| EASTERN VIRGINIA MEDICAL SCHOOL Patent applications |
| Patent application number | Title | Published |
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| 20120016030 | METHOXYPOLYETHYLENE GLYCOL THIOESTER CHELATE AND USES THEREOF - The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to remove electrons from free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca | 01-19-2012 |
| 20110236979 | Apparatus for Generating Electrical Pulses and Methods of Using Same - A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude. | 09-29-2011 |
| 20110136166 | Imaging Mass Spectrometry for Improved Prostrate Cancer Diagnostics - The invention provides biomarkers that can discriminate between prostate cancer and normal tissue as well as identification of associated metastatic disease. One biomarker was identified as a peptide fragment of MEKK2. Methods of diagnosing prostate cancer, including metastatic cancer, by detecting the differential expression of one or more biomarkers are also provided. | 06-09-2011 |
| 20110092973 | NANOSECOND PULSED ELECTRIC FIELDS CAUSE MELANOMAS TO SELF-DESTRUCT - Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin. | 04-21-2011 |
| 20110082375 | TRANSVAGINAL ULTRASOUND PROBE SPECULUM - A transvaginal ultrasound probe speculum is designed for use with a generally cylindrical elongated ultrasound probe. The speculum has an elongated blade having a proximal end and a distal end, and a connector, such as a collar. The speculum has a lever that cooperates with the collar and the elongated blade for pivoting the blade relative to the ultrasound probe so that the blade and the ultrasound probe serve as the blades of the speculum. | 04-07-2011 |
| 20110079226 | CERVICAL OCCLUDER - A device for occluding a cervix has an elongated conduit sized and shaped to extend from a proximal end outside the vagina to a distal end near the cervix. A loop sized to fit around an exocervix is provided at the distal end. The loop is sufficiently flexible to be tightened and loosened around the exocervix. The device has a rod inside the conduit. The rod has a distal end and a proximal end, and the loop is joined to the distal end of the rod. Moving the rod longitudinally relative to the conduit tightens or loosens the loop. | 04-07-2011 |
| 20110045590 | CALCIUM-INFLUX INHIBITORY FACTOR AND METHOD OF ISOLATION THEREOF - A purified factor isolated from human milk is provided. The factor is capable of inhibiting calcium-influx activity in polymorphonuclear leukocytes. A method for purification of the factor is also provided. | 02-24-2011 |
| 20110039798 | SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES - The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS. | 02-17-2011 |
| 20100298645 | MAGNARETRACTOR SYSTEM AND METHOD - A system and method for performing surgical procedures within a body cavity, e.g. abdomen, uses a magnetized device is utilized to allow a surgeon to control intra-abdominal organs and objects. The system and method allows a surgeon to perform an intra-abdominal procedure without the need to position surgical tools inside of the body cavity. Additional surgical ports are not necessary as the magnetized device allows the surgeon to retract or position various objects within the abdomen. | 11-25-2010 |
| 20100055106 | METHODS FOR REGULATING COMPLEMENT CASCADE PROTEINS USING ASTROVIRUS COAT PROTEIN AND DERIVATIVES THEREOF - The present invention provides a method for modulating the complement cascade by depleting the plasma of the functional activity of complement proteins and thereby reducing or eliminating complement-mediated cell lysis. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated cell lysis and peptide mediators of inflammation. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated diseases. Methods are described herein where complement cascade, triggered by either the classical or alternative complement pathways, is prevented from effecting cell lysis and inflammation due to inhibition or depletion of one or more complement components in the serum following administration of astrovirus coat proteins or derivatives. | 03-04-2010 |
| 20090306205 | METHOXYPOLYETHYLENE GLYCOL THIOESTER CHELATE AND USES THEREOF - The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the production of free radicals or oxidants such as peroxides, superoxide anions, hydroxyl radicals or nitric oxides, or heavy metal cations. More particularly, the present invention is concerned with methoxypolyethylene glycol thioester chelate methyl esters that are useful as protectors against tissue damage by penetrating the cell membrane to donate electrons to free radical oxidants and remove heavy metals that may react with peroxides to produce the reactive hydroxyl radical, or remove Ca++ that may be released from organelles. These chelate esters will also have utility in reducing intraocular pressure in glaucoma patients. | 12-10-2009 |
| 20090305212 | System, method and medium for simulating normal and abnormal medical conditions - The present invention provides a system, method and medium for simulating medical conditions to facilitate medical training, that utilizes a roaming device configured to be mobile; a positioning device configured to determine location information of the roaming device; and a computing device configured to receive the location information, compare the location information with a predetermined set of regions, and transmit information indicative of a medical condition when the location information coincides with the predetermined set of regions. | 12-10-2009 |
| 20090275924 | Systems and Methods for Monitoring and Controlling Internal Pressure of an Eye or Body Part - Systems and methods for automatically monitoring and controlling pressure in a body part are disclosed. The systems include an implantable tube with one open end of the tube implanted in the body part, an implantable valve coupled with the tube having at least one open state and a closed state, an implantable sensor for measuring pressure, and an implantable control device coupled with the sensor and the valve. The control device switches the valve between the at least one open state and the closed state, based on pressure information received from the sensor. When the valve is in the at least one open state, the tube drains fluids from the body part due to a difference of pressure between the open ends of the tube. Methods for using the systems to administer drugs and monitor and control fluid pressures in various biological systems are also disclosed. | 11-05-2009 |
| 20090220574 | SURAMIN AND DERIVATIVES THEREOF AS TOPICAL MICROBICIDE AND CONTRACEPTIVE - The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein. | 09-03-2009 |
| 20090215085 | Proteomic Fingerprinting of Human IVF-Derived Embryos: Identification of Biomarkers of Developmental Potential - The present invention discloses biomarkers and biomarker combinations that have prognostic value as predictors of the developmental potential of individual IVF-derived human embryos. In particular, the biomarkers of this invention are useful to classify an embryo with implantation competence after uterine transfer or implantation incompetence. In addition, the biomarkers can be detected by non-invasive methods that do not harm the developing embryo. Also disclosed are kits for the prediction of developmental potential that detect the biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of developmental potential. | 08-27-2009 |
| 20090204334 | LUNG CANCER BIOMARKERS - Disclosed are protein biomarkers and their use in diagnosing lung cancer or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of lung cancer that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of lung cancer. In certain aspects of the invention, the methods include use of a decision tree analysis. Various computer readable media and their use according to the invention are also disclosed. | 08-13-2009 |
| 20090011998 | CALCIUM-INFLUX INHIBITORY FACTOR AND METHOD OF ISOLATION THEREOF - A purified factor isolated from human milk is provided. The factor is capable of inhibiting calcium-influx activity in polymorphonuclear leukocytes. A method for purification of the factor is also provided. | 01-08-2009 |
| 20080248500 | Apolipoprotein A-II Isoform As A Biomarker For Prostate Cancer - The present invention provides a protein-based biomarker, ApoA-II isoform, that is useful in determining prostate cancer status in a patient. In particular, the biomarker of this invention is useful to classify a biological sample as prostate cancer or non-prostate cancer. The ability of ApoA-II to detect disease in patients with a normal prostate-specific antigen (PSA) makes the biomarker of this invention useful in identifying indolent disease. The biomarker can be detected by SELDI mass spectrometry, HPLC, PAGE and Western blotting. | 10-09-2008 |
