the biomass occurs. | 03-03-2011 |
| 20110034374 | Oxyntomodulin for Preventing or Treating Excess Weight - Compositions and methods for use in the prevention or treatment of excess weight in a mammal have been developed. The compositions comprise oxyntomodulin which is shown to reduce food intake. | 02-10-2011 |
| 20110021701 | MATERIAL COMPRISING MICROBIALLY SYNTHESIZED CELLULOSE ASSOCIATED WITH A SUPPORT LIKE A POLYMER AND/OR FIBRE - The invention relates to a material comprising cellulose in association with a support selected from a polymer and/or a fibre, wherein said cellulose is produced by a micro-organism. The cellulose-reinforced material is provided for incorporation into a composite. | 01-27-2011 |
| 20110021420 | MODIFICATION OF FEEDING BEHAVIOUR - The present invention relates to compositions and methods for use in the prevention or treatment of excess weight in a mammal. The compositions comprise oxyntomodulin which is shown to reduce food intake and/or increase energy expenditure. | 01-27-2011 |
| 20110016976 | ULTRASONIC NON-DESTRUCTIVE TESTING - An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test. | 01-27-2011 |
| 20110009511 | Glass Polycarboxylate Cements - The present invention relates to glass compositions for use in formation of polycarboxylate cements and polycarboxylate cements comprising these glasses, wherein the glasses comprise SiO | 01-13-2011 |
| 20110009327 | BIOACTIVE NANOCOMPOSITE MATERIAL - The present invention relates to a porous inorganic/organic hybrid nanoscale composite comprising an enzymatically biodegradable organic polymer and a sol-gel derived silica network, its production and use as a macroporous scaffold in tissue engineering. | 01-13-2011 |
| 20100293942 | PASSIVELY CONTROLLED TURBOCHARGER - A flow control device for a turbocharger, the flow control device comprising a variably restricting flow restrictor for restricting flow in a turbocharger inlet by a variable amount, the flow control device being arranged such that the flow restrictor position varies flow restriction in response to force acting on a surface of the flow restrictor caused by a pressure pulse in a flow direction, the flow restrictor being biased in a direction opposed to the flow direction. | 11-25-2010 |
| 20100280399 | METHOD OF AND APPARATUS FOR GENERATING A MODEL OF A CARDIAC SURFACE HAVING A PLURALITY OF IMAGES REPRESENTING ELECTROGRAM VOLTAGES - A method of generating a model of a cardiac surface having a plurality of images representing electrogram voltages for a plurality of measured points within a heart comprises measuring an electrogram voltage at a plurality of points within a heart, generating a first model of a cardiac surface of the heart, generating an image representing each electrogram voltage, each image having a characteristic representative of the electrogram voltage, and generating a further model of a cardiac surface. The images representing the electrogram voltages protrude from the further model of the cardiac surface at points on the further model corresponding to the points at which the electrogram voltages were measured. There is also disclosed an apparatus for generating a model of a cardiac surface. | 11-04-2010 |
| 20100276342 | METHOD OF FROTH FLOATION CONTROL - A method of controlling operation of a froth floatation cell for separating substances comprises introducing gas into liquid in the cell, creating a froth controlling gas flow rate into the cell in order to maximise gas recovery for the cell. | 11-04-2010 |
| 20100273750 | SEROTONIN RECEPTOR ANTAGONISTS FOR TREATING ARTHRITIS - The present invention relates to serotonin receptor antagonists for treating inflammatory arthritis and related conditions. The present invention also relates to a kit comprising a pharmaceutical composition comprising a serotonin receptor antagonist and instructions indicating that the composition is for use in treating inflammatory arthritis and related conditions. In addition, the present invention relates to a method of treating inflammatory arthritis and related conditions comprising administration of a serotonin receptor antagonist. The method is preferably carried out on a subject in need of treatment. The inflammatory arthritis is preferably rheumatoid arthritis. | 10-28-2010 |
| 20100198051 | ACTUATORS - An actuator comprises an input shaft ( | 08-05-2010 |
| 20100177163 | NON PHOTOREALISTIC RENDERING OF AUGMENTED REALITY - A method and system for rendering a captured image of a scene is disclosed which provide see-through vision through the rendered image, for example of an augmented reality object rendered behind the scene, by assigning pixel transparency values in dependence upon captured image pixels. The method and system preserve some structure of the scene in the rendered image without requiring a model of the scene. | 07-15-2010 |
| 20100163808 | HIGHLY CONDUCTIVE AND STABLE TRANSPARENT CONDUCTING POLYMER FILMS - The invention relates to a process for the synthesis of conducting polymer films by vapour phase polymerization. The invention relates particularly to the synthesis of polymerized thiophene films, for example poly(3,4-ethylenedioxythiophene) (PEDOT) films. | 07-01-2010 |
| 20100152849 | RETINAL PROSTHETIC DEVICES - A retinal prosthetic device comprises image capture means ( | 06-17-2010 |
| 20100113948 | HEART RATE MEASUREMENT - A reflective photoplethysmograph sensor (for example mounted in an earpiece) arranged for photoplethysmograph measurements behind a subject's ear is provided. Also provided is a wearable photoplethysmograph heart rate sensor which includes a plurality of radiation detectors defining respective sensing planes which are tilted with respect to each other. Further there is provided a photoplethysmograph heart rate sensing system which compensates for motion artefacts using a dark signal which may be derived during an off phase of a duty cycle of an emitter and a photoplethysmograph system arranged to select between a plurality of detectors based on a quality measure. Combinations of the systems and sensors are also disclosed. | 05-06-2010 |
| 20100092459 | Protein Complex and Uses - The present invention relates to a complex comprising two or more of the proteins S6K2, PKCε and B-Raf. The invention also relates to antibodies that specifically bind to the complex, inhibitors of the complex and uses of the antibodies, inhibitors and complex in diagnosing and preventing chemoresistance in a patient. | 04-15-2010 |
| 20100069321 | Biological Materials and Uses Thereof - The invention relates to the modification of proteins to improve their, biochemical, immunological or biophysical properties, in turn leading to such proteins having increased diagnostic, biotechnological or therapeutic benefit. In particular the invention relates to polysialylation of proteins or conjugates of proteins. There is also provided, nucleotide sequences and expression vectors encoding, host cells expressing, compositions comprising and uses of the polysialylated molecules of the invention. | 03-18-2010 |
| 20100059755 | IMPROVED OXIDE-BASED FIELD-EFFECT TRANSISTORS - A field-effect transistor includes a source region; a drain region; a semiconductor layer disposed between the source and drain regions; a gate region; and a dielectric region disposed between the semiconductor layer and the gate region. The semiconductor layer comprises a titanium dioxide film. The transistor may be light sending, gas- or bio-sensing, or used in a visual display or in electronic circuits. The transistor is formed by forming a dielectric layer adjacent a gate region; forming a source region and a drain region; and forming a semiconductor layer on the dielectric layer, the semiconductor layer comprising titanium dioxide. The titanium dioxide semiconductor layer may be deposited by spray pyrolysis, or alternatively mesoporous TiO | 03-11-2010 |
| 20100058869 | ULTRASONIC NON-DESTRUCTIVE TESTING - An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test. | 03-11-2010 |
| 20100047256 | METHODS - The present invention relates to methods of diagnosing, prognosing, preventing or delaying onset of or treating rheumatoid arthritis, methods of distinguishing between different types or stages of rheumatoid arthritis, of identifying an individual at risk of developing rheumatoid arthritis, and of monitoring efficacy of a treatment regime in an individual being treated for rheumatoid arthritis, using a citrullinated enolase peptide to detect or capture antibodies associated with rheumatoid arthritis. | 02-25-2010 |
| 20100038306 | ASYMMETRIC MEMBRANES FOR USE IN NANOFILTRATION - Improved integrally skinned asymmetric membranes for organic solvent nanofiltration, and their methods of preparation and use are disclosed. Membranes are formed from polyimides by phase inversion and are then crosslinked by addition of amine crosslinking agents that react with the imide groups of the polyimide, creating amide bonds. These stabilise the membranes and allow solvent nanofiltration to be maintained even in the solvents from which the membranes were formed by phase phase inversion. | 02-18-2010 |
| 20100030295 | Apparatus and method for programming a pacemaker - A pacemaker programming apparatus for programming a pacemaker in an individual. The apparatus comprises means for determining the sensed-paced difference of the pacemaker in the individual: first testing means for determining the optimum AV delay while the pacemaker is atrially pacing at a raised at a heart rate; and calculation means for calculating the optimum AV delay determined by the first testing means minus the sensed-paced difference. | 02-04-2010 |
| 20090318342 | Compounds - A mutant TIMP-3 (Tissue Inhibitor of MetalloProteinase-3) polypeptide wherein an additional residue or residues, for example an alanine residue, precedes the N-terminal residue of the TIMP-3 polypeptide; or wherein the residue corresponding to Threonine2 of TIMP-3 is mutated to Glycine. Such a mutant is considered to retain activity as an inhibitor of ADAMs, such as TACE, ADAMTS-4 and ADAMTS-5, but to have reduced activity as an inhibitor of MMPs. | 12-24-2009 |
| 20090308124 | AEROFOIL MEMBER - An aerofoil member ( | 12-17-2009 |
| 20090304663 | USE OF GSK-3 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER - A method of combating prostate cancer in a mammalian individual, the method comprising administering an inhibitor of glycogen synthase kinase-3 (GSK-3), or a polynucleotide which encodes an inhibitor of GSK-3, to the individual. A further anti-cancer agent can also be administered. Use of an inhibitor of GSK-3, or a polynucleotide which encodes an inhibitor of GSK-3, in the preparation of a medicament for combating prostate cancer. The medicament may contain a further anti-cancer agent. | 12-10-2009 |
| 20090299430 | Method and device for stabilising disordered breathing - A device and method for improving the stability of a ventilation pattern of a patient ( | 12-03-2009 |
| 20090298757 | OXYNTOMODULIN ANALOGUES AND THEIR EFFECTS ON FEEDING BEHAVIOUR - Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the α-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake. | 12-03-2009 |
| 20090292345 | METHOD AND APPARATUS FOR MEASURING ACTIVITY IN THE PERIPHERAL NERVOUS SYSTEM - A method and apparatus for measuring activity in the peripheral nervous system comprises a nerve cuff having an array of chemical detectors such as chemFETS or ISFETS. Activity within the nerve causes chemical responses which can be detected. The use of chemical rather than electrical detection minimises interference problems and allows the cuffs to be made smaller. | 11-26-2009 |
| 20090268200 | APPARATUS AND METHOD FOR OBTAINING SPECTRAL INFORMATION - A method of obtaining spectral information comprises initiating at least a first excitation at a first excitation frequency and a second excitation at a second frequency in a surface enhanced sample. The method further comprises varying one of said first and second excitation frequencies, detecting an output signal having an output signal strength and identifying an output signal peak. In addition the method includes correlating the identified output signal with the first and second excitation frequencies to obtain spectral information, in which the surface enhanced sample substrate is configured to enhance the field corresponding to at least one of the first and second excitation, or output fields initiated in this sample. | 10-29-2009 |
| 20090239250 | METHOD FOR THE ANALYSIS OF CELLS - The present invention provides an improved method of analysing and obtaining reliable data about the plasma membrane of single cells, using a microfluidic cell analyser. The microfluidic cell analyser of the invention comprises a single cell trap, a manipulator arranged to manipulate the outer surface of a cell in the trap, a detection zone in communication with the single cell trap and a detector. | 09-24-2009 |
| 20090232180 | METHOD AND APPARATUS FOR COHERENTLY COMBINING LASER EMISSION - A laser system comprises first and second laser sub-cavities each including a gain medium arranged to produce volume gain gratings. The laser system further includes a beam combiner arranged to combine emission from each cavity and direct emission from one cavity to the other. As a result a stale, phase-locked coherently combined emission system is provided. | 09-17-2009 |
| 20090218527 | Confocal Microscopy with a Two-Dimensional Array of Light Emitting Diodes - A confocal microscope | 09-03-2009 |
| 20090215682 | Modified PYY (3-36) Peptides and Their Effects on Feeding Behaviour - The present invention relates to compounds of formula (1); variants or derivatives thereof, or salts or solvates thereof. The present invention also relates to the use of such compounds to control appetite, feeding, food intake, energy expenditure and calorie intake, particularly in the treatment of obesity. | 08-27-2009 |
| 20090208462 | Methods of Treatment - The invention concerns the use of a nucleic acid encoding a photoactivator in the manufacture of a medicament for inducing photosensitivity in neuronal cells. In particular, the invention concerns the induction of photosensitivity in retinal ganglion cells (RGCs) for restoring sight and/or alleviating blindness in an individual. The invention further concerns vectors, cells and pharmaceutical compositions therefor. | 08-20-2009 |
| 20090208428 | Bioactive Glass - The present invention relates to a bioactive glass comprising strontium and silicon dioxide, processes for the production of the bioactive glass and the use of the bioactive glass in medicine. | 08-20-2009 |
| 20090069846 | TENDON REPAIR - An assembly is described for repairing torn tendons by reattaching them to a bone, in particular although not exclusively for repairing a torn rotator cuff tendon, which allows for reduction of the gap between the tendon and the humerus by pushing the tendon onto its attachment site. Also described is a method of repairing a torn rotator cuff tendon by pushing it onto its attachment site and suturing through the humeral head. | 03-12-2009 |
| 20090030350 | GAIT ANALYSIS - A method and system for analysing gait patterns of a subject by measuring head acceleration in vertical direction. The system comprises an accelerometer mounted on the head of the subject. The analysis includes calculating a signature from the acceleration data, using a Fourier transform, including energy of the first harmonics and comparing the signature with the baseline signature. Baseline signature is a representative of previously stored signatures. The comparison is done in order to monitor changes in the gait signatures over time. The entropy of the signatures may be used to perform the comparison. A self organised map is used to classify the measured gait signals. | 01-29-2009 |
| 20090030275 | Imaging System - A monoscopic imaging system, for example a minimally invasive surgery imaging system, is provided which includes an image capture device for capturing images of a monoscopic, for example endoscopic, field of view, an auxiliary light source operable such that an object within the field of view casts a shadow, an image processor operatively connected to the image capture device and operable to detect shadow pixels in the images corresponding to the shadow and to enhance the shadow in the images. The system is of particular, although not exclusive, application to laparoscopic surgery. | 01-29-2009 |
| 20080301071 | Support Vector Inductive Logic Programming - A computer implemented method of particular, although not exclusive application to analysing a plurality of molecules which comprises computing a kernel function for each pair of the plurality of molecules, the kernel function being representative of the number of features present in both molecules of the pairs and using the kernel function in a kernel based learning algorithm to model the relationship between the features and a property of the molecules. The method is also applicable to predicting a numerical value representing a characteristic of a molecule and, more generally, modelling instances of data in a database. A particular, although again not exclusive application, is the prediction of toxicity of a molecule. | 12-04-2008 |
| 20080300502 | Method Of Correlating Internal Tissue Movement - Internal tissue movement is correlated with the external body surface movement by tracking external surface movement at a plurality of surface point ( | 12-04-2008 |
| 20080299131 | Anti-Viral Compositions - The invention provides a composition comprising for simultaneous, sequential or separate administration a) a polyanion; and b) an antibody reactive against an antigen on the surface of an intracellular form of a virus, which virus has an extracellular form that is surrounded by one lipid membrane more than the intracellular form. The present inventors have found that the compositions according to the invention comprising an antibody and a polyanion can neutralize virus infectivity more efficiently than other compositions reported hitherto. | 12-04-2008 |
| 20080291444 | Method of Spectroscopy - A method of multidimensional spectroscopy has a controllable excitation source parameter and comprises controlling said controllable parameter to excite a vibrational mode of the sample, generating a homodyne reflected signal from the sample and obtaining a spectrum of the sample from the reflected signal. | 11-27-2008 |
| 20080291441 | Spectroscopic Support - A porous sample support provides a matrix into the pores or interstitial spaces of which a sample to be subjected to a spectroscopic analysis can be introduced. 2 D infrared spectroscopy can then be carried out on the sample at higher concentrations with minimized background. | 11-27-2008 |
| 20080288493 | Spatio-Temporal Self Organising Map - A method of classifying a data record as belonging to one of a plurality of classes, the data records comprising a plurality of data samples, each sample comprising a plurality of features derived from a value sampled from a sensor signal at a point in time, the method including: defining a selection variable indicative of the temporal variation of the sensor signals within a time window; defining a selection criterion for the selection variable; comparing a value of the selection variable to the selection criterion to select an input representation for a self organising map, the map having a plurality of input and output units, and deriving an input from the data samples within the time window in accordance with the selected input representation; and applying the input to a self organising map corresponding to the selected input representation and classifying the data record based on a winning output unit of the self organising map. | 11-20-2008 |
| 20080269325 | Methods to Relieve Pain - The invention is directed to a method of providing pain relief to a patient by administering to the patient an effective amount of a compound of Formula (I), which is represented by as RC(O)—NH—(CH | 10-30-2008 |
| 20080228118 | Joint Brace - A joint brace, for example a shoulder brace, includes one or more straps ( | 09-18-2008 |
| 20080199262 | Powder Injection Microchip - The present invention relates to a powder injection microchip, and a method of injecting powder using said powder injection microchip, wherein the microchip comprises a vibratable member associated with a powder inlet to a powder flow channel, wherein the vibration of the vibratable member allows the interparticle forces within cohesive powders to be overcome, resulting in the fluidisation of the powder. A powder inlet orifice with a dimension restricted relative to a powder flow channel dimension, and at least one gas flow channel in fluid connection with a powder flow channel downstream of a powder inlet orifice, are also disclosed. | 08-21-2008 |
