| Colorado State University Research Foundation Patent applications |
| Patent application number | Title | Published |
|---|
| 20120107921 | MODEL BASED CONTROLS FOR USE WITH BIOREACTORS - Embodiments of the present invention include model-based controls to control photobioreactor operation and the growth of algae for use as a biofuels feedstock. In some embodiments, the model-based control can accounts for future conditions such as weather, product pricing, customer demands and/or other variables to operate the reactors in a manner that optimizes product revenues, minimizes costs or energy, maximizes photosynthetic or energy balance efficiency, and/or any combination of the aforementioned factors. | 05-03-2012 |
| 20120088239 | Detection of Chromosomal Inversions - A method and a kit for the identification of chromosomal inversions are described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are attached to oligonucleotide strands designed such that they may hybridize to portions of only one of a pair of single-stranded sister chromatids prepared by the CO-FISH procedure, as an example. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid. | 04-12-2012 |
| 20120088215 | INTEGRATED MODEL FOR OTOSCOPIC PROCEDURES - An otoscopic model is disclosed herein. In one embodiment, the otoscopic model includes an artificial ear, an artificial head and at least one tympanic membrane portion. The artificial ear includes a base portion and an ear portion extending from the base and having ear-like features including an auditory canal. The artificial head includes an opening adapted to receive the base portion. The at least one tympanic membrane portion includes an artificial tympanic membrane. The tympanic membrane portion is configured to be coupled with the artificial ear such that the artificial tympanic membrane is located relative to the auditory canal in a generally anatomically correct manner. | 04-12-2012 |
| 20120073971 | SELF-ASSEMBLY OF COATINGS UTILIZING SURFACE CHARGE - An apparatus and method for measuring the isoelectric pH for materials deposited on or otherwise affixed onto and in contact with an electrode surface, and a method for utilizing the isoelectric pH to form nanometer thickness, self-assembled layers on the material, are described. Forming such layers utilizing information obtained about the isoelectric pH values of the substrate and the coating is advantageous since the growth of the coating is self-limiting because once the surface charge has been neutralized there is no longer a driving force for the solid electrolyte coating thickness to increase, and uniform coatings without pinhole defects will be produced because a local driving force for assembly will exist if any bare electrode material is exposed to the solution. The present self-assembly procedure, when combined with electrodeposition, may be used to increase the coating thickness. Self-assembly, with or without additional electrodeposition, allows intimate contact between the anode, electrolyte and cathode which is required for successful application to solid-state batteries, as an example. | 03-29-2012 |
| 20120068848 | MULTI-SENSOR ENVIRONMENTAL AND PHYSIOLOGICAL MONITOR SYSTEM AND METHODS OF USE - A system and method for monitoring the condition of a human, companion animal, or livestock animal in an extreme environment is disclosed. In particular, a system and method to process at least one environmental measurement and at least one physiological measurement to assess at least one condition of a human, companion animal, or livestock animal in an extreme environment is disclosed. | 03-22-2012 |
| 20120058475 | Detection of Chromosomal Inversions - A method and a kit for the identification of chromosomal inversions is described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are attached to oligonucleotide strands designed such that they may hybridize to portions of only one of a pair of single-stranded sister chromatids prepared by the CO-FISH procedure, as an example. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid. | 03-08-2012 |
| 20120058150 | Methods for Delivering Compositions by Electrospraying a Medical Device - Methods are provided for administering a phospholipid composition to a subject, comprising coating a medical device with at least one layer of a phospholipid composition, wherein the coating is achieved by electrospraying the device with the composition, and wherein the composition is carrying or can carry at least one therapeutic agent. | 03-08-2012 |
| 20120040247 | LAYERED COMPOSITE MATERIALS HAVING THE COMPOSITION: (1-x-y)LiNiO2(xLi2Mn03)(yLiCoO2), AND SURFACE COATINGS THEREFOR - A straightforward and scalable solid-state synthesis at 975° C. used to generate cathode materials in the system Li | 02-16-2012 |
| 20120006809 | SUBLIMATION CRUCIBLE WITH EMBEDDED HEATER ELEMENT - Systems, apparatus and methods for in-line evaporative deposition are described herein that include a nickel chromium wire based heating system that can reach desired operating temperatures while providing opportunities for improved temperature uniformity and energy usage. In some embodiments, an apparatus includes a base member configured to be used as a sublimation crucible and the base member defines a channel in a surface of the base member. A first layer of electrically insulating material is disposed within the channel and has a substantially uniform thickness. A heater coil is disposed within the channel such that the first layer of electrically insulating material is disposed between the heater coil and the surface of the base. A second layer of electrically insulating material is disposed on the heater coil such that the heater coil is disposed between the first layer of electrically insulating material and the second layer of electrically insulating material. | 01-12-2012 |
| 20110319988 | Device and System for Transcatheter Mitral Valve Replacement - This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve. | 12-29-2011 |
| 20110287425 | Assays to Detect Small-Scale Mutations in Individual Cells - Methods, compositions, and assays are described which are useful in identifying point mutations, identifying cancer cells, and diagnosing cancer. | 11-24-2011 |
| 20110284379 | DIRECT DETERMINATION OF CARBOHYDRATES, AMINO ACIDS AND ANTIBIOTICS BY MICROCHIP ELECTROPHORESIS WITH PULSED AMPEROMETRIC DETECTION - The present invention provides a microchip for performing electrophoresis with pulsed amperometric detection (PAD) for the separation and detection of underivatized carbohydrates, amino acids, sulfur-containing antibiotics, etc. PAD allows for the direct detection of amines, thiols, alcohols and carbohydrates and therefore is a useful technique for the development of electrochemical detection for microchip electrophoresis. | 11-24-2011 |
| 20110281299 | Recombinant Pokeweed Antiviral Proteins, Compositions and Methods Related Thereto - The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the proteins. The present invention also provides methods to administer the conjugates to animals, for the purpose of directing toxin to particular cells. | 11-17-2011 |
| 20110257950 | Nonlinear function approximation over high-dimensional domains - An algorithm is disclosed for constructing nonlinear models from high-dimensional scattered data. The algorithm progresses iteratively adding a new basis function at each step to refine the model. The placement of the basis functions is driven by a statistical hypothesis test that reveals geometric structure when it fails. At each step the added function is fit to data contained in a spatio-temporally defined local region to determine the parameters, in particular, the scale of the local model. The proposed method requires no ad hoc parameters. Thus, the number of basis functions required for an accurate fit is determined automatically by the algorithm. The approach may be applied to problems including modeling data on manifolds and the prediction of financial time-series. The algorithm is presented in the context of radial basis functions but in principle can be employed with other methods for function approximation such as multi-layer perceptrons. | 10-20-2011 |
| 20110236949 | Methods for Processing Biological Tissues - Methods are provided for removing or separating the cellular and/or soluble macromolecular component of a biological tissue from the extracellular matrix component of the biological tissue, comprising embedding the biological tissue in an electrically conductive semi-solid or solid supporting medium and applying an electric field to the tissue-medium complex. Additionally, methods are provided for decellularizing a skin fragment. | 09-29-2011 |
| 20110224431 | Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof - Provided herein are triazolium carbine catalysts useful for asymmetric hydration, fluorination, and deuteration, and processes for their preparation. Also provided are synthetic reactions in which these catalysts are used, in particular, in stereoselective formation of carbon-chlorine, carbon-hydrogen, carbon-fluorine, and carbon-deuterium bonds. | 09-15-2011 |
| 20110159116 | BIOCOMPATIBLE MATERIALS FOR MEDICAL DEVICES - The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework. | 06-30-2011 |
| 20110114074 | Combustion Chamber for Charcoal Stove - A combustion chamber may include an upper and a lower chamber. The chambers may be separable to aid in loading fuel and removing spent fuel. The cross-section of the upper combustion chamber may be less than the cross-section of the lower section. Charcoal or other biomass fuel may be added into the lower combustion chamber and may be supported by a grate. Oxygen may be fed into the combustion chamber through a plurality of apertures that may be substantially shielded from direct line of site of the fuel bed. The upper combustion chamber may further include an annular constriction, to aid in constricting the view factor between the cooking vessel and the fuel bed. The constriction may also aid in radiating energy back to the fuel bed. | 05-19-2011 |
| 20110102250 | SENSITIVITY ENHANCEMENT SYSTEM - Sensitivity is a critical aspect of weather radar systems. Such systems not only detect atmospheric patterns but often need to precisely measure weak precipitation echoes. Embodiments of the invention use pulse compression techniques to increase the sensitivity of weather radar systems. These techniques can include sending two waveforms into a region of interest, where the second waveform is designed based on knowledge about the first waveform. Such systems can enhance the sensitivity of weather radars about 10 dB. | 05-05-2011 |
| 20110102249 | RESOLUTION ENHANCEMENT SYSTEM (RES) FOR NETWORKED RADARS - Embodiments provide methods, systems, and/or devices that can provide measurements of the inherent reflectivity distribution from different look angles using N radar nodes. Doppler weather radars generally operate with very good spatial resolution in range and poor cross range resolution at farther ranges. Embodiments provide methodologies to retrieve higher resolution reflectivity data from a network of radars. In a networked radar environment, each radar may observe a common reflectivity distribution with different spreading function. The principle that the underlying reflectivity distribution should remain identical for all the nodes may be used to solve the inverse problem to determine intrinsic reflectivities. | 05-05-2011 |
| 20110086384 | IDENTIFICATION OF BACTERIAL SPECIES AND SUBSPECIES USING LIPIDS - The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. | 04-14-2011 |
| 20110042353 | NANOMETER-SCALE ABLATION USING FOCUSED, COHERENT EXTREME ULTRAVIOLET/SOFT X-RAY LIGHT - Ablation of holes having diameters as small as 82 nm and having clean walls was obtained in a poly(methyl methacrylate) on a silicon substrate by focusing pulses from a Ne-like Ar, 46.9 nm wavelength, capillary-discharge laser using a freestanding Fresnel zone plate diffracting into third order is described. Spectroscopic analysis of light from the ablation has also been performed. These results demonstrate the use of focused coherent EUV/SXR light for the direct nanoscale patterning of materials. | 02-24-2011 |
| 20100322534 | OPTIMIZED CORRELATION FILTERS FOR SIGNAL PROCESSING - A system and method for generating and using a correlation filter. The method includes providing a plurality of training images, each training image being paired with an associated target correlation plane. Each training image and target correlation plane pair is processed. A final filter is generated, wherein the final filter is useable to generate a filtered output correlation plane of each training image. The final filter is selected to collectively minimize errors between the filtered output correlation plane of each training image and its associated target correlation plane. The final filter can be used in a wide variety of still image and video based object location and tracking applications. | 12-23-2010 |
| 20100150983 | OUTER LAYER HAVING ENTANGLEMENT OF HYDROPHOBIC POLYMER HOST AND HYDROPHILIC POLYMER GUEST - An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer. | 06-17-2010 |
| 20100112004 | HYPOXIA INDUCIBLE FACTOR INDUCER AND METHODS FOR USING THE SAME - The present invention provides vaccine compositions and methods for using the same. Generally, the vaccine is used to prevent infection of a microorganism that produces an HIF inducing compound. Accordingly, vaccines of the invention comprise at least a portion of an HIF inducing compound that is produced by the microorganism. | 05-06-2010 |
| 20100090884 | GAUSSIAN MODEL ADAPTIVE PROCESSING IN THE TIME DOMAIN - Embodiments of the present invention provide a Gaussian adaptive filter for ground clutter filtering and signal parameter estimation for weather radars in the time domain. In some embodiments, the filtering can be applied to dual polarization radar systems. In some embodiments, the clutter component of the signal can be transformed to noise. An interpolation procedure can then be used to recover the transformed part of the weather. A unique filter can be designed to use for both H and V channels for dual-polarization parameter estimation. In addition, the filter can be directly extended for staggered PRT 2/3 sampling scheme. | 04-15-2010 |
| 20100087519 | USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes. | 04-08-2010 |
| 20100087504 | Use of Diindolylmethane (DIM) Compounds and Derivatives as Neuroprotective Agents - Presented herein are diindolylmethane derivative compounds useful for the prevention and or treatment of neurological conditions, including neurological conditions related to neuroinflammation. One such neurological condition is Parkinson's disease. | 04-08-2010 |
| 20100079330 | Networked waveform system - Certain embodiments provide a network waveform system that can include multiple radars disposed at different geographical positions within an environment. The multiple radars may be configured to transmit a network waveform. The network waveform may include multiple radar waveforms. Each radar waveform of the multiple waveforms may be transmitted by a specific radar of the multiple radars. The system can also include a computer system coupled with the multiple radars that can include a processor and a memory. The memory may be configured to store information including data received from the multiple radars, data processed by the processor, and processing code executable by the processor. The processing code may include instructions to receive output data from the multiple radars resulting from the transmitted network waveform instructions to jointly process the output data from the multiple radars to determine a measurement of the environment based on the network waveform. | 04-01-2010 |
| 20100029731 | Method for preparing largazole analogs and uses thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 02-04-2010 |
| 20090315762 | Adaptive specific differential phase in dual-polarization radar - Systems and methods are provided for adaptively estimating the specific differential phase (K | 12-24-2009 |
| 20090287037 | REMEDIATION OF FUNCTIONAL CARDIAC MITRAL VALVE REGURGITATION - A dynamic device for reducing functional mitral regurgitation is described. The device is disposed externally to the heart and effectively acts as a splint for reducing further dilation of the heart in patients diagnosed with cardiomyopathy, and for reducing tethering of the papillary muscle on the mitral valve. The device does not require cardiopulmonary bypass for its installation since it is attached to the outside of the left ventricle, thereby reducing surgical risk, and is not exposed to the patient's blood once installed, thereby reducing the risk of thromboembolic disease. | 11-19-2009 |
| 20090214956 | LITHIUM-ION BATTERY - A lithium-ion battery having an anode including an array of nanowires electrochemically coated with a polymer electrolyte, and surrounded by a cathode matrix, forming thereby interpenetrating electrodes, wherein the diffusion length of the Li | 08-27-2009 |
| 20090169612 | Systemic Immune Activation Method Using Nucleic Acid-Lipid Complexes - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, or an infectious disease. Also disclosed are therapeutic compositions useful in such a method. | 07-02-2009 |
| 20090043547 | Nonlinear function approximation over high-dimensional domains - An algorithm is disclosed for constructing nonlinear models from high-dimensional scattered data. The algorithm progresses iteratively adding a new basis function at each step to refine the model. The placement of the basis functions is driven by a statistical hypothesis test that reveals geometric structure when it fails. At each step the added function is fit to data contained in a spatio-temporally defined local region to determine the parameters, in particular, the scale of the local model. The proposed method requires no ad hoc parameters. Thus, the number of basis functions required for an accurate fit is determined automatically by the algorithm. The approach may be applied to problems including modeling data on manifolds and the prediction of financial time-series. The algorithm is presented in the context of radial basis functions but in principle can be employed with other methods for function approximation such as multi-layer perceptrons. | 02-12-2009 |
| 20090033542 | GROUND CLUTTER MITIGATION USING A PARAMETRIC TIME DOMAIN METHOD - Methods and systems are disclosed for investigating a region of interest with a radar. A radar signal is propagated to the region of interest. Sampled time-domain radar data scattered within the region of interest are collected. A likelihood function is calculated with the sampled time-domain data within a parametric model of the region of interest for a defined set of parameters. The set of parameters in varied to find an extremum of the likelihood function. | 02-05-2009 |
| 20090016493 | RENEWABLE LASER TARGET - Generation of 2 μW average output power at 13.9 nm from a table-top laser-pumped Ni-like Ag laser operating at 5 Hz repetition rate using a silver-coated helical target which is rotated and advanced such that the target surface is renewed between pulses, is described. Greater than 2×10 | 01-15-2009 |
| 20080294870 | SWITCH MEMORY ARCHITECTURES - The present invention provides a switch memory architecture (SMA) consisting of: (i) processing elements (PE), (ii) memory banks (MB), and (iii) interconnect switches (ISWITCH). The present invention allows for efficient, potentially unbounded data transfer between two adjacent processes by passing a memory handle and the status registers (memory control information) of the MB. This function may be performed by the ISWITCH. | 11-27-2008 |
| 20080256130 | NONLINEAR SET TO SET PATTERN RECOGNITION - Variations in the states of patterns can be exploited for their discriminatory information and should not be discarded as noise. A pattern recognition system compares a data set of unlabeled patterns having variations of state in a set-by-set comparison with labeled arrays of individual data sets of multiple patterns also having variations of state. The individual data sets are each mapped to a point on a parameter space, and the points of each labeled array define a subset of the parameter space. If the point associated with the data set of unlabeled patterns satisfies a similarity criterion on the parameter space subset of a labeled array, the data set of unlabeled patterns is assigned to the class attributed to that labeled array. | 10-16-2008 |
| 20080212721 | LOW COMPLEXITY MAXIMUM LIKELIHOOD SEQUENCE DETECTION SYSTEM AND METHODS - A system and method implement low complexity maximum likelihood sequence detection. A decision feedback algorithm computes x(M+D+L−1). Optimality examination is performed for x(M), and state values and values of Markov states along paths from states in x(M) to x1(M+L) are computed. | 09-04-2008 |
| 20080200719 | Acid and base stable diphenylmethanol derivatives and methods of use - The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same. | 08-21-2008 |
