| GLAXO GROUP LIMITED Patent applications |
| Patent application number | Title | Published |
|---|
| 20120129778 | LIGAND THAT BIND TGF-BETA RECEPTOR RII - The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis, liver fibrosis, including cirrhosis and chronic hepatitis, rheumatoid arthritis, ocular disorders, or fibrosis of the skin, including keloid of skin, and kidney such as nephritis, kidney fibrosis and nephrosclerosis, and a vascular condition, such as restenosis. | 05-24-2012 |
| 20120128689 | ANTI-IL-23 IMMUNOGLOBULINS - The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA). | 05-24-2012 |
| 20120101134 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS - 5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed. | 04-26-2012 |
| 20120101124 | 1,2,4-OXADIAZOL DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS SPHINGOSINE 1-PHOSPHATE 1 RECEPTOR AGONISTS - 1,2,4-Oxadiazol derivatives represented by formula (I) useful as sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated via S1P1 receptor are disclosed. | 04-26-2012 |
| 20120101086 | THIADIAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF DISORDERS MEDIATED BY S1P1 RECEPTORS - The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 04-26-2012 |
| 20120101083 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING - The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 04-26-2012 |
| 20120065177 | PHARMACEUTICAL FORMULATIONS COMPRISING AZELASTINE AND A CORTICOSTEROID FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS - The present invention relates to method for the treatment of allergic rhinitis comprising: administrating to a patient in need thereof a pharmaceutical formulation comprising a compound for formula (I) | 03-15-2012 |
| 20120058963 | Macrolides with Anti-Inflammatory Activity - The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4″ position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation. | 03-08-2012 |
| 20120046469 | Process for the Preparation of a Biphenyl-2-Yl carbamic Acid Ester - A novel process for the preparation of the compound of formula (II): | 02-23-2012 |
| 20120046258 | NOVEL CRYSTALLINE PHARMACEUTICAL PRODUCT - There are provided crystalline particles of unsolvated Form 1 polymorph of the compound of formula (I): | 02-23-2012 |
| 20120040991 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS - Disclosed are 3-azabicyclo[4.1.0]heptane derivatives of formula (I) and their use as orexin receptor antagonists. | 02-16-2012 |
| 20120039820 | ANTIBACTERIAL COMPOSITION COMPRISING 4-ISOPROPYL-3-METHYLPHENOL AND ZINC IONS - A composition such as an oral care composition comprising an antibacterial system comprising 4-isopropyl-3-methyl phenol (IPMP), a source of zinc ions and an anionic surface active agent is described. | 02-16-2012 |
| 20120004229 | SUBSTITUTED DIKETOPIPERAZINES AND THEIR USE AS OXYTOCIN ANTAGONISTS - Compounds of formula (1) | 01-05-2012 |
| 20110305692 | ANTIGEN-BINDING CONTRUCTS - The invention relates to combinations of RANKL antagonists with TNF-alpha antagonists and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof. | 12-15-2011 |
| 20110281909 | SUBSTITUTED QUINOLINE DERIVATIVES AS H1 RECEPTOR ANTAGONISTS - The present invention relates to compounds of formula (I), | 11-17-2011 |
| 20110275655 | PYRIMIDINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF SYK KINASE - The present invention relates to the compound of formula (I): | 11-10-2011 |
| 20110269970 | Phenethanolamine Derivatives for Treatment of Respiratory Diseases - (1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol and (5R)-3-(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one are claimed | 11-03-2011 |
| 20110269738 | COMPOUNDS - The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 11-03-2011 |
| 20110263588 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS - The present invention relates to compounds that may be negative allosteric modulators of metabotropic receptors-subtype 5, and methods of making and using same. | 10-27-2011 |
| 20110256074 | NOVEL USE - A oral care composition comprising a triple polymer system and a source of fluoride ions for combating (i.e. helping to prevent, inhibit and/or treat) dental erosion and/or tooth wear is described. Such compositions are also of use in combating dental caries. | 10-20-2011 |
| 20110253752 | NOZZLE FOR A NASAL INHALER - A nozzle for use in a fluid dispensing device comprises a body defining a fluid flow channel which is shaped to impart acceleration and angular momentum to fluid passing therethrough. An inlet port is formed in the body and defines an inlet to the channel. An outlet port is formed in the body and defines an outlet from the channel. The fluid flow channel includes a swirl chamber having a plurality of swirl chamber segments. The swirl chamber is located between the channel inlet and the channel outlet. The body is comprised of a mating assembly of a plurality of like component parts. Each of the component parts provides one of the swirl chamber segments. | 10-20-2011 |
| 20110178063 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES - The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity. | 07-21-2011 |
| 20110152262 | NOVEL COMPOUNDS - Compounds of formula (I) | 06-23-2011 |
| 20110150871 | TREATMENT OF AN AUTOIMMUNE DISEASE USING IL-18 ANTAGONISTS - The present invention relates to the field of autoimmune diseases, including rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Specifically, the invention relates to methods of treating autoimmune diseases in patients that are non-responsive or refractory over time to treatment with TNF-α antagonists and/or T-cell co-stimulation antagonists with an IL-18 antagonist. | 06-23-2011 |
| 20110142824 | Antibodies Against Amyloid-Beta Peptide - Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture. | 06-16-2011 |
| 20110065725 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY - The invention relates to triazole amide derivatives of formula (I) for use in therapy, in particular for treating diseases and conditions mediated by antagonism of the mGluR | 03-17-2011 |
| 20110061646 | DRUG DISPENSER - One aspect provides a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply an actuating force to the actuating portion of the transfer clement to move the transfer element from an initial position along the longitudinal axis in a first direction; provided to the container collar, a pre-load mechanism to prevent transfer of the actuating force to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome; and connecting the container collar with the transfer element, a biasing return mechanism acting to bias the transfer element along the longitudinal axis in a second direction to return the transfer element to its initial position. | 03-17-2011 |
| 20110059979 | Piperidine/Cyclohexane Carboxamide Derivatives For Use as Vanilloid Receptor Modulators - Certain compounds of formula (I), | 03-10-2011 |
| 20110045027 | Adjuvant - The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof. | 02-24-2011 |
| 20110034524 | HEMI-FUMARATE SALT OF A 1,3,4-THIADIAZOLYL DERIVATIVE AS MODULATOR OF THE SPHINGOSINE 1-PHOSPHATE RECEPTOR - The invention relates to the compound (2S)-2-amino-2-{5-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1-propanol hemi-fumarate, processes for its preparation, pharmaceutical compositions containing them and its use in the treatment of conditions or disorders which are mediated via the S1P1 receptor. | 02-10-2011 |
| 20110021578 | Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine - Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R | 01-27-2011 |
| 20110009631 | Phenethanolamine Derivatives for Treatment of Respiratory Diseases - Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases. | 01-13-2011 |
| 20110009394 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS - Tricyclic nitrogen containing compounds and their use as antibacterials. | 01-13-2011 |
| 20100324022 | NOVEL COMPOUNDS - Compounds of formula (I), pharmaceutical compositions thereof, and methods for treatment using the same. | 12-23-2010 |
| 20100317672 | Monomaleate Monohydrate Salt of a 5HT1A Receptor Antagonist - The present invention relates to a monomaleate monohydrate salt of 7-methyl-6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4,5-dihydroimidazo[1,5-a]quinoline-3-carboxamide, uses of the salt as a medicament in the treatment of sexual dysfunction and pharmaceutical compositions and dosage forms comprising the salt. | 12-16-2010 |
| 20100308082 | DISPENSING DEVICE - A device for dispensing a substance has a dispensing outlet from which the substance is dispensable, a dispensing member mounted for movement in a dispensing direction U from a first position to a second position, said movement, in use, causing the substance to be dispensed from the dispensing outlet, and an actuator mechanism for moving the dispensing member from the first position to the second position. The actuator mechanism has a first member mounted for movement in a predetermined direction and a second member pivotally mounted on the first member for pivotal movement in a predetermined pivotal sense A. The actuator mechanism is adapted such that movement of the first member in the predetermined direction results in the second member moving therewith and pivoting in the predetermined pivotal sense and said pivotal movement of the second member in the predetermined pivotal sense results in the dispensing member moving from the first position to the second position. | 12-09-2010 |
| 20100305127 | NOVEL COMPOUNDS - Compounds of formula (I) | 12-02-2010 |
| 20100303821 | IMMUNOGLOBULINS - The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF. | 12-02-2010 |
| 20100292295 | 5-OXO-3-PYRROLIDINECARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS - The present invention provides a compound of Formula (IA) or a pharmaceutically acceptable salt thereof:
| 11-18-2010 |
| 20100292224 | ISOTHIAZOLIDINE 1,1-DIOXIDE AND TETRAHYDRO-2H-1,2-THIAZINE 1,1-DIOXIDE DERIVATIVES AS P2X7 MODULATORS - The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof:
| 11-18-2010 |
| 20100286152 | N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR - The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, | 11-11-2010 |
| 20100267755 | PYRIMIDINE DERIVATIVES - The invention provides the compounds of formula (I) | 10-21-2010 |
| 20100267734 | N-[(3,5-DICHLOROPHENYL)METHYL]-2-(4-METHYL-1-PIPERAZINYL)-2-(1-NAPHTHALENY- L)ETHANAMIDE AS GHRELIN RECEPTOR MODULATOR - The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, | 10-21-2010 |
| 20100222349 | QUINOLINE DERIVATIVES USED TO TREAT INFLAMMATORY AND ALLERGIC DISEASES - The present invention relates to compounds of formula (I) | 09-02-2010 |
| 20100216837 | GLYCINE TRANSPORT INHIBITORS - The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. | 08-26-2010 |
| 20100216799 | PHTHALAZINE AND PYRIDO[3,4-D]PYRIDAZINE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS - The present invention relates to compounds of formula (I), | 08-26-2010 |
| 20100203256 | METHOD AND APPARATUS FOR THE APPLICATION OF POWDER MATERIAL TO SUBSTRATES - An apparatus for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms includes a mixer for mixing a sump of the powder material to electrostatically charge the powder material, the mixer including two substantially parallel elongate mixing shafts having oppositely angled mixing paddles thereon and being arranged to rotate in opposite directions; and a feeder for removing the electrostatically charged powder material from the sump and supplying it to the applicator, and a method for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms. | 08-12-2010 |
| 20100184996 | PROCESS OF AMIDE FORMATION - A process for the formation of 2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide is disclosed, comprising treatment of 2,4-ditrifluoromethyl-6-methoxy-benzoic acid with an arylsulphonyl halide, C | 07-22-2010 |
| 20100175698 | CAPSULE - A capsule for a powder has a body which is provided with an internal chamber to hold the powder and first and second openings to an exterior environment. The body is adapted to be displaced from a filling state, in which the first and second openings are placed in fluid communication with one another through the internal chamber thereby enabling an airflow to be created through the body from the second opening to the first opening which is able to entrain powder in the exterior environment into the internal chamber for filling thereof, to a sealing state in which the internal chamber is sealed from the exterior environment so as to retain the powder held therein. | 07-15-2010 |
| 20100174065 | COMPOUNDS - The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 07-08-2010 |
| 20100144755 | Novel Compounds - Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors. | 06-10-2010 |
| 20100137378 | Pyridine Compounds For The Treatment Of Prostaglandin Mediated Diseases - Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein X, Y, Z, R | 06-03-2010 |
| 20100137353 | TRICYCLIC COMPOUNDS AS ANTIBACTERIALS - Tricyclic nitrogen containing compounds and their use as antibacterials. | 06-03-2010 |
| 20100130583 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS - The invention relates to quaternary α-aminocarboxyamide derivatives of formula (I) and their pharmaceutically salts or solvates | 05-27-2010 |
| 20100113521 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL-BENZYL)-(2S-PHENYLPIPERIDIN-- 3S-YL-) - The present invention relates to pharmaceutical compositions comprising the NK1 receptor antagonist [2-Methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-(2S-phenyl-piperidin-3S-yl)-amine, or a pharmaceutically acceptable salt or solvate thereof, and a sodium channel blocker, as a combined preparation for simultaneous or sequential administration and to the use of such compositions in the treatment of certain disorders, including epilepsy, mood disorders and pain. | 05-06-2010 |
| 20100105754 | 5-(4PHENYL)PROLINAMIDE FOR TREATMENT OF EPILEPSY - The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, | 04-29-2010 |
| 20100105713 | GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders - Compounds of formula (I) or a salt thereof are provided: | 04-29-2010 |
| 20100105688 | PHARMACEUTICAL COMPOSITIONS COMPRISING 3,5-DIAMINO-6-(2,3-DICHLOPHENYL)-1,2,4-TRIAZINE OR R(-)-2,4-DIAMINO-5-(2,3-DICHLOROPHENYL)-6-FLUOROMETHYL PYRIMIDINE AND AN NK1 - The present invention relates to pharmaceutical compositions comprising an NK1 receptor antagonist and a sodium channel blocker, wherein at least one of them is at subtherapeutic dose, as a combined preparation for simultaneous or sequential administration, and to the use of such compositions in the treatment of certain disorders, including epilepsy, mood disorders and pain. | 04-29-2010 |
| 20100087667 | METHODS OF SYNTHESIZING 1-(ACYLOXY)-ALKYL CARBAMATE PRODRUGS - The present disclosure relates to methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs and to intermediates used in the methods. | 04-08-2010 |
| 20100087502 | Indazoles Used To Treat Estrogen Receptor Beta Mediated Disorders - The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases. | 04-08-2010 |
| 20100081830 | METHODS OF SYNTHESIZING N-HYDROXYSUCCINIMIDYL CARBONATES - The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the preparation of 1-(acyloxy)-alkyl carbamate prodrugs. | 04-01-2010 |
| 20100075953 | SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS - The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease. | 03-25-2010 |
| 20100069409 | "NOVEL COMPOUNDS" - Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(M)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors. | 03-18-2010 |
| 20100068166 | ORAL COMPOSITION COMPRISING DIMETHICONE COPOLYOL - Oral compositions comprising silicone polyols are described for lubricating and hydrating the buccal cavity and are of benefit in alleviating the symptoms of xerostomia (dry mouth). | 03-18-2010 |
| 20100059052 | SHEET DRIVER FOR USE IN A DRUG DISPENSER - The present invention relates to a sheet driver for use in a drug dispenser including a drug carrier ( | 03-11-2010 |
| 20100056595 | Pyrazole Derivatives as P2X7 Modulators - The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: | 03-04-2010 |
| 20100056502 | COMPOUNDS - Tricyclic nitrogen containing compounds and their use as antibacterials. | 03-04-2010 |
| 20100048639 | OXADIAZOLE DERIVATES AS S1P1 RECEPTOR AGONISTS - The present invention relates to novel oxadiazole compounds of formula (I) | 02-25-2010 |
| 20100041672 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME - The use of 5-HT | 02-18-2010 |
| 20100016371 | Indole Compounds - The present application relates to compounds of formula (I) or a pharmaceutically acceptable derivative thereof; wherein X, R | 01-21-2010 |
| 20100016287 | COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF" - Compounds of formula (I) | 01-21-2010 |
| 20100004240 | Indole Compounds - Compounds of Formula (I) or a pharmaceutically acceptable derivative thereof: wherein R | 01-07-2010 |
| 20100004230 | AZATRICYCLIC COMPOUNDS AND THEIR USE - Tricyclic nitrogen containing compounds and their use as antibacterials. | 01-07-2010 |
| 20100003420 | MEDICAMENT DISPENSER - A dispenser for dispensing a medicament that includes a canister for housing the medicament and a fluid propellant therefor and a drug-dispensing valve wherein one or more of the internal surfaces of the canister and/or valve includes a fluorinated coating prepared from plasma polymerisation of one or more fluorinated monomers selected from the group consisting of CH | 01-07-2010 |
| 20100000528 | MANIFOLD FOR USE IN MEDICAMENT DISPENSER - There is provided a manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack. The manifold comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from the chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit. The chimney exit and said chamber inlet lie side-by-side each other such that when said open blister pocket of said blister pack is positioned adjacent thereto said airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain said medicament powder and enable transport thereof in the airflow from the chamber inlet to said chamber outlet. The chamber is arranged to promote break up of said entrained medicament powder by exposing the entrained medicament powder to one or more regions of differential force during its transport through the chamber. | 01-07-2010 |
| 20090326032 | PHARMACEUTICAL COMPOSITIONS COMPRISING NK1 RECEPTOR ANTAGONISTS AND SODIUM CHANNEL BLOCKERS - The present invention relates to pharmaceutical compositions comprising an NK1 receptor antagonist and a sodium channel blocker compound of formula (I) | 12-31-2009 |
| 20090318530 | PHARMACEUTICAL COMPOSITIONS COMPRISING NK1 RECEPTOR ANTAGONISTS AND SODIUM CHANNEL BLOCKERS - The present invention relates to pharmaceutical compositions comprising an NK1 receptor antagonist and a sodium channel blocker compound of formula (I) | 12-24-2009 |
| 20090298742 | PROCESS FOR MANUFACTURING LACTOSE - A process for forming crystalline lactose suitable for use in a pharmaceutical formulation comprises subjecting a solution comprising a plurality of nanosized lactose particles to conditions sufficient to cause crystallization to occur on the nanosized lactose particles such that a plurality of lactose particles are formed therefrom having a median diameter ranging from about 4 μm to about 20 μm. | 12-03-2009 |
| 20090286762 | Pharmaceutical Formulations Comprising Azelastine and a Corticosteroid for the Treatment of Inflammatory or Allergic Conditions - The present invention relates to pharmaceutical formulations comprising an anti-inflammatory glucocorticoid compound of formula (II), (III), (IV) | 11-19-2009 |
| 20090270510 | GLYCINE TRANSPORT INHIBITORS - The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. | 10-29-2009 |
| 20090270355 | Compounds - The present invention relates to a compound which is N-(4-{4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide | 10-29-2009 |
| 20090239846 | Novel Compounds - Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors. | 09-24-2009 |
| 20090236445 | FLUID DISPENSER - A fluid dispenser that includes a dosing chamber, a piston member, a fluid outlet through which fluid will be dispensed, a fluid conduit configured to convey fluid from the dosing chamber towards the fluid outlet, and a seal for sealing the fluid outlet is described. | 09-24-2009 |
| 20090211201 | Apparatus and method for printing packaging elements - An apparatus for printing isolated packaging elements ( | 08-27-2009 |
| 20090209472 | AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS - This invention relates to newly identified spermidine based surfactant compounds, to the use of such compounds and to their production. The invention also relates to the use of the spermidine based compounds to facilitate the transfer of polynucleotides into cells. | 08-20-2009 |
| 20090203677 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics - The present invention relates to novel compounds of Formula (I) | 08-13-2009 |
| 20090203657 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics - The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, | 08-13-2009 |
| 20090197871 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics - The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis. | 08-06-2009 |
| 20090188492 | CANISTERS FOR USE IN METERED DOSE INHALERS - A canister for use in metered dose inhalers and fitted with a metering valve has walls that are formed of a laminate that includes a first layer which is composed of a metal and a second layer which is composed of a strengthening material. | 07-30-2009 |
| 20090188491 | Medicaments - This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation which comprises particulate salbutamol and physiologically acceptable salts and solvates thereof and a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant, which formulation is substantially free of surfactant. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described. | 07-30-2009 |
| 20090181950 | Histamine Receptor Antagonists Comprising an Azepin Core - The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis. | 07-16-2009 |
| 20090178673 | Actuation Indicator for a Dispensing Device - An actuation indicator which includes a drums sub-assembly including a rotatable actuation indicator wheel, a rocking ratchet pawl for rotating the indicator wheel in a set direction and a rocking mechanism for the pawl driven by a slipping clutch arrangement, wherein the slipping clutch arrangement includes a slipping clutch spring engaged at one end to a pinion of a rack and pinion assembly and at a second end to the ratchet pawl is described. | 07-16-2009 |
| 20090176746 | THROMBOPOIETIN MIMETICS - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 07-09-2009 |
| 20090163495 | MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES - There are provided according to the invention, novel compounds of formula (I) | 06-25-2009 |
| 20090156567 | NOVEL ANTI-INFLAMMATORY ANDROSTANE DERIVATIVE - According to one aspect of the invention, there is provided a compound of formula (I) | 06-18-2009 |
| 20090155203 | THROMBOPOIETIN MIMETICS - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 06-18-2009 |
| 20090149447 | Novel M3 Muscarinic Acetylcholine Receptor Antagonists - Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. | 06-11-2009 |
| 20090124653 | Muscarinic Acetylcholine Receptor Antagonists - Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. | 05-14-2009 |
| 20090124588 | Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions - The present invention is directed to compounds of formula (I): | 05-14-2009 |
| 20090118495 | Process for the Preparation of 6-alpha,9-alpha-difluoro-17-alpha-((2-furanylcarbonyl)oxy)-11-beta-hydrox- y-16-alpha-methyl-3-oxo-androsta-1,4-diene-17-beta- -carbothioic acid S-fluoromethyl - A novel process for preparing a compound of formula (I) | 05-07-2009 |
| 20090105309 | Medicinal Compounds - Compounds of formula (I): | 04-23-2009 |
| 20090105225 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists - The present invention relates to compounds of formula (I), | 04-23-2009 |
| 20090099169 | Benzofuran Compounds As EP1 Receptor Antagonists - Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: | 04-16-2009 |
| 20090090787 | Counter for Use with a Medicament Dispenser - A dose counter for use with a medicament dispenser which comprises a ratchet; a first count wheel arranged to rotate about a first axis of rotation, the first count wheel including one or more ratchet drive receipt elements arranged thereon for receipt of drive from the ratchet to rotate the first count wheel about the first axis of rotation; a second count wheel arranged to rotate about the first axis of rotation, the second count wheel including a set of teeth arranged annularly thereon; and a kick wheel arranged to rotate about a second axis of rotation offset from the first axis of rotation, the kick wheel including a set of kick teeth arranged annularly thereon and in meshed relationship with the teeth of the second count wheel such that rotary motion of the kick wheel results in rotary motion of the second count wheel is described. | 04-09-2009 |
| 20090074675 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS - A compound of formula (I): | 03-19-2009 |
| 20090068273 | Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases - The invention provides inhalation devices comprising a compound which is 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; or a salt or solvate thereof, inhalation devices comprising formulations and combinations of the compound or a salt or solvate thereof, and methods for the treatment or prophylaxis of a clinical condition in a mammal by employing the inhalation devices | 03-12-2009 |
| 20090062218 | MACROLONE COMPOUNDS - A compound of formula (I) | 03-05-2009 |
| 20090054261 | METHOD - A method of controlling a system having a microfluidic channel structure in which fluids are able to interact to produce at least one product comprises the steps of:
| 02-26-2009 |
| 20090042897 | Chemical Compounds - The present invention relates to novel compounds or a pharmaceutically acceptable salt or solvate thereof, selected from a group consisting of:
| 02-12-2009 |
| 20090013652 | Method and Apparatus for Loading a Container with a Product - There is provided a method of loading a container with a defined quantity of product which comprises the steps of a) closing off a perforation ( | 01-15-2009 |
| 20090012056 | Quinoline Compounds Capable of Binding the Cb2 and/or the 5-Ht6 Receptor - The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which possess antagonist potency for the 5-HT | 01-08-2009 |
| 20080312213 | 7-Pyrazolylbenzazepines Having Affinity For D3 Receptor - Compounds of formula (I) or a salt thereof are disclosed: | 12-18-2008 |
| 20080293770 | Compounds Which Have Activity at M1 Receptor and Their Uses In Medicine - Compounds of formula (I) and salts are provided: | 11-27-2008 |
| 20080293720 | Pyridinyl Sulfonamide Modulators of Chemokine Receptors - The present invention relates to compounds of following formula: | 11-27-2008 |
| 20080283553 | Closure for a Dispensing Device - A closure is provided for use with a dispensing device which comprises a housing having a dispensing outlet, a supply of a substance and a dispensing member mountable in the housing in a rest position relative to the housing and movable from the rest position to an actuated position, said movement from the rest position to the actuated position causing dispensing of said substance out of the dispensing outlet. The closure is adapted to close the dispensing outlet in two different orientations of the closure. Moreover, the closure has a restricting member which, when the closure closes the dispensing outlet in either orientation, prevents movement of the dispensing member from the rest position to the actuated position so that dispensing of the substance is prevented when the closure closes the dispensing outlet. | 11-20-2008 |
| 20080280911 | Cinnoline Compounds as Inhibitors of Phosphodiesterase Type IV (Pde4) - There are provided according to the invention novel compounds of formula (I) | 11-13-2008 |
| 20080275251 | Novel Intermediates and Their Use - The invention is directed to novel acyloxy imidazole intermediates useful for making certain C-14 oxycarbonyl carbamate pleuromutilin derivatives. The invention is further directed to a process for making such acyloxy imidazole intermediates and to a process for making C-14 oxycarbonyl carbamate pleuromutilin derivatives using such acyloxy imidazole intermediates. | 11-06-2008 |
| 20080275078 | Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors - The invention provides a compound of formula (I) or a salt thereof: | 11-06-2008 |
| 20080275040 | 8-(1-Piperazinyl)-Quinoline Derivatives and Their Use in the Treatment of Cns Disorders - This invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders. | 11-06-2008 |
| 20080274067 | Tooth Whitening Composition - An oral care composition comprising an active agent e.g. a whitening agent and a carrier including a carrier base comprising a wax and a substantivity agent. A method of whitening the teeth using the composition is also disclosed. | 11-06-2008 |
| 20080249459 | Fluid Dispensing Device - A fluid dispensing device for dispensing a fluid product having a dispensing member mounted for movement along an axis X-X from a first position to a second position which causes a dose of a fluid product to be dispensed, and a finger-operable actuator member movable in an actuating direction generally transverse to the axis to cause at least one cam surface thereof to cam the dispensing member from the first position to the second position. The at least one cam surface has a commitment section, oriented at a first angle to the axis selected such that a minimum actuating force is required to be applied to the actuator member to cause the at least one cam follower surface to ride over the commitment section onto the drive section. The commitment section of the cam surface is arcuate. | 10-09-2008 |
| 20080234256 | Antibacterial Agents - Naphthyridine and related derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein. | 09-25-2008 |
| 20080221158 | Novel 14 and 15 Membered Ring Compounds - The present invention relates to 15-membered macrolides substituted at the 4″ position of formula (I) | 09-11-2008 |
| 20080210230 | Inhalation Devices - An inhaler for delivering medicament by inhalation, comprising: a canister which comprises a body which defines a chamber containing medicament and a valve stem which extends from the body and from which medicament is in use delivered on actuation of the canister; and an actuator comprising a main body comprising a housing receiving the canister and actuating mechanism for actuating the canister, wherein the actuating mechanism comprises a loading member which engages or is comprised in the canister, and at least one actuating member which is depressible by a user to drive the loading member in an actuating direction from a first, rest position to a second, actuated position in which the canister is actuated to deliver medicament, wherein the at least one actuating member is a flexible element which has a first, flexed configuration when the loading member is in the first, rest position and, on depression, is extended in the actuating direction, such as to drive the loading member in the actuating direction from the first, rest position to the second, actuated position. | 09-04-2008 |
| 20080207708 | Oxazole and Thiazole Compounds and Their Use in the Treatment of Pge2 Mediated Disorders - Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: | 08-28-2008 |
| 20080196718 | Medicament Dispenser - A medicament dispenser for use with at least one medicament carrier carrying multiple distinct medicament portions, said medicament dispenser comprising | 08-21-2008 |
