20110003753 | COMPOSITIONS AND METHODS FOR DISRUPTING THE FUNCTION OF THE TRANSCRIPTIONAL REPRESSOR COMPONENT Sin3A-PAH2 DOMAIN TO INDUCE DIFFERENTIATION AND GROWTH INHIBITION IN BREAST CANCER - The present invention relates, generally, to compositions for treating breast cancer, use of the compositions to sensitize breast cancer cells to treatment, and methods for treating breast cancer by administering the compositions. The compositions comprise peptides derived from the mSin3A interaction domain (SID) and derivatives thereof, as well as small molecule inhibitors (SMIs) capable of interfering with interactions between SID and the paired amphipathic helix domain 2 (PAH2) domain of the transcription repressor Sin3A. The present invention further relates to compositions for treating triple-negative breast cancer, use of the compositions to render the breast cancer cells susceptible to treatment using hormonal therapies and HER2-based therapies, and methods for treating triple-negative breast cancer by administering the compositions. | 01-06-2011 |