| DH TECHNOLOGIES DEVELOPMENT PTE. LTD. Patent applications |
| Patent application number | Title | Published |
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| 20120091334 | METHOD OF OPERATING TANDEM ION TRAPS - A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time. | 04-19-2012 |
| 20120025070 | METHOD AND APPARATUS FOR ENHANCED ION MOBILITY BASED SAMPLE ANALYSIS USING VARIOUS ANALYZER CONFIGURATIONS - A ion mobility-based analyzer system including a first ion mobility-based filter for passing selected ions through a time-varying field where the time-varying field being compensated by an adjustable compensation setting. The analyzer also includes a second ion mobility-based filter for receiving a first portion of ions from the first ion mobility-based filter. The second ion mobility-based filter includes a voltage gradient for separating ions of the first portion of ions where the ions have associated retention times based on their times of flight through the voltage gradient. The second ion mobility-based filter includes a detector for detecting the ions at their retention times. The analyzer system further includes a display that displays the detected ions in a plot relating the retention times of the ions in the second ion mobility-based filter with compensation settings of the first ion mobility-based filter. | 02-02-2012 |
| 20110278946 | APPARATUS FOR PROVIDING POWER TO A MULTIPOLE IN A MASS SPECTROMETER - An apparatus for providing power to a multipole in a mass spectrometer is provided. The apparatus comprises a first resonant LC circuit; at least one inductor for forming a second resonant LC circuit with the multipole, the second resonant LC circuit connected in cascade with the first resonant LC circuit, when the at least one inductor is connected to the multipole; an RF power source for providing an RF signal; and a step-up transformer connected in parallel to the RF power source on a primary side and the first resonant LC circuit on a secondary side, the step-up transformer providing voltage gain for the RF signal thereby reducing the loaded Q of the resonant LC circuits. | 11-17-2011 |
| 20110278917 | APPARATUS AND METHOD FOR COUPLING RF AND AC SIGNALS TO PROVIDE POWER TO A MULTIPOLE IN A MASS SPECTROMETER - An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit. A second circuit comprises: an AC power source for providing common mode power to the multipole via the AC signal, an output from the second circuit connected to the secondary tap such that the common mode power is injected into the first circuit and the multipole can be operated in common mode and difference mode simultaneously; and at least one inductor for forming a resonant LC circuit with the multipole via the transformer, to provide voltage gain for the AC signal. | 11-17-2011 |
| 20110253888 | INDUCTIVELY COUPLED PLASMA MASS SPECTROMETER - A mass analysis system including a sample inlet arranged to introduce a sample and an ion source coupled to the sample inlet and arranged to ionize a portion of the sample into ions. The system also includes a sampler element having a sample orifice arranged to receive the sample ions into a first vacuum chamber. The system includes a skimmer element having a skimmer orifice arranged to receive the sample ions from the first vacuum chamber into a second vacuum chamber where the skimmer orifice is of a first size. The system further includes a third cone element having a third cone orifice of a second size arranged to receive the sample ions from the second vacuum chamber into a third vacuum chamber where the third cone is configured to allow a continuum flow of ions through the third cone orifice. The third chamber includes an ion optics assembly and mass analyzer. | 10-20-2011 |
| 20110236982 | ANALYSIS OF MASS SPECTRAL DATA IN THE QUIET ZONES - Embodiments of this invention relate to the analysis of mass spectral data in the quiet zones. | 09-29-2011 |
| 20110210241 | Gas Delivery System For Mass Spectrometer Reaction And Collision Cells - A gas delivery system for a cell-based mass spectrometer includes a mass flow controller having an input coupled to a gas source. A three-way valve includes an input coupled to an output of the mass flow controller, a first output coupled to a vacuum system, and a second output normally coupled to a reaction or collision cell. A cell is positioned inside a vacuum chamber of the mass spectrometer where the second output of the three-way valve is coupled to an inlet of the cell and the mass flow controller provides a gas to the cell that increases a pressure inside the cell relative to the pressure in the vacuum chamber. | 09-01-2011 |
| 20110204218 | Method of Processing Ions - A method for obtaining fragment ions having product ion spectrum with a mixture of high, medium and lower energy product ions. The method includes (a) providing a selected RF field to an ion optical element upstream of an ion containment field; (b) transmitting ions through the ion optical element and into the ion containment field such that the selected RF field determines, at least in part, a selected kinetic energy profile of the ions within the ion containment field, wherein the selected kinetic energy profile is selected to fragment the ions to concurrently provide a plurality of groups of product ions; and (c) detecting each group of product ions in the plurality of groups of product ions. | 08-25-2011 |
| 20110183420 | MASS TAG REAGENTS FOR SIMULTANEOUS QUANTITATION AND IDENTIFICATION OF SMALL MOLECULES - A molecule identification and quantitation method is provided wherein a mass tag is conjugated to an analyte and the signature ion of the mass tag remains attached to the analyte after tandem mass spectrometry fragmentation (MS-MS or MS | 07-28-2011 |
| 20110143445 | Analysis of Amino Acids And Amine-Containing Compounds Using Tagging Reagents and LC-MS Workflow - A plurality of mass differential tagging reagents is used to label amine functionality in amine-containing compounds. The labeled analytes have distinct retention times on a reversed phase column, and distinct masses. Under high energy collision, reporter groups can be generated and the intensity or the peak area detected for each reporter group can be used for quantitation. One exemplary set of reagents includes a set of three different mass differential reagents comprising tagging weights of 140 atomic mass units, 144 atomic mass units, and 148 atomic mass units, respectively, with reporter groups of 113, 117, and 121 atomic mass units, respectively. A package including each of the mass differential reagents is also provided and can include separate respective containers, for example, one for each of the different reagents. The package can also include one or more standards each comprising a respective known concentration of a respective known amine-containing compound. | 06-16-2011 |
| 20110091981 | Mass Spectrometry Quantitation of P450 Isoforms in Hepatocytes - A method for screening a drug for cytochrome P450 (CYP) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome P450 isoform. The isoforms can be selected from 2B6, 3A4, 1A2, and 3A5 isoforms. In some embodiments, the method uses liquid chromatography tandem mass spectrometry (LC-MSMS). A quantitated value can be compared to a threshold value and the drug can be determined to exhibit an acceptable CYP induction potential when the quantitated value does not exceed the threshold value. Isolated peptides are also provided. | 04-21-2011 |
| 20110084690 | APPARATUS FOR MEASURING RF VOLTAGE FROM A QUADRUPOLE IN A MASS SPECTROMETER - An apparatus for measuring RF voltage from a quadrupole in a mass spectrometer are provided. The apparatus comprises at least one rectifying diode circuit for rectifying the RF voltage of the quadrupole to produce a rectified RF voltage. The apparatus further comprises at least one operational amplifier configured as a current to voltage converter, a negative input of the at least one operational amplifier connected to the output of at least one diode in the at least one rectifying diode circuit, a positive input of the at least one operational amplifier at ground, and an output of the at least one operational amplifier in a feedback look with the negative input, to reduce reverse leakage current from the at least one diode. | 04-14-2011 |
| 20110057095 | METHOD, SYSTEM AND APPARATUS FOR FILTERING IONS IN A MASS SPECTROMETER - A method and mass spectrometer for filtering ions are provided. The mass spectrometer generally comprises an ion guide, a quadrupole mass filter, a collision cell and a time of flight (ToF) detector, and is enabled to transmit an ion beam through to the ToF detector. The mass spectrometer is operated in MS mode, such that ions in the ion beam remain substantially unfragmented, the quadrupole mass filter operating at a pressure substantially lower than in either of the ion guide and the collision cell. The quadrupole mass filter is operated in a bandpass mode such that ions outside of a range of interest are filtered from the ion beam, leaving ions inside the range of interest in the ion beam. The ions inside the range of interest are analyzed at the ToF detector. | 03-10-2011 |
| 20110042561 | METHODS AND APPARATUS FOR ENHANCED ION BASED SAMPLE DETECTION USING SELECTIVE PRE-SEPARATION AND AMPLIFICATON - The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification. | 02-24-2011 |
| 20110006200 | Methods And Apparatus For Mass Spectrometry With High Sample Utilization - A method of measuring a mass spectrum with high sample utilization includes mass filtering a first group of precursor ions from a mass spectrum that has a first predetermined range of mass-to-charge ratios. At least one type of precursor ion in the first group of precursor ions is then selectively fragmented. A first fragment mass spectrum of the fragmented precursor ions in the first group of precursor ions is measured while maintaining other precursor ions in the first predetermined range of mass-to-charge ratios. A second group of precursor ions having a second predetermined range of mass-to-charge ratios is mass filtered from the mass spectrum. At least one type of precursor ion is selectively fragmented in the second group of precursor ions. A second fragment mass spectrum of the fragmented precursor ions in the second group of precursor ions is then measured. | 01-13-2011 |
| 20110003395 | SPECIFIC ANALYSIS OF ANALYTES USING REAGENT COMPOUNDS, LABELING STRATEGIES, AND MASS SPECTROMETRY WORKFLOW - Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry. | 01-06-2011 |
| 20100243882 | HEATED OPTICAL COMPONENTS - Applicant's teachings relate to apparatuses and methods of cleaning laser optical components, particularly in, for example, but not limited to, high throughput matrix-assisted laser desorption ionization (MALDI) applications. In accordance with various embodiments of applicant's teachings, the optical component is heated. | 09-30-2010 |
| 20100243881 | HEATED TIME OF FLIGHT SOURCE - A lens assembly for use in mass spectrometry and a method for reducing contaminant build up on ion optic components in a lens assembly for use in a mass spectrometer are disclosed herein. In various embodiments of applicant's teachings, the lens assembly comprises a plurality of ion optic components assembled to form an ion lens and a heater. The plurality of ion optic components has a generally similar expansion coefficient. The heater is operatively coupled to the ion optic components. The heater heats the ion optic components to reduce the accumulation of debris on the ion optic components. In various embodiments, the method includes receiving, in a lens assembly, ions from an ion source. The lens assembly includes a plurality of ion optic components assembled to form an ion lens, the plurality of ion optic components having a generally similar expansion coefficient. The method also comprises heating the ion optic components to a first temperature. | 09-30-2010 |
| 20100207023 | APPARATUS AND METHOD OF PHOTO FRAGMENTATION - A method of photo-fragmentation is provided generating a beam of ions from a sample with an ion source, filtering the beam of ions in a filtering region to select desired ions, and photo-fragmenting the desired ions in a photo-fragmentation region having a higher pressure than the filtering region to generate fragment ions predominantly by prompt fragmentation. An apparatus for photo-fragmentation is provided having an ion source configured to generate a beam of ions from a sample, a filtering region for selecting desired ions, a photo-fragmentation region having a higher pressure than the filtering region to generate predominantly prompt fragmentation of the selected desired ions, an inlet for providing gas to the photo-fragmentation region to maintain a pressure in the photo-fragmentation region that is higher than the pressure in the filtering region, and a photon source emitting a beam of light for photo-fragmenting the selected ions in the photo-fragmentation region. | 08-19-2010 |
