CONTIPRO BIOTECH S.R.O.
|CONTIPRO BIOTECH S.R.O. Patent applications|
|Patent application number||Title||Published|
|20150175717||Hyaluronic Acid Derivative, Method of Preparation Thereof, Method of Modification Thereof and Use Thereof - The invention relates to the preparation and use of α,β-unsaturated aldehyde of hyaluronan having a double bond in the positions 4 and 5 and an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. The method of preparation is based on dehydration of hyaluronan having an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. Two methods have been described, which are dehydration in a solution or heating in solid state in absence of solvents, bases or other additives. This derivative allows stabilization of conjugates of hyaluronan with amino compounds by means of a multiple bond from the aldehyde side, and therefore, it is possible to effectively immobilize practically any compound containing an amino group to such modified hyaluronan in physiological conditions. In case of using a diamine or compounds or polymers containing three or more amino groups, it is possible to prepare crosslinked hyaluronan derivatives. The described solution brings along a significant advantage not only in the field of carriers of biologically active substances, but also in tissue engineering where crosslinking with biologically acceptable amino compounds in physiological conditions is very much demanded.||06-25-2015|
|20140284827||METHOD FOR PRODUCTION OF MATERIALS HAVING ANISOTROPIC PROPERTIES COMPOSED OF NANOFIBRES OR MICROFIBRES AND AN APPARATUS FOR IMPLEMENTATION OF SAID METHOD - A method of producing fibres includes continuously drawing a fibre out of a solution, and pulling it to a rotary set of n electrodes by means of an electrostatic field. The individual electrodes of the set are arranged at regular spacing to each other and at the same distance from the set's rotation axis, and parallel with it. The fibre is wound on the set of electrodes by rotating the set of electrodes. The electrostatic field is disconnected and rotation of the set of electrodes is stopped. A layer of the fibres formed in the field between two adjacent electrodes is removed. The rotating set of electrodes turns through an angle of 360/n, the layer of the fibres formed between two adjacent electrodes in the field adjacent to the field from which the layer was removed, is removed, and this step is repeated in total n-times.||09-25-2014|
|20140120069||Amphoteric Materials Based on Crosslinked Hyaluronic Acid, Method of Preparation Thereof, Materials Containing Entrapped Active Agents, Method of Preparation Thereof, and Use of Said Materials - The present invention describes novel amphoteric materials based on crosslinked hyaluronic acid, according to the general formula (I), and a method of preparation of said materials. Further, the invention relates to the material containing entrapped active agents (e.g. drugs, growth factors etc.) and a method of preparation thereof. Moreover, the present invention relates to the use of said materials for controlled release systems, in tissue engineering, wound dressing or tissue regeneration.||05-01-2014|
|20140030370||COMBINED SPINNING NOZZLE FOR THE MANUFACTURE OF NANOFIBROUS AND MICROFIBROUS MATERIALS - The combined spinning nozzle for the production of nanofibrous or microfibrous materials according to the invention comprises a thin-walled electrode and a first non-conductive body adjoining the first wall of said thin-walled electrode, said first body having its wall, which faces the thin-walled electrode, provided with an array of grooves formed therein, said grooves leading to the distal end of the combined spinning nozzle and having their proximal ends connected to a supply of spinning mixture. The thin-walled electrode as well as the first non-conductive body may assume either plate-like or cylindrical shapes. The combined spinning nozzle may further comprise the second non-conductive body adjoining the second wall of the thin-walled electrode and directing the air from the proximal end towards the distal end of the nozzle. The combined spinning nozzle is easy to dismantle and clean since the spinning capillaries assume the shape of the grooves formed on the surfaces of the first or third non-conductive bodies.||01-30-2014|
|20130309494||HYALURONAN FIBRES, METHOD OF PREPARATION THEREOF AND USE THEREOF - The invention relates to the method of preparation of hyaluronic acid-based fibres, where first the spinning solution of hyaluronic acid and/or a metal compound thereof, optionally containing a metal salt or a hyaluronic acid compound and metal ions, is prepared, then the spinning solution is introduced into the coagulation bath comprising an acid, an alcohol and not more than 10% wt. of water, and optionally a metal salt, resulting in forming a fibre which is preferably left in the coagulation bath and/or is drawn, then the fibre is washed with alcohol and dried. After washing of the fibre, metal ions may be introduced in the fibre by means of the metalization bath. Further, the invention relates to the fibres based on hyaluronic acid and/or a metal compound thereof, having the fibre (monofilament) diameter 4 μm to 1 mm, linear weight 0.1 to 30 g/1000 m (0.1 to 30 tex), tensile strength 0.5 to 3 cN·dtex||11-21-2013|
|20120301567||APPARATUS FOR PRODUCTION OF TWO-DIMENSIONAL OR THREE-DIMENSIONAL FIBROUS MATERIALS OF MICROFIBRES AND NANOFIBRES - An apparatus for a production of two-dimensional or three-dimensional fibrous materials of microfibers or nanofibers containing a set of spinning metal nozzles connected to a first potential, a set of electrodes of a collector facing the set of the nozzles, arranged at regular spacing and connected to a second potential, and a collecting plate or a collecting cylinder for collecting microfibers or nanofibers settled between couples of adjacent electrodes of the collector. The substance of the invention is as follows: the set of the electrodes of the collector contains at least two electrodes of the collector arranged in a plane and the collecting plate in line of its intersection or a tangent to the collecting cylinder, that is perpendicular to a contact line with the plane of the electrodes of the collector, form with the plane of the electrodes of the collector an angle α, the size of which ranging between 0° and 90°, the collecting plate or the collecting cylinder being supported movably in relation to the electrodes of the collector in a direction lying in the plane that is perpendicular to the plane of the electrodes of the collector and in which the axis of the electrode lies, the direction of the collecting plate or the collecting cylinder movement forming with this electrode axis an angle β, the size of which ranging between 0° and 90°. Such arrangement enables creating of large areal and voluminous objects of ordered nanofibers.||11-29-2012|
Patent applications by CONTIPRO BIOTECH S.R.O.