| DEPARTMENT OF VETERANS AFFAIRS Patent applications |
| Patent application number | Title | Published |
|---|
| 20130095139 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
| 20130095075 | BONE MORPHOGENIC PROTEIN BINDING PEPTIDE - A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis. | 04-18-2013 |
| 20130040844 | BIOMARKERS OF AGING FOR DETECTION AND TREATMENT OF DISORDERS - Provided are methods of diagnosis, prognosis, and monitoring of aging using biomarkers that have been discovered to be linked to biological aging process. Methods for increasing neural cell regeneration and cognitive function are also provided. The methods are, at least in part, based on a discovery that altered expression patterns of certain biological markers are associated with biological aging processes. These markers comprise at least Eotaxin/CCL11, 2-microglobulin, MCP-1 and Hap-toglobulin, increased expression of which has been shown to be associated with increase in biological aging process. | 02-14-2013 |
| 20120295855 | METHODS FOR REDUCING OXIDATIVE STRESS IN A CELL WITH A SULFHYDRYL PROTECTED GLUTATHIONE PRODRUG - The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug. | 11-22-2012 |
| 20120143038 | FUNCTIONAL ASSESSMENT OF A NETWORK - A computer-implemented method for performing a functional assessment of a network is disclosed. The network includes a plurality of interacting network elements. The method includes measuring a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements, and calculating for each element an associated median value representing a median of the state values associated with that element. The method further includes identifying for each time instance a first total number of elements with an associated state value at that time instance that is above its median value, and a second total number of elements with an associated state value at that time instance that is below its median value, and determining whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance. | 06-07-2012 |
| 20120023050 | CLASSIFYING AN ITEM TO ONE OF A PLURALITY OF GROUPS - A method of classifying an item to one of a plurality of groups includes providing a plurality of predictors associated with the item. For each predictor, the item is assigned to one of the groups. An assignment number is determined for each group. The item is classified to one of the groups based on the assignment number for each group. | 01-26-2012 |
| 20110212472 | Asbestos Exposure, Pleural Mesothelioma and Osteopontin Levels - The present invention provides diagnostic and disease progression or recurrence prediction methods based on osteopontin levels in a biological sample. | 09-01-2011 |
| 20090130083 | Therapeutic Agents Targeting the NCCA-ATP Channel and Methods of Use Thereof - The present invention is directed to therapeutic compositions targeting the NC | 05-21-2009 |
| 20080229436 | METHODS FOR IDENTIFYING MODULATORS OF LIFESPAN AND RESISTANCE TO OXIDATIVE STRESS - The present invention provides methods for identifying agents that increase lifespan and increase resistance to oxidative and/or electrophilic stress. Also provided are methods for identifying biomarkers of longevity or identifying pathways governing longevity in response to phosphatidylinositol 3,4,5-triphosphate signaling. | 09-18-2008 |
