| 20090239875 | Protection of ferulic acid and/or tetramethylpyrazine against retinal ischaemia, glaucoma and siderosis oculi - A method for preventing and/or treating ischaemic and/or iron-related retinal or brain disorders comprising administering an effective amount of ferulic acid (FA), tetramethylpyrazine (TMP) or their pharmaceutically acceptable salt, ester, solvate, hydrate, analogs, metabolite, enantiomer, isomer, tautomer, amide, derivative or prodrug to a subject. The former diseases comprise retinal ischemia, glaucoma as well as brain ischaemia (i.e. stroke, infarction typed). The latter ones comprise age-related macular degeneration, intraocular hemorrhage, siderosis oculi (due to retained intraocular iron), oxidative stress of the retina as well as brain hemorrhage (stroke, hemorrhagic type) or Alzheimer disease. Clinically, FA alone or in combination of TMP can be administered systemically, orally, intravitreously, topically (in form of eyedrops), as well as other routes such as periocular, subconjunctival, and intracamera. | 09-24-2009 |
