| Florida Atlantic University Patent applications |
| Patent application number | Title | Published |
|---|
| 20110306556 | NEUROPROTECTION FROM BRAIN ANOXIA AND REPERFUSION INJURY DURING STROKE AND COMPOSITIONS OF PKG PATHWAY ACTIVATORS AND METHOD OF USE THEREOF - A pharmaceutical composition for treating or preventing one or both of neural anoxia and reperfusion injury, which includes a pharmacological activator of the PKG pathway, and methods of treating or preventing medical conditions using a pharmacological activator of the PKG pathway. | 12-15-2011 |
| 20110039282 | METHOD OF DETECTING CALCIFYING NANOPARTICLES AND SUSCEPTIBILITY TO CALCIFYING NANOPARTICLE INFORMATION - A method of measuring the susceptibility of a subject to calcifying nanoparticle formation is disclosed. The method can include obtaining a cell culture comprising peripheral blood mononuclear cells, immune cells, or both, from a peripheral blood mononuclear fraction of a subject in a complete culture media; extracting a first aliquot and a second aliquot from the cell culture; and dispensing the first and second aliquot in different wells. The surface of the well containing the first aliquot can include a calcifying nanoparticle biofilm, while the well containing the second aliquot does not. The first and second aliquots can be incubated and the concentration of osteopontin in each aliquot determined. An osteopontin factor can be calculated and compared to osteopontin factors from a representative sample of other subjects. The osteopontin factor can be defined as the osteopontin concentration in the first aliquot divided by the osteopontin concentration in the second aliquot. | 02-17-2011 |
| 20100279309 | MICROFLUIDIC CHIPS AND SYSTEMS FOR ANALYZING PROTEIN EXPRESSION, AND METHODS OF USE THEREOF - Microfluidic chips, systems including at least one integrated microfluidic chip operably connected to hardware (e.g., docking device, high voltage electrodes, portable fluorescence microscope, computer, etc.), and methods for analyzing peptides (e.g., toxins), proteins (e.g., cancer biomarkers, recombinant human growth hormone, recombinant human erythropoietin), and protein expression in biological samples (e.g., human serum, urine, or tissue, marine organism, seafood, etc.) have been developed. On a single microfluidic chip as described herein, several sequential processes for analyzing a protein (e.g., cell culturing, cell lysis, protein enrichment, protein labeling, and protein detection) can be performed in an automated fashion. The microfluidic chips, systems, and methods described herein provide real-time, high-throughput, highly-specific detection of proteins such as recombinant erythropoietin, recombinant human growth hormone and marine biotoxins, as well as important biomarkers in the cancer signaling pathway network for early and precise cancer diagnosis. | 11-04-2010 |
| 20100260864 | TREATMENT OR PREVENTION OF CANCER AND PRECANCEROUS DISORDERS - The NSAID, sulindac and/or its metabolites and derivatives, in combination with hydrogen peroxide or another oxidizing agent, such as arsenic trioxide that generates reactive oxygen species (ROS), significantly enhances the killing of cancer cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against cancer cells. A skin cream has been developed and used to treat skin cancer and precancerous skin growths that effectively removes the lesions with no effect on surrounding normal skin. | 10-14-2010 |
| 20100223074 | APPARATUS AND METHOD FOR MANAGING INTERACTION-BASED SERVICES - A system that incorporates teachings of the present disclosure may include, for example, a syntactic component for retrieving records corresponding to an individual and analyzing the records to assess a condition for the individual; a user interface for capturing interaction data that is associated with an encounter between the individual and a service provider; and a semantic component for comparing the interaction data to interaction criteria, where an action plan for the individual is generated based at least in part on the assessed condition and the comparison of the interaction data to the interaction criteria. Other embodiments are disclosed. | 09-02-2010 |
| 20100098289 | SYSTEM AND METHOD FOR ANALYSIS OF SPATIO-TEMPORAL DATA - A system and method of analyzing at least one dataset having temporal and spatial content is provided. A method includes the steps of applying a colorimetric mapping to the dataset based on the spatial content ( | 04-22-2010 |
| 20100069331 | TREATMENT OR PREVENTION OF CANCER AND PRECANCEROUS DISORDERS - The NSAID, sulindac and/or its metabolites and derivatives, in combination with an agent that generates or induces reactive oxygen species (ROS), significantly enhances the killing of abnormal cells but does not affect normal cells. This effect occurs at concentrations of each compound that individually have little or no activity directed against the abnormal cells. | 03-18-2010 |
| 20090324624 | Chitin micro-particles as an adjuvant - A composition and method for the preparation of micro-particles of chitin (a naturally occurring polymer of N-acetyl-D-glucosamine), the characterization of chitin micro-particles as an immune adjuvant and the use of chitin micro-particles to enhance protective immunity against intracellular infectious agents and diseases as well as to inhibit allergic responses and diseases. | 12-31-2009 |
| 20090312238 | Protection Against Oxidative Damage in Cells - The present invention relates to the use of MT as a reducing system for the Msr enzymes and other oxioreductase enzymes which form similar intermediates. Specifically, the invention provides for a reduction in the level of oxidative damage in cells through an increase in levels of MT by administration of suitable compounds, resulting in an increase in the activity of the Msr enzymes. | 12-17-2009 |
| 20090291104 | NOVEL CONOTOXIN FRAMEWORK WITH A HELIX-LOOP-HELIX FOLD - A new family Here we report a new family of four-cystine/three-loop conotoxins (designated framework 14). Three peptides of this family (flf14a-c) were isolated from the venom of | 11-26-2009 |
| 20090124558 | COMPOSITIONS AND METHODS FOR TREATING NEURAL ANOXIA AND SPREADING DEPRESSION - Compositions and methods for protecting neural tissue (e.g., neurons) from anoxia and spreading depression (SD) involve inhibiting the cGMP-dependent protein kinase (PKG) pathway. It was discovered that the PKG pathway plays a crucial role in regulating SD and tolerance to anoxia in the central nervous system (CNS). Inhibition of the PKG pathway greatly reduces SD and increases tolerance to anoxia (i.e., hypoxia), while activation of the pathway exacerbates SD pathology. The compositions and methods can be used to treat any condition associated with SD or anoxia, including stroke, spinal cord injury, neurogenerative disease, dizziness, headaches, and migraines. | 05-14-2009 |
| 20090064051 | INTERACTIVE SYSTEM FOR VISUALIZATION AND RETRIEVAL OF VIDEO DATA - A cube-based three-dimensional interactive system is provided for visualization and retrieval of video data. The system includes at least one interactive cube having eight nodes, each node being linked to a specific data item. The data items on the nodes are organized in space or time. Textual information about a respective data item appears upon traversing the corresponding node and the data items opens up upon selection. The interactive cube can be expanded to include more than eight nodes, such as 12 or 18 nodes. The system can also have multiple cubes that are connected to form a one-level, multi-level or multi-dimensional hypercube | 03-05-2009 |
| 20090062211 | CONOPEPTIDES AND METHODS OF USE - Isolation, synthesis and therapeutic use of conotoxin and conophan compounds and related compositions including a new class of conopeptides including the modified amino acid D-γ-hydro-oxyvalinie (D-Hyv=V*) are described herein. These isolated peptides are the first known example of a naturally occurring polypeptide chain containing D-Hyv. The active peptides, termed γ-Hydroxyconophans are heavily hydroxylated small peptides. These peptides contain a definitive structural motif which is a double modification of the polypeptide chain (γ-D-OH-Hyv-Trp). | 03-05-2009 |
| 20080305083 | GFAP-BASED GENE THERAPY FOR TREATMENT OF RETINAL DISEASES - Compositions and methods for reducing neovascularization. Purified nucleic acid constructs and vectors encoding an anti-angiogenic protein operably linked to a GFAP promoter. Vectors can include at least one hypoxia regulated element, enhancer element and silencer element. Gene therapy methods for reducing, delaying or preventing neovascularization based on the nucleic acid constructs and vectors. | 12-11-2008 |
| 20080300176 | METHODS OF TREATING NEURODEGENERATIVE DISEASES - The invention relates to the discovery that in an animal model of Parkinson's disease (PD), administration of granulocyte colony-stimulating factor (G-CSF) to rodents having 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD restored the function of dopamine neurons. In these animals, G-CSF treatment increased the number of dopamine neurons in the substantia nigra (SN), G-CSF treatment partially restored the nigrostriatal pathway, and G-CSF restored the function of dopamine to the level before MPTP treatment. The invention also relates to the discovery that treatment of a human patient with corticobasilar ganglionic degeneration, a rare progressive neurological disorder characterized by Parkinsonism and coritcal dysfunction, with G-CSF resulted in a significant improvement in the patient's Unified Parkinson's Disease Rating Scale evaluations as well as measures of activity of daily living. The invention further relates to the discovery that G-CSF treatment of a patient who had suffered an acute stroke resulted in a significant improvement in neurological function, the patient having minimal observable disability seven years later. The methods described herein can be used to treat PD in a mammalian subject (e.g., rodent, human) as well as other neurodegenerative diseases such as Alzheimer's disease, spinal cord injury, and stroke. | 12-04-2008 |
| 20080245285 | SELF CONTAINED INTEGRATED MOORING SYSTEM - A self contained integrated mooring system configured to contain items within a payload container in a water body is disclosed. The self contained integrated mooring system may include components for conveniently collecting and storing the components of the self contained integrated mooring system. The self contained integrated mooring system may be formed from the payload container, a mooring line handling and storage module, an anchor and a system container in a single system that eliminates having to work and rework anchor lines on a deck of a boat. | 10-09-2008 |
| 20080205795 | System and methods of image retrieval - A visual image retrieval system is provided. The system includes an image database for storing images. The system also includes a preprocessor communicatively linked to the image database for segmenting the images and generating based upon segmented images a region-of-interest (ROI) extraction output. Additionally, the system includes an ROI feature extraction module for computing ROI feature vectors based upon the output, and a global feature extraction module for computing global feature vectors based upon the output. The system further includes an ROI feature vectors database for storing the ROI feature vectors, and a global feature vectors database for storing the global feature vectors. The system also includes a perceptually-relevant image search machine (PRISM) interface for displaying query images and retrieved images, the retrieved images being retrieved in response to a user selecting at least one displayed query image. The system also includes a search-and-retrieval module for searching and retrieving stored images for display with the PRISM interface in response to a user selecting at least one displayed query image, and a global/ROI search module for selecting between a global search or an ROI search if more than one query image is selected, and for trigging the selected search. | 08-28-2008 |
