CORNELL UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160138192 | NANOFIBERS, NANOTUBES AND NANOFIBER MATS COMRPISING CRYSTALLINE METAL OXIDES AND METHODS OF MAKING THE SAME - Inorganic nanofibers comprise an inorganic matrix material surface functionalized with at least one metal oxide in crystalline form. Crystal growth on external surfaces may occur in substantial alignment with a longitudinal axis of the nanofibers, and the crystals are typically between about 10.0 nm and 30.0 nm in size. The nanofibers may be hollow (i.e., nanotubes) or they may be randomly dispersed together in the form of a nanofiber mat. Methods for making the nanofibers comprise spinning a dispersion comprising linear polymers and metal oxide precursors. | 05-19-2016 |
20160138078 | MODULATORS FOR SIRT6 AND ASSAYS FOR SCREENING SAME - Method for identifying a modulator of Sirt6, PfSir2a, or Sirt7 deacylase activity, wherein a fatty-acylated substrate containing an acyl-lysine moiety and an indicator moiety is contacted with Sirt6, PfSir2a, or Sirt7 in the presence of a candidate compound under conditions for Sirt6, PfSir2a, or Sirt7 to deacylate the substrate, wherein the acyl is a hydrophobic fatty acyl group containing a hydrocarbon group having at least three carbon atoms connected by carbon-carbon bonds; contacting the deacylated substrate with a cleavage agent that cleaves the linkage between the lysine and indicator moiety to generate a detectable signal; and correlating a quantified Sirt6, PfSir2a, or Sirt7 deacylase activity therefrom. Modulating compounds of Sirt6, PfSir2a, or Sirt7 deacylase activity are also described, as are pharmaceutical compositions thereof, methods of treatment by administration of the modulating compounds, and kits for practicing the method. | 05-19-2016 |
20160131613 | FLOATING GATE BASED SENSOR APPARATUS AND RELATED FLOATING GATE BASED SENOR APPLICATIONS - A floating gate based sensor apparatus includes at least two a separate electrical bias components with respect to a floating gate based sensor surface within the floating gate based sensor apparatus. By including the at least two electrical bias components, the floating gate based sensor apparatus provides enhanced capabilities for biomaterial and non-biomaterial detection and manipulation while using the floating gate based sensor apparatus. | 05-12-2016 |
20160131609 | CARBON MATERIAL SUPPORTED HOLLOW METAL OXIDE NANOPARTICLES, METHODS AND APPLICATIONS - A method for preparing a material composition comprising a hollow transition metal oxide nanoparticle supported upon a carbon material support includes a solution impregnation process step, followed by a thermal reduction process step and finally a thermal oxidation process step. The material composition, an electrode and an electrical component such as but not limited to a battery are all predicated at least in-part upon the material composition prepared in accord with the foregoing method. The foregoing material composition, electrode, battery and method may ultimately provide a LIB with enhanced performance. | 05-12-2016 |
20160115448 | CORTICAL INTERNEURONS AND OTHER NEURONAL CELLS PRODUCED BY THE DIRECTED DIFFERENTIATION OF PLURIPOTENT AND MULTIPOTENT CELLS - Provided are cortical interneurons and other neuronal cells and in vitro methods for producing such cortical interneurons and other neuronal cells by the directed differentiation of stem cells and neuronal progenitor cells. The present disclosure relates to novel methods of in vitro differentiation of stem cells and neural progenitor cells to produce several type neuronal cells and their precursor cells, including cortical interneurons, hypothalamic neurons and pre-optic cholinergic neurons. The present disclose describes the derivation of these cells via inhibiting SMAD and Wnt signaling pathways and activating SHH signaling pathway. The present disclosure relates to the novel discovery that the timing and duration of SHH activation can be harnessed to direct controlled differentiation of neural progenitor cells into either cortical interneurons, hypothalamic neurons or pre-optic cholinergic neurons. The present disclosure also relates to compositions of cortical interneurons, hypothalamic neurons or pre-optic cholinergic neurons, and their precursors, that are highly enriched and can be used in variety of application. These cells can be used therapeutically to treat neurodegenerative and neuropsychiatric disorders, and can be used for disease modeling and drug screening. | 04-28-2016 |
20160114516 | ELECTROSPINNING APPARATUS AND NANOFIBERS PRODUCED THEREFROM - Provided herein are gas and/or temperature assisted electrospinning apparatus, processes, components and polymer nanofibers. | 04-28-2016 |
20160106800 | METHODS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE - The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. | 04-21-2016 |
20160106110 | COMPOSITIONS AND METHODS FOR ENHANCING GERMINATION - Described herein are compositions comprising one or more microorganisms and one or more germinants. Further described herein are methods for treating plants, plant parts, soils, with one or more microorganisms and one or more germinants, and compositions thereof. | 04-21-2016 |
20160097140 | ENHANCED CONDUCTIVITY METAL-CHALCOGENIDE FILMS VIA POST ELECROPHORETIC DEPOSITION (EPD) TREATMENT - A facile room-temperature method for assembling colloidal copper sulfide (Cu | 04-07-2016 |
20160080548 | Smartphone-Based Apparatus and Method - A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications. | 03-17-2016 |
20160072041 | MONOLITHIC PZT ACTUATOR, STAGE, AND METHOD FOR MAKING - A monolithic, bulk piezoelectric actuator includes a bulk piezoelectric substrate having a starting top surface and an opposing starting bottom surface and a at least two electrodes operatively disposed on the bulk piezoelectric substrate consisting of at least two discrete electrodes disposed on either/both of the starting top surface and the starting bottom surface and at least one electrode disposed on the respective other starting bottom surface or starting top surface. A stage includes a base, at least two of the monolithic, bulk piezoelectric actuators disposed on the base, a movable platform disposed on the base, and a respective number of deformable connectors each having a first connection to a respective one of the piezoelectric actuators and a second connection to a respective portion of the movable platform. A method for monolithically making a monolithic, bulk piezoelectric actuator involves a direct write micropatterning technique. | 03-10-2016 |
20160070010 | SYSTEM AND METHODS FOR REMOTE MONITORING - A system that detects signals and transmits data regarding certain detected signals for further analysis is disclosed. The detected signals may be analyzed to determine whether any of the detected signals correspond to a source. The system may transfer in near-real time data and information regarding the data to one or more client devices. Methods for detecting signals and transmitting data associated with the detected signals are also disclosed. | 03-10-2016 |
20160054253 | Carbon-Sulfur Based Core-Shell Materials Compositions, Methods, and Applications - A materials composition and a method for preparing the materials composition provide: (1) a core material comprising a reactive carbon material-sulfur material composite; surrounded by and chemically coupled with (2) a shell material comprising a reactive sheath material. The material composition is useful within electrodes within electrical components including but not limited to electrochemical gas cells, supercapacitors and batteries where enhanced cycling may be realized. | 02-25-2016 |
20160047944 | METHODS AND APPARATUS FOR MONITORING INTERACTIONS BETWEEN PARTICLES AND MOLECULES USING NANOPHOTONIC TRAPPING - A method for characterizing an interaction between a first particle and a second particle is provided. The method includes the steps of: (i) providing an optical trap system including a photonics-based trap, a light source, and a camera; (ii) optically trapping, using the photonics-based trap, the first particle; (iii) obtaining a first measurement of a trap stiffness of the photonics-based trap; (iv) introducing the second particle to the optically trapped particle; (v) incubating the first and second particles under conditions suitable for an interaction between the first and second particles; (vi) obtaining a second measurement of the trap stiffness of the photonics-based trap after the incubation; and (vii) determining, using the first measurement of trap stiffness and the second measurement of trap stiffness, a property of the interaction between the first particle and the second particle. | 02-18-2016 |
20160032357 | METHOD FOR RELATIVE QUANTIFICATION OF CHANGES IN DNA METHYLATION, USING COMBINED NUCLEASE, LIGATION, AND POLYMERASE REACTIONS - The present invention is directed to methods for identifying the presence of one or more methylated or unmethylated target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction. The ligated product sequences or extension products thereof are detected, and the presence of one or more methylated or unmethylated target nucleotide sequences in the sample is identified based on the detection. | 02-04-2016 |
20160018404 | MULTILAYER FLUORESCENT NANOPARTICLES AND METHODS OF MAKING AND USING SAME - A multilayer, fluorescently responsive material (FRM)-containing nanoparticle and compositions comprising such nano-particles. The nanoparticles can be made using a layer-by-layer deposition method. The nanoparticles can be used in imaging methods such as, for example, cellular imaging methods. | 01-21-2016 |
20160002580 | PHOTOBIOREACTOR APPARATUS, METHOD AND APPLICATION - A photobioreactor includes an input light delivery component and a plurality of photobioreactor media disposed in a stacked relationship, each of which is coupled to the input light delivery component, wherein each photobioreactor medium is adapted to be inoculated with a photosynthetic, biofuel-producing culture, further wherein each photobioreactor medium includes at least one hollow fiber membrane (HFM) disposed thereon in a region that is adapted to be inoculated with the photosynthetic, biofuel-producing culture, that can transport at least one of a gas and a photobioreactor product producible by the photosynthetic, biofuel-producing culture, wherein each photobioreactor medium is characterized by an input light-scattering mechanism. A method for making a biofuel including providing a stacked photobioreactor assembly including a plurality of unit photobioreactor mediums each of which is inoculated with a photosynthetic, biofuel-producing culture, characterized by a light scattering mechanism and including at least one hollow fiber membrane (HFM) disposed in-situ on the photobioreactor medium; providing a nutrient gas to the biofuel-producing culture via the at least one HFM; and illuminating each unit photobioreactor medium with a selected spectrum of input light via the light scattering mechanism in each unit photobioreactor medium. | 01-07-2016 |
20150372687 | QUASI-LINEAR SPIN TORQUE NANO-OSCILLATORS - Techniques, systems, and devices are disclosed for implementing a quasi-linear spin-torque nano-oscillator based on exertion of a spin-transfer torque on the local magnetic moments in the magnetic layer and precession of the magnetic moments in the magnetic layer within a spin valve. Examples of spin-torque nano-oscillators (STNOs) are disclosed to use spin polarized currents to excite nano magnets that undergo persistent oscillations at RF or microwave frequencies. The spin currents are applied in a non-uniform manner to both excite the nano magnets into oscillations and generate dynamic damping at large amplitude as a feedback to reduce the nonlinearity associated with mixing amplitude and phase fluctuations. | 12-24-2015 |
20150360195 | DEVICE FOR RECOVERY AND ISOLATION OF BIOMOLECULES - The present invention relates to a device for isolating and recovering a biomolecule from a test sample. The device includes a support and at least one peelable layer deposited on at least a portion of the support. The peelable layer includes a substrate having a target component immobilized on the substrate. The device is effective for isolating and recovering a biomolecule having affinity to the target component. The present invention also relates to systems and methods of using the device. The present invention also relates to a biomolecule elution strip and related methods. | 12-17-2015 |
20150359839 | METHODS FOR PREVENTING OR TREATING INSULIN RESISTANCE - The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p | 12-17-2015 |
20150359458 | SMARTPHONE-BASED APPARATUS AND METHOD FOR OBTAINING REPEATABLE, QUANTITATIVE COLORIMETRIC MEASUREMENT - A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications. | 12-17-2015 |
20150342740 | AN ARTIFICIAL HIP JOINT REPLACEMENT SYSTEM - The present invention relates to an artificial hip joint replacement system. The system includes an acetabulum portion comprising a cup suitable to be received by a subject's acetabular bone. The cup includes a rigid portion and an elastic portion attached to the rigid portion. Also included in the system is a ball received within the cup and in contact with the elastic portion and a femoral stem attached to the ball. The elastic portion is positioned to cause expansion and contraction of a space between the ball and the rigid portion of the cup so they are further apart from one another during periods of low mechanical loads. | 12-03-2015 |
20150342101 | Apple tree named 'G.814' - The present invention relates to a new and distinct variety of apple tree named ‘G.814.’ ‘G.814’ is useful in that it can be propagated clonally and used as a rootstock or root system for apple trees as well as for interstems of apple trees. When used as a rootstock, ‘G.814’, is: dwarfing, induces scion precocity, is cold hardy, induces scion precocity, has a high yield efficiency, is tolerant to replant disease, and is resistant to: crown and root rot ( | 11-26-2015 |
20150341326 | System And Method For A Practical, Secure And Verifiable Cloud Computing For Mobile Systems - Disclosed are systems and methods for delegating computations of resource-constrained mobile clients, in which multiple servers interact to construct an encrypted program representing a garbled circuit. Implementing the garbled circuit, garbled outputs are returned. Such implementations ensure privacy of each mobile client's data, even if an executing server has been colluded. The garbled circuit provides secure cloud computing for mobile systems by incorporating cryptographically secure pseudo random number generation that enables a mobile client to efficiently retrieve a result of a computation, as well as verify that an evaluator actually performed the computation. Cloud computation and communication complexity are analyzed to demonstrate the feasibility of the proposed system for mobile systems. | 11-26-2015 |
20150336097 | MICROFLUIDIC CHIP HAVING ON-CHIP ELECTRICALLY TUNABLE HIGH-THROUGHPUT NANOPHOTONIC TRAP - In one implementation, a microfluidic device based on optical trapping of particles is disclosed to include a substrate structured to include a fluidic channel which can carry a fluid having particles; and an optical waveguide loop formed on the substrate to include one or more waveguide sections that reside within the fluidic channel, an input optical port for the optical waveguide to receive an input optical beam, and an optical power splitter coupled to the optical waveguide loop to split the received input optical beam into two counter-propagating optical beams that prorogate in the optical waveguide loop in opposite directions and interfere with each other to form standing optical waves in at least the one or more waveguide sections that reside within the fluidic channel to optically trap particles at or near a surface of the one or more waveguide sections that reside within the fluidic channel. This device further includes an electrically controllable phase control device formed on the substrate and coupled to a location of the optical waveguide loop and operable to control an optical delay experienced by guided light at the coupled location, wherein the electrically controllable phase control device is configured to respond to an electrical control signal to adjust an amount of the optical delay at the coupled location to cause a shift in locations of nodes of each optical standing wave to change trapping locations of the trapped particles in the fluidic channel. | 11-26-2015 |
20150335725 | VACCINE FOR INTRAUTERINE DISEASE - Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition can contain whole cells selected from whole cells of | 11-26-2015 |
20150328340 | METHODS AND COMPOSITIONS FOR ALTERING PHOTOPHYSICAL PROPERTIES OF FLUOROPHORES VIA PROXIMAL QUENCHING - The invention is directed to fluorophore-containing compositions and configurations wherein proximity between the fluorophore and one or more protective agents (PAs) modifies the lifetime of fluorescent and/or dark states, their frequency of occurrence, and the total lifetime of fluorescence in order to appropriately modify the photophysical characteristics of the fluorophore. The invention is also directed to methods that utilize these compositions and configurations. | 11-19-2015 |
20150315249 | CROSSLINKED THERMOSET RESINS AND METHODS THEREOF - The present invention relates to a method of making a crosslinked thermoset resin. One embodiment of this method comprises: (i) separating a plant-derived flour mixture into a protein fraction comprising proteins and a carbohydrate fraction comprising carbohydrates; (ii) subjecting the carbohydrate fraction to an oxidizing agent to yield oxidized carbohydrates comprising aldehyde functional groups or both aldehyde functional groups and carboxyl functional groups; and (iii) reacting the oxidized carbohydrates with the protein fraction under conditions effective to crosslink the proteins, thereby yielding a crosslinked thermoset resin. The present invention also relates to a crosslinked thermoset resin and composites, nanofiber membranes, and adhesives comprising the crosslinked thermoset resin. | 11-05-2015 |
20150297564 | METHOD OF ENHANCING GLUCOSE-STIMULATED INSULIN SECRETION AND OF TREATING TYPE 2 DIABETES OR HYPOGLYCEMIA - The present invention is directed to a method of enhancing glucose-stimulated insulin secretion in a subject. The method involves selecting a subject with: (1) an antioxidant deficiency and (2) a need for enhanced glucose-stimulated insulin secretion, and administering to the selected subject an agent selected from the group consisting of (1) a compound according to Formula I or a pharmaceutically acceptable salt thereof: | 10-22-2015 |
20150291952 | RNA APTAMER ISOLATION VIA DUAL-CYCLE (RAPID) SELECTION - The present invention relates to a method for selecting an aptamer for a target molecule. The method involves providing a random oligonucleotide library comprising a plurality of unique random sequence oligonucleotides; providing a target mixture comprising at least one target molecule; and subjecting the random oligonucleotide library and the target mixture to at least one round of an aptamer isolation protocol to yield at least one aptamer for the target molecule, wherein a round of the aptamer isolation protocol comprises at least one selection cycle followed by an amplification cycle. The present invention also relates to systems and devices for implementing or performing the method of the present invention. The present invention further relates to using the method to isolate aptamers for high-throughput sequencing analysis and other aptamer analysis protocols. | 10-15-2015 |
20150287967 | CERAMIC NANOFIBER SEPARATORS - Provided herein are ceramic nanofibers and processes for preparing the same. In specific examples, provided herein are ceramic nanofiber mats for use as separators in batteries, particularly lithium ion batteries. | 10-08-2015 |
20150282507 | EXTRUSION OF AGRO-FOOD INDUSTRY BYPRODUCTS AND PROTEIN CONCENTRATES INTO VALUE-ADDED FOODS - The present invention relates to a process for preparing an edible foodstuff from food industry waste stream byproducts. This process involves the steps of: (i) combining, in an extruder, an extrusion formulation comprising a first food byproduct and at least one additional ingredient; (ii) introducing supercritical carbon dioxide (SC—CO | 10-08-2015 |
20150275118 | BIOMIMETIC BOUNDARY LUBRICANTS FOR ARTICULAR CARTILAGE - This invention relates to methods of lubrication for biological tissue, especially joint and cartilage surfaces, and to methods of treating osteoarthritis using high molecular weight, hydrophilic polymer brushes, which mimic the structure and activity of lubricin. These synthetic lubricin analog polymer brushes (termed herein graft brush polymers), include poly(acrylic acid) back-bones grafted with polyethylene glycol. | 10-01-2015 |
20150262055 | NEUROMORPHIC EVENT-DRIVEN NEURAL COMPUTING ARCHITECTURE IN A SCALABLE NEURAL NETWORK - An event-driven neural network includes a plurality of interconnected core circuits is provided. Each core circuit includes an electronic synapse array has multiple digital synapses interconnecting a plurality of digital electronic neurons. A synapse interconnects an axon of a pre-synaptic neuron with a dendrite of a post-synaptic neuron. A neuron integrates input spikes and generates a spike event in response to the integrated input spikes exceeding a threshold. Each core circuit also has a scheduler that receives a spike event and delivers the spike event to a selected axon in the synapse array based on a schedule for deterministic event delivery. | 09-17-2015 |
20150252352 | MAGNETIC HIERARCHICAL CATALYSTS OF NANOPARTICLES AND ENZYMES FORMING MESOPOROUS ASSEMBLIES EMBEDDED IN MACROPOROUS SCAFFOLDS, AND THEIR USE WITH MAGNETICALLY-DRIVEN REACTORS AND IN CHEMICAL REACTIONS - A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic nanoparticles, wherein an enzyme is embedded in mesopores of the mesoporous aggregates of magnetic nanoparticles. Methods for synthesizing the hierarchical catalyst composition are also described. Also described are processes that use the recoverable hierarchical catalyst composition for depolymerizing lignin, remediation of water contaminated with aromatic substances, polymerizing monomers by a free-radical mechanism, epoxidation of alkenes, halogenation of phenols, inhibiting growth and function of microorganisms in a solution, and carbon dioxide conversion to methanol. Further described are methods for increasing the space time yield and/or total turnover number of a liquid-phase chemical reaction that includes magnetic particles to facilitate the chemical reaction, the method comprising subjecting the chemical reaction to a plurality of magnetic fields of selected magnetic strength, relative position in the chemical reaction, and relative motion. | 09-10-2015 |
20150249252 | STRUCTURALLY ORDERED NANOPARTICLES, METHODS AND APPLICATIONS - Embodiments provide a nanoparticle and a method for preparing the nanoparticle, as well as a membrane that includes the nanoparticle and a fuel cell that includes the membrane. The method comprises a thermal treatment method that provides from a nanoparticle comprising a structurally disordered material the nanoparticle comprising: (1) a structurally ordered core comprising a first material; and (2) a shell surrounding and further structurally aligned with the structurally ordered core and comprising a second material different from the first material. Particularly desirable is a nanoparticle comprising a Pt | 09-03-2015 |
20150247263 | CARBONACEOUS METAL/CERAMIC NANOFIBERS - Provided herein are nanofibers and processes of preparing carbonaceous nanofibers. In some embodiments, the nanofibers are high quality, high performance nanofibers, highly coherent nanofibers, highly continuous nanofibers, or the like. In some embodiments, the nanofibers have increased coherence, increased length, few voids and/or defects, and/or other advantageous characteristics. In some instances, the nanofibers are produced by electrospinning a fluid stock having a high loading of nanofiber precursor in the fluid stock. In some instances, the fluid stock comprises well mixed and/or uniformly distributed precursor in the fluid stock. In some instances, the fluid stock is converted into a nanofiber comprising few voids, few defects, long or tunable length, and the like. | 09-03-2015 |
20150244852 | APPARATUS AND METHOD FOR POINT-OF-COLLECTION MEASUREMENT OF A BIOMOLECULAR REACTION - A system, methods, and apparatus for biomolecular measurements, monitoring, and tracking uses a smartphone-based system. A biological sample, including, but not limited to blood, saliva, biopsy, or sweat, is collected on a modular diagnostic test platform, which is then inserted into a smartphone accessory. Optical, electrical, mechanical, or other means are used to transduce a biomolecular binding event, including antibody, aptamer, enzymatic, base-pair matching, or other biological recognition reaction and communicate the results with the smartphone. Some specific examples of targets include 25-hydroxyvitamin D, folic acid, DNA, or proteins from infectious agents, and zinc. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later comparison, and communicated to a central hub location where medical professionals can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with friends, to compete in health based games, create mappings, and other applications. | 08-27-2015 |
20150240388 | REINFORCING NANOFIBER ADDITIVES - Provided herein are high performance reinforcing nanostructure additives, high throughput processes for using such additives, and composites comprising such additives. Such nanostructure additives include nanofibers, including nanofiber fragments, of various matrix materials, including metal(s) (e.g., elemental metal(s), metal alloy(s), etc.), metal oxide(s), ceramic(s), metal carbide(s), carbon (e.g., carbon nanocomposites comprising carbon matrix with metal component embedded therein), and/or combinations thereof. | 08-27-2015 |
20150240241 | PAIN TREATMENT USING ERK2 INHIBITORS - This application describes methods and compositions for reducing, inhibiting and/or treating pain that involve use of ERK2 inhibitors. | 08-27-2015 |
20150238967 | METHODS, SYSTEMS, AND APPLICATIONS FOR SOLAR-THERMAL MICROFLUIDIC PCR - Disclosed are methods and apparatus for solar-thermal microfluidic polymerase chain reaction. A device comprises a microfluidic chip including at least one PCR region, an energy absorption layer disposed adjacent to the microfluidic chip, a solar energy concentrator adapted to produce a plurality of temperature profiles on the microfluidic chip adapted to facilitate PCR, and a photomask disposed between the solar energy concentrator and the microfluidic chip. | 08-27-2015 |
20150236945 | SYSTEM AND METHODS FOR IMPROVED NETWORK ROUTING - Known intra-domain routing methods (e.g., OSPF and IS-IS) are link-state routing protocols with hop-by-hop forwarding that sacrifice optimal traffic engineering for ease of implementation and management. Known optimal traffic engineering procedures are either not link-state methods or require source routing—characteristics that make them difficult to implement. Certain embodiments of the present invention include a fully distributed, adaptive, link-state routing protocol with hop-by-hop forwarding configured to achieve optimal traffic engineering. Such embodiments facilitate significant performance improvements relative to known intra-domain routing methods and decrease network infrastructure requirements. | 08-20-2015 |
20150234272 | METAL OXIDE NANOPARTICLES AND PHOTORESIST COMPOSITIONS - The invention provides new nanoparticles that include a Group 4 metal oxide core and a coating surrounding the core, where the coating contains a ligand according to Formula (I), or a carboxylate thereof. The invention also provides new photoresist compositions that include a photoacid generator and a ligand acid or carboxylate thereof, where pKa | 08-20-2015 |
20150233804 | APPARATUS AND METHODS FOR LOW TEMPERATURE SMALL ANGLE X-RAY SCATTERING - Apparatus and methods for performing small angle X-ray scattering (SAXS) at low (cryogenic) temperatures for determining the structure of and changes in the structure of proteins, DNA, RNA, and other biological molecules and biomolecular assemblies and structures. A cryogenic, small angle X-ray scattering (SAXS) application sample holder, includes a sample cell including a base portion and at least two parallel walls disposed on the base, wherein the sample cell has a liquid volume capacity defined by the walls and the base portion of 0.001 to 10 microliters. A method for performing cryogenic SAXS on a sample includes the steps of providing a sample biomolecule solution containing an aqueous buffer, a biomolecule, and a cryoprotectant agent, wherein the cryoprotectant agent comprises up to 60% (w/w) of the biomolecule solution, and other known components as necessary to solubilize and stabilize the biomolecule, in a sample holder of claim | 08-20-2015 |
20150225254 | METAL CHALCOGENIDE SYNTHESIS METHOD AND APPLICATIONS - A method for synthesizing a metal chalcogenide nanocrystal (NC) material includes reacting a metal material and an ammonium chalcogenide material in an organic solvent material. The method provides that the metal chalcogenide nanocrystal material may be synthesized by a heating-up method at large scale (i.e., greater than 30 grams). Ammonium chalcogenide salts exhibit high reactivity and metal chalcogenide nanocrystals can be synthesized at low temperatures (i.e., less than 200° C.) with high conversion yields (i.e., greater than 90 percent). | 08-13-2015 |
20150224739 | HIGH PERFORMANCE NANOFIBERS AND MATS - Provided herein are nanofibers, nanofiber mats, and processes for preparing the same. In particular, provided herein are improved nanofibers and nanofiber mats, as well as processes for preparing nanofibers and nanofiber mats, having high performance characteristics. In some instances, such processes involve depositing nanofibers in a distinctly layered structure, which allows nanofibers to retain structural integrity upon post-electrospinning processing, which in turn provides resultant nanofibers with high performance characteristics. | 08-13-2015 |
20150219885 | Solar-Concentrating Solarization Apparatus, Methods, and Applications - Methods, structures, devices and systems are disclosed for solarizing soil using a moveable optical focusing array. In one example, an apparatus to solarize soil from a moveable platform includes a vehicle, an array of mirrors located on the exterior of the vehicle, in which the mirrors are steerable to control the orientation of the mirrors to direct sunlight to a spot on soil that generates heat to a solarize the soil, and a sensor coupled to the vehicle to measure the temperature of the soil, in which the orientation of the mirrors is determined based at least in part on the measured temperature to control the temperature of the soil. | 08-06-2015 |
20150218651 | USE OF DNA IN CIRCULATING EXOSOMES AS A DIAGNOSTIC MARKER FOR METASTATIC DISEASE - The present invention is directed to methods of diagnosing, prognosing, and monitoring cancer in a subject. These methods involves selecting a subject having cancer, and obtaining, from the selected subject, a sample containing exosomal DNA. The presence or absence of one or more mutations in BRAF and/or EGFR is detected in the exosomal DNA sample from the subject, and a diagnosis and/or prognosis of the cancer is given based on the detection of the one or more mutations in BRAF and/or EGFR. The present invention further relates to methods of treating a subject having cancer and/or monitoring a subject response to therapy based on the detection of one or more mutations in BRAF and/or EGFR in the exosomal DNA sample. | 08-06-2015 |
20150217457 | GRIPPING AND RELEASING APPARATUS AND METHOD - A passive universal gripper includes a mass of granular material encased in an elastic membrane. Using a combination of positive and negative pressure, the gripper can rapidly grip and release a wide range of objects that are typically challenging for conventional universal grippers, such as flat objects, soft objects, or objects with complex geometries. The gripper passively conforms to the shape of a target object, then vacuum-hardens to grip it rigidly; later using positive pressure to reverse this transition—releasing the object and returning to a deformable state. The apparatus and method enable the fast ejection of objects from the gripper, as well as essentially instantaneous reset time between releasing and gripping. | 08-06-2015 |
20150204859 | MULTIPLEXED MICROCOLUMN DEVICES AND PROCESSES FOR SELECTION OF NUCLEIC ACID APTAMERS - The present invention relates to a microcolumn device for selecting nucleic acid aptamers for single and multiple target molecules, as well as a method for making the microcolumn device. The present invention also relates to a system for selecting nucleic acid aptamers for single and multiple target molecules. The present invention further relates to methods of using the microcolumn device for selecting nucleic acid aptamers for multiple target molecules. Kits that include one or more microcolumn device and/or system of the present invention are also disclosed. | 07-23-2015 |
20150203667 | CROSSLINKED NATIVE AND WAXY STARCH RESIN COMPOSITIONS AND PROCESSES FOR THEIR MANUFACTURE - The present invention relates to an enhanced starch resin composition, methods of making the enhanced starch resin composition using environmentally benign, water-based processes, and products produced using the enhanced starch resin composition. The enhanced starch resin composition comprises a native starch and/or a waxy starch crosslinked with a multi-functional polycarboxylic acid. The starch resin composition is formed by a water-based reaction comprising using a non-toxic, water-soluble catalyst to catalyze esterification of the native starch and/or the waxy starch with the multi-functional polycarboxylic acid, thereby yielding a crosslinked starch resin composition having at least one enhanced mechanical property and/or reduced moisture absorption as compared to the native starch and/or the waxy starch. | 07-23-2015 |
20150201649 | ALGAL-BASED ANIMAL FEED COMPOSITION, ANIMAL FEED SUPPLEMENT, AND USES THEREOF - The present invention relates to an animal feed composition comprising one or more grains in an amount totaling 50-70% w/w of the composition; a non-algal protein source in an amount totaling 15-30% w/w of the composition; algae in an amount totaling 3-15% w/w of the composition; an oil heterologous to the algae in an amount totaling 0.5-15% w/w of the composition; an inorganic phosphate source in an amount totaling up to 1.5% w/w of the composition; a sodium source in an amount totaling up to 0.5% w/w of the composition; and one or more amino acids selected from the group consisting of lysine, threonine, isoleucine, tryptophan, and methionine in an amount totaling up to 0.5% w/w of the composition. Also disclosed are an animal feed supplement, methods of feeding animals, methods of improving the feed efficiency of an animal, and an improvement to animal feed. | 07-23-2015 |
20150197811 | Spectral Imaging for Measurement of Nuclear Pathology Features in Cancer Cells Prepared for In Situ Analysis - In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer. | 07-16-2015 |
20150188659 | OPTICAL MODE-DIVISION MULTIPLEXING USING SELECTED MODE COUPLING BETWEEN AN OPTICAL RESONATOR AND A SIGNAL TRANSMISSION LINE - Methods, systems, and devices are disclosed for using optical modes in optical waveguides to carry different optical communication signals. In one aspect, an optical device for optical MDM in optical communications includes an optical waveguide configured to support multiple optical waveguide modes and to carry light of different optical communication channels in different optical waveguide modes, respectively, of the multiple optical waveguide modes. The optical device includes an optical resonator configured to be capable of carrying an optical communication channel in one optical resonator mode and optically coupled to the optical waveguide to selectively couple the optical communication channel in the optical resonator into the optical waveguide to add a channel into the optical waveguide via optical mode division multiplexing. In another aspect, an optical mode division demultiplexing can be performed by coupling an optical waveguide and an optical resonator. | 07-02-2015 |
20150188128 | Binder-Free And Carbon-Free Nanoparticle Containing Component, Methods and Applications - A method for forming an adherent metal based nanoparticle material layer upon a substrate includes an electrophoretic deposition method for depositing a metal nanoparticle material layer upon the substrate. The metal nanoparticle material layer may then be treated to form the adherent metal based nanoparticle material layer comprising a material selected from the group consisting of a metal oxide material, a metal nitride material, a metal oxynitride material and a metal chalcogenide material. The method is particularly useful for fabricating a battery electrode comprising a Co | 07-02-2015 |
20150187134 | ARTICULATED CHARACTER FABRICATION - Fabrication of a posable physical embodiment from an articulated deformable model is made possible by first transforming a deformable surface volumetric model to a segmented, rigid volume model including identifying a plurality of rigid, linked segments. The rigid volume model approximates the deformable surface volumetric model. Linkage structures (i.e., hinges, ball joints) coupling pairs of the rigid, linked segments are then automatically determined. | 07-02-2015 |
20150185228 | METHODS FOR DETECTING ANTIBODIES IN MUCOSAL SAMPLES AND DEVICE FOR SAMPLING MUCOSAL MATERIAL - A method to detect local antibodies such as antigen-specific IgE via a brush biopsy specimen of a mucosal surface of a subject is disclosed. The method is easily performed in an office setting on both adult and pediatric patients. Also disclosed is a brush device specially designed for harvesting materials from a mucosal surface such as the medial surface of the inferior turbinate. | 07-02-2015 |
20150183188 | GROUP IV NANOWIRE STRUCTURES, METHODS AND APPLICATIONS - Methods for fabricating a nanowire composite, and a resulting article that includes the nanowire composite, are all adaptable to roll-to-roll processing by using a flexible substrate including a group IV nanowire growth surface, and locating and forming a group IV nanowire material layer upon the group IV nanowire growth surface. Under particular conditions of processing, group IV nanowire material layer nanowires may be located and formed perpendicular to a plane of the flexible substrate. Exemplary roll-to-roll processing apparatus are also considered. | 07-02-2015 |
20150174573 | POROUS MEMBRANE APPARATUS, METHOD, AND APPLICATIONS - Microporous membranes formed in a microfluidic device, and methods of manufacture. A method comprises the steps of etching a plurality of pillars in a microfluidic chamber, applying a first polymer material layer, applying a photoresist layer, exposing the photoresist layer to radiation to cross-link it to the microfluidic chamber, masking the photoresist layer with a porous mask, exposing the top layer of the masked photoresist layer to radiation to form a porous membrane layer of cross-linked photoresist material, removing the non-exposed photoresist material from under the porous membrane layer, drying the porous membrane layer, and removing the first polymer material from under the porous membrane layer. | 06-25-2015 |
20150147616 | BUTTON CELL CASINGS SUITABLE FOR NON-AQUEOUS CELLS - Provided herein are button cell housing components configured to be suitable for lithium ion battery cells. | 05-28-2015 |
20150147299 | GENERATION OF FUNCTIONAL AND DURABLE ENDOTHELIAL CELLS FROM HUMAN AMNIOTIC FLUID-DERIVED CELLS - This disclosure is directed to methods for reproducibly generating substantial amounts of endothelial cells from amniotic cells. The endothelial cells generated in accordance with the present methodology, as well as therapeutic methods utilizing these cells, are also disclosed. | 05-28-2015 |
20150140596 | MICROFLUIDIC DEVICE, SYSTEM, AND METHOD FOR TRACKING SINGLE CELLS AND SINGLE CELL LINEAGES - The present invention relates to a microfluidic device, a microfluidic system, and methods for tracking single cells, multiple cells, single cell lineages, and multiple cell lineages in series and/or in parallel. The microfluidic device comprises a substrate having one microfluidic channel formed therein or a plurality of microfluidic channels formed therein and arranged in parallel. The microfluidic system comprises: a microfluidic device according to the present invention; a cell loading reservoir in fluid communication with the inlet end of each microfluidic channel of the microfluidic device; and an outlet reservoir in fluid communication with the outlet end of each microfluidic channel of the microfluidic device. The present invention also relates to a high throughput microfluidic system and a kit for tracking single cells and/or single cell lineages. | 05-21-2015 |
20150132767 | ERG/TFF3/HMWCK TRIPLE IMMUNOSTAIN FOR DETECTION OF PROSTATE CANCER - This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer. | 05-14-2015 |
20150132642 | LITHIUM CONTAINING NANOFIBERS - Lithium-containing nanofibers, as well as processes for making the same, are disclosed herein. In some embodiments described herein, using high throughput (e.g., gas assisted and/or water based) electrospinning processes produce nanofibers of high energy capacity materials with continuous lithium-containing matrices or discrete crystal domains. | 05-14-2015 |
20150131147 | DUAL MODE MICROENDOSCOPE APPARATUS, METHOD AND APPLICATIONS - A microendoscope, and a microendoscopy method related to the microendoscope, each include a tube housing, where an end of the tube housing is shaped and finished to facilitate collection of light emitted from a sample when examined using the microendoscope. In addition, a catadioptric lens assembly, an endomicroscope that includes the catadioptric lens assembly and a microendoscopy method for microscopic analysis that uses the endomicroscope are predicated upon a second element and a third element within the catadioptric lens assembly that each has a dichroic coating. The placement of the dichroic coating on the second element and the third element provides for different magnification factors as a function of illumination wavelength when using the microendoscopy method. | 05-14-2015 |
20150129752 | POLYSILICON PHOTODETECTOR, METHODS AND APPLICATIONS - A silicon photonic photodetector structure, a method for fabricating the silicon photonic photodetector structure and a method for operating a silicon photonic photodetector device that results from the photonic photodetector structure each use a strip waveguide optically coupled with a polysilicon material photodetector layer that may be contiguous with a semiconductor material slab to which is located and formed a pair of electrical contacts separated by the polysilicon material photodetector layer. Alternatively, the pair of electrical contacts may be located and formed upon separated locations of the polysilicon photodetector layer. Within the foregoing silicon photonic photodetector structure and related methods the polysilicon material photodetector layer includes defect states suitable for absorbing an optical signal from the strip waveguide and generating an electrical output signal using at least one of the electrical contacts when the optical signal includes a photon energy less than a band gap energy of a polysilicon material from which is comprised the polysilicon material photodetector layer. Alternatively, the silicon photonic photodetector structure may include appropriate photodetection circuitry. The silicon photonic photodetector structure and related methods avoid the use of germanium and indium phosphide-based materials. | 05-14-2015 |
20150125943 | LIGHT FIELD IMAGE SENSOR, METHOD AND APPLICATIONS - An angle-sensitive pixel (ASP) device that uses the Talbot effect to detect the local intensity and incident angle of light includes a phase grating disposed above a photodiode assembly or a phase grating disposed above an analyzer grating that is disposed above a photodiode assembly. When illuminated by a plane wave, the upper grating generates a self-image at a selected Talbot depth. Several such structures, tuned to different incident angles, are sufficient to extract local incident angle and intensity. Arrays of such structures are sufficient to localize light sources in three dimensions without any additional optics. | 05-07-2015 |
20150119446 | CUL4B AS PREDICTIVE BIOMARKER FOR CANCER TREATMENT - The current disclosure describes materials and methods for identifying subjects that would benefit from treatment with a DNA topoisomerase 1 inhibitor, based on the levels of cullin 4B gene, RNA and protein levels in the subject. The disclosure identifies CUL4B as a predictive biomarker for cancer diagnosis and the subsequent treatment with directed therapeutic agents. The current disclosure also identifies novel therapeutic agents that modulate the level of CUL4B expression, and sensitize a subject to treatment with a second therapeutic agent. | 04-30-2015 |
20150118218 | IMMOBILIZED PROTEIN SYSTEM FOR RAPID AND ENHANCED MULTIPLEXED DIAGNOSTICS - The disclosure relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay disclosed that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the neural injury biomarker in the sample, and thereby diagnosing a subject as having a neural injury. The disclosure further relates to methods of determining the state of a subject's neural injury. Further disclosed are systems and devices useful in carrying out the methods disclosed. | 04-30-2015 |
20150105255 | BIOLOGICAL CONTROL OF CROWN GALL DISEASE ON GRAPEVINES - Derivatives of | 04-16-2015 |
20150104440 | MiRNA-31 AS A DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC AGENT IN CANCER - The current disclosure reveals a complex regulatory pattern between miR-31 and AR, indicating that miR-31 plays a key role in prostate cancer development and progression. Another aspect of the current disclosure shows that miR-31 directly targets and destabilizes AR mRNA through interaction with the AR mRNA coding sequence showing that miR-31, or a fragment thereof has the ability to act as a novel therapeutic agent in treating cancer. The current disclosure also shows that AR indirectly represses miR-31 expression by binding to the miR-31 promoter region and modulating methyltransferase activity. Another aspect of the current disclosure shows that miR-31 indirectly modulates AR activity by modulating regulators of cell cycle progression. The disclosure further provides an isolated nucleic acid that modulates the activity of the androgen receptor in a cell. The disclosure further provides a method of treating a prostate cancer in a subject, by administering to the subject an effective amount of an agent that modulates the activity or levels of miR-31. | 04-16-2015 |
20150099642 | METHODS AND DEVICES FOR DNA SEQUENCING AND MOLECULAR DIAGNOSTICS - The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices. | 04-09-2015 |
20150099186 | SILICON NANOCOMPOSITE NANOFIBERS - Provided herein are silicon nanocomposite nanofibers and processes for preparing the same. In specific examples, provided herein are nanocomposite nanofibers comprising continuous silicon matrices and nanocomposite nanofibers comprising non-aggregated silicon domains. | 04-09-2015 |
20150099185 | LITHIUM ION BATTERIES COMPRISING NANOFIBERS - Lithium ion batteries, electrodes, nanofibers, and methods for producing same are disclosed herein. Provided herein are batteries having (a) increased energy density; (b) decreased pulverization (structural disruption due to volume expansion during lithiation/de-lithiation processes); and/or (c) increased lifetime. In some embodiments described herein, using high throughput, water-based electrospinning process produces nanofibers of high energy capacity materials (e.g., ceramic) with nanostructures such as discrete crystal domains, mesopores, hollow cores, and the like; and such nanofibers providing reduced pulverization and increased charging rates when they are used in anodic or cathodic materials. | 04-09-2015 |
20150087043 | MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION THAT EMPLOY BIOORTHOGONAL CHEMISTRIES, AND METHODS OF USING SAME - Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 03-26-2015 |
20150080570 | ALPHA,BETA-UNSATURATED MONOMERS CAPABLE OF MULTIMERIZATION IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME - Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 03-19-2015 |
20150076742 | CARBON AND CARBON PRECURSORS IN NANOFIBERS - Provided herein are nanofibers comprising carbon precursors, nanofibers comprising carbon matrices, and processes for preparing the same. In specific examples, provided herein are high performance lithium ion battery anodic nanofibers comprising non-aggregated silicon domains in a continuous carbon matrix. | 03-19-2015 |
20150073045 | POLYCYCLIC COMPOUNDS AND METHODS RELATED THERETO - The invention relates to a novel compound of the formula | 03-12-2015 |
20150057415 | THERMOPLASTIC ELASTOMER COMPOSITION AND PROCESS FOR MANUFACTURING THE SAME - The present invention relates to a thermoplastic elastomer composition which comprises a branched olefin copolymer comprising: a main chain of an ethylene/α-olefin copolymer; and a side chain derived from a crystalline propylene polymer containing a vinyl group at one end, wherein the content of α-olefin in the main chain is 70 mol % or less, the composition has an elongation at break of 500% or higher, and has an elastic recovery rate of 70% or more when recovering from an extension to 300% elongation, and a process for manufacturing the same. | 02-26-2015 |
20150057236 | MODULATORS FOR SIRT5 AND ASSAYS FOR SCREENING SAME - Sirt5, a mitochondrial Sirtuin, has been identified herein as an efficient demalonylase and desuccinylase. Disclosed herein are assays to identify Sirt5 modulators based on this robust enzymatic activity. Sirt5-specific modulators can be used study the biological function of Sirt5 and to target Sirt5 activities in treating human diseases. | 02-26-2015 |
20150056471 | ORDERED POROUS NANOFIBERS, METHODS, AND APPLICATIONS - Described herein are nanofibers and methods for making nanofibers that have a plurality of pores. The pores have of any suitable size or shape. In some embodiments the pores are “mesopores”, having a diameter between 2 and 50 nm. In some embodiments, the pores are “ordered”, meaning that they have a substantially uniform shape, a substantially uniform size and/or are distributed substantially uniformly through the nanofiber. Ordering of the pores results in a high surface area and/or high specific surface area. Ordered pores, without limitation, result in a nanofiber that is substantially flexible and/or non-brittle. The nanofibers and methods for making nanofibers may be used, without limitation, in batteries, capacitors, electrodes, solar cells, catalysts, adsorbers, filters, membranes, sensors, fabrics and/or tissue regeneration matrixes. | 02-26-2015 |
20150050293 | FLAGELLUM AND ANTI-FLAGELLUM ANTIBODY LEVELS IN SAMPLES AS A DIAGNOSTIC BIOMARKER AND THERAPEUTIC TARGET FOR METABOLIC SYNDROME - High levels of bacterial flagella in a sample such as a gastrointestinal sample and/or low levels of anti-flagella antibodies serve as an indication for metabolic syndrome (such as insulin resistance, hypertension, elevated cholesterol, increased risk for blood clotting, and obesity) with highest levels of adiposity. An intervention that reduces the level and/or activity of flagella in the gastrointestinal tract can mitigate the severity of metabolic syndrome or in protecting against the development of metabolic syndrome. | 02-19-2015 |
20150049338 | TUNABLE OPTOFLUIDIC APPARATUS, METHOD, AND APPLICATIONS - Embodiments include optofluidic apparatus that may be used to detect and manipulate nanoparticles or biomolecules within a fluid. To achieve that result, the embodiments use a fluidic channel located over a substrate. Particular embodiments also use: (1) an optical waveguide located over the substrate and particularly within the fluidic channel along with an optical resonator that may or may not be located within fluidic channel; and also (2) a phase shifter component coupled to either the waveguide or the optical resonator. Additional embodiments use an MZI or an MZI with an optical resonator to further provide the phase shifter component coupled to one arm of the MZI or the optical resonator. | 02-19-2015 |
20150044464 | CHARGED NANOFIBERS AND METHODS FOR MAKING - Described herein are nanofibers and methods for making nanofibers that include any one or more of (a) a non-homogeneous charge density; (b) a plurality of regions of high charge density; and/or (c) charged nanoparticles or chargeable nanoparticles. In one aspect, the present invention fulfills a need for filtration media that are capable of both high performance (e.g., removal of particle sizes between 0.1 and 0.5 ?m) with a low pressure drop, however the invention is not limited in this regard. | 02-12-2015 |
20150041708 | GYROIDAL MESOPOROUS CARBON MATERIALS AND METHODS THEREOF - The present invention relates to, inter alia, gyroidal mesoporous carbon materials and methods of use and manufacture thereof. In one embodiment, the present invention relates to a mesoporous carbon composition comprising a gyroidal mesoporous carbon having an ordered gyroidal structure and mesopores having a pore size of greater than 2 nanometers (nm) in diameter, and more particularly greater than 11 nm in diameter. | 02-12-2015 |
20150032145 | METHOD AND APPARATUS FOR RESTRICTING FLOW THROUGH AN OPENING IN THE SIDE WALL OF A BODY LUMEN, AND/OR FOR REINFORCING A WEAKNESS IN THE SIDE WALL OF A BODY LUMEN, WHILE STILL MAINTAINING SUBSTANTIALLY NORMAL FLOW THROUGH THE BODY LUMEN - An expandable substantially spherical structure for deployment in a blood vessel or other body lumen, comprising:
| 01-29-2015 |
20150011731 | DYE COMPOSITIONS, METHODS OF PREPARATION, CONJUGATES THEREOF, AND METHODS OF USE - Dye compounds of the formula (1) wherein A is a protective agent group that has a characteristic of modifying the singlet-triplet occupancy of the shown cyanine moiety, and M is a reactive crosslinking group or a group that can be converted to a reactive crosslinking group. Methods for synthesizing the dye compounds and applications for their use are also described. | 01-08-2015 |
20150011425 | METHODS AND ARRAYS FOR CONTROLLED MANIPULATION OF DNA AND CHROMATIN FRAGMENTS FOR GENETIC AND EPIGENETIC ANALYSIS - The present invention relates to methods and arrays for use in high resolution imaging of individual nucleic acid molecules and chromatin fragments, including native chromatin fragments. In one aspect, the present invention relates to a chromatin array that includes a transfer platform having a support and a transfer surface layered on the support. The chromatin array also includes a plurality of elongated individual native chromatin fragments coupled to the transfer surface in an orderly pattern suitable for high resolution imaging of the plurality of native chromatin fragments. The native chromatin fragments of the chromatin array include both DNA and histones. | 01-08-2015 |
20150010588 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, and inhibition of apoptosis and necrosis to treat, prevent or ameliorate the symptoms of autoimmune diseases or condition. | 01-08-2015 |
20140374576 | IMAGING DEVICE AND METHOD - The resolution of conventional imaging devices is restricted by the diffraction limit ‘Perfect’ imaging devices which can achieve a resolution beyond the diffraction limit have been considered impossible to implement. However, the present disclosure provides an imaging device which can achieve improved resolution beyond the diffraction limit and which can be implemented in practice. Said imaging device comprises: a. a lens having a refractive index that varies according to a predetermined refractive index profile; b. a source; c. an outlet for decoupling waves from the device; and d. a reflector provided around the lens, the source and the outlet, wherein the reflector and the refractive index profile of the lens are together arranged to direct waves transmitted in any of a plurality of directions from the source to the outlet. | 12-25-2014 |
20140372784 | ENERGY-EFFICIENT PIPELINE CIRCUIT TEMPLATES FOR HIGH-PERFORMANCE ASYNCHRONOUS CIRCUITS - Asynchronous circuits and techniques are described for asynchronous processing without synchronization to a common clock. Two specific energy-efficient pipeline templates for high throughput asynchronous circuits are provided as examples based on single-track handshake protocol. Each pipeline contains multiple stages of logic. The handshake overhead is minimized by eliminating validity and neutrality detection logic gates for all input tokens as well as for all intermediate logic nodes. Both of these templates can pack significant amount of logic within each pipeline block, while still maintaining a fast cycle time. | 12-18-2014 |
20140371712 | CONVECTION ENHANCED DELIVERY APPARATUS, METHOD, AND APPLICATION - An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue. In certain “functionalized” embodiments of the invention, the CED device is equipped with integrated electrodes and/or a sensor (e.g., glutamate) to detect and convey selective parametric information. Another embodiment of the invention is directed to a CED method for drugs and/or other agents. The method may comprise the delivery of enzymes or other materials to modify tissue permeability and improve drug diffusion. Another embodiment of the invention is directed to a method for making a device for CED of drugs. | 12-18-2014 |
20140371080 | HIGH-THROUGHPUT RNA INTERACTION ASSAY - The present invention is directed to a method for detecting an interaction between a ribonucleic acid (RNA) molecule and a second molecule. This method involves providing a nucleic acid construct that contains a promoter sequence, a nucleotide sequence encoding the RNA molecule, and an RNA polymerase blocking site. The nucleotide sequence encoding the RNA molecule is transcribed in vitro to produce an RNA transcript corresponding to the RNA molecule. Transcription is halted by the RNA polymerase blocking site under conditions effective for the RNA transcript to remain tethered to the nucleic acid construct. The tethered RNA transcript is contacted with the second molecule and any interaction between the tethered RNA transcript and the second molecule is detecting and identified based on said contacting. | 12-18-2014 |
20140370442 | BLOCK COPOLYMERS AND LITHOGRAPHIC PATTERNING USING SAME - Block copolymers and methods of making patterns of organic thin films using the block copolymers. The block copolymers comprise a fluorinated block. Thin films of the block copolymers have microdomains that can be aligned. As a result the patterns of organic thin films having smaller dimensions than the pattern of incident deep-UV or e-beam radiation can be formed. For example, the block copolymers can be used in lithography, filtration, and templating applications. | 12-18-2014 |
20140355861 | RETINAL ENCODER FOR MACHINE VISION - A method is disclosed including: receiving raw image data corresponding to a series of raw images; processing the raw image data with an encoder to generate encoded data, where the encoder is characterized by an input/output transformation that substantially mimics the input/output transformation of one or more retinal cells of a vertebrate retina; and applying a first machine vision algorithm to data generated based at least in part on the encoded data. | 12-04-2014 |
20140355513 | METHOD AND APPARATUS TO CONTROL INTERFERENCE IN MULTI-HOP NETWORK AND RELAY NODE AND NODE PAIR USING THE METHOD - A method and apparatus to control interference in a relay node are provided and include simultaneously receiving a symbol from source nodes, adjusting channel coefficients; and relaying the symbol to destination nodes with adjusted channel coefficients. The simultaneously receiving and the relaying are performed during a symbol transmission process between the source and destination nodes. | 12-04-2014 |
20140355381 | COMPUTATION DEVICES AND ARTIFICIAL NEURONS BASED ON NANOELECTROMECHANICAL SYSTEMS - Techniques, systems, and devices are described for implementing for implementing computation devices and artificial neurons based on nanoelectromechanical (NEMS) systems. In one aspect, a nanoelectromechanical system (NEMS) based computing element includes: a substrate; two electrodes configured as a first beam structure and a second beam structure positioned in close proximity with each other without contact, wherein the first beam structure is fixed to the substrate and the second beam structure is attached to the substrate while being free to bend under electrostatic force. The first beam structure is kept at a constant voltage while the other voltage varies based on an input signal applied to the NEMS based computing element. | 12-04-2014 |
20140353882 | ELECTROSPINNING APPARATUSES & PROCESSES - Provided herein are electrospinning systems, apparatuses, components, and processes for the preparation of nanofibers, including high throughput systems, apparatuses, and processes for producing high performance nanofibers. | 12-04-2014 |
20140350671 | BIOMEDICAL IMPLANT FOR USE IN FLUID SHEAR STRESS ENVIRONMENTS - The present invention relates to a biomedical implant for use in a fluid shear stress environment of a subject. The biomedical implant of the present invention includes a patterned surface having a plurality of cellular niches. The cellular niches of the patterned surface are effective to maintain at least one localized layer of living cells within the plurality of cellular niches by decreasing fluid shear stress within the cellular niches as compared to fluid shear stress measured outside of the cellular niches, with the fluid shear stress measured outside of the cellular niches having a peak fluid shear stress of at least about 50 dynes per square centimeter (dynes/cm | 11-27-2014 |
20140350397 | ULTRASOUND TRANSDUCER PROBE AND METHODS - There is set forth herein a uterine probe having one or more transducer for detecting a uterine parameter. The one or more parameter can be a fetal heart rate. The one or more parameter can be uterine contraction. In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a fetal heart rate (FHR). In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a uterine contraction. The one or more transducer can be of a common technology or can be of different technology. In one embodiment a uterine probe can include one or more transducer that is operative to be driven in different signaling configurations. A first signaling configuration can be a signaling configuration for detection of a fetal heart rate. A second signaling configuration can be a signaling configuration for detection of uterine contraction. | 11-27-2014 |
20140350107 | Use of Pan-PPAR Agonists for Prevention and Treatment of Huntington's Disease and Tauopathies - The present invention provides a therapeutic treatment for a neurodegenerative disease with a pan-PPAR agonist, such as bezafibrate. In particular, the present invention provides that pan-PPAR agonists enhance PPAR related responses in both the central nervous system and peripheral tissues in Huntington's Disease (HD) and tauopathy. Therapeutic compositions comprising one or more pan-PPAR agonist(s), and kit thereof, for treating a neurodegenerative disease or disorder are also provided. | 11-27-2014 |
20140349941 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, apoptosis inhibition and electrical conductance. | 11-27-2014 |
20140332733 | PURE METAL AND CERAMIC NANOFIBERS - Provided herein are nanofibers and processes of preparing nanofibers. In some instances, the nanofibers are metal and/or ceramic nanofibers. In some embodiments, the nanofibers are high quality, high performance nanofibers, highly coherent nanofibers, highly continuous nanofibers, or the like. In some embodiments, the nanofibers have increased coherence, increased length, few voids and/or defects, and/or other advantageous characteristics. In some instances, the nanofibers are produced by electrospinning a fluid stock having a high loading of nanofiber precursor in the fluid stock. In some instances, the fluid stock comprises well mixed and/or uniformly distributed precursor in the fluid stock. In some instances, the fluid stock is converted into a nanofiber comprising few voids, few defects, long or tunable length, and the like. | 11-13-2014 |
20140328860 | METHODS FOR STIMULATING HEMATOPOIETIC RECOVERY BY INHIBITING TGF BETA SIGNALING - This disclosure demonstrates that blockade of TGFβ signaling after a hematopoietic stress (e.g., chemotherapy, transplantation, and infection) accelerates hematopoietic reconstitution and delays the return of cycling hematopoietic stem and progenitor cells (HSPCs) to quiescence. TGFβ blockade in these settings promotes multilineage hematopoietic regeneration by prolonging HSPC cycling and by promoting HSC self-renewal, and is useful for treating hematologic deficiencies caused various hematopoietic stresses. | 11-06-2014 |
20140322772 | PRODUCTION OF CARBOXYLATES AND METHANE FROM BIOMASS WASTE - Methods and systems for producing and removing C | 10-30-2014 |
20140322710 | DEVICE AND METHODS FOR EPIGENETIC ANALYSIS - Provided herein are methods and devices for single object detection. The methods and devices can be used to identify a plurality epigenetic markers on a genetic material, or a chromatin, encompassing fragments thereof. The invention provides for the characterization of the genetic material flowing through a channel in a continuous body of fluid based on detection of one or more properties of the genetic material. The methods and systems provided herein allow genome-wide, high-throughput epigenetic analysis and overcome a variety of limitations common to bulk analysis techniques. | 10-30-2014 |
20140319044 | NANOPARTICLE-FUNCTIONALIZED MEMBRANES, METHODS OF MAKING SAME, AND USES OF SAME - Nanoparticle functionalized membranes, where the surface of the membranes is nanoparticle functionalized. The nanoparticles closest to the membrane surface are covalently bonded to the membrane surface. For example, the membranes are forward osmosis, reverse osmosis, or ultrafiltration membranes. The membranes can be used in devices or water purification methods. | 10-30-2014 |
20140314322 | SYSTEM AND METHODS FOR WORLD-SCALE CAMERA POSE ESTIMATION - System and methods for determining where a digital photograph was taken by estimating the camera pose with respect to a global scale three-dimensional database. Accurate location and orientation of the digital photograph is established through feature correspondence and geometry estimated from photograph collections. | 10-23-2014 |
20140313559 | OPTOMECHANICAL OSCILLATOR NETWORK, CONTROL AND SYNCHRONIZATION METHODS, AND APPLICATIONS - A synchronizable optomechanical oscillator (OMO) network including at least two dissimilar silicon nitride (Si | 10-23-2014 |
20140304814 | SYSTEM AND METHODS FOR AUTOMATICALLY DETECTING DECEPTIVE CONTENT - Systems and methods for detecting deceptive opinion spam. Certain embodiments include a classifier with improved accuracy for detecting deceptive opinion entries. A feature analysis of learned models reveals a relationship between deceptive opinions and imaginative writing. By modeling deception in a generative framework, the prevalence of deception in two popular online review communities may be determined. Deceptive opinion spam is a rapidly growing and widespread problem, especially in review communities with minimal posting requirements. | 10-09-2014 |
20140304600 | SYSTEMS AND METHODS FOR IDENTIFYING OBJECTS - System and methods for providing and organizing information related to an object. Certain embodiments are directed to permitting a user to identify an object given certain observable characteristics about the object, but generally not all of the characteristics about the object. The identification may occur by comparing user-provided information with dynamically updated stored information. | 10-09-2014 |
20140304302 | COMPUTER SYSTEM AND METHODS FOR PERFORMING DATA-DRIVEN COORDINATION - A computer system and computer implemented method that obtains coordinated results from at least two queries by utilizing context data of each query. Specifically, the computer system and computer implemented method facilitates enhanced querying functionality by matching entangled queries to achieve coordinated results. | 10-09-2014 |
20140302323 | MESOPOROUS METAL NITRIDE MATERIALS AND METHODS - A plurality of mesoporous metal nitride materials may be formed by a method that includes treating with ammonia (or a related bonded nitrogen and hydrogen containing reducing material) a mixed metal oxide material that comprises at least one first metal that forms an unstable product with ammonia and at least one second metal that forms a stable product with ammonia to form the metal nitride materials that include the second metal but not the first metal. The method contemplates forming metal nitride materials, as well as metal oxynitride materials. A related method that uses a non-bonded nitrogen and hydrogen containing reducing material may yield a mesoporous metal oxide. In particular the at least one metal that forms an unstable product with ammonia comprises zinc metal. | 10-09-2014 |
20140296088 | Spectral Imaging for Measurement of Nuclear Pathology Features in Cancer Cells Prepared for In Situ Analysis - In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer. | 10-02-2014 |
20140269202 | SYSTEM AND METHODS OF ACOUSTIC MONITORING - A high performance computing strategy along with the capability to integrate various layers of data within a modeling framework incorporates various tools such as ambient noise, vessel and animal data to measure acute and chronic noise levels, detect and classify marine mammal vocalizations, and compute various metrics such as receive levels, signal excess, masking and communication space over relatively large temporal and spatial scales. | 09-18-2014 |
20140264400 | INTEGRATED MULTI-CHIP MODULE OPTICAL INTERCONNECT PLATFORM - Techniques, systems, and devices are disclosed to provide multilayer platforms for integrating semiconductor integrated circuit dies, optical waveguides and photonic devices to provide intra-die or inter-die optical connectivity. For example, an integrated semiconductor device having integrated circuits respectively formed on different semiconductor integrated circuit dies is provided to include a carrier substrate structured to form openings on a top side of the carrier substrate; semiconductor integrated circuit dies fixed to bottom surfaces of the openings of the carrier substrate, each semiconductor integrated circuit die including a semiconductor substrate and an integrated circuit formed on the semiconductor substrate to include one or more circuit components, and each semiconductor integrated circuit die being structured to have a top surface substantially coplanar with the top side of the carrier substrate; and planar layers formed on top of the top surfaces of the semiconductor integrated circuit dies and the top side of the carrier substrate to include optical waveguides and photonic devices to provide (1) intra-die optical connectivity for photonic devices associated with a semiconductor integrated circuit die, or (2) inter-die optical connectivity for photonic devices associated with different semiconductor integrated circuit dies. | 09-18-2014 |
20140260614 | GYROSCOPES BASED ON OPTOMECHANICAL SENSING - Gyroscopes based on optomechanical designs to provide sensitive sensing while providing relatively large bandwidth and dynamic range with enhanced noise performance. | 09-18-2014 |
20140255987 | PROKARYOTE-BASED CELL-FREE SYSTEM FOR THE SYNTHESIS OF GLYCOPROTEINS - The present invention is directed to a cell-free system for producing a glycosylated protein. This system comprises an isolated oligosaccharyltransferase capable of transferring a glycan from a lipid carrier molecule to a glycoprotein target, one or more isolated glycans, where each glycan is linked to a lipid carrier molecule, and a glycoprotein target comprising one or more glycan acceptor amino acid residues or a nucleic acid molecule encoding said glycoprotein target. The present invention further relates to kits and methods for producing a glycosylated protein in this cell-free system. | 09-11-2014 |
20140249216 | METHODS OF TREATMENT USING MODULATORS OF SIRT2 - The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2, with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, methods of treatment (i.e., cancer and neurodegenerative disease) by administration of the modulating compounds, assay methods for finding modulators of Sirt2, and kits for practicing the assay method. | 09-04-2014 |
20140248210 | MULTIMODAL SILICA-BASED NANOPARTICLES - The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle. | 09-04-2014 |
20140247448 | FIBER SOURCE OF SYNCHRONIZED PICOSECOND PULSES FOR COHERENT RAMAN MICROSCOPY AND OTHER APPLICATIONS - Devices and techniques that use nonlinear optical effects in optical fiber to generate optical pulses via nonlinear optical wave mixing for various applications such as coherent Raman microscopic measurements and optical parametric oscillators. | 09-04-2014 |
20140242602 | USES OF LABELED HSP90 INHIBITORS - The disclosure provides evidence that the abundance of this particular “oncogenic HSP90” species, which is not dictated by HSP90 expression alone, predicts for sensitivity to HSP90 inhibition therapy, and thus is a biomarker for HSP90 therapy. The disclosure also provides evidence that identifying and measuring the abundance of this oncogenic HSP90 species in tumors predicts of response to HSP90 therapy. “Oncogenic HSP90” is defined herein as the HSP90 fraction that represents a cell stress specific form of chaperone complex, that is expanded and constitutively maintained in the tumor cell context, and that may execute functions necessary to maintain the malignant phenotype. Such roles are not only to regulate the folding of overexpressed (i.e. HER2), mutated (i.e. mB-Raf) or chimeric proteins (i.e. Bcr-Abl), but also to facilitate scaffolding and complex formation of molecules involved in aberrantly activated signaling complexes (i.e. STATS, BCL6). | 08-28-2014 |
20140242457 | ALUMINUM ION BATTERY INCLUDING METAL SULFIDE OR MONOCRYSTALLINE VANADIUM OXIDE CATHODE AND IONIC LIQUID BASED ELECTROLYTE - An aluminum ion battery includes an aluminum anode, a vanadium oxide material cathode and an ionic liquid electrolyte. In particular, the vanadium oxide material cathode comprises a monocrystalline orthorhombic vanadium oxide material. The aluminum ion battery has an enhanced electrical storage capacity. A metal sulfide material may alternatively or additionally be included in the cathode. | 08-28-2014 |
20140240702 | LASER BASED APPARATUS, METHODS AND APPLICATIONS - Embodied is a two-color, fiber-delivered picosecond source for coherent Raman scattering (CRS) imaging. A wavelength tunable picosecond pump is generated by nonlinear spectral compression of a prechirped femtosecond pulse from a mode-locked titanium:sapphire (Ti:S) laser. A 1064-nm picosecond Stokes pulse is generated by an all-fiber time-lens source (or suitable alternative source) that is synchronized to the Ti:S laser. The pump and Stokes beams are combined in an optical fiber coupler, which serves not only as the delivery fiber but also as the nonlinear medium for spectral compression of the femtosecond pulse. CRS imaging of mouse skin is performed to demonstrate the practicality of this source. | 08-28-2014 |
20140237073 | PATIENT CONTROLLED BRAIN REPAIR SYSTEM AND METHOD OF USE - A method of maintaining an information rate of a Brain-computer interface (BCI) system, implanted in a patient's brain, by regulating arousal level in the patient's brain is disclosed. The method includes selecting a patient with the implanted BCI device configured to receive neuronal activity from one or more electrodes connected to the patient's brain and to establish a communication channel between the patient and an external device controlled by the patient. Accordingly, a rate of information passage through the communication channel from the BCI device is measured, and a region of the patient's brain involved in arousal regulation, is stimulated in response to said measuring, under conditions effective to adjust the rate of information passing from the BCI device through the communication channel. A computer medium for carrying out this method and a BCI Arousal Regulation system are also disclosed. | 08-21-2014 |
20140234256 | Commensal Bacteria As Signal Mediators Within A Mammalian Host - Genetically engineered cells and microorganisms are provided for preventing or ameliorating diseases through genetically engineered quorum signaling. Therapeutic methods for using the cells and microorganisms to prevent or ameliorate diseases are also provided. The genetically engineered cells or microorganisms can be engineered to express a signal and used to interrupt the signaling-dependent virulence of an invading pathogen. The cells or microorganisms can be used to provide signal-dependent expression of a desirable gene in order to interrupt, prevent, and/or ameliorate a disease of mammals, such as parasitic diseases, infectious diseases, autoimmune diseases and genetic disorders. | 08-21-2014 |
20140221161 | Head-wearable Training Tool and Method - A head-wearable training tool used for functional neck musculature training to help lower the risk and reduce the number of sport-related concussions. The head-wearable training tool is weighted in a manner to have a substantially identical weight to that of and identified sport (e.g., football) helmet. An associated method involves off-season training using the head-wearable training tool. | 08-07-2014 |
20140220560 | METHODS FOR RNA DETECTION AND QUANTIFICATION - The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described. | 08-07-2014 |
20140217012 | MULTIBLOCK COPOLYMER FILMS, METHODS OF MAKING SAME, AND USES THEREOF - A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. The surface layer can have at least 1×10 | 08-07-2014 |
20140213738 | POLY(ESTER AMIDE)S AND POLY(ESTER ETHER AMIDE)S WITH ALIPHATIC POLYESTERS, METHOD OF MAKING SAME, AND USES THEREOF - Polymers and copolymers having one or more aliphatic polyester groups or blocks. For example, the aliphatic polyester groups or blocks can be derived from a caprolactone such as, for example, ε-caprolactone. The polymers and copolymers can have desirable properties such as, for example, improved solubility and improved thermal properties. | 07-31-2014 |
20140213530 | METHODS FOR TREATMENT OF CANCER BY TARGETING SIRT5 - This disclosure demonstrates that inhibition of Sirt5 can suppress malignant transformation of cells. Therefore, methods of treating cancer based on inhibition of Sirt5 are disclosed. | 07-31-2014 |
20140212668 | GRAPHENE NANORIBBONS, METHODS OF MAKING SAME, AND USES THEREOF - Provided are graphene nanoribbons (GNRs), methods of making GNRs, and uses of the GNRs. The methods can provide control over GNR parameters such as, for example, length, width, and edge composition (e.g., edge functional groups). The methods are based on a metal catalyzed cycloaddition reaction at the carbon-carbon triple bonds of a poly(phenylene ethynylene) polymer. The GNRs can be used in devices such a microelectronic devices. | 07-31-2014 |
20140208449 | GENETICS OF GENDER DISCRIMINATION IN DATE PALM - This invention relates to the genetics of gender discrimination in the dioecious date palm. Methods of the present invention involve analyzing DNA or RNA from a date palm plant, tissue, germplasm, or seed for the presence of (i) a nucleic acid sequence or genotype that identifies the sex of the plant, tissue, germplasm, or seed or (ii) a molecular marker in linkage disequilibrium with the nucleic acid sequence or genotype. Also disclosed are kits for selecting male and female date palm plants prior to flowering, methods of breeding a date palm plant, and a method of planting a date palm seed of a known sex. | 07-24-2014 |
20140206829 | ISOSELECTIVE POLYMERIZATION OF EPOXIDES - The present invention provides novel bimetallic complexes and methods of using the same in the isoselective polymerization of epoxides. The invention also provides methods of kinetic resolution of epoxides. The invention further provides polyethers with high enantiomeric excess that are useful in applications ranging from consumer goods to materials. | 07-24-2014 |
20140201870 | TRICHODERMA STRAINS THAT INDUCE RESISTANCE TO PLANT DISEASES AND/OR INCREASE PLANT GROWTH - The present invention relates to a method for enhancing growth of plants which comprises contacting a | 07-17-2014 |
20140201869 | TRICHODERMA STRAINS THAT INDUCE RESISTANCE TO PLANT DISEASES AND/OR INCREASE PLANT GROWTH - The present invention relates to a method for enhancing growth of plants which comprises contacting a | 07-17-2014 |
20140200623 | Adaptive Airway Treatment of Dorsal Displacement Disorders in Horses - A method of using an airway treatment system for treating a dorsal displacement disorder in a horse includes detecting an elevated activity level of the horse using one or more treatment sensors, generating a treatment signal based on the detected elevated activity level, using a pacemaker processor, to strengthen one or more muscles involved in displacing a laryngeal anatomical structure relative to an airway of the horse, and using one or more stimulation electrodes, configured to interface with tissue of the horse, to deliver the treatment signal to the tissue of the horse to maintain an unobstructed airway. | 07-17-2014 |
20140194383 | MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME - Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 07-10-2014 |
20140194313 | MICROFLUIDIC DEVICE FOR EXTRACTING, ISOLATING, AND ANALYZING DNA FROM CELLS - The present invention relates to a microfluidic device for extracting and isolating DNA from cells. The device includes a support having an inlet port for receiving a sample containing a cell, an outlet port for dispensing DNA isolated from the cell, and a microfluidic channel disposed within the support and extending from the inlet port to the outlet port. The microfluidic channel includes a micropillar array, an inflow channel disposed between the inlet port and the micropillar array, and an outflow channel disposed between the micropillar array and the outlet port. The micropillar array includes micropillars spatially configured to entrap, by size exclusion, the cell, to immobilize DNA released from the cell, and to maintain the immobilized DNA in elongated or non-elongated form when hydrodynamic force is applied to the microfluidic channel. Systems and methods of making and using the device are also provided herein. | 07-10-2014 |
20140193466 | SILK COMPOSITIONS AND METHODS OF USING SAME - The present invention provides for silk-derived compositions for treating a wide variety of ocular conditions. The composition is produced by processing the silk cocoon into a water-based solution (i.e., a dissolved silk), which is then cast into a film. The film may be transparent to visible light, and curved in shape for easy application to the ocular surface. The silk film may either self-adhere or be sutured to cover the wound. The degradation time of the film may range from 1 minute to 24 hours, or from 2 hours to 20 hours. The present compositions can help regenerate damaged corneal tissue, thus promoting healing. | 07-10-2014 |
20140193361 | SYSTEMIC GLUCOSE TOLERANCE IN TYPE-2 DIABETES - Obesity is associated with a state of chronic low-grade inflammation and the present invention establishes that adipose-resident natural killer T (NKT) cells attenuate inflammation in adipose tissue and improves systemic glucose homeostasis in mice at different stages of obesity. Accordingly, the present invention provides methods of treating type-2 diabetes or those at risk for type-2 diabetes using activators of adipose-resident NKT cells. Such activators include particular glycolipids (e.g., a-galactosyl-ceramide and its analogs other than sulfated analogs) and cytokines that promote M2 macrophage polarization. The invention also includes methods to screen for activators of adipose-resident NKT cells. | 07-10-2014 |
20140186860 | NOVEL IMMUNOGENIC PROTEINS OF LEPTOSPIRA - The invention provides novel immunogenic proteins LigA and LigB from | 07-03-2014 |
20140186835 | IDENTIFICATION OF THE CAUSATIVE MUTATION FOR INHERITED CONNECTIVE TISSUE DISORDERS IN EQUINES AND METHODS FOR TESTING FOR SAME - Provided is a description of a mutation which is positively correlated with Warmblood Fragile Foal Syndrome Type 1 (WFFST1). The mutation is a G to A change at a specific location in the equine lysyl hydroxylase 1 (LH1) gene. Compositions and methods for use in diagnosing WFFST1 are provided. | 07-03-2014 |
20140186679 | SHAPE MEMORY POLYMER MATERIAL COMPOSITIONS, METHODS AND APPLICATIONS - A shape memory polymer material composition comprises: (1) a plurality of inorganic core nanoparticles as netpoints to which is connected; (2) a switching segment that comprises a polymer network. The polymer network comprises: (1) a corona component bonded to each inorganic core nanoparticle through a first chemical linkage; (2) a canopy component bonded to each corona component through a second chemical linkage; and (3) a plurality of cross-linking components cross-linking between different canopy components through a third chemical linkage. Given various selections for the inorganic core nanoparticles, the corona component, the canopy component, the cross-linking component, the first chemical linkage, the second chemical linkage and the third chemical linkage, various performance and composition characteristics of the shape memory polymer material compositions may be readily tailored. | 07-03-2014 |
20140179895 | POLYETHERS, METHODS OF MAKING SAME, AND USES THEREOF - Isotactic polyethers, methods of making polyethers, and uses of polyethers. The polyethers have a chain transfer group formed from a chain transfer agent. The methods of making the polyethers use monoalcohol chain transfer agents or multifunctional chain transfer agents. The polyethers can be used in materials, such as polyurethanes, elastomers, thermoset plastics, and thermoplastics, and as non-ionic surfactants. | 06-26-2014 |
20140179889 | Apparatus and Method for Elevated Temperature Electrospinning - Elevated temperature electrospinning apparatus comprises a pump upstream of or containing a resistance heater, means to shield applied electrostatic field from the resistance heater, and a temperature modulator for modulating temperature in the spinning region. | 06-26-2014 |
20140176270 | COMPACT UNDULATOR SYSTEM AND METHODS - An undulator with a compact construction is provided that reduces weight, complexity and cost. The compact undulator system and methods provides mechanical integrity without compromising magnetic field quality. | 06-26-2014 |
20140169104 | NONVOLATILE FLASH MEMORY STRUCTURES INCLUDING FULLERENE MOLECULES AND METHODS FOR MANUFACTURING THE SAME - Embodiments of tunneling barriers and methods for same can embed molecules exhibiting a monodispersion characteristic into a dielectric layer (e.g., between first and second layers forming a dielectric layer). In one embodiment, by embedding C | 06-19-2014 |
20140169088 | SPIN HALL EFFECT MAGNETIC APPARATUS, METHOD AND APPLICATIONS - An ST-MRAM structure, a method for fabricating the ST-MRAM structure and a method for operating an ST-MRAM device that results from the ST-MRAM structure each utilize a spin Hall effect base layer that contacts a magnetic free layer and effects a magnetic moment switching within the magnetic free layer as a result of a lateral switching current within the spin Hall effect base layer. This resulting ST-MRAM device uses an independent sense current and sense voltage through a magnetoresistive stack that includes a pinned layer, a non-magnetic spacer layer and the magnetic free layer which contacts the spin Hall effect base layer. Desirable non-magnetic conductor materials for the spin Hall effect base layer include certain types of tantalum materials and tungsten materials that have a spin diffusion length no greater than about five times the thickness of the spin Hall effect base layer and a spin Hall angle at least about 0.05. | 06-19-2014 |
20140163229 | SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME - Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 06-12-2014 |
20140161729 | COFLUORONS AND METHODS OF MAKING AND USING THEM - The present invention is directed to method of using a collection of monomers capable of forming multimers as a fluorescence reporter in different applications such as ligand detection/screening, disease diagnosis, drug discovery or screening, fluorescent labeling and imaging, or other fluorescent methodologies. Each monomer in the collection includes one or more ligand elements useful for binding to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the ligand elements directly or indirectly through a connector. Association of linker elements of different combinations of monomers, with their ligand elements bound to the target molecule to form a multimer, will generate a unique fluorescent signature different from that produced by those monomers either alone or in association with each other in the absence of the target molecule, when subjected to electromagnetic excitement. | 06-12-2014 |
20140154588 | IONIC-LIQUID NANOSCALE IONIC MATERIAL (IL-NIM) COMPOSITIONS, METHODS AND APPLICATIONS - A method for preparing an ionic liquid nanoscale ionic material, the ionic liquid nanoscale ionic material and a battery that includes a battery electrolyte that comprises the ionic liquid nanoscale ionic material each provide superior performance. The superior performance may be manifested within the context of inhibited lithium dendrite formation. | 06-05-2014 |
20140149301 | SOCIAL NETWORK DRIVEN SYSTEM AND METHODS FOR ENVIRONMENTAL PLANNING AND DESIGN - A social network driven system and methods directed to the planning and design of an environment that enables users to share and exchange information related to components and elements related to the parcel as well as the consequences or impact of a particular architectural landscape. | 05-29-2014 |
20140148596 | Covalent Organic Frameworks and Methods of Making Same - Crystalline COFs comprising a phthalocyanine moiety and a boron-containing multifunctional linking group joined by boronate ester bonds. A method for making crystalline COFs comprising Lewis acid catalyzed formation of boronate ester bonds between protected catechol subunits and multifunctional linkers comprising boronic acid groups. The COFs can be used in applications such as, for example, electronic devices. | 05-29-2014 |
20140134493 | MANGANESE OXIDE NANOPARTICLES, METHODS AND APPLICATIONS - Manganese oxide nanoparticles having a chemical composition that includes Mn | 05-15-2014 |
20140134190 | BONE MARROW-DERIVED HEMATOPOIETIC PROGENITOR CELLS AND ENDOTHELIAL PROGENITOR CELLS AS PROGNOSTIC INDICATORS FOR CANCER - Methods of determining cancer progression or cancer relapse in a subject at risk for cancer progression or cancer relapse, the methods comprising: obtaining a sample from said subject; measuring the level of VEGFR1 | 05-15-2014 |
20140130570 | CALIBRATION APPARATUS, METHODS AND APPLICATIONS - An inertial sensor calibration method and inertial sensor calibration apparatus. One or more diffraction patterns are generated by one or more fixed and/or moveable gratings (inertial sensors) illuminated by an atomically stabilized source attached to a base and detected by an imager. The grating and/or inertial sensor has a designed parameter value and an actual respective parameter value, such as motion or distance that can be determined upon ultra-precise measurement. Such ultra-precise measurement can be used to calibrate the grating or inertial sensor. | 05-15-2014 |
20140128458 | POLYCYCLIC COMPOUNDS AND METHODS RELATED THERETO - The invention relates to a novel compound of the formula | 05-08-2014 |
20140127750 | FAGOPYRITOL SYNTHASE GENES AND USES THEREOF - The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor. | 05-08-2014 |
20140127682 | NEW RIBOSOMAL TARGETS FOR ANTIBIOTIC DRUG DISCOVERY - The present invention relates to methods to identify molecules that binds in the neomycin binding pocket of a bacterial ribosome using structures of an intact bacterial ribosome that reveal how the ribosome binds tRNA in two functionally distinct states, determined by x-ray crystallography. One state positions tRNA in the peptidyl-tRNA binding site. The second, a fully rotated state, is stabilized by ribosome recycling factor (RRF) and binds tRNA in a highly bent conformation in a hybrid peptidyl/exit (P/E) site. Additionally, the invention relates to various assays, including single-molecule assay for ribosome recycling, and methods to identify compounds that interfere with ribosomal function by detecting newly identified intermediate FRET states using known and novel FRET pairs on the ribosome. The invention also provides vectors and compositions with an N-terminally tagged S13 protein | 05-08-2014 |
20140127681 | SIGNAL AMPLIFICATION METHODS FOR THE IMAGING OF PROTEIN SYNTHESIS AND NEUROTRANSMITTER TRANSPORT - The present invention describes the synthesis of biological samples that can be used for the purpose of enhancing the signal-to-noise ratios achievable during the imaging of protein synthesis, amino acid transport and neurotransmitter transport, particularly in applications where single-molecule resolution is demanded. The present invention provides quencher-labeled elongation factor (EF-Tu) and fluorophore-labeled tRNA. When these molecules are present in a ternary complex with GTP, the fluorescently-labeled tRNA is quantitatively quenched. Once the tRNA is incorporated into an actively translating ribosome, however, a burst of fluorescence is released and can be detected by a variety of techniques, including smFRET imaging. The invention further provides novel EF-Tu constructs for achieving quencher labeling at high levels while retaining native or near native activity in the translation reactions, as well as methods for preparing stable ternary complexes, methods of protein sequencing, methods of detecting amino acid transport using a proteoliposome assay system and the proteoliposomes systems and methods of imaging translation events in single living cells. The present invention should have an immediate impact on next-generation sequencing technologies and the detection of neurotransmitter transporter activities in both in vitro and in vivo settings, a critical component of drug activity/screening assays targeting this important class of molecules. | 05-08-2014 |
20140123350 | Raspberry plant named "Crimson Night' - This invention relates to a new and distinct primocane bearing red raspberry plant designated as ‘Crimson Night’ primarily adapted to growing conditions of west central New York and other regions of similar climate. The new plant is primarily characterized by highly pigmented canes, conical fruit that is longer than broad, late mid-season primocane production and dark greyed purple fruit color. | 05-01-2014 |
20140123349 | Raspberry plant named 'Double Gold' - This invention relates to a new and distinct everbearing raspberry plant designated as ‘Double Gold’ primarily adapted to growing conditions of west central New York and other regions of similar climate. The new plant is primarily characterized by golden to orange/red conical fruit that is equally long and broad, vigorous tall canes, late season primocane production and early mid-season floricane production. | 05-01-2014 |
20140121132 | SYSTEMS AND METHODS FOR HIGH RESOLUTION BIOMOLECULAR IMAGING AND ANALYSIS - The present invention relates to a system for producing a nucleic acid molecule imaging array for use in high resolution imaging of individual nucleic acid molecules. The system includes a micro/nanostructured capture array having a hydrophobic surface having topographical features effective to assist in capillary-based trapping and elongation of individual nucleic acid molecules. The system also includes a transfer platform having a support and a hydrophobic substrate layered on the support. The transfer platform is effective to receive and capture, through solvent mediation, the trapped and elongated individual nucleic acid molecules from the micro/nanostructured capture array. The present invention also relates to a nucleic acid molecule imaging array, a transfer platform for use in preparing a nucleic acid molecule array, and a kit for producing a nucleic acid molecule imaging array for use in high resolution imaging of individual nucleic acid molecules. | 05-01-2014 |
20140112922 | TARGETED PROTEIN SILENCING USING CHIMERAS BETWEEN ANTIBODIES AND UBIQUITINATION ENZYMES - The present invention relates to an isolated chimeric molecule comprising a degradation domain including a eukaryotic U-box motif and a targeting domain capable of immuno specifically directing the degradation domain to a substrate where the targeting domain is heterologous to the degradation domain. A linker couples the degradation domain to the targeting domain. Also disclosed are compositions as well as methods of treating a disease, substrate silencing, screening agents for therapeutic efficacy against a disease, and methods of screening for disease biomarkers. | 04-24-2014 |
20140112340 | SOURCE, RELAY, AND DESTINATION EXECUTING COOPERATION TRANSMISSION AND METHOD FOR CONTROLLING EACH THEREOF - A method for controlling a first node transmitting a transmission message to a plurality of second nodes may be provided. The method includes dividing the transmission message into at least one sub-message, encoding the at least one sub-message to a data stream, determining a first transmission direction of the data stream toward at least one of the plurality of second nodes, based on a polynomial of a channel gain between the first node and the at least one of the plurality of second nodes, and transmitting the data stream to the at least one of the plurality of second nodes, based on the determined first transmission direction. | 04-24-2014 |
20140107339 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES - Catalysts and methods for the carbonylation of epoxides to substituted 3-hydroxy-δ-lactones and β-lactones are disclosed. | 04-17-2014 |
20140107033 | METHODS FOR PREVENTION AND TREATMENT OF ACUTE RENAL INJURY - The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof. | 04-17-2014 |
20140105861 | COMPOSITIONS AND METHODS FOR TREATING ENDOCRINE, GASTROINTESTINAL OR AUTOIMMUNE DISORDERS - Recombinant cells and methods are provided that relate to the use of isolated, engineered recombinant cells to directly or indirectly treat diseases or disorders in a mammalian host such as endocrine, gastrointestinal or autoimmune disorders. A recombinant cell is provided that comprises a signal sequence and a promoter, wherein: the signal sequence is capable of regulating signal-dependent expression of a target nucleic acid in a host or is capable of regulating signal-dependent expression of a target nucleic acid in response to an environmental stimulus, the cell is derived from an enteric or a commensal bacterium, and the target nucleic acid encodes a mammalian factor that promotes normal functioning of a physiological process in the host or is effective in preventing onset, establishment, or spread of a non-infectious disease in the host. The recombinant cell is administered to the host to treat the disease or disorder. | 04-17-2014 |
20140100166 | METHODS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE - The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. | 04-10-2014 |
20140099261 | DISTINGUISHING BENIGN AND MALIGNANT INDETERMINATE THYROID LESIONS - The application describes methods for accurately evaluating whether thyroid test samples, especially indeterminate thyroid samples, are benign or malignant. | 04-10-2014 |
20140099257 | Androgen Suppression, Prostate-Specific Membrane Antigen and the Concept of Conditionally Enhanced Vulnerability - Anti-androgen therapies represent the cornerstone of prostate cancer (PC) treatment. Yet all PC patients ultimately fail efforts to rein in the androgen receptor (AR). This invention is based on the discovery that prostate-specific membrane antigen (PSMA), a highly PC-specific and clinically validated cell surface target, is AR-suppressed and up-regulated in PC as a result of hormonal manipulation. This up-regulation occurs in an unexpected timeframe and it occurs even in the castrate-resistant setting. As a result, hormonal therapy creates a state of conditionally enhanced vulnerability of PC to PSMA-targeted anti-cancer/cytotoxic agents that can be exploited by leveraging anti-AR therapy by the addition of PSMA-targeted agents. We demonstrate this conditionally enhanced vulnerability in a castrate-resistant animal model. The state of conditionally enhanced vulnerability may be relevant for other cancer targets and efforts to screen for them may improve other cancer therapies. | 04-10-2014 |
20140097332 | IMAGING DEVICE AND METHOD - The resolution of conventional imaging devices is restricted by the diffraction limit ‘Perfect’ imaging devices which can achieve a resolution beyond the diffraction limit have been considered impossible to implement. However, the present disclosure provides an imaging device which can achieve improved resolution beyond the diffraction limit and which can be implemented in practice. Said imaging device comprises: a. a lens having a refractive index that varies according to a predetermined refractive index profile; b. a source; c. an outlet for decoupling waves from the device; and d. a reflector provided around the lens, the source and the outlet, wherein the reflector and the refractive index profile of the lens are together arranged to direct waves transmitted in any of a plurality of directions from the source to the outlet. | 04-10-2014 |
20140096296 | Strawberry Plant Named 'HERRIOT' - This invention relates to a new and distinct June-bearing (short day responsive) strawberry plant named ‘Herriot’ primarily adapted to the growing conditions of the west central New York and other regions of similar climate. The new plant is primarily characterized by strong vigor, longer than broad fruit, conical fruit shape, uniformity in-shape between primary and secondary fruit, reflexed calyx, bright red fruit color, glossy fruit skin and highly pigmented petioles. | 04-03-2014 |
20140093897 | AROMATIC-CATIONIC PEPTIDES AND USES OF SAME - The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport and electrical conductance. | 04-03-2014 |
20140093870 | SINGLE MOLECULE IMAGING TECHNIQUES TO AID CRYSTALLIZATION - This invention relates to a method to rapidly find crystallization conditions for a biomolecule in a desired conformation using single-molecule, fluorescent resonance energy transfer (smFRET) imaging techniques. The method provides significant cost and time advantages over the empricial exploration for crystallization conditions. | 04-03-2014 |
20140093778 | SINGLE CRYSTAL MIXED METAL OXIDE NANOSHEET MATERIAL COMPOSITIONS, METHODS AND APPLICATIONS - A nanosheet comprises a single crystal mixed metal oxide M1 | 04-03-2014 |
20140088560 | INTRA-LUMINAL ACCESS APPARATUS AND METHODS OF USING THE SAME - Apparatus and methods providing intra-luminal access and, in particular, to needle, catheter, and guidewire structures and methods of using the same to access a vascular or other body tissue lumen. | 03-27-2014 |
20140084727 | ELECTRICAL GENERATOR APPARATUS, SYSTEM, METHOD, AND APPLICATIONS - An electrical generator apparatus, an electrical generator system and a method for generating electricity while using the electrical generator apparatus or the electrical generator system each include at least one hollow tubular arc component (i.e., generally a hollow tubular ring), at least one coil winding surrounding the at least a portion of the at least one hollow tubular arc component and at least one magnet movably located within a bore within the at least one hollow tubular arc component to pass through the at least one coil winding. By effecting a relative motion of the at least one magnet with respect to the at least one coil winding, an electrical output may be generated at the terminals of the at least one coil winding. The electrical generator apparatus, system and method may be particularly useful in generating electricity from water wave motion when the electrical generator apparatus is housed within a watertight enclosure that may serve as a buoy enclosure. | 03-27-2014 |
20140083859 | BIOFUNCTIONAL NANOFIBERS FOR ANALYTE SEPARATION IN MICROCHANNELS - A method is provided for producing, in a substrate, an enclosed channel or enclosed cavity comprising at least one functional nanofiber, the method comprising the steps of providing a first substrate and a second substrate; forming a channel or cavity on the first substrate or the second substrate; electrospinning at least one functional nanofiber on the first substrate; assembling the first and second substrates, wherein the first substrate is placed over the second substrate, or the second substrate is placed over the first substrate; and bonding the first substrate and the second substrate to form the substrate, thereby forming an enclosed channel or enclosed cavity comprising the at least one functional nanofiber in the substrate. An enclosed channel or cavity comprising at least one functional electrospun nanofiber is also provided. A microfluidic device is also provided comprising an enclosed channel or cavity comprising at least one functional electrospun nanofiber. | 03-27-2014 |
20140083327 | BACTERIAL CELLULOSE BASED 'GREEN' COMPOSITES - ‘Green’ composites are fabricated using resins, such as soy-based resins, and reinforced with crystalline high strength bacterial cellulose (BC) fibers. Bacterial cellulose is produced by providing a bacterial cellulose-producing bacterium such as | 03-27-2014 |
20140080784 | USE OF URIDINE AND DEOXYURIDINE TO TREAT FOLATE-RESPONSIVE PATHOLOGIES - The present invention relates to a pharmaceutical or dietary composition comprising deoxyuridine and a pharmaceutically or dietetically suitable carrier. Another aspect of the present invention relates to a method of supplementing the dietary needs of a subject. This method includes administering to the subject a dietary supplementing effective amount of deoxyuridine. Yet another aspect of the present invention relates to a method of treating cancer in a subject. This method includes selecting a subject having cancer and administering to the selected subject a therapeutically effective amount of uridine, thereby treating the cancer in the selected subject. | 03-20-2014 |
20140079717 | Compositions and Methods to Prevent Cell Transformation and Cancer Metastasis - Provided are methods for characterizing microvesicles or other membranous structures. The methods involve assaying samples for microvesicles or other membranous structures, and include in certain aspects determining the presence or absence of tissue transglutaminase (tTG) and/or cross-linked fibronection (FN). The microvesicles or other membranous structures can be separated from a sample using recombinant tTG or a derivative of it, or tTG or FN binding partners. Also provided are methods for inhibiting the transfer of cargo from microvesicles which contain tTG to one or more cells. This involves administering to the individual a tTG inhibitor, such as a cell-impermeable tTG inhibitor. Also provided are compositions which contain a population of microvesicles or other membranous structures, where the population is attached to tTG or a derivative thereof, or to tTG or an FN binding partner. Kits which contain reagents and other components for carrying out the method are also provided. | 03-20-2014 |
20140078568 | MULTI-AXIS, LARGE TILT ANGLE, WAFER LEVEL MICROMIRROR ARRAY FOR LARGE SCALE BEAM STEERING APPLICATIONS | 03-20-2014 |
20140073519 | LUNG CANCER-RELEVANT HUMAN EMBRYONIC STEM CELL SIGNATURE - The invention provides a method of detecting cancer, a progression of cancer, or a predisposition to cancer in a human, comprising (a) obtaining a sample of airway basal cells from the human, and (b) analyzing the sample to determine expression of one or more hESC-signature genes, wherein the expression or lack of expression of the one or more hESC-signature genes is indicative of a presence or absence of cancer, a progression of cancer, or a predisposition to cancer in the human. The invention also provides an in vitro model for lung cancer, comprising airway basal cells that express one or more hESC-signature genes. | 03-13-2014 |
20140072672 | HYDROCOLLOID STABILIZED DEHYDRATED FOOD FOAM - The present invention relates to a dehydrated and aerated food product. The dehydrated and aerated food product includes a plant puree mixture and a hydrocolloid. The plant puree mixture and hydrocolloid combine to form a dehydrated and aerated plant puree foam having a hydrocolloid-based aeration network dispersed throughout the plant puree mixture. The present invention also relates to methods of making and using the dehydrated and aerated food product, and combination food products that include the dehydrated and aerated food product. | 03-13-2014 |
20140070139 | NANOSCALE IONIC MATERIAL (NIM) COMPOSITIONS VIA ACID/BASE REACTION - A nanoscale ionic material composition, such as but not limited to a nanoscale ionic solid material composition, a nanoscale ionic gel material composition or a nanoscale ionic liquid material composition, may be prepared using an acid/base reaction directly between: (1) one of an acid functional and a base functional inorganic metal oxide nanoparticle core absent an organofunctional corona; and (2) a corresponding complementary one of a basic and acidic functional organic polymer material canopy. Desirably, the nanoscale ionic material composition is formed absent an intervening chemical functionalization process step with respect to the inorganic metal oxide nanoparticle core that provides the corona, such as but not limited to a silane coupling agent chemical functionalization process step with respect to the inorganic metal oxide nanoparticle core to provide the corona. | 03-13-2014 |
20140069813 | SYSTEM AND METHODS FOR MOVING OBJECTS INDIVIDUALLY AND IN PARALLEL - Electro-osmosis is used to create droplets in order to easily, carefully, and quickly pick-and-place millions of objects (ranging in size from millimeters to nanometers) individually or in parallel. Droplets are formed within channels that are individually controlled in order to achieve a predetermined configuration of the selected objects. | 03-13-2014 |
20140052285 | METHOD FOR SPECIFYING AND FABRICATING AN OBJECT, ASSOCIATED APPARATUS, AND APPLICATIONS - A method for specifying and fabricating non-homogeneous, anisotropic, truly functionally graded objects. The objects may have defined spatial heterogeneity (e.g., a gradient in material concentration) with local randomized distributions. This local randomness is designed in such a way that global averaging results in the specified spatial heterogeneity. The fabrication of structures is an additive process in which a material is deposited in defined patterns. | 02-20-2014 |
20140039803 | Method for Rapid Identification of Drug Targets and Drug Mechanisms of Action in Human Cells - A method of identification of drug targets and drug resistance mechanisms in human cells of a drug comprising the steps of: generating at least one drug-resistant sample and at least one drug-sensitive sample; analyzing substantial portions of the genome and/or transcriptome of the least one drug-resistant sample and drug-sensitive sample to obtain sequencing data; detecting substantially all alterations in the at least drug-resistant sample; deriving a resistance signature; and performing analysis of the drug resistance signature of at least one recurrently altered gene using bioinformatic tools and cellular biology methods to determine if alteration of the at least one gene of the drug resistance signature is sufficient to confer at least partial resistance to cells or tissues against the drug. | 02-06-2014 |
20140038918 | TREATMENTS FOR RETINAL DISORDERS - The present invention relates to the use of cyclic oligosaccharides as chemical complexants of lipofuscin bisretinoids (A2E) to prevent and treat eye (i.e., retinal or macular) disease. Monomeric, dimeric, multimeric, or polymeric oligosaccharide rings act as pharmacologic agents to prevent and treat ophthalmologic disorders triggered by the accumulation of lipofuscin in the retinal pigment epithelium (RPE), which occurs as a consequence of either genetic disorders, such as Stargardt Disease (SD) and Best Disease (BD), or aging, such as Age-Related Macular Degeneration (AMD), or other diseases, such as retinitis pigmentosa, and cone-rod dystrophy. | 02-06-2014 |
20140038901 | CIRCULATING EXOSOMES AS DIAGNOSTIC/PROGNOSTIC INDICATORS AND THERAPEUTIC TARGETS OF MELANOMA AND OTHER CANCERS - The present invention is directed to methods of diagnosing, preventing, and treating metastatic disease in a subject. The present invention is also directed to a method of inhibiting primary tumor growth in a subject. Methods of identifying candidate compounds useful for preventing and treating metastatic disease and primary tumor growth in a subject are also disclosed. | 02-06-2014 |
20140037944 | COVALENT ORGANIC FRAMEWORK FILMS, AND METHODS OF MAKING AND USES OF SAME - Multilayer structures comprising a covalent organic framework (COF) film in contact with a polyaromatic carbon (PAC) film. The multilayer structures can be made by combining precursor compounds in the presence of a PAC film. The PAC film can be for example, a single layer graphene film. The multilayer structures can be used in a variety of applications such as solar cells, flexible displays, lighting devices, RFID tags, sensors, photoreceptors, batteries, capacitors, gas-storage devices, and gas-separation devices. | 02-06-2014 |
20140037647 | MOLECULAR SUBTYPING, PROGNOSIS AND TREATMENT OF PROSTATE CANCER - Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN define a distinct subgroup of prostate cancer that is predisposed to the development of lethal NEPC, who will benefit from early intervention. | 02-06-2014 |
20140030294 | METHODS FOR INCREASING IMMUNE RESPONSES USING AGENTS THAT DIRECTLY BIND TO AND ACTIVATE IRE-1 - The invention provides, e.g., compositions and methods for increasing activation of immune cells. | 01-30-2014 |
20140017696 | Measuring Subcellular Concentrations in Vivo - An isolated nucleic acid reporter construct, the protein for which it encodes and methods for its use for the in vivo or in vitro measurement of the concentration of a specific biologically important molecule in a subcellular compartment or locale are provided. Certain constructs described are useful in measuring the local concentration of ATP at synapses. | 01-16-2014 |
20140016856 | PREDICTION OF SUCCESSFUL GRASPS BY END OF ARM TOOLING - Given an image and an aligned depth map of an object, the invention predicts the 3D location, 3D orientation and opening width or area of contact for an end of arm tooling (EOAT) without requiring a physical model. | 01-16-2014 |
20140004583 | MESOPOROUS CATALYSTS OF MAGNETIC NANOPARTICLES AND FREE-RADICAL-PRODUCING ENZYMES, AND METHODS OF USE | 01-02-2014 |
20130345155 | MODULATORS FOR SIRT6 AND ASSAYS FOR SCREENING SAME - Method for identifying a modulator of Sirt6, PfSir2a, or Sirt7 deacylase activity, wherein a fatty-acylated substrate containing an acyl-lysine moiety and an indicator moiety is contacted with Sirt6, PfSir2a, or Sirt7 in the presence of a candidate compound under conditions for Sirt6, PfSir2a, or Sirt7 to deacylate the substrate, wherein the acyl is a hydrophobic fatty acyl group containing a hydrocarbon group having at least three carbon atoms connected by carbon-carbon bonds; contacting the deacylated substrate with a cleavage agent that cleaves the linkage between the lysine and indicator moiety to generate a detectable signal; and correlating a quantified Sirt6, PfSir2a, or Sirt7 deacylase activity therefrom. Modulating compounds of Sirt6, PfSir2a, or Sirt7 deacylase activity are also described, as are pharmaceutical compositions thereof, methods of treatment by administration of the modulating compounds, and kits for practicing the method. | 12-26-2013 |
20130338001 | METAL OXIDE FOAM, AMINE FUNCTIONAL SOLID SORBENT, METHODS AND APPLICATIONS - Amine functional solid sorbents for carbon dioxide capture and sequestration may be prepared from metal oxide foam solid sorbent supports by treating an appropriate metal oxide foam solid sorbent support with an amine material. Desirable are metal oxide foam solid sorbent supports with a foam structure and morphology at least substantially absent hollow sphere, layered sphere, wormlike and amorphous structure and morphology components. The amine materials may be sorbed into the metal oxide foam solid sorbent support, or alternatively chemically bonded, such as but not limited to covalently bonded, to the metal oxide foam solid sorbent support. | 12-19-2013 |