GOVERNMENT OF THE UNITED STATES OF AMERICA, Patent applications |
Patent application number | Title | Published |
20140322216 | GLYPICAN-3-SPECIFIC ANTIBODY AND USES THEREOF - The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of GPC3. The invention provides novel antibodies that specifically bind to glypican-3 (GPC3). The invention also relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able to target GPC3. | 10-30-2014 |
20120072252 | TALENT MANAGEMENT DASHBOARD - A dashboard is developed to assess the ability of workers in an organization to accomplish one or more goals of the organization. The dashboard permits defining one or more competencies employees in the organization are required to have, and defining a skill set for each competency. Each skill set has one or more skills the employees are required to have to carry out each competency. Each skill under each competency for each employee is rated according to degree of experience in that skill. A discrete skill level in each competency for each of the employees is determined or calculated from the above rating information. Once the rating information is processed, the information can be instantaneously displayed in various viewing formats to give a snapshot look at the breadth of skill in the organization. | 03-22-2012 |
20100122907 | SINGLE MOLECULE MASS OR SIZE SPECTROMETRY IN SOLUTION USING A SOLITARY NANOPORE - A nanopore conductance measurement method and system is provided. The system has reservoirs of conductive fluid separated by a resistive barrier, which is perforated by a single nanometer scale pore commensurate in size with an analyte molecule in at least one of the reservoirs. The system is configured to have an ionic current driven across the reservoirs by an applied potential and the pore may be treated so that the pore surface can form associations with the analyte molecules of interest to increase the analyte molecule residence times on or in the pore. The system also comprises a means of measuring the ionic current, which current may be either direct or alternating in time, induced by an applied potential between electrodes in the conductive fluid, on each side of the barrier. The system also comprises a means of recording the ionic current time course as a time series, which includes time periods when the pore is unobstructed and also in periods when analyte molecules cause pulses of reduced conductance. The method comprises methods to delineate segments of the conductance time series into regions statistically consistent with the unobstructed pore conductance level, and pulses of reduced conductance, and also statistically stationary segments within individual pulses of reduced conductance. The method may also provide steps for interpreting the statistical analysis to yield parameters such as size, mass, and/or concentration of at least one type of analyte in solution. | 05-20-2010 |