HYCLONE LABORATORIES, INC. Patent applications |
Patent application number | Title | Published |
20140178983 | HEAT EXCHANGER SYSTEM WITH FLEXIBLE BAG - A heat exchanger system includes a heat exchanger having a body plate with a first side face and an opposing second side face, the body plate bounding a fluid channel disposed between the opposing side faces and extending between an inlet port and an outlet port, and a first side plate having an inside face. A flexible first bag includes of one or more sheets of polymeric material, the first bag bounding a fluid pathway that extends between a fluid inlet and a fluid outlet, the first bag being removably retained between the body plate and the first side plate so that at least a portion of the first bag rests against the first side face of the body plate when the fluid pathway of the first bag is filled with a fluid. | 06-26-2014 |
20140144714 | LOAD CELL LOCKOUTS AND RELATED FLUID DISPENSING SYSTEMS - A load cell lockout system includes a lower support, an upper support, and a load cell disposed between the lower support and the upper support. The upper support is movable relative to the lower support between a first position wherein a first load is applied by the upper support to the load cell and a second position wherein either a second load that is lighter than the first load is applied by the upper support to the load cell or no load is applied by the upper support to the load cell. A lockout includes a cam with an eccentric perimeter side edge, the cam being rotatable between a first orientation whereby the upper support is placed in the first position and a second orientation whereby the upper support is placed in the second position. | 05-29-2014 |
20140137519 | FLUID MANIFOLD SYSTEMS - A fluid manifold system includes a manifold having at least portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. A plurality of receiving containers are in fluid communication with the fluid flow path of the manifold, each receiving container bounding a compartment. The receiving containers can be formed integral with the manifold by welding together a second portion of the opposing flexible sheets or can comprise separate containers that are coupled to the manifold. | 05-22-2014 |
20140106453 | STIRRED TANK REACTOR SYSTEMS AND METHODS OF USE - A method of mixing a fluid includes positioning a flexible bag into the chamber of a support housing, the support housing having a plurality of baffles positioned so that the bag folds around the baffles. A fluid is delivered into a compartment of the flexible bag. A mixing element, such as an impeller, is moved within the compartment of the flexible bag so as to mix the fluid therein. | 04-17-2014 |
20140087457 | GAS SPARGERS AND RELATED CONTAINER SYSTEMS - A container system includes a bag having of one or more sheets of flexible polymeric material, the bag having an interior surface at least partially bounding a chamber that is adapted to hold a fluid. A sparger is secured to the interior surface of the bag so that a compartment is formed between the interior surface of the bag and the sparger. At least a portion of the sparger includes a sparging sheet formed from a flexible sheet of a gas permeable material. A tubular port or tube is coupled with the bag so that a passage bounded by the tubular port or tube communicates with the compartment. | 03-27-2014 |
20140076454 | FLUID MANIFOLD SYSTEM WITH ROTATABLE PORT ASSEMBLY - A fluid manifold system includes a manifold port assembly having a housing with an inlet port and a plurality of outlet ports formed thereon and a carousel having a plurality of spaced apart fluid paths that extend therethrough from a first end to an opposing second end. The carousel is rotatably coupled with the housing so that when the first end of each fluid path is aligned with the inlet port on the housing, the second end of each fluid path is aligned with a corresponding different one of the plurality of outlet ports. A container is fluid coupled to each outlet port by a fluid line. The inlet port can be selectively coupled with a fluid source while a motor can control rotation of the carousel relative to the housing. | 03-20-2014 |
20140065015 | METHODS FOR INACTIVATING FLUID CULTURES THROUGH HEATING - A method for inactivating a fluid culture includes inserting a collapsible bag within a chamber of a tank assembly. A fluid is dispensed into a compartment of the collapsible bag, the fluid including a culture containing live cells or microorganisms. A lid is positioned over an opening of the tank assembly so that the collapsible bag is substantially enclosed within the tank assembly. The fluid within the collapsible bag is heated to an inactivation temperature that is sufficiently high to kill all of the live cells or microorganisms within the fluid. In one embodiment, the fluid within the flexible bag is mixed while the fluid is being heated to the inactivation temperature. | 03-06-2014 |
20130260463 | METHODS FOR CONDENSING A HUMID GAS - A method for processing a fluid includes sparging a fluid within the compartment of a container with an initial gas so that the initial gas passes through a portion of the fluid to form a humid gas within the compartment. The humid gas is passed out of the compartment of the container and into a flexible condenser bag. The humid gas within the condenser bag is cooled so as to separate the humid gas within the condenser bag into a condensed fluid and a dehumidified gas. The condensed fluid and the dehumidified gas is then removed from the condenser bag. | 10-03-2013 |
20130101982 | FLUID MIXING SYSTEMS WITH ADJUSTABLE MIXING ELEMENT - A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm. | 04-25-2013 |
20130084030 | DISPOSABLE PLUG AND SENSOR FITTINGS FOR BIOREACTOR BAGS - A port fitting for use with a barbed fluid connector includes a plug having a first end and an opposing second end with a guide outwardly projecting from the second end. An O-ring is disposed on and encircling the plug. A pair of elongated arms project alongside the length of the plug. Each arm has a first end secured to the first end of the plug and an opposing second end that is freely disposed so that the arms can be flexed by manipulation of the second end. Each arm has a catch that inwardly projects toward to the guide. In one embodiment the guide terminates at an end wall and a channel extends through the plug and guide to the end wall. An optical sensor is mounted on the end wall. | 04-04-2013 |
20130082410 | CONTAINER WITH FILM SPARGER - A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface, the bag having a top end wall, a bottom end wall, and an encircling sidewall extending therebetween, the bottom end wall including a first polymeric sheet overlying a second polymeric sheet. A first weld line welds the first polymeric sheet to the second polymeric sheet, the first weld line bounding a first sparging area formed between the first polymeric sheet and the second polymeric sheet. A plurality of first perforations are formed through a portion of the first polymeric sheet that overlies the first sparging area so that gas can pass from the first sparging area, through the first perforations and into the chamber of the bag. | 04-04-2013 |
20130081995 | FILTER SYSTEMS FOR SEPARATING MICROCARRIERS FROM CELL CULTURE SOLUTIONS - A filter assembly for separating microcarriers from a fluid medium includes a collapsible container bounding a sterile compartment adapted to hold a fluid. An inlet port is attached to the container through which fluid flows into the compartment. An outlet port is attached to the container through which fluid flows out of the compartment. A filter is disposed within the compartment, the filter dividing the compartment into an inlet chamber that is fluidly coupled with the inlet port and an outlet chamber that is fluidly coupled with the outlet port, the filter allowing a medium to pass therethrough but preventing microcarriers disposed in the medium from passing therethrough. | 04-04-2013 |
20120218855 | STIRRED TANK REACTOR SYSTEMS AND METHODS OF USE - A reactor system includes a flexible bag having an interior surface bounding a compartment. An elongated tubular connector is disposed within the compartment of the flexible bag, the tubular connector having a first end and an opposing second end, the first end of the tubular connector being coupled with the flexible bag. An impeller is disposed within the compartment of the flexible bag and is secured to the tubular connector. A drive shaft is removably received within the tubular connector such that rotation of the drive shaft facilitates rotation of the impeller. | 08-30-2012 |
20120177533 | METHODS AND SYSTEMS FOR HEATING AND MIXING FLUIDS - A fluid heating system includes a tank assembly having an interior surface bounding a chamber, the tank assembly including a sidewall and a lid. A collapsible bag is removably disposed within the chamber of the tank assembly, the collapsible bag bounding a compartment adapted to hold a fluid. A boiler can be used for pumping heated fluid through the wall of the tank assembly for heating the fluid within the collapsible bag. An impeller is disposed within the compartment of the collapsible bag. An elongated drive shaft is removably coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller within the compartment of the collapsible bag. A drive motor assembly is coupled with the drive shaft, the drive motor assembly being adapted to rotate the drive shaft when the lid is in an open or closed position. | 07-12-2012 |
20120175012 | METHODS AND APPARATUS FOR MIXING AND SHIPPING FLUIDS - A method for mixing includes releasably coupling a first container station to a docking station, the first container station having a shipping vessel bounding a compartment, the docking station having a stand and a drive motor assembly adjustably mounted to the stand. The vertical or horizontal position of the drive motor assembly is adjusted relative to the stand so that the drive motor assembly is in a first position. A drive shaft is advanced through the drive motor assembly and into a chamber of a first collapsible bag disposed within the compartment of the shipping vessel. The drive motor assembly is activated so that the mixer rotates the drive shaft causing mixing of the fluid within the first collapsible bag. | 07-12-2012 |
20110310696 | FLUID MIXING SYSTEM WITH HANGERS - A fluid mixing system includes a support housing having an interior surface bounding a compartment, the support housing having a floor and a sidewall upstanding therefrom, an opening extending through the sidewall and communicating with the compartment. An elongated rack is mounted to the support housing adjacent to the opening. A first hanger includes an elongated shaft having a first end and an opposing second end, the first end of the shaft being removably mounted to the rack so that the second end projects outwardly away from the sidewall of the support housing, the second end of the shaft having a fastener disposed thereat. | 12-22-2011 |
20110271646 | FLUID BIN ASSEMBLY WITH HOIST - A method for filling a dispensing bag includes inserting a collapsed bag within a chamber of a bin and securing a lower end of the collapsed bag to the bin. After securing the lower end of the collapsed bag to the bin, a hoist coupled to an upper end of the collapsed bag is manipulated so that the hoist raises the upper end of the collapsed bag within the chamber while the lower end of the collapsed bag remains secured to the bin so as to expand the collapsed bag within the chamber of the bin. | 11-10-2011 |
20110207218 | MIXING SYSTEM WITH CONDENSER - A system for mixing a liquid solution or suspension includes a support housing bounding a compartment and a collapsible bag disposed within the compartment. A mixer is disposed within the collapsible bag while a sparger delivers a gas to the lower end of the collapsible bag. A gas outlet line extends from an upper end of the collapsible bag to a condenser assembly. A gas exhaust line and a fluid collection line both extend from the condenser assembly. | 08-25-2011 |
20110188928 | SELF ALIGNING COUPLING FOR MIXING SYSTEM - A shaft coupling assembly includes a hub bounding an opening. The interior surface of the hub includes an annular coupling surface and a receiving surface, the receiving surface sloping away from opening. An alignment rib projects from the receiving surface into the opening. An elongated shaft includes a driver that is configured to be received within the opening of the hub. The driver has an exterior surface that includes an annular engaging surface, a guide surface, and a guide rib radially, outwardly projecting from the guide surface. The guide rib is configured such that when the driver is being inserted within the opening with the guide rib being aligned with the alignment rib, the guide rib contacts the alignment rib so that the guide rib must be offset from the alignment rib before the driver can be fully received within the opening. | 08-04-2011 |
20110188922 | QUICK COUPLING FOR DRIVE SHAFT - A quick coupling for a shaft includes a male coupling having a locking portion with a locking groove formed thereon. A female coupling includes a female body having an interior surface bounding a socket. A tapered port is formed on the female body and extending from the exterior surface to the interior surface thereof. The locking portion of the male coupling is received within the socket so that the tapered port is aligned with the locking groove. A ball bearing is disposed within the tapered port so that a portion of the ball bearing can project into the socket and into the locking groove. A locking sleeve is slidably mounted along the female body so as to cover and interact with the ball bearing. | 08-04-2011 |
20110117594 | PROBE CONNECTOR ASSEMBLY AND MEHTOD OF USE - A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the opposing second end are moved closer together. A connector is secured to the second end of the tubular sleeve, the connector having an opening extending therethrough that communicates with the passage of the tubular sleeve, a sealing layer removably covering the opening of the connector. An elongated probe has a first end and an opposing second end, the second end of the probe being positioned within the passage of the tubular sleeve, the second end of the probe being configured to pass through the opening of the connector when the sealing layer is removed therefrom. | 05-19-2011 |
20110113900 | SAMPLING PORTS AND RELATED CONTAINER SYSTEMS - A sampling port includes an elongated flexible support tube having an interior surface bounding a first passageway extending between a first end and an opposing second end, the first passageway being closed at the first end of the support tube and open at the second end of the support tube. An elongated flexible sampling tube has an interior surface bounding a second passageway extending between a first end and an opposing second end, the second passageway being open at the first end of the sampling tube, at least a portion of the sampling tube adjacently extending along the length of the support tube and being connected to the support tube. A flange encircles and radially outwardly projecting from the support tube and the sampling tube at a location spaced apart from the first end of the support tube and the first end of the sampling tube. | 05-19-2011 |
20110097789 | TUBE PORTS AND RELATED CONTAINER SYSTEMS - A tube port includes a tubular first stem having an interior surface and an exterior surface extending between a first end and a longitudinally spaced apart second end. The interior surface bounds a passage that longitudinally extends through the first stem. The tube port also includes a flange encircling and radially outwardly projecting from the first end of the first stem. The flange and the first stem are integrally formed as a unitary member comprised of a flexible elastomeric material having a durometer on a Shore A scale with a value of less than 90. | 04-28-2011 |
20100133807 | STERILE CONNECTOR SYSTEMS - A system for forming a fluid connection includes a first connector ( | 06-03-2010 |
20100000626 | FLUID BIN ASSEMBLY WITH HOIST - A method for filling a dispensing bag includes inserting a collapsed bag within the chamber of a bin, the chamber being bounded by a floor and an upstanding sidewall. A first port formed on the collapsed bag is securely fixed within a port hole formed on the floor of the bin. A hoist mounted on the bin is manipulated so that the hoist raises an upper end of the collapsed bag within the chamber while the first port remains fixed within the port hole so as to expand the collapsed bag within the chamber of the bin. | 01-07-2010 |
20090126515 | SAMPLING PORTS AND RELATED CONTAINER SYSTEMS - A sampling port includes an elongated flexible support tube having an interior surface bounding a first passageway extending between a first end and an opposing second end, the first passageway being closed at the first end of the support tube and open at the second end of the support tube. An elongated flexible sampling tube has an interior surface bounding a second passageway extending between a first end and an opposing second end, the second passageway being open at the first end of the sampling tube, at least a portion of the sampling tube adjacently extending along the length of the support tube and being connected to the support tube. A flange encircles and radially outwardly projecting from the support tube and the sampling tube at a location spaced apart from the first end of the support tube and the first end of the sampling tube. | 05-21-2009 |
20080265561 | STERILE CONNECTOR SYSTEMS - A system for forming a fluid connection includes a first connector and a second connector. Both connectors include a tubular body having a membrane mounted on a distal end thereof. A support member facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant energy is applied to the abutted membranes so as to first sterilize the membranes and then melt the membranes so that a passage is formed therethrough. | 10-30-2008 |
20080206847 | PROBE CONNECTOR ASSEMBLY AND METHOD OF USE - A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the opposing second end are moved closer together. A connector is secured to the second end of the tubular sleeve, the connector having an opening extending therethrough that communicates with the passage of the tubular sleeve, a sealing layer removably covering the opening of the connector. An elongated probe has a first end and an opposing second end, the second end of the probe being positioned within the passage of the tubular sleeve, the second end of the probe being configured to pass through the opening of the connector when the sealing layer is removed therefrom. | 08-28-2008 |