| CIS BIO INTERNATIONAL Patent applications |
| Patent application number | Title | Published |
|---|
| 20120115176 | METHOD FOR DETECTING COMPOUNDS MODULATING DIMERS OF VFT DOMAIN MEMBRANE PROTEINS - The invention relates to a method for selecting compounds having a modulating effect on the activation state of a dimer of VFT-domain proteins expressed in cell membranes present in a measuring medium, said dimer consisting of a first protein and of a second protein, said proteins being identical or different, wherein this method comprises the following steps:
| 05-10-2012 |
| 20120009599 | METHOD FOR DETECTING MEMBRANE PROTEIN INTERNALIZATION - A method for detecting the internalization of a transmembrane protein of interest expressed at the surface of a cell, comprising the following steps:
| 01-12-2012 |
| 20110236952 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF - The invention relates to compounds of formula (I′): | 09-29-2011 |
| 20100204467 | LANTHANIDE (III) ION COMPLEXING COMPOUNDS, LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS - Lanthanide (III) ion complexing compound comprising: | 08-12-2010 |
| 20100143960 | CYANINE DERIVATIVES, FLUORESCENT CONJUGATES CONTAINING SAME AND USE THEREOF - A subject matter of the invention is cyanine derivatives of formula: | 06-10-2010 |
| 20100086943 | METHOD FOR THE DETECTION OF POST-TRANSLATIONAL MODIFICATIONS - Method for the detection in homogeneous medium of a post-translational modification of a protein substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the protein substrate and a first coupling domain and in that it comprises the following stages: (v) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (vi) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the protein substrate, (vii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific to the site of the protein substrate having undergone the post-translational modification and not binding to the non-modified protein substrate, (i) Measurement of the FRET signal emitted by the sample, this signal being representative of the quantity of protein substrate having undergone said post-translational modification; and cells for the implementation of said method. | 04-08-2010 |
| 20090294691 | Method for Improving the Detection of Fluorescence Signals During a Resonance Energy Transfer - The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium. | 12-03-2009 |
