FLUGEN, INC. Patent applications |
Patent application number | Title | Published |
20140127249 | INFLUENZA VIRUS MUTANTS AND USES THEREFOR - Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein include a mutant M2 sequence, and are useful in immunogenic compositions, e.g., as vaccines. Also disclosed herein are methods, compositions and cells for propagating the viral mutants, and methods, devices and compositions related to vaccination. | 05-08-2014 |
20110172645 | WEARABLE DRUG DELIVERY DEVICE INCLUDING INTEGRATED PUMPING AND ACTIVATION ELEMENTS - A drug delivery device for delivering a drug to a subject is provided. The drug delivery device includes a housing, a drug reservoir supported by the housing containing the drug and a hollow microneedle supported by the housing. The hollow microneedle is moveable from an inactive position to an activated position, wherein, when the hollow microneedle is moved to the activated position, the tip portion of the hollow microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a channel having an input in communication with the drug reservoir and an output in communication with the hollow microneedle. The channel provides fluid communication between the drug reservoir and the hollow microneedle, such that the drug is permitted to flow from the drug reservoir through the channel and through the hollow microneedle. The channel moves from a first position to a second position as the hollow microneedle moves from the inactive position to the activated position, and the position of the drug reservoir relative to the housing remains fixed as the hollow microneedle moves from the inactive position to the activated position. | 07-14-2011 |
20110172639 | DEVICE AND METHOD FOR DELIVERY OF MICRONEEDLE TO DESIRED DEPTH WITHIN THE SKIN - A device for delivering a drug into the skin of a subject is provided. The device includes a drug reservoir and a microneedle having a tip, a length, and a tip sharpness. The microneedle is coupled to the reservoir. The device includes a microneedle actuator coupled to the microneedle configured to drive the microneedle into the skin of the subject upon activation. The tip sharpness and the actuator allow the microneedle to pass through an outer layer of the skin upon activation, and the length is limited such that the tip does not extend past a desired depth below the surface of the skin of the subject, wherein the desired depth is located in the papillary dermis or the reticular dermis. | 07-14-2011 |
20110172638 | DRUG DELIVERY DEVICE INCLUDING MULTI-FUNCTIONAL COVER - An apparatus for delivering a drug to a subject is provided. The apparatus includes a housing, a microneedle coupled to the housing and configured to extend from the housing when activated, an activation control coupled to the housing and an outer shell. The outer shell includes a top wall having an inner surface and a sidewall extending from the top wall, the sidewall having an inner surface. The outer shell includes a first attachment structure configured to attach to the housing. The outer shell covers the activation control when the first attachment structure is attached to the housing. The outer shell includes a second attachment structure configured to attach to the housing. The outer shell covers the activated microneedle when the second attachment structure is attached to the housing. | 07-14-2011 |
20110172637 | DRUG DELIVERY DEVICE INCLUDING TISSUE SUPPORT STRUCTURE - A drug delivery device for delivering a drug to a subject includes a microneedle configured to facilitate delivery of the drug to the subject. The microneedle includes a tip portion and is moveable from an inactive position to an activated position. When the microneedle is moved to the activated position, the tip portion of the microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a tissue support structure that includes a channel and an engagement element. The channel has a first end and a second end and is in axial alignment with the microneedle. At least the tip portion of the microneedle extends past the second end of the channel in the activated position. The engagement element is positioned adjacent to the channel, and the engagement element is configured to engage with the skin of the subject such that the engagement element resists downward deformation of the skin caused by the microneedle as the microneedle moves from the inactive position to the activated position. | 07-14-2011 |
20110172609 | MICRONEEDLE COMPONENT ASSEMBLY FOR DRUG DELIVERY DEVICE - A device for delivering a drug to a subject is provided. The device includes a drug reservoir, a conduit coupled to the drug reservoir and a microneedle component. The microneedle component includes a body, an engagement structure coupling the microneedle component to the conduit, a hollow microneedle extending from the body, and a handling feature located on the body. The microneedle component is configured to be releasably coupled to an assembly tool via the handling feature during assembly of the device. | 07-14-2011 |
20110150925 | CELL-BASED SYSTEMS FOR PRODUCING INFLUENZA VACCINES - The present invention relates to a cell-based method for producing influenza virus vaccines by enriching the population of surface-bound α2,6-sialic acid receptors on a cell surface, such as on a Chinese Hamster Ovary (CHO) cell surface. The host cell therefore presents numerous binding sites to which an influenza virus can bind via its hemagglutinin spike protein and infect the host cell. In contrast to wild-type CHO cells, the surface of the mutated CHO cells of the present invention contains an enriched population of α2,6-sialic acid receptors which makes the inventive CHO cells highly susceptible to viral infection, and therefore safe, effective, and highly efficient cells for rapidly producing influenza vaccines. | 06-23-2011 |