Freie Universitat Berlin Patent applications |
Patent application number | Title | Published |
20150283094 | METHOD FOR PRODUCING A POLYGLYCEROL NANOGEL FOR THE ENCAPSULATION AND RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES - A method for producing a polyglycerol nanogel is disclosed, the method comprising the following steps: Mixing an aqueous solution of first polyglycerol macromonomers, which are modified with a first reactive group, with an aqueous solution of second polyglycerol macromonomers, which are modified with a second reactive group, wherein the first reactive group and the second reactive group can react with each other forming a chemical bond; transferring the mixture into an organic non-solvent; and precipitation of a polyglycerol nanogel consisting of first polyglycerol macromonomers and second polyglycerol macromonomers which are covalently bound to each other. According to an aspect of the invention, the method is characterized in that the organic non-solvent is miscible with water and in that the method is carried out without adding surface-active substances. | 10-08-2015 |
20140363507 | DENTRIC POLYGLYCEROL SULFATES AND SULFONATES AND THEIR USE FOR INFLAMMATORY DISEASES - The present invention relates to the novel compound classes of dendritic polyglycerol sulfates and sulfonates as well as to their production and use for the treatment of diseases, particularly inflammatory diseases, and to their use as selectin inhibitors and selectin indicators. The dendritic polyglycerol sulfates and sulfonates are also suitable for imaging diagnostics, particularly with respect to inflammatory diseases. | 12-11-2014 |
20140194549 | METHOD FOR POLYMERIZING MONOMER UNITS AND/OR OLIGOMER UNITS BY MEANS OF INFRARED LIGHT PULSES - A method for polymerizing monomer units and/or oligomer units is disclosed. Said method is characterized in that the energy required for polymerization is introduced into the monomer units and/or oligomer units to be polymerized by means of infrared light pulses, wherein the infrared light pulses have a wavelength of 2500 to 20000 nm, an intensity of more than 10 | 07-10-2014 |
20130130906 | SUBSTITUTED 6-(ALKYLBENZYLAMINO) PURINE DERIVATIVES FOR USE AS CYTOKININ RECEPTOR ANTAGONISTS AND PREPARATIONS CONTAINING THESE DERIVATIVES - 6-(alkylbenzylamino)purine derivatives of the general formula I for use as cytokinin receptor antagonists. R1 is selected from a group which includes, but is not limited to, hydroxyl, amino, nitro, thio and alkyl group. R2 denotes one to four alkyl groups. The invention also relates to preparations containing these derivatives and methods of using the derivatives. | 05-23-2013 |
20110082090 | COMPOUNDS SUITED AS NANOCARRIERS FOR ACTIVE AGENTS AND THEIR USE - The invention relates to a compound suited as entity carrier, having the general formula (I) | 04-07-2011 |
20110045568 | METHOD FOR RESTORING BMP-RECEPTOR SIGNALING IN A CELL - The invention relates to a method for restoring BMP-receptor signaling in a cell. According to the invention, the activity of the protein cGKI is increased in a cell. Furthermore, the invention relates to the use of cGKI for the treatment of a disease selected from the group consisting of pulmonary artery hypertension (PAH), cancer, fibrosis, bone diseases, and neurodegenerative diseases, and the use of cGKI for manufacturing a pharmaceutical composition for the treatment of said diseases, the use of a BMP receptor for screening for compounds having cGKI activity, the use of cGKI for screening for receptors associated with it, and the use of cGKI for the transcriptional activation of genes containing a BMP response element. | 02-24-2011 |
20100291596 | SCREENING METHOD FOR AGENTS SUITABLE FOR THERAPY OF ALZHEIMER'S DISEASE - Described is a method of screening for therapeutic agents for the prophylaxis and therapy of Alzheimer's disease (AD), wherein agents that (i) do not interfere with the biological activity of gamma-secretase, (ii) do not exhibit cytotoxicity, (iii) lead to reduced amounts of Abeta42 and (iv) are capable of binding to an APP-GxxxG motif thereby weakening or inhibiting dimerization of the APP transmembrane sequence are suitable for prophylaxis or treatment of AD. | 11-18-2010 |
20100143880 | ANALYSIS METHOD FOR DETERMINING A FUNCTIONAL PARAMETER OF AN ORGAN USING PREFERABLY AN AQUEOUS 13C-METHACETIN SOLUTION - The invention relates to an analysis method for determining a functional parameter of an organ of a human or animal individual by measuring the | 06-10-2010 |
20100115666 | Transcriptional Repressors of Cytokinin Signaling and Their Use - The invention relates to fusion proteins capable of acting as transcriptional repressors of cytokinin signaling, to polynucleotides encoding these fusion proteins, to vectors and cells comprising these polynucleotides, and to transgenic plants and parts thereof comprising these polynucleotides, vectors, and cells. | 05-06-2010 |
20100081773 | DIVALENT METAL-ION LOADED NANO-TRANSPORT SYSTEM HAVING A DENDRITIC ARCHITECTURE USEFUL FOR THERAPY - Described is the use of a nanocarrier having a dendritic structure which is composed of a dendritic core and at least one shell for the non-covalent encapsulation and/or transport of divalent metal-ions, preferably Cu-ions or Zn(II) -ions. Also described is a pharmaceutical composition containing such nanocarrier complexed divalent metal-ions in a non-covalent encapsulated form. Finally several therapeutic uses of such a nanocarrier divalent metal-ion complex are described, for example for slowing down ageing or for the treatment of Cu-ion transport disorders like Alzheimer's disease (AD) or Menkes disease. | 04-01-2010 |
20090053759 | METHOD AND DEVICE FOR PREPARING BIOLOGICAL SAMPLES - A method for preparing biological samples by means of a series of different liquids containing preparation agents in a chamber is provided. The chamber comprises a first and a second opening for supplying and removing liquid to and from the chamber. The chamber is brought into a first position, in which the first opening is located above the second opening when the liquid to be introduced into the chamber has a lower density than the liquid in the chamber. The chamber is brought into a second position, in which the first opening is located below the second opening when the liquid to be introduced into the chamber has a higher density than the liquid in the chamber. | 02-26-2009 |