| DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN Patent applications |
| Patent application number | Title | Published |
|---|
| 20120045458 | USE OF NOTCH REGULATORS FOR MODULATING THE IMMUNE RESPONSE BY INDUCTION/SUPPRESSION OF INTERLEUKIN-22 - The invention relates to the use of notch regulators for modulating IL-22 production in T-cells, by influencing the activity or activation of the notch signal path. The invention further relates to the use of modulating the immune response, primarily in case of infection reactions. The invention in particular relates to the use for treating illnesses associated with infections. The invention further relates to the use for reducing IL-22 production in T-cells. | 02-23-2012 |
| 20100136022 | METHOD FOR MODULATING THE IMMUNE RESPONSE BY ACTIVATING OR INACTIVATING THE NOTCH AND/OR STAT4 SIGNAL PATH - The invention relates to a method for modulating the inflammatory potential of T cells, in particular by regulating the IL-10 production in pro-inflammatory T cells, by influencing the activity or activation of the Notch and STAT4 signaling pathways. The invention also relates to the use of the method for inhibiting inflammations or in immunosuppression. More specifically, the invention relates to the use of the method in the treatment of diseases associated with inflammations. Furthermore, the invention relates to the use of the method for reducing the IL-10 production in pro-inflammatory T cells and thus the enhancement of T cell-mediated immune reaction, especially in the event of infections, tumor diseases or vaccinations against infections or tumors. | 06-03-2010 |
| 20100055720 | USE OF THE 4-lBB RECEPTOR FOR IDENTIFYING AND/OR SEPARATING ACTIVATED REGULATORY TH CELLS (TREG) - The invention relates to the use of the 4-1BB receptor for identifying and/or separating specific regulatory Th cells after activation with an antigen, polyclonal regulatory Th cells after polyclonal activation and to a method for the identification and/or separation of regulatory Th cells, the regulatory T cells being detected on the basis of the expression of the 4-1BB receptor by an antibody, an antigen or ligands which are coupled to a fluorescent substance, haptenes or magnetic microparticles. The invention also relates to a kit comprising an antibody, an antigen or ligands for detecting the 4-1BB receptor for the identification and/or separation of a regulatory Th cell, the antibody being coupled to a fluorescent substance, haptenes or magnetic microparticles. | 03-04-2010 |
