| Council of Scientific and Industrial Research Patent applications |
| Patent application number | Title | Published |
|---|
| 20120070908 | IMMUNO CONJUGATE AND PROCESS FOR PREPARATION THEREOF - Present invention deals with a new immuno-reagent comprising hapten (MPAD)-protein-gold for pesticides detection. The conjugate MPAD-protein-gold competes with the analyte of interest for a finite number of binding sites provided by anti-atrazine antibodies coated on nitrocellulose membrane. The newly developed conjugate has a long shelf life with high stability at 4° C. The dynamic concentration range for standard atrazine solutions shows a linear inhibition (decrease in intensity of color) between 10 ppb to 1 ppm atrazine in water samples. | 03-22-2012 |
| 20120028295 | SYNERGISTIC COMPOSITION USEFUL AS MICROBIOLOGICAL GROWTH MEDIUM FOR RAPID SCREENING OF PHOSPHATE ACCUMULATING MICROORGANISMS - Screening isolates for phosphate accumulation by quantitative methods requires investment of time, labour and chemicals. There has been paucity of a medium and method for screening phosphate-accumulating microorganisms (PAOs) from the environment. Therefore, a new screening strategy is needed towards isolating effective PAOs in environments with diverse microbial populations and limited organic resources, where it is possible that PAOs are often out-competed by organisms capable of utilising available nutrients more rapidly. In view of these problems, a medium optimal for an efficient screening of P-accumulating microorganisms was developed, which is rapid and allows many PAOs to be screened. Thus, the present invention utilizes Toluidine Blue-O (TBO) a blue coloured dye, which decolorizes due drop in the concentration of phosphate in the medium, as an indicator to quickly evaluate the P-accumulating microorganisms based upon visual observations. Fast decolorization of the dye is an indicator of a superior phosphate accumulating microbe. Therefore, colorimetric reaction using PAM-TBO of the present work was further applied in a novel, extremely high-throughput manner to detect individual microbial isolates, growing on a PAM Petri plate. Adaptation of PAM-TBO assay in screening PAOs in environmental samples for microtitre plate assay enhanced the effectiveness of the assay system efficiently and effectively. | 02-02-2012 |
| 20120016033 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 01-19-2012 |
| 20120000852 | POLYBENZIMIDAZOLE BASED MEMBRANE FOR DEACIDIFICATION - A membrane comprising polybenzimidazole and aromatic polyester wherein said aromatic polyester is removed is disclosed. The membrane is used for a process of deacidification. | 01-05-2012 |
| 20110311628 | PULSATILE RELEASE COMPOSITION OF THERAPEUTIC AGENT - A pulsatile release composition which releases the content rapidly after a predetermined lag time comprising a drug containing a core, coated with a pH sensitive graft copolymer. The coating suppresses the drug release at acidic pH prevalent in the stomach and releases it either immediately or after a lag time in the intestinal region. Combinations of multiple numbers of coated and uncoated units provide a sequential pulsatile release of same or different therapeutic agents. | 12-22-2011 |
| 20110263003 | Microbacterial Peptide Deformylase - The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from | 10-27-2011 |
| 20110245492 | NOVEL ALLELIC VARIANT OF CYP2C19 ASSOCIATED WITH DRUG METABOLISM - The invention provides methods, PCR primers and sequence determination oligonucleotides for determining a human's capacity to metabolise a substrate of the CYP2C19 enzyme using genetic analysis. | 10-06-2011 |
| 20110237827 | FAST ISOLATION METHOD FOR THE NATURAL SCAFFOLD URSOLIC ACID FROM DIOSPYROS MELANOXYLON - The present invention relates to a process for the fast isolation of ursolic acid, a highly potent natural scaffold, from the leaves of | 09-29-2011 |
| 20110184162 | METHOD FOR RAPID ISOLATION OF RNA AND A KIT THEREOF - The present invention relates to a method for rapid isolation of RNA. More particularly, it relates to a method for isolation of RNA using two-solution system. The present invention also relates to a RNA isolation kit. | 07-28-2011 |
| 20110092585 | IMMUNOMODULATORY PHARMACEUTICAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF - The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant | 04-21-2011 |
| 20110076702 | RECOMBINANT 12-KDA PROTEIN USEFUL FOR THE DETECTION OF RESPIRATORY ALLERGIES - The present invention discloses the detection of an important 12K-Da protein having cross-reactivity amongst different prevalent allergenic grasses and fungi can be useful for detection of respiratory allergies. Conventionally, the whole extracts that are used for diagnosis are unable to specifically detect the causative agents. In addition, they are also responsible for additional non-specific sensitivities in patients to other components present in the extract. If a single cross-reactive protein is available, it can replace large number of extracts used for detection of raised IgE levels in allergy by ELISA, immunoblotting and the likes. Further, number of pricks would be reduced and this would benefit both patient and clinicians. It is further realized that production of such a protein by recombinant methods can lead to its availability in pure form and bulk amounts required for routine diagnosis. | 03-31-2011 |
| 20110059913 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL INDICATIONS - The present invention relates to identification of | 03-10-2011 |
| 20100273861 | MYCOBACTERIAL PEPTIDE DEFORMYLASE - The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from | 10-28-2010 |
| 20100234289 | INTEGRIN BINDING RGD-LIPOPEPTIDES WITH GENE TRANSFER ACTIVITIES - The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high L27 (transformed S1 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since 127 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins). | 09-16-2010 |
| 20100228023 | ONE STEP PROCESS FOR THE PREPARATION OF SUBSTITUTED 5, 10-DIHYDRODIBENZO [b,e][1, 4]DIAZEPINE-11-ONES - The present invention provides one step processes for the preparation of substituted dibenzo[b,e][1,4]-diazepine-11-ones by the reaction of substituted isatoic anhydrides with substituted 1,2-phenylenediamines in the presence of aqueous acetic acid. | 09-09-2010 |
| 20100216121 | Method for the detection of predisposition to high altitude pulmonary edema - The present invention encompasses methods, compositions and kits for the detection of susceptibility to high altitude pulmonary edema in a human subject. The present invention further encompasses isolated polynucleotides for the detection of susceptibility to high altitude pulmonary edema in a human subject. | 08-26-2010 |
| 20100075868 | METHOD FOR DEVELOPING A TISSUE PROTEOME LIBRARY - The present invention relates to the description of an approach for developing tissue proteome library, which overexpresses all the transcripts (mRNAs) present in a given tissue. Transcripts of interest present in a tissue are normally cloned and overexpressed individually to enable purification of expressed protein and for conducting its structure-function studies. Methods for identification of novel and low abundant transcripts present in tissues are not available, particularly of specimen tissue samples, oocytes and early embryos, for which tissue availability is also a serious limitation. Expression of all the transcripts present in a tissue and comparison of the profile of total expressed protein with that of appropriate controls can be used in identification of all and particularly novel transcripts present in a tissue. This novel proteome library construction approach enables expression of all the transcripts present in a tissue just in one go and analysis of all the expressed proteins employing proteomics and/or other suitable approaches. | 03-25-2010 |
| 20100068314 | HERBAL COMPOSITION FOR TREATING CD33+ ACUTE AND CHRONIC MYELOID LEUKEMIA AND A METHOD THEREOF - A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of | 03-18-2010 |
| 20100016588 | CAFFEINE FRACTION OBTAINED FROM TEA LEAVES AND A METHOD FOR INDUCING AGROBACTERIUM TUMEFACIENS-MEDIATED GENETIC TRANSFORMATION IN PLANTS USING SAID CAFFEINE FRACTION - The present invention relates to a thermolabile caffeine fraction useful for an efficient | 01-21-2010 |
| 20100016414 | TARGETS FOR HUMAN MICRO RNAS IN AVIAN INFLUENZA VIRUS (H5N1) GENOME - The present invention relates to targets for Human microRNAs in Avian Influenza Virus (H5N1) Genome and provides specific miRNA targets against H5N1 virus. Existing therapies for Avian flu are of limited use primarily due to genetic re-assortment of the viral genome, generating novel proteins, and thus escaping immune response. In animal models, baculovirus-derived recombinant H5 vaccines were immunogenic and protective, but results in humans were disappointing even when using high doses. Currently, two classes of drugs are available with antiviral activity against influenza viruses: inhibitors of the M2 ion channel, amantadine and rimantadine, and inhibitors of neuraminidase, oseltamivir, and zanamivir. There is paucity of information regarding effectiveness of these drugs in H5N1 infection. These drugs are also well known to have side effects like neurotoxicity. Thus there exists a need to develop alternate therapy for targeting the Avian flu virus (H5N1). The present invention addresses this need in the field. | 01-21-2010 |
| 20090306240 | PROCESS FOR SYNTHESIS OF TELECHELIC URETHANE ACRYLATE UV CURABLE PRE-POLYMERIC MATERIALS - The present invention involves the design of a radiation curable organic pre polymer resin material based on urethane acrylic linkage synthesized from the natural renewable resource cardanol or a derivative thereof, for coating application. These new molecules have a faster and better curing rate compared to the starting renewable resource—cardanol. This is brought about by the hydrogen bonding of the urethane linkage which leads to a pre organization of the molecules in such a way as to bring the cross linkable double bonds closer to each other. The present invention also involves a UV curable formulation of the above mentioned resins along with 2-10 parts by weight of a photopolymerization initiator. The resin, either in a formulation or alone turns into a cross linked film upon photopolymerization in presence of photoinitiator under a UV curable radiation source like a mercury vapor pressure lamp. | 12-10-2009 |
| 20090240078 | MULTIFUNCTIONAL ALCOHOLS OBTAINED FROM CARDANOL, MULTIFUNCTIONAL ACRYLIC CROSSLINKER AND PENDANT PHOSPHOROUS FLAME RETARDANT DERIVATIVES THEREOF - Multifunctional alcohols, polyols derived from cardanol containing at least 3 hydroxyl groups are disclosed. Such alcohols allow for synthesis of multifunctional crosslinkers such as acrylates, epoxies, and vinyl ethers and flame retardants such as >phosphates. The multifunctional alcohols or polyols can be used in polyurethanes and polycarbonates. The multifunctional crosslinkers can be used in optical coating and waveguide compositions to increase curing speed and crosslink density. The multifunctional phosphates can be used in flame resistant plastics as the highly pendant phosphorus containing phosphate non-halogen flame retardant additives. | 09-24-2009 |
| 20090221729 | WATER-SOLUBLE MACROMONOMERS CONTAINING TERMINAL UNSATURATION AND A PROCESS FOR THE PREPARATION THEREOF - This invention provides a water-soluble macromonomer having terminal unsaturation obtained by polymerization of monomers in the presence of inclusion complex of chain transfer agent in aqueous system. Hydrophobic chain transfer agent AMSD forms an inclusion complex with methylated cyclodextrin. The complexation enhances its solubility in water and enables the polymerization of water-soluble monomers in aqueous medium. After polymerization cyclodextrin is removed and the macromer with terminal unsaturation obtained can be used further for copolymerization with any vinyl monomer. | 09-03-2009 |
| 20090221690 | Pharmaceutical Composition for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof - Osteoporosis is one of the major problems in our aging society. Osteoporosis results in bone fracture in older members of the population, especially in post-menopausal women. In traditional medicine, there are many natural crude drugs that have the potential for use to treat bone diseases. So far, there is no report in literature on anti-osteoporosis (bone forming) activity of | 09-03-2009 |
| 20090203937 | PROCESS FOR PREPARING L- (+) -LACTIC ACID - The present invention provides a commercially viable process for the preparation of highly pure and optically active L-(+)-lactic acid and S-(−)-methyl lactate, in high yield, obtained from esterification of aqueous crude lactic acid solution produced by sugar cane juice fermentation broth and methanol in continuous counter current trickle phase approach or in continuous counter current bubble column manner, using stabilizers and the methyl lactate so obtained is recovered and followed by purification of reasonably pure methyl lactate using reagent mixture such as sodium bi-carbonate, mono-ethanolamine or di-ethanolamine, urea or sodium-bicarbonate, mono-ethanolamine or di-ethanolamine, thiourea to reduce the impurity of dimethyl ester of dicarboxylic such as dimethyl oxalate or di-methyl succinate or methyl ester of mono-carboxylic acid such as methyl pyruvate present as an impurity, so as to get highly pure S-(−)-methyl lactate followed by hydrolyzing highly pure S-(−)-methyl lactate using highly pure lactic acid as a catalyst, using highly pure water as the hydrolysis media and by using pre-treated activated carbon with dilute L-(+)-lactic acid, in batch or continuous mode. This very high pure S-(−)-methyl lactate constitutes an important product having interesting possibilities of application at an industrial level, in pharmaceuticals. Highly pure L-(+)-lactic acid thus obtained is used as an acidulant, as a food additive, for pharmaceutical applications, a monomer for making poly-lactic acid, as a monomer to prepare biodegradable polymer which are useful for manufacturing bags, application films, in the field of sanitary field, and has medical applications. | 08-13-2009 |
| 20090081322 | Process for the preparation of antioxidant conserve from Indian curry leaves (MURRAYA KOENIGII SPRENG.) - The present invention relates to a simple process for the preparation of safe, environmental friendly, and natural antioxidant conserve of activity ranging between 80-85%, comprising oleoresin from Indian curry leaves ( | 03-26-2009 |
| 20090068113 | AMPHIPHILIC SQUARAINE DYES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF - The present invention relates to amphiphilic squaraine dyes of the general formula (1) as shown below Formula (1) wherein, R | 03-12-2009 |
| 20090062474 | NOVEL MULTIFUNCTIONAL ADDITIVE GRAFTED RUBBER AND PROCESS FOR THE PREPARATION THEREOF - The present invention relates to a novel multi functional additive grafted rubber. More particularly the present invention relates to novel grades of rubber and in particular to chemically grafted with cardanol (meta-penta decenyl phenol) and/or its derivatives. Importantly the rubber grades of the invention involve chemically anchored/grafted selective meta alkenyl phenol and/or its derivatives in the backbone of natural or synthetic rubber. Importantly, such rubber variant of the invention have high plasticity, lower Mooney and melt viscosities, better cure properties as compared to conventional virgin natural rubber or natural rubber plasticised with aromatic process oils. | 03-05-2009 |
| 20090047682 | Method of detecting and predicting bronchodilatory response to beta agonist - Present invention relates to a method for predicting an individual's bronchodilatory response to a β agonist. Present invention particularly relates to the detection of specific allelic variants of the β2AR gene and their use as pharmacogenetic markers towards response to β agonist. | 02-19-2009 |
| 20080286394 | NOVEL HERBAL FORMULATION AS BRAIN TONIC - The invention provides a novel herbal formulation used to improve the memory and in treatment of amnesia as a brain tonic. Formulation(s) comprises of oleaginous oil of | 11-20-2008 |
| 20080233103 | Mycobacterial peptide deformylase - The present invention relates to the design of the Antisense-oligonucleotide complementary to the specific region of peptide deformylase gene from | 09-25-2008 |
