ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM Patent applications |
Patent application number | Title | Published |
20150050668 | ASSAY FOR ANTI-TR ANTIBODIES - The present invention relates to a method for determining the presence of anti-Tr antibodies in a subject comprising the steps of obtaining a sample from said subject testing the presence of said antibodies in said sample by addition of DNER protein or an antigenic part thereof and checking whether said DNER protein is bound by any antibodies in said sample Such an assay is useful for the diagnosis of paraneoplastic cerebellar degeneration that is associated with Hodgkin lymphoma, or, more generally, to type patients suffering from cerebellar ataxia. Also comprised in the invention is a kit for performing such an assay. | 02-19-2015 |
20140336734 | HYPERTHERMIA SYSTEM AND A METHOD FOR GENERATING A FOCUSED THREEDIMENSIONAL RF FIELD - The invention relates to a hyperthermia system for treating a patient, comprising an RF power unit, one or more RF antenna's connected to the RF power unit for generating a focused three-dimensional RF field, a controller for adjusting the RF power source and/or the one or more RF antenna's for steering the focused three-dimensional RF field; a sensor for sensing a parameter representative of the focused three-dimensional RF field; a communication environment for inputting data from the said sensor and/or additional information provided by the patient, said communication environment being capable of generating trigger signals to the controller for in use steering the focused three-dimensional RF filed in real time. The invention further relates to a method for generation a focused three-dimensional RF field. | 11-13-2014 |
20140322715 | NEW METHOD AND KIT FOR PREDICTION SUCCESS OF IN VITRO FERTILIZATION - The invention comprises a method to determine the chance of a successful pregnancy based on the ratio of said ratio indicated as a formula that uses the presence of | 10-30-2014 |
20140315749 | METHODS AND KITS FOR DETECTING IGE-EXPRESSING B CELLS - The invention relates to the field of medical diagnostics. In particular, it relates method and kits for identification and classification of IgE-related diseases, e.g. Type I hypersensitivity, as well as for monitoring of treatment efficacy, for instance anti-IgE therapy. Provided is a multi-color flow cytometric method for analyzing memory B cell and plasma cell subsets in a biological sample, comprising staining the sample with a panel of fluorochrome-conjugated antibodies comprising antibodies against IgM, IgA, IgG, IgD and IgE; an antibody against a B cell marker and an antibody against the CD38 antigen; subjecting the sample to flow cytometry and gating for lymphocytes based on forward scatter and side scatter pattern; gating the lymphocytes for expression of the B cell specific marker and CD38 to discriminate between CD38 | 10-23-2014 |
20140287943 | ASSAY FOR SHIP1 EXPRESSION, ACTIVITY AND SEQUENCE ALTERATIONS AS A PREDICTOR OF INFLAMMATORY BOWEL DISEASE RISK - The present disclosure is directed to detecting colon disorders by measuring the expression of SHIP1 in a sample of PBMCs. One method includes the following steps, obtaining a sample including peripheral blood mononuclear cells (PBMCs) from a subject and determining whether SHIP1 is underexpressed in the PBMCs or lacks normal enzymatic activity. The present disclosure is also directed to a method of determining the expression of SHIP1 protein expression and SHIP1 enzyme activity in PBMCs. This method includes the following steps, obtaining a sample comprising PBMCs from a subject and determining the amount of SHIP1 in the PBMCs. | 09-25-2014 |
20140221313 | A NEW CLASSIFIER FOR THE MOLECULAR CLASSIFICATION OF MULTIPLE MYELOMA - The present invention is in the field of molecular diagnostics and relates to a method for classifying samples obtained from patients diagnosed with multiple myeloma into three newly defined clusters. The invention also relates to a method for determining the prognosis of an individual diagnosed with multiple myeloma as well as a method for the prediction of the response to treatment of an individual diagnosed with multiple myeloma. More in particular, the invention provides a method for determining the disease outcome or the prognosis of a patient diagnosed with multiple myeloma by classifying said patient into a high risk or a low risk category, based on a 92 gene classifier. | 08-07-2014 |
20140107951 | METHOD TO DETERMINE THE ABSORPTION COEFFICIENT IN TURBID MEDIA - The invention relates to a method to determine the wavelength dependent absorption coefficient of a turbid medium using overlapping illumination-detection areas comprising the steps of a) retrieving a calibration spectrum (CA) from a reference measurement using a reference sample; b) carrying out a measurement on an actual sample for determining the absolute reflection spectrum (R | 04-17-2014 |
20140024019 | Methods and Means for Monitoring Disruption of Tissue Homeostasis in the Total Body - The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease. | 01-23-2014 |
20130096025 | MOLECULAR CLASSIFICATION OF MULTIPLE MYELOMA - The present invention is in the field of molecular diagnostics and relates to a method for classifying samples obtained from patients diagnosed with multiple myeloma into three newly defined clusters. The invention also relates to a method for determining the prognosis of an individual diagnosed with multiple myeloma as well as a method for the prediction of the response to treatment of an individual diagnosed with multiple myeloma. | 04-18-2013 |
20120184495 | TARGETED NANO-PHOTOMEDICINES FOR PHOTODYNAMIC THERAPY OF CANCER - The present invention relates to a photosensitizer-containing nanoparticle, comprising a photosensitizer covalently bonded throughout at least a part of said nanoparticle to the nanoparticle matrix material and incorporated therein in a quasi-aggregated state. The present invention further relates to methods for producing the invention nanoparticles, and to methods of killing cancer cells by PDT treatment using the said nanoparticles. | 07-19-2012 |
20120165213 | Methods, Reagents and Kits for Flow Cytometric Immunophenotyping - The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least three identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions. | 06-28-2012 |
20120156241 | RESCUE OF INFLUENZA VIRUS - The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens' eggs for over 50 years, but recently there have been considerable efforts to develop cell culture systems for vaccine production. In one embodiment, the invention provides a nucleic acid comprising an influenza gene segment and a bacteriophage polymerase promoter or a complementary strand of said nucleic acid, and a cell comprising such a nucleic acid capable of producing desired influenza virus. In another embodiment, the invention provides a composition comprising a cell or material derived from a cell according to the invention and a virus or material derived from a viral particle according to the invention. | 06-21-2012 |
20120101023 | METHOD OF DIAGNOSING BLADDER CANCER - The present invention relates to a method of diagnosing cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated. | 04-26-2012 |
20120088811 | METHOD FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA - The invention is in the field of molecular medicine and provides methods for the treatment of acute myeloid leukemia. These methods are based on the observation that microRNA-9 and microRNA-9* are involved in the pathogenesis of the disease in that the overexpression of microRNA-9/9* block myeloid differentiation in vitro. More in particular, microRNA-9/9* were found to play a role in leukemic transformation in acute myeloid leukemia. | 04-12-2012 |
20120022026 | METHOD OF TREATING CANCER - The present invention relates to a method of treating or preventing hyperproliferative disease in a body tissue of a subject, comprising the steps of administering to a subject in need thereof a therapeutically effective amount of an agent that induces double strand breaks in the DNA of the hyperproliferative cells of said body tissue; and subjecting the hyperproliferative cells of said body tissue prior to, simultaneously with or subsequent to step a) to hyperthermia to thereby induce in said cells the degradation, inhibition and/or inactivation of BRCA2. | 01-26-2012 |
20110312534 | METHOD FOR PREDICTION OF HUMAN IRIS COLOR - A method for predicting the iris color of a human, the method comprising:
| 12-22-2011 |
20110281270 | EFFICIENT DETECTION OF DOUBLE MUTANTS OF THE CEBPA GENE IN ACUTE MYELOID LEUKEMIA - The invention is in the field of molecular diagnostics for cancer, in particular, for acute myeloid leukemia (AML). The invention provides methods for diagnosing AML patients with a favorable prognosis. We have found that not all AML patients carrying a CEBPA mutation may have a more favorable prognosis. We found that only the group with double mutations, i.e., biallelic mutations, have a particularly favorable prognosis. We also found a method that distinguishes mono-allelic CEBPA mutations from bi-allelic mutations. | 11-17-2011 |
20110200584 | METHOD TO STIMULATE IMMUNE FUNCTION AND REGENERATION - The present relates to a method to stimulate thymocytes to differentiate, proliferate and increase thymic output by administration of a hormone-based reagent. | 08-18-2011 |
20110185442 | Method of generating transgenic organisms using transposons - The invention relates to a method for generating a transgenic organism. The invention also relates to a method for detecting and characterizing a genetic mutation in a transgenic organism. The invention further relates to a method for isolating a gene which is correlated with a phenotypic characteristic in a transgenic animal. The invention further relates to a method for isolating an exon in a transgenic animal. The invention also relates to a method for modulating the expression of a gene in an organism. | 07-28-2011 |
20110129472 | METHODS FOR CONTROLLING VASCULOGENESIS - The present invention relates to a method for detecting the presence and/or progress of vasculogenesis in a subject, said method comprising the steps of detecting the presence of activated endothelial progenitor cells (EPCs) in a sample of a circulation fluid of said subject. | 06-02-2011 |
20110123534 | NOVEL COMPOUNDS FOR MODULATING NEOVASCULARISATION AND METHODS OF TREATMENT USING THESE COMPOUNDS - The invention relates to a method for modulating neovascularisation comprising administering to a subject one or more compound selected from an isolated nucleic acid molecule comprising a gene selected from the group consisting of RIKEN cDNA 9430020K01, Agtrl1, Apelin, Stabilin 1, Stabilin 2, TNFaip8l1, TNFaip8 and FGD5, and homologues thereof; a gene product encoded by said genes or their homologues genes, and functional fragments thereof; an antibody or derivative thereof directed against a gene product of said genes or their homologues genes, and functional fragments thereof; an antisense molecule capable of binding to a gene or an mRNA gene product of said genes and homologues thereof; a small molecule interfering with a biological activity of a gene product of said genes and homologues thereof, and a (glyco)protein, a hormone and other biologically active compounds capable of interacting with said genes and homologues thereof or with a gene product thereof. | 05-26-2011 |
20110083199 | Non-Human Animal Model for Cardiovascular Disease Characterized by a Disrupted Fibulin-4 Gene - The invention relates to an animal model of cardiovascular disease and a method of preparation and use thereof. In particular, it relates to a genetically engineered animal model of aortic aneurysms and methods for screening drugs using the animal model. Provided is a genetically-modified, non-human mammal, wherein the modification results in a disrupted Fibulin-4 gene. Also provided is a genetically-modified animal cell containing a disrupted Fibulin-4 gene. The mammal or animal cell can be used as a model for a cardiovascular condition or disease, preferably aortic aneurysm, more preferably thoracic aortic aneurysm. Furthermore, methods for identify or validating a compound that can be used to treat or to prevent an aberrant cardiovascular condition are provided, as well as method to identify a gene involved in the response to aortic failure. | 04-07-2011 |
20110027808 | METHODS AND KITS FOR DETECTING TUMOR-SPECIFIC FUSION PROTEINS - The invention relates to the field of cancer diagnosis and the application of diagnostic techniques in pathology and hematology. Specifically, the invention relates to improved flow cytometric techniques, and kits related thereto, for the detection of chromosomal aberrations and the detection of tumor specific gene products exclusively expressed by tumor cells. | 02-03-2011 |
20110008346 | BIOMARKERS FOR CARDIOVASCULAR DISEASE - The present invention relates to a method of diagnosis or prognosis of cardiovascular disease in a subject, said method comprising the steps of detecting the presence of activated endothelial progenitor cells (EPCs) in a sample of a circulation fluid of said subject. The invention further relates to biomarkers for diagnosis or prognosis of cardiovascular disease in a patient, said biomarker comprising the expression product of a gene the expression of which is regulated during vasculogenesis. | 01-13-2011 |
20100312134 | Apparatus for Evaluation of a Device for Measuring Lung Diffusion Capacity - A test apparatus for evaluating a measuring device for measuring a diffusion capacity of a person's lungs by measuring a change of concentration of a gas species in a mixture, when the mixture is inhaled and subsequently exhaled by a person, wherein the test apparatus includes (a) a port for connecting to the measuring device; (b) a compartment coupled to the port; (c) a circulation circuit configured to circulate gas from the compartment back to the compartment; and (d) a gas species removing element configured to selectively reduce a partial pressure of the gas species at a point in the circulation circuit. | 12-09-2010 |
20100291612 | Peptide Markers for Diagnosis of Preeclampsia - The present invention relates to a method for detecting preeclampsia, comprising determining the expression level of calcyclin in chorionic villi. The invention further relates to a marker for detecting preeclampsia wherein said marker is calcyclin. | 11-18-2010 |
20100240088 | Peptide Markers for Diagnosis of Angiogenesis - The present invention relates to a method for detecting physiological or pathological blood vessel formation, preferably glioma activity, comprising determining the expression level of colligin 2 in blood, cerebrospinal fluid or tissue vasculature. The invention further relates to the use of a method for detecting physiological or pathological blood vessel formation wherein said use is for monitoring a disease process; a healing process; or a response to a disease therapy. | 09-23-2010 |
20100191116 | Method, A Computer Program And An Apparatus For Quantification Of A Degree Of Obstruction In A Liquid Passageway - The invention relates to a method for quantification of a degree of obstruction in a liquid passageway, notably a male urethra. Data related to sonic waves generated by a liquid passing the obstruction may be accessed from a suitable file, or, alternatively may be directly obtained as a result of a measuring step | 07-29-2010 |
20100003677 | IDENTIFICATION OF TUMOR SUPPRESSOR GENES IN AN ACUTE MYELOID LEUKAEMIA MODEL - The present invention comprises a method method to identify tumor suppressor genes by detecting genes in a mouse retroviral insertion mutagenesis model which expression is inhibited by methylation of the viral insertion or the VIS-flanking gene. This is preferably accomplished by first randomly cutting the mouse genomic DNA, immunoprecipitating the methylated DNA and amplifying the VIS-flanking DNA by inverse PCR, optionally followed by cloning and sequencing of the amplicons. | 01-07-2010 |
20090215055 | Genetic Brain Tumor Markers - The invention relates to method of genetic analysis for the prediction of treatment sensitivity and survival prognosis of patients with brain tumors, especially oligodendroglial tumors. The invention provides a method for producing a classification scheme for oligodendroglial tumors comprising the steps of a) providing a plurality of reference samples, said reference samples comprising cell samples from a plurality of reference subjects suffering from oligodendroglial tumors; b) providing reference profiles by establishing a gene expression profile for each of said reference samples individually; c) clustering said individual reference profiles according to similarity; and d) assigning an oligodendroglial tumor class to each cluster. | 08-27-2009 |
20090038371 | Method and Apparatus for Evaluation of a Device for Measuring Lung Diffusion Capacity - A method of evaluating a measuring device for measuring, in normal operation, a diffusion capacity of a person's lungs by measuring a change of concentration of a gas species in a mixture, when the mixture is inhaled and subsequently exhaled by the person or imposed by an artificial ventilator, the method comprising the steps of: (a) receiving the mixture in a compartment; (b) circulating gas from the compartment back to the compartment through a circulation circuit; and (c) selectively reducing partial pressure of the gas species in the circulation circuit to a predetermined level. A device for implementing the evaluation method is also disclosed. | 02-12-2009 |