ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Patent applications |
Patent application number | Title | Published |
20160033771 | METHOD AND APPARATUS FOR HEAD WORN DISPLAY WITH MULTIPLE EXIT PUPILS - A method for displaying an image viewable by an eye, the image being projected from a portable head worn display, comprises steps of: emitting a plurality of light beams of wavelengths that differ amongst the light beams; directing the plurality of light beams to a scanning mirror; modulating in intensity each one of the plurality of light beams in accordance with intensity information provided from the image, whereby the intensity is representative of a pixel value within the image; scanning the plurality of light beams in two distinct axes with the scanning mirror to form the image; and redirecting the plurality of light beams to the eye using a holographic optical element acting as a reflector of the light beams, whereby the redirecting is dependent on the wavelength of the light beam, to create for each light beam an exit pupil at the eye that is spatially separated from the exit pupils of the other light beams. | 02-04-2016 |
20150335488 | APPARATUS AND METHODS FOR TREATING EXCESS INTRAOCULAR FLUID - An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure. | 11-26-2015 |
20140329867 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS - The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers. | 11-06-2014 |
20140277258 | MICROFABRICATED SURFACE NEUROSTIMULATION DEVICE AND METHODS OF MAKING AND USING THE SAME - Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged along an supportive backing layer. The microelectrode elements are dimensioned and shaped so as to target individual neurons, groups of neurons, and neural tissue as may be located in an animal nervous system, such as along a region of a cortex of a human brain. Beneficially, the neurological probe can be used to facilitate location of the neurological target and remain implanted for long-term monitoring and/or stimulation. | 09-18-2014 |
20140187611 | MITOCHONDRIAL RIBOSOMAL PROTEINS AS AGING REGULATORS - The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrial disease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods for screening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject. | 07-03-2014 |
20140060641 | REDOX COUPLE FOR ELECTROCHEMICAL AND OPTOELECTRONIC DEVICES - The present invention provides an improved redox couple for electrochemical and optoelectronic devices. The redox couple is based on a complex of a first row transition metal, said complex containing at least one mono-, bi-, or tridentate ligand comprising a substituted or unsubstituted ring or ring system comprising a five-membered N-containing heteroring and/or a six-membered ring comprising at least two heteroatoms, at least one of which being a nitrogen atom, said five- or six-membered heteroring, respectively, comprising at least one double bond. The invention also relates to electrolytes and to the devices containing the complex, and to the use of the complex as a redox couple. The invention further provides electrochemical and/or optoelectronic devices comprising a first and a second electrode and, between said first and second electrode, a charge transport layer, said a charge transport layer comprising tetracyanoborate ([B(CN) | 03-06-2014 |
20130341527 | ELECTRON BEAM APPARATUS - A method suitable for preparing a specimen for inspection, the method comprising the steps of: irradiating a photocathode so that the photocathode emits electrons from a surface of the photocathode, wherein the emitted electrons each follow a trajectory, and the trajectories of the electrons are such that they can be extrapolated to intersect at a region within the photocathode, the region defining a virtual source, and wherein the photocathode comprises a rounded tip which has a radius of curvature; configuring the emitted electrons so that they form an electron beam; focusing the electron beam onto a specimen to form an image of the virtual source on the specimen. There is further provided a corresponding electron beam apparatus. | 12-26-2013 |
20130211424 | ADJUSTABLE FIXATION SYSTEM FOR NEUROSURGICAL DEVICES - The system comprises at least a support ( | 08-15-2013 |
20130130291 | Labelling of Fusion Proteins with Synthetic Probes - The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O | 05-23-2013 |
20130085361 | DEVICE FOR INTERACTING WITH NEUROLOGICAL TISSUE AND METHODS OF MAKING AND USING THE SAME - Described herein are microelectrode array devices, and methods of fabrication, assembly and use of the same, to provide highly localized neural recording and/or neural stimulation to a neurological target. The device includes multiple microelectrode elements arranged protruding shafts. The protruding shafts are enclosed within an elongated probe shaft, and can be expanded from their enclosure. The microelectrode elements, and elongated probe shafts, are dimensioned in order to target small volumes of neurons located within the nervous system, such as in the deep brain region. Beneficially, the probe can be used to quickly identify the location of a neurological target, and remain implanted for long-term monitoring and/or stimulation. | 04-04-2013 |
20130057869 | COMPLEX INDEX REFRACTION TOMOGRAPHY WITH SUB LAMBDA/6-RESOLUTION - The present invention discloses a method to improve the image resolution of a microscope. This improvement is based on the mathematical processing of the complex field computed from the measurements with a microscope of the wave emitted or scattered by the specimen. This wave is, in a preferred embodiment, electromagnetic or optical for an optical microscope, but can be also of different kind like acoustical or matter waves. The disclosed invention makes use of the quantitative phase microscopy techniques known in the sate of the art or to be invented. In a preferred embodiment, the complex field provided by Digital Holographic Microscopy (DHM), but any kind of microscopy derived from quantitative phase microscopy: modified DIC, Shack-Hartmann wavefront analyzer or any analyzer derived from a similar principle, such as multi-level lateral shearing interferometers or common-path interferometers, or devices that convert stacks of intensity images (transport if intensity techniques: TIT) into quantitative phase image can be used, provided that they deliver a comprehensive measure of the complex scattered wavefield. The hereby-disclosed method delivers superresolution microscopic images of the specimen, i.e. images with a resolution beyond the Rayleigh limit of the microscope. It is shown that the limit of resolution with coherent illumination can be improved by a factor of 6 at least. It is taught that the gain in resolution arises from the mathematical digital processing of the phase as well as of the amplitude of the complex field scattered by the observed specimen. In a first embodiment, the invention teaches how the experimental observation of systematically occurring phase singularities in phase imaging of sub-Rayleigh distanced objects can be exploited to relate the locus of the phase singularities to the sub-Rayleigh distance of point sources, not resolved in usual diffraction limited microscopy. In a second, preferred embodiment, the disclosed method teaches how the image resolution is improved by complex deconvolution. Accessing the object's scattered complex field—containing the information coded in the phase—and deconvolving it with the reconstructed complex transfer function (CTF) is at the basis of the disclosed method. In a third, preferred embodiment, it is taught how the concept of “Synthetic Coherent Transfer Function” (SCTF), based on Debye scalar or Vector model includes experimental parameters of MO and how the experimental Amplitude Point Spread Functions (APSF) are used for the SCTF determination. It is also taught how to derive APSF from the measurement of the complex field scattered by a nanohole in a metallic film. In a fourth embodiment, the invention teaches how the limit of resolution can be extended to a limit of λ/6 or smaller based angular scanning. In a fifth embodiment, the invention teaches how the presented method can generalized to a tomographic approach that ultimately results in super-resolved 3D refractive index reconstruction. | 03-07-2013 |
20130017374 | CARBON NANOTUBES NANOCOMPOSITES FOR MICROFABRICATION APPLICATIONSAANM Mionic; MarijanaAACI LausanneAACO CHAAGP Mionic; Marijana Lausanne CHAANM Magrez; ArnaudAACI MieussyAACO FRAAGP Magrez; Arnaud Mieussy FRAANM Forro; LaszloAACI EcublensAACO CHAAGP Forro; Laszlo Ecublens CHAANM Jiguet; Sebastien MauriceAACI Chavannes-pres-RenensAACO CHAAGP Jiguet; Sebastien Maurice Chavannes-pres-Renens CHAANM Judelewicz; Moshe PatrickAACI PullyAACO CHAAGP Judelewicz; Moshe Patrick Pully CHAANM Stora; ThierryAACI ThoiryAACO FRAAGP Stora; Thierry Thoiry FR - A composite epoxy resin consisting in a SU-8 epoxy resin, a solvent, with or without photoinitiator and carbon nanotubes in powder. When the resin is combined with the carbon nanotubes, the mechanical, thermal and electrical properties of the nanocomposite are enhanced. That offers a wide range of composites which can be used with different micro-fabrication techniques, such as: lamination, spin-coating, spraying and screening for assembly, interconnect and packaging applications. | 01-17-2013 |
20120313798 | Encoding and Decoding Information - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for encoding and decoding information. In one aspect, methods of encoding information in an encoder include receiving a signal representing information using a collection of discrete digits, converting, by an encoder, the received signal into a time-based code, and outputting the time-based code. The time-based code is divided into time intervals. Each of the time intervals of the time-based code corresponds to a digit in the received signal. Each digit of a first state of the received signal is expressed as an event occurring at a first time within the corresponding time interval of the time-based code. Each digit of a second state of the received signal is expressed as an event occurring at a second time within the corresponding time intervals of the time-based code, the first time is distinguishable from the second time. | 12-13-2012 |
20120178062 | Haptic Interface for Simulator, Such as a Colonoscopy Simulator - A device for endoscopic simulation includes an endoscopic interface with a guiding tube for guiding an endoscope. The tube is mounted on bearings for free rotation and includes windows for allowing a contact between the endoscope and friction rollers for tracking axial displacement of the endoscope and for imposing a linear force feedback on the endoscope. One friction roller is connected to a motor for transmission of torque generated by the motor. Another friction roller is connected to an encoder for tracking its axial displacement. The device further includes an axial brake for blocking axial movement of the endoscope while allowing rotation of the endoscope. The axial brake includes two pairs of brake rollers placed around the endoscope. One pair of brake rollers is movable relatively to another pair for realizing the axial blocking. One friction roller is mounted on the tube via a lever actuated by spring means for allowing smooth insertion of endoscopes having different sizes and ensuring sufficient contact force on the endoscope of the brake rollers. | 07-12-2012 |
20120134381 | VERTICAL CAVITY SURFACE EMITTING DEVICES INCORPORATING WAFER FUSED REFLECTORS - A method of forming an optoelectronic device comprising growing a first multi-layer | 05-31-2012 |
20120119926 | Encoding and Decoding Information - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for encoding and decoding information. In one aspect, methods of encoding information in an encoder include the actions of receiving a signal representing information using a collection of discrete digits, converting, by an encoder, the received signal into a time-based code, and outputting the time-based code. The time-based code is divided into time intervals. Each of the time intervals of the time-based code corresponds to a digit in the received signal. Each digit of a first state of the received signal is expressed as a event occurring at a first time within the corresponding time interval of the time-based code. Each digit of a second state of the received signal is expressed as a event occurring at a second time within the corresponding time intervals of the time-based code, the first time is distinguishable from the second time. All of the states of the digits in the received signal are represented by events in the time-based code. | 05-17-2012 |
20110299555 | ERROR CONTROL CODING FOR ORTHOGONAL DIFFERENTIAL VECTOR SIGNALING - Using a transformation based, at least in part, on a non-simple orthogonal matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. The transformation may be combined with methods from forward error correction to lower the required transmission power. | 12-08-2011 |
20110236432 | Coated Medical Device and Method of Coating a Medical Device to Reduce Fibrosis and Capsule Formation - Coating for a medical device comprising cell-adhesive proteins having the ability to reduce fibrous reaction, said coating being in the form of separate islets having an individual area which is less than 12 μm | 09-29-2011 |
20110207157 | Labelling of Fusion Proteins With Synthetic Probes - The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O | 08-25-2011 |
20110201514 | Methods Using 06-Alkylguanine-DNA Alkytransferase - A method of using O | 08-18-2011 |
20110165593 | Mutants of 06-Alkylguanine-DNA Alkyltransferase - The invention relates to AGT mutants showing, when compared to the wild type human AGT, two or more advantageous properties selected from (a) reduced DNA interaction; (b) localisation of the expressed protein in eukaryotic cells that is no longer restricted to the nucleus; (c) improved expression yield as soluble protein and improved stability in various hosts; (d) improved stability under oxidising conditions; (e) improved stability within cells after reaction with a substrate; (f) improved stability outside cells before and after reaction with a substrate; (g) improved in vitro solubility; (h) improved reactivity against O | 07-07-2011 |
20110106062 | System and Method For In Vivo Delivery of Antibodies and Fragments Thereof - The present invention is directed to devices and methods for in situ delivering an antibody or a fragment thereof to a host. In particular, the invention relates to devices and methods for in situ delivering an antibody or a fragment thereof to patient suffering for a neurodegenerative disorder or other diseases treated by antibody administration. | 05-05-2011 |
20100248388 | Solid Phase Extraction and Ionization Device - A plate for laser desorption ionization mass spectrometry comprising an electrically conductive substrate ( | 09-30-2010 |
20100133636 | SINGLE PHOTON DETECTOR AND ASSOCIATED METHODS FOR MAKING THE SAME - A semiconductor device includes a semiconductor substrate, a photon avalanche detector in the semiconductor substrate. The photon avalanche detector includes an anode of a first conductivity type and a cathode of a second conductivity type. A guard ring is in the semiconductor substrate and at least partially surrounds the photon avalanche detector. A passivation layer of the first conductivity type is in contact with the guard ring to reduce an electric field at an edge of the photon avalanche detector. | 06-03-2010 |
20100090105 | Ionization Device - A plate for matrix-assisted laser desorption ionization (MALDI) mass spectrometry comprising an electrically conductive substrate ( | 04-15-2010 |
20100075394 | Method of Crosslinking Two Objects of Interest - The invention provides a method of crosslinking two objects of interest, comprising the steps of: i) providing a fusion protein comprising at least a first protein and a second protein, wherein both the first and the second protein are, based on their structure and function, capable of forming a covalent bond with given substrates, and which first and second proteins are of substantially non-overlapping substrate selectivity, preferably of different substrate specificity; ii) providing a first object of interest, comprising a substrate moiety for the first protein of the said fusion protein, and providing a second object of interest, comprising a substrate moiety for the second protein of the said fusion protein; and iii) reacting said first protein of the fusion protein with the substrate moiety of said first object, and reacting said second protein of the fusion protein with the substrate moiety of said second object, thereby covalently crosslinking the first object to the second object via the said fusion protein. Most prominent applications of the disclosed method are, due to the straight-forward, reliable, directional and fast crosslinking reactions: the derivatization of cells, antibodies and the crosslinking of proteins. | 03-25-2010 |
20100014642 | COLLIMATOR - The present invention is directed to a collimator that comprises grooves or channels in the submicrometer to micrometer range. The present invention is also related to uses of a collimator and collimator holder as described herein as well as apparatuses comprising the same. | 01-21-2010 |
20100009409 | MOLECULAR VARIANT FIBRINOGEN FUSION PROTEINS - Fibrinogen fusion proteins, methods of making, and methods of using fibrinogen fusion proteins are described. In a preferred embodiment the fibrinogen fusion protein contains a truncated Aα chain of fibrinogen. The Aα chain contains truncation site, which is a deletion of amino acids at its C-terminal region. A non-fibrinogen protein or peptide is C-terminally attached to the truncation site. The fibrinogen fusion proteins can be used alone or mixed with native fibrinogen to form fibrin polymer. | 01-14-2010 |
20100006441 | APPARATUS FOR MANIPULATING, MODIFYING AND CHARACTERIZING PARTICLES IN A MICRO CHANNEL - Microfluidic system comprising a space for containing a liquid and at least one lateral chamber in communication with said space, said lateral chamber containing a metal electrode. The lateral chamber and the space are designed to be filled by the same or different liquid when the system is active. | 01-14-2010 |
20090305286 | Method for the Identification of Suitable Fragmentation Sites in a Reporter Protein - The invention concerns a combinatorial method for the generation of new split-protein sensors, and its application towards the (β/α) | 12-10-2009 |
20090143597 | Ionic Liquids Based on Imidazolium Salts Incorporating a Nitrile Functionality - Novel chemical compounds of the general formula | 06-04-2009 |
20090068275 | Process for the Manufacture of Powders of Inhalable Medicaments - The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor
| 03-12-2009 |