| 20090087569 | Methods for Preparing Highly Stable Hyaluronic Acid - Embodiments of the present disclosure relate to methods for preparing highly stable HA. Preparation of the highly stable HA comprises the steps of: preparing HA or its salt solution; preparing a water solution of negative-charge-carrying coat material; preparing a solution of positive-charge-carrying coat material; HA or its salt: negative-charge-carrying coat material: positive-charge-carrying coat material that ranges 1:1:2˜1:4:8; preparing a water solution of Hydroxypropyl methylcellulose; embedding for the first time: mixing HA or hyaluronate salt, negative-charge-carrying coat material and positive-charge-carrying coat material with the above mentioned proportion; embedding for the second time: adding water solution of Hydroxypropyl methylcellulose to the above mixture at a mass proportion 1:1 obtaining a second embedded compound; drying and solidifying the compound obtained from the second embedding using a spray dry method. The method for preparing HA microcapsules using the present disclosure is able to improve stability of the microcapsule, helping unique molecular structure and physical and chemical nature keep stable, which is very useful for food industry. | 04-02-2009 |
