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FORMAC Pharmaceuticals N.V.
| FORMAC Pharmaceuticals N.V. Patent applications | ||
| Patent application number | Title | Published |
|---|---|---|
| 20110081416 | ORDERED MESOPOROUS SILICA MATERIAL - A process for preparing a 2D-hexagonal ordered mesoporous silica material with a substantially uniform pore size in the range of 4 to 30 nm comprising the steps of: preparing an aqueous solution comprising an alkali silicate solution; preparing an aqueous solution comprising a poly(alkylene oxide) triblock copolymer and a buffer with a pH greater than 2 and less than 8, adding said aqueous alkali silicate solution to said aqueous solution giving a pH greater than 2 and less than 8 and allowing a reaction between the components to take place at a temperature in the range of 10 to 100° C., and filtering off, drying and calcinating the reaction product to produce said 2D-hexagonal ordered mesoporous silica material with a substantially uniform pore size. In an alternative procedure both aqueous solutions are fed as liquid streams into an elongated mixing receptacle having a first and a second opening such that the liquid streams of the solutions are each discharged independently into said first opening of said elongated mixing receptacle such that they directly impinge thereby giving a pH in the resulting mixture of greater than 2 and less than 8 and producing a reaction product at a temperature in the range of 10 to 100° C. in said elongated mixing receptacle, which upon emergence from said second opening of said elongated mixing receptacle is filtered off, dried and the surfactant removed. | 04-07-2011 |
| 20110018154 | PREPARATION METHOD FOR SOLID DISPERSIONS - A method of preparation of a solid dispersion of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR with a BCS Class II drug or a BCS Class IV drug, whereby the method comprises: a) dissolving the polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer) separately in a water/first alcohol mixture; and b) dissolving the BCS Class II drug or a BCS Class IV drug, in a mixture of a second alcohol with a non alcoholic organic solvent in which the compound has an high solubility; and c) mixing the both solutions to obtain a third solution with a total amount of solved solid of 1 to 15 g per 100 ml, and optionally having an acid, including inorganic acids including hydrohalic acids, e.g. hydrochloric or hydrobromic acid; sulfuric; nitric; phosphoric and the like acids; or organic acids including acetic, propanoic, hydroxyacetic, lactic, pyruvic, oxalic, malonic, succinic, maleic, fumaric, malic, tartaric, citric, methane-sulfonic, ethanesulfonic, benzenesulfonic, p-toluenesulfonic, cyclamic, salicylic, p-aminosalicylic, palmoic and the like acids in the mixture of both the solutions to achieve an acid pH; and d) spray drying the third solution. | 01-27-2011 |