| Health Protection Agency Patent applications |
| Patent application number | Title | Published |
|---|
| 20120121607 | ANTIBODIES TO CLOSTRIDIUM DIFFICILE TOXINS - The present invention provides an antibody composition comprising ovine antibodies, for use in the prevention or treatment of | 05-17-2012 |
| 20120088297 | MYCOBACTERIAL ANTIGENS EXPRESSED UNDER LOW OXYGEN TENSION - A method is provided for identifying mycobacterial genes that are induced or up-regulated under continuous culture conditions defined by a dissolved oxygen tension of up to 10% air saturation measured at 37° C. when compared with a dissolved oxygen tension of at least 40% air saturation measured at 37° C. Said induced or up-regulated genes form the basis of nucleic acid vaccines, or provide targets to allow preparation of attenuated mycobacteria for vaccines against mycobacterial infections. Similarly, peptides encoded by said induced or up-regulated genes are employed in vaccines. In a further embodiment, the identified genes/peptides provide the means for identifying the presence of a mycobacterial infection in a clinical sample by nucleic acid probe or antibody detection. | 04-12-2012 |
| 20110318729 | Rapid Bioluminescence Detection Assay - An assay is provided for detecting the activity of a reporter kinase comprising (i) adding said reporter kinase to an assay mixture wherein said reporter kinase is contacted with bioluminescent reagent no more than minutes after being contacted with ADP, and wherein, prior to contacting the reporter kinase with ADP, the assay mixture is substantially free from kinase other than reporter kinase; and (ii) detecting light output from the assay mixture. Methods for detecting the presence of an analyte in a sample and methods for validating a treatment process using the above assay are also provided. Further provided are devices for conducting these assays and methods. | 12-29-2011 |
| 20110262484 | OUTER MEMBRANE VESICLE PRIME-PROTEIN BOOST VACCINE - The present invention provides a method of immunizing a subject against a disease caused by | 10-27-2011 |
| 20110244453 | SALMONELLA DETECTION ASSAY - There is provided a method and reagents for detecting | 10-06-2011 |
| 20110183372 | STIMULATED CELL STANDARDS - Methods for producing stimulated, positive and negative control reference standard for monitoring intracellular cytokine levels and cytokine release in test samples by stimulating cells to produce cytokines in the presence of a cytokine release inhibitor, fixing the stimulated cells with a fixative such as paraformaldehyde, washing to remove excess fixatives and freeze-drying the stimulated, fixed cells. Methods for producing labeled reference standards for cell proliferation assays are also disclosed, in which proliferation-competent mammalian cells, isolated from a human or animal body are labeled with a label, such as a dye, that is divided between daughter cells during cell proliferation (e.g., carboxyfluorescein succinimidyl ester), the cells are stimulated to proliferate, the proliferated cells are fixed by addition of a fixative and then preserved by freeze drying or cryopreservation. | 07-28-2011 |
| 20110177539 | COVALENTLY LINKED THERMOSTABLE KINASE FOR DECONTAMINATION PROCESS VALIDATION - A biological process indicator is provided for validating a treatment process in which the amount or activity of a contaminant in a sample is reduced. The indicator comprises a thermostable kinase covalently linked to a biological component, with the proviso that the biological component is not an antibody. Methods of preparing the indicator, and methods of using the indicator, are also provided. | 07-21-2011 |
| 20110097725 | RAPID DETECTION OF MYCOBACTERIA - The invention provides a method for detecting a | 04-28-2011 |
| 20100301222 | RADIATION DETECTION - An instrument for detecting radiation is provided, which comprises an inner core housing a neutron detector, and an outer core comprising a neutron-moderating material, the instrument further including at least one elongate thermal neutron guide located within the outer core and having an inner end that terminates proximal to the neutron detector. In use, the elongate thermal neutron guide channels thermal neutrons towards the neutron detector. Also provided is a method for using said instrument. | 12-02-2010 |
| 20100092519 | COMPOSITIONS COMPRISING POLYSACCHARIDE CONJUGATES AND THEIR USE AS VACCINES - The present invention is in the field of combination therapies, including vaccine compositions, which comprise polysaccharide-protein conjugates and outer membrane vesicles (OMVs) from commensal bacteria, particularly commensal | 04-15-2010 |
| 20100091476 | ELECTRICAL DEVICE WITH SCREEN - An electronic device ( | 04-15-2010 |
| 20100089751 | MYCOPLASMA GENITALIUM DETECTION ASSAY BASED ON THE MG219 GENE - There is provided a method for detecting | 04-15-2010 |
| 20100003740 | CHEMICALLY DEFINED CULTURE MEDIUM FOR NEISSERIA - There is provided a chemically-defined liquid culture medium comprising an energy source, a carbon source, a nitrogen source, an amino acid source, a purine synthesis source, a pyrimidine synthesis source and a buffer; characterised in that the culture medium has a pH less than 7, preferably less than 6.9, most preferably about 6.8. | 01-07-2010 |
| 20090274708 | Recombinant Toxin Fragments - Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain H | 11-05-2009 |
| 20090087877 | INFECTIVITY ASSAY - There is provided a method for infecting a target cell with a TSE agent, comprising: i) contacting said target cell with a membrane preparation, wherein the membrane preparation comprises the TSE agent and a donor membrane; and ii) infecting said target cell with the TSE agent. There is also provided a contiguous membrane, comprising a donor membrane and a membrane containing a TSE agent, wherein the TSE agent is selected from the group consisting of CJD, vCJD, familial CJD (e.g. FFI or CSS), iatrogenic CJD, BSE, ovine BSE, and CWD. | 04-02-2009 |
| 20080261200 | Detection of Nucleic Acid Mutations - A method for detecting a mutation in a target nucleic acid sequence in a sample, the target nucleic acid sequence comprising a first DNA strand and optionally the complementary strand thereof, said method comprising: (a) adding a detection primer to the nucleic acid, wherein the detection primer binds to the first DNA strand at a DNA sequence that comprises the mutation site; (b) extending the detection primer to form second DNA strands that are complementary to the first DNA strand; (c) adding an amplification primer to the nucleic acid, wherein the amplification primer binds to the second DNA strand and/or to the complementary strand, at a position away from the mutation site; (d) extending the amplification primer to form third DNA strands that are complementary to the second DNA strands, and/or additional copies of the first DNA strand; (e) annealing the DNA strands by complementary base pairing, to form nucleic acid duplexes, wherein if the two strands of the duplex have a mismatched residue at the mutation site, the duplex is a heteroduplex, and. wherein if the two strands of the duplex do not have a mismatched residue at the mutation site, the duplex is a homoduplex; and (d) detecting the presence of heteroduplexes and/or homoduplexes. | 10-23-2008 |
