| HISAMITSU PHARMACEUTICAL CO., INC. Patent applications |
| Patent application number | Title | Published |
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| 20120136312 | MICRONEEDLE ARRAY - Relations between crystallinity and performance of a biodegradable resin, between weight-average molecular weight and strength thereof, and between weight-average molecular weight and performance thereof were clarified. As a result thereof, when a microneedle array was provided with microneedles containing noncrystalline polylactic acid which had a weight-average molecular weight of 40,000 to 100,000, it was possible to obtain a microneedle array which could maintain its functional performance. | 05-31-2012 |
| 20120130306 | MICRONEEDLE DEVICE - Provided is a microneedle device where a coating agent has been applied to microneedles having a biodegradable resin. It has been found that the application of the coating agent to microneedles of a biodegradable resin having a predetermined strength allows the microneedles to have excellent performance. Further, with regard to the coating agent, a predetermined type and amount thereof are also useful to demonstrate performance. Accordingly, when a microneedle device | 05-24-2012 |
| 20120101457 | NEEDLE DEVICE - A needle device is provided, which includes a support portion having a first and second main surface and at least one projecting portion extending from the first main surface of the support portion. The projecting portion is constituted of a material includes pectin and an alginate. | 04-26-2012 |
| 20120095386 | COMPOSITION AND DEVICE STRUCTURE FOR IONTOPHORESIS - Device structure | 04-19-2012 |
| 20120090275 | ADHESIVE PATCH-CONTAINING PACKAGE BAG AND METHOD FOR STORING ADHESIVE PATCH - The present invention relates to an adhesive patch-containing package bag | 04-19-2012 |
| 20120031047 | METHOD FOR STORING TRANSDERMALLY/TRANSMUCOSALLY ABSORBABLE PREPARATION AND PACKAGE OF TRANSDERMALLY/TRANSMUCOSALLY ABSORBABLE PREPARATION - A method for storing a transdermally/transmucosally absorbable preparation, comprising keeping a transdermally/transmucosally absorbable preparation enclosed in a container in a low oxygen atmosphere, the transdermally/transmucosally absorbable preparation comprising a drug whose molecule has an amino group substituted with a lower alkyl group. | 02-09-2012 |
| 20120029446 | TRANSDERMAL PREPARATION - By providing a non-liquid drug reservoir layer | 02-02-2012 |
| 20120004626 | MICRONEEDLE DEVICE - The present invention aims to allow high molecular weight active ingredients to be contained in a coating agent substantially uniformly. For this purpose, a microneedle device | 01-05-2012 |
| 20110288485 | MICRONEEDLE DEVICE - Provided is a microneedle device having a microneedle base and microneedles capable of piercing the skin and being from 300 μm to 500 μm in height disposed on the base, where at least a part of the surface of the microneedles and/or the microneedle base is coated with a coating agent containing an active ingredient and a coating carrier, and a blending ratio of the active ingredient and the coating carrier is 10:0.1 to 1:10. Also provided are methods for administering active ingredients efficiently and simply through the skin using the microneedle device. | 11-24-2011 |
| 20110269794 | External Preparation for Athlete's Foot Treatment - External preparations for athlete's foot treatment capable of enhancing patient's compliance and capable of reducing the symptom of rubefaction, comprising an anti-trichophyton drug mixed with at least one compound selected from among 1-menthol, menthol analogue compounds and bactericidal compounds. | 11-03-2011 |
| 20110253304 | PRESSURE-SENSITIVE ADHESIVE TAPE PACKAGE - A pressure-sensitive adhesive tape package is provided. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, the adhesive tape being bent into a first portion and a second portion such that the adhesive agent layer faces outward. Moreover, the pressure-sensitive adhesive tape package can include a first release sheet releasably attached to the adhesive agent layer of the first portion of the adhesive tape, and a second release sheet releasably attached to the adhesive agent layer of the second portion of the adhesive tape to seal the adhesive tape with the first release sheet between the first and second release sheets. In this configuration, the conventionally existing package can be eliminated. Moreover, when the second release sheet is removed from the adhesive agent layer of the second portion of the adhesive tape, half of the adhesive agent layer is exposed. | 10-20-2011 |
| 20110253303 | PRESSURE-SENSITIVE ADHESIVE TAPE PACKAGE - A pressure-sensitive adhesive tape package is described in which while easiness in applying the adhesive tape is pursued, an effect of saving in resources can be obtained. The pressure-sensitive adhesive tape package accommodates an adhesive tape having a support and an adhesive agent layer provided on one surface of the support, and includes a release sheet releasably attached to the adhesive agent layer. Moreover, in the pressure-sensitive adhesive tape package, the release sheet is bent along a predetermined bending line with the adhesive tape, and the adhesive tape is sealed inside of the bent release sheet. | 10-20-2011 |
| 20110220265 | Preparation for External Use - A preparation for external use which, even when ingredients such as a drug, absorption accelerator, and plasticizer are contained therein in a large amount, is excellent in pressure-sensitive adhesive properties including cohesive force and which, when a drug is contained therein, enables the drug to have excellent percutaneous absorbability. The preparation for external use includes a pressure-sensitive-adhesive matrix layer, wherein the pressure-sensitive-adhesive matrix layer comprises a pressure-sensitive adhesive base comprising a hydroxylated polymer, a boron compound, and silicic acid. | 09-15-2011 |
| 20110195109 | ADHESIVE SKIN PATCH AND PACKAGED PRODUCT - Provided is a patch | 08-11-2011 |
| 20110189261 | TRANSDERMALLY ABSORBABLE PREPARATION - Disclosed is a transdermally absorbable preparation in which the crystallization of a medicinal agent can be prevented even when the medicinal agent has poor solubility in a base material and is contained in the base material at a high concentration, and which exhibits excellent long-term stability and transdermal absorbability of the medicinal agent. By adding a complex of an organic acid and an organic acid salt and a medicinal agent to a base material, it becomes possible to produce a transdermally absorbable preparation in which the crystallization of the medicinal agent can be prevented and which has excellent preparation properties and transdermal absorbability. Also disclosed is use of a complex of an organic and an organic acid salt for preventing the crystallization of a medicinal agent in a transdermally absorbable preparation. | 08-04-2011 |
| 20110112509 | MICRONEEDLE DEVICE, AND METHOD FOR ENHANCING THE EFFICACY OF INFLUENZA VACCINE BY USING MICRONEEDLE DEVICE - The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact. | 05-12-2011 |
| 20110028880 | PATCH - Provided is a patch containing a drug, a metal salt, an adsorbent and a pressure-sensitive adhesive base, where the metal salt is a salt containing a substance capable of forming a drug salt by bonding to the drug or a component thereof, a content of the metal salt is the same or less number of moles of the substance capable of forming a drug salt by bonding to the drug or a component thereof when a drug salt is formed, and the adsorbent is an adsorbent that adsorbs a polar solvent contained in the patch. | 02-03-2011 |
| 20110028555 | Antiinflammatory and Analgesic Preparation for External Use - It is intended to provide an antiinflammatory and analgesic preparation for external use whereby side effects of a nonsteroidal antiinflammatory and analgesic drug on the skin can be regulated, the nonsteroidal antiinflammatory and analgesic drug can be prevented from degeneration with time due to a dibenzoylmethane derivative contained as an UV absorbent therein, the dibenzoylmethane derivative can be prevented from crystallization and sedimentation due to an oily phase component contained therein, and the inherent effects of the nonsteroidal anti-inflammatory and analgesic drug can be fully exerted without showing skin irritation caused by the oily phase component, an emulsifier and a thickener. The above problem can be solved by providing an antiinflammatory and analgesic preparation for external use which comprises a base for external use containing an oily phase component, a nonsteroidal antiinflammatory and analgesic drug and a dibenzoylmethane derivative and in which the total amount of fatty acid esters in the oily phase component is at least thrice as much as the content of the dibenzoylmethane derivative. | 02-03-2011 |
| 20110027365 | Patch Formulation For External Use - A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate. | 02-03-2011 |
| 20110021972 | Composition and Device Structure For Iontophoresis - Device structure | 01-27-2011 |
| 20110008398 | MEDICATED PATCH - Provided is a medicated patch containing a medicinal agent and an adhesive base material and having an acid value of no greater than 28, where the medicinal agent is varenicline or a pharmaceutically acceptable salt of varenicline. | 01-13-2011 |
| 20110002976 | MEDICATED PATCH - Provided is a medicated patch containing a medicinal agent, an adhesive base material and a tackifier, where the medicinal agent is varenicline or a pharmaceutically acceptable salt thereof, the adhesive base material is a rubbery adhesive base material and the tackifier is a rosin-based tackifier selected from the group consisting of rosin, rosin derivatives and hydrogenated products of the foregoing, or a non-rosin-based tackifier selected from the group consisting of aliphatic hydrocarbon resins and alicyclic hydrocarbon resins, and when a non-rosin-based tackifier is added as the tackifier, a solubilizer for the medicinal agent is further added, the solubilizer containing an alcohol-based solubilizer having at least a solubility parameter of 20-35. | 01-06-2011 |
| 20100318042 | ADHESIVE PATCH - Provided is an adhesive patch including a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a woven fabric knitted in stockinette stitch on both sides having two or more rows of crimped polyethylene terephthalate multifilament yarns, the adhesive layer contains 25 to 50% by mass of a liquid organic ingredient and 25 to 50% by mass of a thermoplastic elastomer based on the total mass of the layer and contains 10% by mass or more of methyl salicylate as the liquid organic ingredient based on the total mass of the layer, and the storage elastic modulus (G′) of the adhesive layer is 30000 to 75000 Pa at 10 rad/s and 37° C. | 12-16-2010 |
| 20100311700 | Transdermal preparation for external use containing nonsterioidal antiinflammatory/analgesic agent - A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component. | 12-09-2010 |
| 20100280457 | Method Of Coating Microneedle - The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device ( | 11-04-2010 |
| 20100279312 | METHOD OF SCREENING APOPTOSIS ACCELERATING COMPOUND OR ANTI-APOPTOTIC COMPOUND AND METHOD OF DETERMINING MALIGNANCY OF NEURODEGENERATIVE DISEASE - Screening methods for determining pro-apoptotic compounds or anti-apoptotic compounds comprise measuring the interaction between p53 and NEDL1 in the presence and in the absence of a test compound, and comparing the strength of interaction between p53 and NEDL1 in the presence and in the absence of the test compound. | 11-04-2010 |
| 20100249236 | ADHESIVE AND PLASTER - An adhesive comprising a base with tackiness, an oil and ketoprofen, wherein the adhesive contains no L-menthol, the base is composed at least of a tacky composition comprising an elastomer and a tackifier and/or a tacky polymer containing an unsaturated monomer with a total of 5 or more carbon atoms as the monomer unit, the oil is an oil that is compatible with the tacky composition and the tacky polymer, and the oil content is 150-175 parts by weight with respect to 100 parts by weight as the total of the tacky composition and the tacky polymer. | 09-30-2010 |
| 20100240758 | EXTERNAL PREPARATION FOR PERCUTANEOUS ADMINISTRATION CONTAINING NONSTEROIDAL ANTI-INFLAMMATORY ANALGESIC - An external preparation for percutaneous administration which contains a light-sensitive nonsteroidal anti-inflammatory analgesic and a UVA-shielding agent which inhibits the analgesic to cause light toxicity and a light allergy. This external preparation for percutaneous administration, which contains a nonsteroidal anti-inflammatory analgesic, can be prevented, with higher certainty, from causing the hypersensitivity to light attributable to light toxicity and a light allergy. | 09-23-2010 |
| 20100239639 | MEDICATED PATCH - A conventional medicated patch containing an anti-inflammatory agent causes a dermatitis or the like on rare occasion by excess irradiation with light. For overcoming the problem, a medicated patch is provided, which comprises an anti-inflammatory agent, BM-DBM as an ultraviolet absorber, and hexyl laurate as an agent for accelerating the migration of the ultraviolet absorber into the skin in an adhesive base material thereof. | 09-23-2010 |
| 20100221314 | Microneedle Device - A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided. | 09-02-2010 |
| 20100136139 | CANCER MARKER AND THERAPEUTIC AGENT FOR CANCER - A novel cancer marker is provided. A method for detecting cancer using a level of BMCC1 gene expression as an indication is provided, in which the cancer is selected from the group consisting of prostate cancer, lung cancer, gastric cancer, bladder cancer, and uterine cancer. | 06-03-2010 |
| 20100047328 | Adhesive preparation - An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein
| 02-25-2010 |
| 20100030100 | Microneedle Device For Diagnosis Of Allergy - There is provided an inexpensive microneedle device for diagnosis of an allergy, enabling one to perform a clear skin test with simple operation for a short period of time in the diagnosis of allergies. The microneedle device ( | 02-04-2010 |
| 20100022942 | DEVICE FOR PERCUTANEOUS ABSORPTION PREPARATION - The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member ( | 01-28-2010 |
| 20090285877 | Percutaneous absorption preparation containing palonosetron - There is provided a percutaneous absorption preparation that has a simple laminated structure and a long shelf life, while maintaining excellent percutaneous absorption for palonosetron. The percutaneous absorption preparation comprises a support and a drug-containing pressure-sensitive adhesive layer formed on at least one side of the support, wherein the drug-containing pressure-sensitive adhesive layer comprises, as essential constituent components, an adhesive base, palonosetron or a pharmaceutically acceptable acid addition salt thereof, and at least one type of fatty alcohol selected from the group consisting of C6-12 straight-chain saturated alcohols, C10-22 straight-chain unsaturated alcohols, C10-22 branched alcohols and C10-15 cyclic alcohols, and the constituent components other than palonosetron or its pharmaceutically acceptable acid addition salt are carboxyl group-free components. | 11-19-2009 |
| 20090269794 | SCREENING METHOD FOR COMPOUND INHIBITING DEVELOPMENT OR PROGRESSION OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS AND DIAGNOSTIC METHOD FOR FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS - A screening method comprising the following steps is provided.
| 10-29-2009 |
| 20090258952 | Patch containing anti-inflammatory agent - An anti-inflammatory-containing plaster is provided. The anti-inflammatory-containing plaster may include, e.g., a styrene-isoprene-styrene block copolymer, a high molecular weight polyisobutylene, a low molecular weight polyisobutylene, a tackifier, a plasticizer, a dispersant, and an anti-inflammatory having a carboxyl group or a salt thereof. However, the anti-inflammatory-containing plaster does not contain L-menthol. The anti-inflammatory-containing plaster has medicament release rates of 20-64% by mass and 40-93% by mass at one hour and three hours, respectively. | 10-15-2009 |
| 20090240190 | Iontophoresis Device and Method for Producing Same - To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer ( | 09-24-2009 |
| 20090238860 | Adhesive Patch Less Irritative to Skin - Disclosed is an adhesive patch composed of an adhesive base agent and a supporting body wherein the adhesive base agent contains 3-30% by mass of a low-molecular-weight polyisobutylene and aluminum hydroxide and/or titanium oxide but not substantially containing water. Also disclosed is a skin irritation reducing agent used therefore. Further disclosed is an adhesive patch composed of a supporting body and an adhesive base agent which contains a thermoplastic rubber and a low-molecule-weight polyisobutylene but not substantially containing water. This adhesive patch is characterized in that the adhesive base agent further contains aluminum hydroxide and/or titanium oxide. Also disclosed is a skin irritation reducing agent used for such an adhesive patch. | 09-24-2009 |
| 20090208560 | Cover material and plaster with cover material - A cover material adapted to cover the entirety of a patch is provided. The cover material has a support layer and, superimposed on a surface thereof, a pressure sensitive adhesive layer. The patch has a support film with a thickness of 12- to 30 μm and, superimposed thereon, a drug containing layer. The cover material may be attached to the surface of the support film and to the skin around the patch so that the pressure sensitive adhesive layer is brought into contact with edges of the drug containing layer. Additionally, the pressure sensitive adhesive layer contains an adhesive resulting from the polymerization of vinyl acetate or N-vinyl-2-pyrrolidone and a C | 08-20-2009 |
| 20090149794 | Adhesive Preparation - An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein
| 06-11-2009 |
| 20090123526 | Transdermally Absorbable Preparation - A transdermally absorbable preparation that even when a drug with poor solubility in a base is added in high concentration, is stable over time and can suppress crystallization of the drug, excelling in transdermal absorbability. There is provided a transdermally absorbable preparation, comprising a base and, added thereto, at least composite particles which are composed of a silicate compound and an organic acid and a drug. | 05-14-2009 |
| 20090105660 | Syringe Cylinder - A syringe cylinder | 04-23-2009 |
| 20090099502 | Microneedle Device And Transdermal Administration Device Provided With Microneedles - The present invention provides a microneedle device having a coating, which is effective even with a low molecular weight active compound and can sustain the effect of the drug for a long period of time, and a transdermal drug administration apparatus with microneedles. The microneedle device ( | 04-16-2009 |
| 20090068252 | Transdermal Absorption Preparation - A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced. | 03-12-2009 |
| 20090030365 | Transdermal Drug Administration Apparatus Having Microneedles - It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device ( | 01-29-2009 |
| 20090004256 | Lowly irritative adhesive patch - An adhesive patch for external use which is significantly inhibited from causing a rash, is less irritative to the skin, and sufficiently retains adhesion to the skin. The adhesive patch is characterized by employing a pressure-sensitive adhesive base into which a sucrose fatty acid ester has been incorporated. It does not exert physical influences on the skin, such as stresses imposed on the skin during wear and upon peeling, while sufficiently retaining adhesion to the skin. It is significantly inhibited from causing a rash, and the skin irritation thereof has been minimized. This adhesive patch for external use has ideal, lowly irritative properties which have been impossible to any conventional adhesive patch for external use. | 01-01-2009 |
| 20090004255 | Adhesive patch for external use with improved cohesive force and sustained-release characteristics - The amount of penetration into the skin in adhesive patches generally tends to show a certain peak and trough. An adhesive patch is provided in which the drug shows satisfactory penetrability because of a polymer proportion and drug penetration is constant over a certain period. The adhesive patch for external use has a pressure-sensitive adhesive layer containing a drug. It is characterized in that the pressure-sensitive adhesive layer comprises: polyvinylpyrrolidone and/or a copolymer of monomers including vinylpyrrolidone as the main ingredient; and a (meth)acrylic ester copolymer having a basic nitrogen atom and/or cationic nitrogen atom. | 01-01-2009 |
| 20080317689 | Transdermal Preparation for External Use Containing Antiinflammatory/Analgesic Agent - A transdermal preparation for external use which contains a photosensitive NSAID and a UV blocker having a high ability to migrate into the skin. Thus, it becomes possible to ensure, in a transdermal preparation for external use containing a NSAID, the inhibition of the onset of light-induced non-immunological or immunological skin symptoms by the above-described component. | 12-25-2008 |
| 20080292670 | Adhesive and plaster - An adhesive comprising a base with tackiness, an oil and ketoprofen, wherein the adhesive contains no L-menthol, the base is composed at least of a tacky composition comprising an elastomer and a tackifier and/or a tacky polymer containing an unsaturated monomer with a total of 5 or more carbon atoms as the monomer unit, the oil is an oil that is compatible with the tacky composition and the tacky polymer, and the oil content is 150-175 parts by weight with respect to 100 parts by weight as the total of the tacky composition and the tacky polymer. | 11-27-2008 |
| 20080255521 | Prefilled syringe - In a prefilled syringe separately containing both a lidocaine solution and a hyaluronic acid solution, the viscosity of the hyaluronic acid solution is set so as to be sufficiently higher than the viscosity of the lidocaine solution. When lidocaine discharge from the tip of a hypodermic needle ends, the force f (N) required to discharge the hyaluronic acid solution from the needle tip suddenly increases, imparting sort of a jolt to the hand of the operator and creating a momentary sensation that the plunger is at rest. Letting the force f (N) required to discharge the lidocaine solution be P | 10-16-2008 |
| 20080226697 | Patch for External Use with Elevated Content of Absorption Promoter in Pressure-Sensitive Adhesive Base - A pressure-sensitive adhesive composition for transdermal absorption which contains a drug and a transdermal absorption promoter for the drug, characterized by further containing polyvinylpyrrolidone so as to stabilize the transdermal absorption promoter contained in the adhesive composition. Thus, the transdermal absorption promoter can be prevented from vaporization or degradation and a patch for external use containing the transdermal absorption promoter at a high concentration in using can be provided. | 09-18-2008 |
