| Girindus AG Patent applications |
| Patent application number | Title | Published |
|---|
| 20110224424 | Method for preparing oligonucleotides - A solution phase synthesis method for preparing an oligonucleotide, wherein at least some of the reagents are solid supported. The method suitable for large- scale synthesis comprises coupling a protected compound with a nucleotide derivative having a protection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond; optionally processing the elongated oligonucleotide by capping by reaction with a solid supported capping agent and/or by oxidizing or sulfurizing by reaction of the oligonucleotide with a solid supported oxidizing or sulfurization reagent; and removing the protection group. The coupling may include reacting a 3′-protected compound of formula: | 09-15-2011 |
| 20110201799 | Synthesis of oligonucleotides - A method for preparing an oligonucleotide comprising the steps of a) providing a hydroxyl containing compound having formula (1), wherein B is a heterocyclic base, and radicals R | 08-18-2011 |
| 20110065909 | SYNTHESIS OF OLIGONUCLEOTIDES - A method for preparing an oligonucleotide comprising the steps of | 03-17-2011 |
| 20100087635 | PURIFICATION OF OLIGONUCLEOTIDES - A method for purifying a protected oligonucleotide comprising the steps of:
| 04-08-2010 |
| 20100081802 | Synthesis of Phosphitylated Compounds Using a Quaternary Heterocyclic Activator - A method for preparing a phosphitylated compound comprising the step of: -reacting hydroxyl containing compound with a phosphitylating agent in the presence of an activator having the formula (I) wherein R=alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl R | 04-01-2010 |
| 20100069623 | Method for preparing oligonucleotides - A solution phase synthesis method for preparing an oligonucleotide, wherein at least some of the reagents are solid supported. The method suitable for large-scale synthesis comprises coupling a protected compound with a nucleotide derivative having a protection group in the presence of a solid supported activator to give an elongated oligonucleotide with a P(III)-internucleotide bond; optionally processing the elongated oligonucleotide by capping by reaction with a solid supported capping agent and/or by oxidizing or sulfurizing by reaction of the oligonucleotide with a solid supported oxidizing or sulfurization reagent; and removing the protection group. The coupling may include reacting a 3′-protected compound of formula: | 03-18-2010 |
| 20090216002 | SYNTHESIS OF HYDROQUINONE DERIVATIVES - A method for synthesising a compound having the general formula (I) wherein R represents substituents selected independently from the group of H, F, Cl, Br, NO | 08-27-2009 |
