| Hadasit Medical Research Services and Development Ltd Patent applications |
| Patent application number | Title | Published |
|---|
| 20110281921 | NOVEL ANTI-BIOFILM AGENTS - Novel agents exhibiting anti-biofilm formation activity while being non-cytotoxic are provided, as well as methods of using the same, either per se or conjugated to a polymer, for preventing and/or reducing the formation of microbial biofilms and/or for disrupting microbial biofilms. The novel agents described herein include thiazolidine-2,4-diones (TZDs), pyrrolidine-2,5-diones (PYDs), imidazolidine-2,4-diones or oxazolidine-2,4-diones, substituted by an alkyl having 7-20 carbon atoms in its backbone chain. | 11-17-2011 |
| 20110179594 | MANEUVERABLE BRISTLE TOOTHBRUSH - The present invention provides a toothbrush having a bristle-carrying head portion ( | 07-28-2011 |
| 20110160629 | CERVICAL COLLAR - The present invention discloses a novel cervical collar for maintaining the airways in head and neck immobilized trauma patient open. This collar comprises a rigid motion-restricting frame ( | 06-30-2011 |
| 20110111003 | STABLE CELL BINDING CHIMERIC PEPTIDES - The present invention relates to novel family of homologous cell attachment chimeric peptides. In particular, the present invention relates to chimeric peptides, each comprising synthetic peptides comprising (a) an M-tide comprising an amino acid sequence that is at least 80% homologous to the amino acid sequence selected from the group consisting of: SEQ ID NO:1, 2 and 37; and (b) a core haptide comprising an amino acid sequence homologous to amino acid sequences at the carboxy termini of the and E chains of fibrinogen or other proteins comprising C-termini that are homologous to said fibrinogen sequences, wherein the M-tide and the core haptide originate from the same protein. The synthetic peptides are linked to one another thereby providing the chimeric peptides of the invention which does not occur in the native protein as a continuous sequence. The present invention further discloses pharmaceutical compositions comprising said chimeric peptides and uses thereof. | 05-12-2011 |
| 20110053853 | USE OF COPOLYMER 1 FOR TREATMENT OF MUSCULAR DYSTROPHY - The invention provides an active agent selected from the group consisting of Copolymer 1, a Copolymer 1 related-peptide and a Copolymer 1-related polypeptide, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising the active agent, for use in treating a muscular dystrophy disease or disorder. | 03-03-2011 |
| 20110045589 | Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells - A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an amount and for a time period for permitting the stem cells to proliferate and, at the same time, for reducing a capacity of the stem cells to differentiate | 02-24-2011 |
| 20110027333 | STEM CELL-DERIVED RETIN RETINAL PIGMENT EPITHELIAL CELLS - The present invention concerns RPE cells obtainable by directed differentiation from stem cell, particularly, human stem cells. It has been specifically found that culturing stem cells in the presence of one or more member of the TGFβ superfamily, such as Activin A) induced directed differentiation into mature and functional RPE cells. This was evidenced by the expression of markers specific to mature RPE cells, including MiTF-A, RPE65 or Bestrophin). In accordance with one particular embodiment, the cells are a priori cultured with nicotinamide (NA) which was found to augment the cells' response to the inductive effect of the one or more member of the TGFβ superfamily. The invention also provides methods of performing the directed differentiation, as well as methods for use of the resulting RPE cells. | 02-03-2011 |
| 20100267569 | Compositions, methods and kits for the diagnosis of carriers of mutations in the BRCA1 and BRCA2 genes and early diagnosis of cancerous disorders associated with mutations in BRCA1 and BRCA2 genes - The present invention relates to diagnostic compositions methods and kits for the detection of carriers of mutations in the BRCA1 and BRCA2 genes. The detection is based on the use of detecting nucleic acids or amino acid based molecules, specific for determination of the expression of at least six marker genes of the invention, in a test sample. The invention thereby provides methods compositions and kits for the diagnosis of cancerous disorders associated with mutations in the BRCA1 and BRCA2 genes, specifically, of ovarian and breast cancer. | 10-21-2010 |
| 20100136012 | VARIANTS OF VEGFR AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF PREGNANCY ASSOCIATED MEDICAL CONDITIONS - An isolated polypeptide variant of VEGFR comprising an amino acid sequence at least 70% homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed. Pharmaceutical compositions, methods of diagnosing and treating comprising same are also disclosed. | 06-03-2010 |
| 20100055088 | CXCR4 Antagonists for Wound Healing and Re-Epithelialization - The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelialisation in a subject in need thereof, and for preventing or inhibiting fibrosis and excessive scar formation, using peptide inhibitors of the T-140 family as well as other CXCR4 antagonists. | 03-04-2010 |
| 20090281488 | PTCA GUIDING CATHETER WITH EXTRA LUMEN FOR CONTINUOUS MEDICATION INFUSION - A multi-lumen guiding catheter for PTCA is disclosed. The guiding catheter comprises of a tubular body having a first and at least one second continuous lumen there-through from a proximal end to a distal end thereof The first lumen is having a cross-section and a length, the cross-section of the lumen is being large enough to permit passage there-through of a balloon of the balloon dilatation catheter The at least one second continuous lumen is positioned either in a concentric or eccentric manner in respect to the first lumen, and is adapted provide continuous intra-coronary infusion of a flowing matter A method of continuous intra-coronary infusion of flowing matter thorough a guiding catheter for PTCA is also presented. It comprises of steps of obtaining the aforesaid guiding catheter, and then, administrating a flowing matter thorough this second lumen from its proximal end. | 11-12-2009 |
| 20090269331 | CASPASE-8 AND INFLAMMATION, INFECTION AND WOUND HEALING - The present invention relates to the regulatory role of caspase-8 in infection by intracellular pathogen, inflammation and wound healing | 10-29-2009 |
| 20090112285 | AORTIC PACEMAKER - The present invention depicts an implantable artificial pacemaker (AAP) comprising oscillatory means providing pulsating signals at a pre-selected frequency, wherein the pacemaker is pacing the aorta. The invention also describes an AAP further comprising; (i) a plurality of sensors disposed internally or externally to the aorta; and (ii) a pacing means in which the AAP stimulates the aortic media, augmenting physiological aortic elastic recoil. An AAP further comprising a processor capable of obtaining information from sensors and triggering an appropriate contraction wave in the aortic media is also introduced. A method of managing aortic rhythm comprising; (i) implanting an AAP comprising oscillatory means; and (ii) pulsating signals at a preselected frequency, so as to pace the aorta and in which the pulsating signals are provided by synchronizing and coordinating activation impulses in a portion of the aorta using electrical impulses is also taught. | 04-30-2009 |
| 20080213237 | Antigen Specific Lymphocytes, Compositions Thereof, and Methods for Isolation and Preparation Thereof - The invention relates to a method for the isolation of T cell lymphocyte, preferably, CD8 | 09-04-2008 |
