CLEVELAND CLINIC FOUNDATION Patent applications |
Patent application number | Title | Published |
20140294900 | FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF - The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptsis is described. | 10-02-2014 |
20140220037 | METHODS FOR TREATING REPERFUSION INJURIES - The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin | 08-07-2014 |
20140194995 | GLENOID VAULT FIXATION - A system is provided which includes an articulating component, a post, a reception member and a bone engaging member. The articulating component includes an articulating surface and a second surface opposite the articulating surface. The post is disposed below the second surface. The reception member is configured to receive the post. The bone engaging member is configured to be embedded in a bone, wherein the bone engaging member is configured to receive the reception member. The reception member includes a reception member inside surface, wherein the reception member inside surface faces the post when the post is received by the reception member. A first portion of the reception member inside surface defines a tapered configuration and the reception member inside surface comprises at least one ratchet interface. | 07-10-2014 |
20140194879 | GLENOID AUGMENT PREPARATION INSTRUMENT - A system for preparing a bone for receiving an articulating member is provided. The system includes a superior inferior component, a connection feature, a housing, at least one rotating member and a cutter. The superior inferior component is engaged to a structure. The connection feature is engaged with the superior inferior component. The housing is engaged with the connection feature. The rotating member is configured to rotate within the housing. The first cutter is engaged with the rotating member such that the rotation of the rotating member translates into rotation of the first cutter, wherein the first cutter rotates about an axis that is generally parallel to a natural surface of the bone. | 07-10-2014 |
20140172087 | METHOD FOR PHYSIOLOGIC CONTROL OF A CONTINUOUS FLOW TOTAL ARTIFICIAL HEART - A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter which is a function of electrical power delivered to the motor; (c) determining a flow rate through the first fluid circuit based on a second motor parameter which is a function of electrical power delivered to the motor; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit. | 06-19-2014 |
20140012134 | System and Method for Characterizing Vascular Tissue - A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter and/or substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. The backscattered ultrasound data is used, together with an algorithm, to estimate at least one transfer function. The transfer function(s) can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.). In some embodiments, the backscattered data is acquired during a cyclical portion of the heartbeat data so that the blood vessel can be analyzed or imaged as if it were standing still, or not expanding and relaxing. | 01-09-2014 |
20130178905 | MODULAR BONE FIXATION SYSTEM - Systems for modular bone fixation may include first, second, and at least one third portion to aid in fracture reduction, simplify the surgical procedure, increase fracture fixation strength, and reduce irritation to the patient caused by the implant. In some examples, the at least one third portion may be separable from the first and second portions to further simplify the surgical procedure and reduce irritation to the patient. | 07-11-2013 |
20130172984 | ENDOLUMINAL PROSTHESIS WITH A VALVE ARRANGEMENT - The present embodiments provide a stent graft having a tubular configuration defining a lumen therethrough, the stent graft having a proximal section and a distal section. A folded section is positioned between the proximal section and the distal section. The folded section includes a first fold directed toward the distal end and engaged with the proximal section and a second fold directed toward the proximal end and engaged with the distal section. A valve arrangement is positioned in at least one of the first and second folds providing access from an exterior of the graft to the interior of the stent graft for insertion of an additional device. | 07-04-2013 |
20130150975 | Shoulder Arthroplasty - A joint prosthesis system, specifically a shoulder prosthesis, for shoulder replacement, revision and repair. The implants provide fixation into the best bone available to a surgeon. The implants are used in a superior-inferior and anterior-posterior construct forming a type of cross or X-shape. The implants allow for interchangeability of the articulating component as well as rotational orientation. The systems will allow for augments to accommodate bone loss. The implants may allow for additional security using screws or anchors inserted into the scapula. | 06-13-2013 |
20130150974 | GLENOID VAULT FIXATION - A joint prosthesis system, specifically a shoulder prosthesis, for shoulder replacement, revision and repair. The implants provide fixation into the best bone available to a surgeon. The implants are used in a superior-inferior and anterior-posterior construct forming a type of cross or X-shape. The implants allow for interchangeability of the articulating component as well as rotational orientation. The systems will allow for augments to accommodate bone loss. The implants may allow for additional security using screws or anchors inserted into the scapula. | 06-13-2013 |
20130150972 | GLENOID VAULT FIXATION - A joint prosthesis system, specifically a shoulder prosthesis, for shoulder replacement, revision and repair. The implants provide fixation into the best bone available to a surgeon. The implants are used in a superior-inferior and anterior-posterior construct forming a type of cross or X-shape. The implants allow for interchangeability of the articulating component as well as rotational orientation. The systems will allow for augments to accommodate bone loss. The implants may allow for additional security using screws or anchors inserted into the scapula. | 06-13-2013 |
20130053945 | RETENTION SYSTEM FOR AN ENDOLUMINAL DEVICE - A delivery system for an endoluminal device including an introducer, the introducer having a distal end intended to remain outside a patient in use and a proximal end. A stent graft having a first and second end is retained upon the introducer, the stent graft defining a fenestration disposed through a wall of the stent graft between the first and second end. A valve arrangement is disposed within an interior lumen of the stent graft about the fenestration. A retention system including a trigger wire engages and retains the valve arrangement away from the fenestration. The fenestration is in fluid communication with the interior lumen of the stent graft. | 02-28-2013 |
20110319595 | FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF - The use of flagellin and flagellin related polypectides for the protection of mammals from the effects of apoptsis is described. | 12-29-2011 |
20110319344 | FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF - The use of flagellin and flagellin related polypectides for the protection of mammals from the effects of apoptsis is described. | 12-29-2011 |
20110311118 | Techniques for 3-D Elastic Spatial Registration of Multiple Modes of Measuring a Body - Techniques for registration of multiple measurement modes of a body include receiving first and second data from different modes. Each includes measured values with coordinate values. For two mechanically aligned modes, any non-rigid registration is performed. For some modes, the non-rigid registration includes a coarse transformation and multiple fine scale transformations. The coarse transformation maximizes a coarse similarity measure. The second data is sub-divided into contiguous sub-regions. Fine transformations are determined between the sub-regions and corresponding portions of the first data to maximize a fine similarity measure. Sub-dividing and determining fine transformations repeats until stop conditions are satisfied. Transformations between the last-divided sub-regions are interpolated. Any of the fine similarity measure, a search region, interpolation method, sub-division location, and the use of rigid or non-rigid fine transformations are adaptive to properties of the first or second data so that the registration is automatic without human intervention. | 12-22-2011 |
20110237507 | METHODS OF PROTECTING AGAINST APOPTOSIS USING LIPOPEPTIDES - The use of lipopeptides as inducers of NF-κB for the protection of mammals from the effects of apoptosis is described. | 09-29-2011 |
20110193882 | TECHNIQUES FOR 3-D ELASTIC SPATIAL REGISTRATION OF MULTIPLE MODES OF MEASURING A BODY - Techniques for registration of multiple measurement modes of a body include receiving first and second data from different modes. Each includes measured values with coordinate values. For two mechanically aligned modes, any non-rigid registration is performed. For some modes, the non-rigid registration includes a coarse transformation and multiple fine scale transformations. The coarse transformation maximizes a coarse similarity measure. The second data is sub-divided into contiguous sub-regions. Fine transformations are determined between the sub-regions and corresponding portions of the first data to maximize a fine similarity measure. Sub-dividing and determining fine transformations repeats until stop conditions are satisfied. Transformations between the last-divided sub-regions are interpolated. Any of the fine similarity measure, a search region, interpolation method, subdivision location, and the use of rigid or non-rigid fine transformations are adaptive to properties of the first or second data so that the registration is automatic without human intervention. | 08-11-2011 |
20110135665 | METHODS FOR TREATING REPERFUSION INJURIES - The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin. | 06-09-2011 |
20100174231 | METHOD FOR PHYSIOLOGIC CONTROL OF A CONTINUOUS FLOW TOTAL ARTIFICIAL HEART - A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter; (c) determining a flow rate through the first fluid circuit based on a second motor parameter; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit. | 07-08-2010 |
20100150749 | CENTRIFUGAL PUMP WITH OFFSET VOLUTE - A pump includes: (a) an elongated pump housing having first and second ends; (b) a primary impeller mounted in the housing for rotation about an axis, the impeller comprising a plurality of vanes whose outer tips define an impeller plane; (c) an inlet disposed in fluid communication with the primary impeller; and (d) an annular volute housing communicating with the primary impeller and with an outlet, where the volute housing is axially offset from the impeller plane. | 06-17-2010 |
20100112012 | MODULATION OF IMMUNE RESPONSES - Compositions and methods for modulating an NF- | 05-06-2010 |
20090292211 | Methods and Apparatus for Optical Spectroscopic Detection of Cell and Tissue Death - A method for detecting death process of a cell or tissue of a living subject. In one embodiment, the method includes the steps of illuminating the cell or tissue of the living subject with a coherent light, collecting fluorescent light returned from the illuminated cell or tissue of the living subject, identifying a NAD(P)H peak of a spectrum of the collected fluorescent light with a wavelength, λ | 11-26-2009 |