| GE HEALTHCARE UK LIMITED Patent applications |
| Patent application number | Title | Published |
|---|
| 20120101005 | METHODS FOR PREDICTING THE TOXICITY OF A CHEMICAL - The invention relates to methods and kits for predicting the effect of a chemical on a developmental pathway. In particular, the invention relates to methods and kits for predicting the toxicity of a chemical on human developmental pathways. The methods and kits of the invention can be used for predicting changes in a cellular biomap or a developmental pathway during human foetal development. | 04-26-2012 |
| 20120058467 | APPARATUS AND METHOD FOR DETECTING DNA DAMAGE - The invention relates to an apparatus and an in-situ method for detecting cellular DNA damage. The invention is particularly suited for use in Comet assays and for automation of such assays. The apparatus comprises a multiwell plate, the plate comprising an array of wells held in fixed relationship with each other and each well having an axis, side walls, and a base and wherein the well is provided with electrode pairs disposed therein; and wherein there is provided means for parallel connection of the electrode pairs to an external voltage supply. | 03-08-2012 |
| 20120045834 | METHOD AND APPARATUS FOR MAINTAINING MICROCARRIER BEADS IN SUSPENSION - The invention relates to an impeller for growing adherent mammalian cells on microcarrier beads. In other aspects, the invention relates to methods of using the impeller and to bioreactors or cell separators comprising the impeller. | 02-23-2012 |
| 20120035859 | METHOD AND APPARATUS FOR MULTI-PARAMETER DATA ANALYSIS - In one aspect, the present invention relates to a method | 02-09-2012 |
| 20120021440 | METHODS FOR TESTING LIGAND BINDING TO G PROTEIN-COUPLED RECEPTORS - The present invention relates to methods for testing for the binding of a ligand to a G Protein-Coupled Receptor. In particular, the methods of the invention are useful in high throughput screening for ligands which bind to G Protein-Coupled Receptors. | 01-26-2012 |
| 20120015373 | ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS - Disclosed are methods for assay of an analyte employing acridone dyes having the structure: | 01-19-2012 |
| 20110280803 | RADIOIODINATION METHOD - The present invention provides a method for the synthesis of radioiodinated compounds which is advantageous over prior art methods. Using a hydrazine or an aminoxy in place of a primary amine for indirect radioiodination facilitates a much quicker reaction thus reducing reaction time and increasing the yield. In addition, where there are primary amines in the molecule to be radioiodinated, such as the N-terminus of a peptide or lysine residues, reaction at the hydrazine or aminoxy is greatly favoured. | 11-17-2011 |
| 20110267448 | MICROSCOPY - According to one aspect, the present invention relates to an imaging system ( | 11-03-2011 |
| 20110250632 | METHODS FOR CONDUCTING CELLULAR ASSAYS - The present invention relates to cryopreserved cell cultures, methods for cryopreserving cells and methods for conducting cellular assays on such cells. A cryopreserved cell culture of the invention comprises a container having at least a surface which is coated with poly-lysine and frozen cells supported on the surface. | 10-13-2011 |
| 20110244487 | METHODS FOR TESTING BINDING OF A LIGAND TO A G PROTEIN-COUPLED RECEPTOR - The present invention relates to methods for testing for the binding of a ligand to a G Protein-Coupled Receptor. In particular, the methods of the invention are useful in high throughput screening for ligands which bind to G Protein-Coupled Receptors. | 10-06-2011 |
| 20110236921 | CELL SYSTEM - The present invention relates to cellular systems for testing drug candidates and for evaluating the function of mitochondrial proteins. The invention is particularly useful for evaluating drug candidates for cancer and for conducting studies on drug resistance. | 09-29-2011 |
| 20110177527 | METHODS AND COMPOUNDS FOR TESTING BINDING OF A LIGAND TO A G PROTEIN-COUPLED RECEPTOR - The present invention relates to compounds and methods for testing for the binding of a ligand to a G Protein-Coupled Receptor. In particular, the compounds of the invention are useful in high throughput screening for ligands which bind to G Protein-Coupled Receptors. | 07-21-2011 |
| 20110134233 | IMAGING SYSTEM AND METHOD FOR ENHANCING MICROSCOPIC IMAGES OF UNSTAINED CELLS - According to one aspect, the present invention relates to an imaging system | 06-09-2011 |
| 20110014641 | METHOD FOR MEASURING AROMATASE ACTIVITY - The present invention relates to compounds useful for measuring aromatase activity. The invention further provides methods for measuring aromatase activity and for screening test agents which modulate aromatase activity. A kit is also provided for use in such screening methods. | 01-20-2011 |
| 20100311069 | MULTIPLEX CELL SIGNALLING ASSAYS - Disclosed are methods useful in multiplex cell-based assays for compound screening employing imaging instrumentation. The methods described herein offer high content information relating to the biological potency of test agents, off-target effects and cellular toxicity of potential drug candidates. | 12-09-2010 |
| 20100267008 | CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS - This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3′-dimethyl-3H-indole and its derivatives as intermediates for preparation of cyanine dyes, to methods of preparing these dyes and the dyes so prepared. | 10-21-2010 |
| 20100261811 | MICROSCOPY IMAGING PHANTOMS - The invention relates to imaging phantoms for validation, optimisation and calibration of microscopy instrumentation and software used for analysis of microscope images. The materials and methods of the invention find particular use in high content screening and high content analysis. | 10-14-2010 |
| 20100249385 | WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS - Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): | 09-30-2010 |
| 20100233681 | METHOD FOR CELL BASED ASSAYS - Disclosed is a method for cell storage on beads and subsequent utilisation of cryogenically stored cells in cellular assays. | 09-16-2010 |
| 20100184098 | METHODS FOR MEASURING ENZYME ACTIVITY - The invention relates to fluorescence methods for measuring enzyme activity, in particular enzyme cleaving and joining activities. The invention also relates to fluorogenic substrates which are useful for measuring enzyme activity and as in vitro and in vivo imaging probes. | 07-22-2010 |
| 20100178237 | PROCESS FOR RECOVERY OF WATER ISOTOPOLOGUES - Disclosed is a process and a system for recovery of isotopologues of water from an aqueous vapour stream optionally containing acidic gases. | 07-15-2010 |
| 20100139537 | THERMAL OXIDISER - Thermal oxidiser ( | 06-10-2010 |
| 20100028899 | CELL CYCLE PHASE MARKERS - The present invention relates to polypeptide and nucleic acids constructs which are useful for determining the cell cycle status of a mammalian cell. Host cells transfected with these nucleic acid constructs can be used to determine the effects that test agents have upon the mammalian cell cycle. | 02-04-2010 |
| 20100021372 | PROCESS FOR RECOVERY OF WATER ISOTOPOLOGUES FROM IMPURE WATER - Disclosed is a process and a system for recovery of isotopologues of water from an aqueous liquid stream containing dissolved impurities. | 01-28-2010 |
| 20100015054 | FLUORO-SUBSTITUTED BENZOXAZOLE POLYMETHINE DYES - Disclosed are reactive polyfluoro benzoxazole polymethine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): | 01-21-2010 |
| 20090325209 | METHOD AND REAGENT FOR MEASURING NITROREDUCTASE ENZYME ACTIVITY - Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays. The dyes are of the structure: | 12-31-2009 |
| 20090232370 | METHOD OF, AND APPARATUS AND COMPUTER SOFTWARE FOR, IMAGING BIOLOGICAL OBJECTS - A method of imaging one or more biological objects using imaging apparatus capable of capturing an image across an imaging area. The method includes: placing the one or more biological objects ( | 09-17-2009 |
| 20080300397 | MODIFIED SPIN COLUMN FOR SIMPLE AND RAPID PLASMID DNA EXTRACTION - The invention relates to a modified spin column for the isolation and purification of plasmid DNA. A pre-filtration disc is included in a traditional spin column. During plasmid DNA isolation, the lysate can be loaded directly to the modified spin column, eliminates the need to first remove the flocculants containing cellular debris. This results in a much shortened process. Variation of the invention includes a depth filter in between the pre-filtration disc and the main separation matrix. Also provided are kits for isolation of plasmid DNA including the modified spin columns. | 12-04-2008 |
| 20080299621 | MINIPREP SYSTEM FOR SIMPLE AND RAPID PLASMID DNA EXTRACTION - The invention relates to a modified microspin system for the isolation and purification of plasmid DNA. A disposable pre-filter column is used in combination with the traditional microspin column for increase speed and quality of plasmid DNA preparation. The disposable pre-filter column includes a pre-filter and a depth filter for optimal result. During plasmid DNA isolation, the lysate can be loaded directly to the assembly including the disposable pre-filter column and the microspin column. A quick spin causes the plasmid DNA to bind to the microspin column while the flocculents remain on top of the disposable pre-filter column, eliminates the need to first remove the flocculants containing cellular debris. This results in a much shortened process. Also provided are kits for isolation of plasmid DNA including the pre-filter column and the microspin columns. | 12-04-2008 |
| 20080253642 | Method of Processing an Image - A method of processing an input image produces an output image emphasising peak-like structures. The input image comprises input pixels and each input pixel has an intensity characteristic. The output image comprises corresponding output pixels and each output pixel has a value. The method comprises the step of calculating for an input pixel the second derivative of the intensity characteristic in two orthogonal directions, one of the directions being the direction of maximum curvature. The product of the two second derivatives is calculated and the value of the output pixel corresponding to the input pixel is determined in dependence on the product. | 10-16-2008 |
| 20080227131 | Signalling Assay and Cell Line - The invention relates to a sensor for indicating the transduction and inhibition of stress signals through the p38-MAPK pathway in living cells. The sensor comprises a reporter gene product and an isoform of p38 Mitogen Activated Protein Kinase (MAPK). The invention also provides plasmid and viral vectors containing nucleic acids encoding the sensor for the transfection of living cells. Stable cell lines expressing the sensor can be used in a live-cell or fixed-cell assay to measure activation or modulation of the pathway. | 09-18-2008 |
| 20080219529 | Method of, and Apparatus and Computer Software for, Performing Image Processing - A computer-implemented method of performing image processing for images of biological objects includes: storing definitions of a plurality of descriptors; receiving image data relating to an image of a reference population of biological objects; receiving image data relating to an image of a target population of biological objects; processing the reference population image data to obtain a reference set of measurements, containing data for each of the descriptors; processing the target population image data to obtain a target set of measurements, containing data for each of the descriptors; and selecting a combination of the descriptors on the basis of comparing the reference set with the target set to define a preferred combination of the descriptors for use in identifying characteristics of a further population of biological objects which are similar to those of the target population. | 09-11-2008 |
