DEPARTMENT OF VETERANS AFFAIRS Patent applications |
Patent application number | Title | Published |
20150133317 | IDENTIFICATION OF POLYNUCLEOTIDES ASSOCIATED WITH A SAMPLE - Disclosed herein are compositions and methods for sequencing, analyzing, and utilizing samples such as single samples. Also disclosed herein are compositions and methods for matching together two or more sequences from a sample. Also disclosed herein are compositions and methods for expressing and screening molecules of interest. | 05-14-2015 |
20140255424 | BIOMARKERS OF AGING FOR DETECTION AND TREATMENT OF DISORDERS - Provided are methods of diagnosis, prognosis, and monitoring of aging using biomarkers that have been discovered to be linked to biological aging process. Methods for increasing neural cell regeneration and cognitive function are also provided. The methods are, at least in part, based on a discovery that altered expression patterns of certain biological markers are associated with biological aging processes. These markers comprise at least Eotaxin/CCL11, β2-microglobulin, MCP-1 and Haptoglobulin, increased expression of which has been shown to be associated with increase in biological aging process. | 09-11-2014 |
20140221412 | THERAPEUTIC COMPOUNDS AND METHODS - The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating cancer using compounds of formula I. | 08-07-2014 |
20140197950 | SYSTEMS AND METHODS FOR DETECTING OUTAGES IN A MEDICAL RECORD EXCHANGE SYSTEM - Systems and methods for detecting an issue with a message flow between two or more data systems. In an embodiment, at a first time, a number of first request messages and a number of first response messages transmitted or received during a first look-back period are determined. A first ratio is calculated based on these numbers and compared to an alerting threshold. If the first ratio is less than the alerting threshold, an alert is generated. Then, at a second time, a number of second request messages and a number of second response messages transmitted or received during a second look-back period are determined. A second ratio is calculated based on these numbers and compared to a clearing threshold. Based on this comparison, it is determined whether to maintain or clear the alert. | 07-17-2014 |
20140142172 | Medical Food for Cognitive Decline - Nutraceutical formulations that improve cognitive function in adults diagnosed with neurodegenerative disease are provided, which comprise a combination of fisetin and DHA. | 05-22-2014 |
20140093974 | METHODS FOR ASSESSING MODIFIED LDL IMMUNE COMPLEXES IN SUBJECTS HAVING OR AT RISK OF CORONARY ARTERY DISEASE - The present invention relates to the analysis of modified LDL in the context of immune complexes. In particular, ox-LDL and AGE-LDL are shown to predict the development of coronary artery disease and other micro- and macrovascular disorders, particularly in the context of diabetes. | 04-03-2014 |
20130245253 | Conjugated Neuroactive Steroid Compositions And Methods Of Use - The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety. The modified neuroactive steroid can have modified characteristics as compared to native neuroactive steroids that do not include a modifying moiety and/or therapeutic agent. The modified neuroactive steroid may be, for example, modified pregnenolone, pregnenolone metabolites, allopregnanolone, and/or allopregnanolone metabolites. The modified neuroactive steroids can be used to treat, prevent and/or ameliorating a phenotypic state of interest in a subject. | 09-19-2013 |
20130164322 | CULTURED EXTREMOPHILIC ALGAE SPECIES NATIVE TO NEW MEXICO - Provided herein is an extremophile green alga designated as | 06-27-2013 |
20130095139 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
20130095075 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
20130040844 | BIOMARKERS OF AGING FOR DETECTION AND TREATMENT OF DISORDERS - Provided are methods of diagnosis, prognosis, and monitoring of aging using biomarkers that have been discovered to be linked to biological aging process. Methods for increasing neural cell regeneration and cognitive function are also provided. The methods are, at least in part, based on a discovery that altered expression patterns of certain biological markers are associated with biological aging processes. These markers comprise at least Eotaxin/CCL11, 2-microglobulin, MCP-1 and Hap-toglobulin, increased expression of which has been shown to be associated with increase in biological aging process. | 02-14-2013 |
20120295855 | METHODS FOR REDUCING OXIDATIVE STRESS IN A CELL WITH A SULFHYDRYL PROTECTED GLUTATHIONE PRODRUG - The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug. | 11-22-2012 |
20120143038 | FUNCTIONAL ASSESSMENT OF A NETWORK - A computer-implemented method for performing a functional assessment of a network is disclosed. The network includes a plurality of interacting network elements. The method includes measuring a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements, and calculating for each element an associated median value representing a median of the state values associated with that element. The method further includes identifying for each time instance a first total number of elements with an associated state value at that time instance that is above its median value, and a second total number of elements with an associated state value at that time instance that is below its median value, and determining whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance. | 06-07-2012 |
20120023050 | CLASSIFYING AN ITEM TO ONE OF A PLURALITY OF GROUPS - A method of classifying an item to one of a plurality of groups includes providing a plurality of predictors associated with the item. For each predictor, the item is assigned to one of the groups. An assignment number is determined for each group. The item is classified to one of the groups based on the assignment number for each group. | 01-26-2012 |
20110212472 | Asbestos Exposure, Pleural Mesothelioma and Osteopontin Levels - The present invention provides diagnostic and disease progression or recurrence prediction methods based on osteopontin levels in a biological sample. | 09-01-2011 |
20090130083 | Therapeutic Agents Targeting the NCCA-ATP Channel and Methods of Use Thereof - The present invention is directed to therapeutic compositions targeting the NC | 05-21-2009 |
20080229436 | METHODS FOR IDENTIFYING MODULATORS OF LIFESPAN AND RESISTANCE TO OXIDATIVE STRESS - The present invention provides methods for identifying agents that increase lifespan and increase resistance to oxidative and/or electrophilic stress. Also provided are methods for identifying biomarkers of longevity or identifying pathways governing longevity in response to phosphatidylinositol 3,4,5-triphosphate signaling. | 09-18-2008 |